Characterization of Alisertib (MLN8237), an Investigational Small-Molecule Inhibitor of Aurora A Kinase Using Novel In Vivo Pharmacodynamic Assays
MANFREDI, Mark G, ECSEDY, Jeffrey A, WYSONG, Deborah R, JANOWICK, David A, HYER, Marc L, LEROY, Patrick J, GERSHMAN, Rachel E, SILVA, Matthew D, GERMANOS, Melissa S, BOLEN, Joseph B, CLAIBORNE, Christopher F, SELLS, Todd B, CHAKRAVARTY, Arijit, SILVERMAN, Lee, MENGKUN ZHANG, HOAR, Kara M, STROUD, Stephen G, WEI CHEN, SHINDE, Vaishali, HUCK, Jessica J
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Published in Clinical cancer research (15.12.2011)
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Discovery and optimization of pyrazolopyrimidine sulfamates as ATG7 inhibitors
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Published in Bioorganic & medicinal chemistry (01.10.2020)
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Antitumor activity of MLN8054, an orally active small-molecule inhibitor of Aurora A kinase
Manfredi, Mark G, Ecsedy, Jeffrey A, Meetze, Kristan A, Balani, Suresh K, Burenkova, Olga, Chen, Wei, Galvin, Katherine M, Hoar, Kara M, Huck, Jessica J, LeRoy, Patrick J, Ray, Emily T, Sells, Todd B, Stringer, Bradley, Stroud, Stephen G, Vos, Tricia J, Weatherhead, Gabriel S, Wysong, Deborah R, Zhang, Mengkun, Bolen, Joseph B, Claiborne, Christopher F
Published in Proceedings of the National Academy of Sciences - PNAS (06.03.2007)
Published in Proceedings of the National Academy of Sciences - PNAS (06.03.2007)
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MLN8054 and Alisertib (MLN8237): Discovery of Selective Oral Aurora A Inhibitors
Sells, Todd B., Chau, Ryan, Ecsedy, Jeffrey A., Gershman, Rachel E., Hoar, Kara, Huck, Jessica, Janowick, David A., Kadambi, Vivek J., LeRoy, Patrick J., Stirling, Matthew, Stroud, Stephen G., Vos, Tricia J., Weatherhead, Gabriel S., Wysong, Deborah R., Zhang, Mengkun, Balani, Suresh K., Bolen, Joseph B., Manfredi, Mark G., Claiborne, Christopher F.
Published in ACS medicinal chemistry letters (11.06.2015)
Published in ACS medicinal chemistry letters (11.06.2015)
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Identification of a lung cancer cell line deficient in atg7-dependent autophagy
Mandelbaum, Jonathan, Rollins, Neil, Shah, Pooja, Bowman, Doug, Lee, Janice Y, Tayber, Olga, Bernard, Hugues, LeRoy, Patrick, Li, Ping, Koenig, Erik, Brownell, James E, D'Amore, Natalie
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Genome-Wide siRNA Screen for Modulators of Cell Death Induced by Proteasome Inhibitor Bortezomib
SIQUAN CHEN, BLANK, Jonathan L, BURKHARDT, Anne L, WEI CHEN, GARCIA, Khristofer, SAPPAL, Darshan S, GRAY, Jesse, HALES, Paul, LEROY, Patrick J, RINGELING, John, RABINO, Claudia, SPELMAN, James J, PETERS, Theodore, MORGENSTERN, Jay P, LIGHTCAP, Eric S, LIU, Xiaozhen J, RAPPOLI, David M, PICKARD, Michael D, MENON, Saurabh, JIE YU, DRISCOLL, Denise L, LINGARAJ, Trupti
Published in Cancer research (Chicago, Ill.) (01.06.2010)
Published in Cancer research (Chicago, Ill.) (01.06.2010)
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Automated High-Throughput Flow Cytometry for High-Content Screening in Antibody Development
Wang, Yana, Yoshihara, Tomoki, King, Samson, Le, Tinh, Leroy, Patrick, Zhao, Xiansi, Chan, Ching Kit, Yan, Zhong-Hua, Menon, Saurabh
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Published in SLAS discovery (01.08.2018)
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Plasmodium falciparum erythrocyte membrane protein 1 is anchored to the actin–spectrin junction and knob-associated histidine-rich protein in the erythrocyte skeleton
Oh, S.Steven, Voigt, Sabine, Fisher, Derek, Yi, Scott J, LeRoy, Patrick J, Derick, Laura H, Liu, Shih-Chun, Chishti, Athar H
Published in Molecular and biochemical parasitology (01.05.2000)
Published in Molecular and biochemical parasitology (01.05.2000)
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Localization of human TACC3 to mitotic spindles is mediated by phosphorylation on Ser558 by aurora A : A novel pharmacodynamic method for measuring aurora a activity
LEROY, Patrick J, HUNTER, John J, HOAR, Kara M, BURKE, Krissy E, SHINDE, Vaishali, RUAN, Jason, BOWMAN, Douglas, GALVIN, Katherine, ECSEDY, Jeffrey A
Published in Cancer research (Chicago, Ill.) (01.06.2007)
Published in Cancer research (Chicago, Ill.) (01.06.2007)
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The cytoadherence ligand Plasmodium falciparum Erythrocyte Membrane Protein 1 (PfEMP1) binds to the P. falciparum Knob-associated Histidine-rich Protein (KAHRP) by electrostatic interactions
Voigt, Sabine, Hanspal, Manjit, LeRoy, Patrick J, Zhao, Pei-shan, Oh, S.Steven, Chishti, Athar H, Liu, Shih-Chun
Published in Molecular and biochemical parasitology (01.10.2000)
Published in Molecular and biochemical parasitology (01.10.2000)
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Abstract LB-319: Establishment of automated multiplex immunofluorescence T-cell panel for baseline screening of syngeneic mouse models and evaluation of T-cell infiltration in A20 syngeneic tumors treated with TAK-981, a first-in-class SUMO inhibitor
Ghasemi, Omid, Zawadzka, Agatha, Luongo, Evan, Tse, Aimy, Chouitar, Johara, Casson, Cierra, Ganno-Sherwood, Michelle, He, Xingyue, LeRoy, Patrick, Xega, Kristina, Grossman, Stephan, Song, Keli, Berger, Allison, Galvin, Katherine, Huszar, Dennis, Shinde, Vaishali
Published in Cancer research (Chicago, Ill.) (01.07.2019)
Published in Cancer research (Chicago, Ill.) (01.07.2019)
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Abstract A41: Validated immunohistochemistry assay for measuring total Aurora A kinase protein levels in FFPE human tumors
Danaee, Hadi, Leroy, Patrick, Lichter, David I., Ecsedy, Jeffrey, Mulligan, George, Trepicchio, William L.
Published in Molecular cancer therapeutics (12.11.2011)
Published in Molecular cancer therapeutics (12.11.2011)
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Abstract A70: A genome-wide siRNA screen for modulators of cell death induced by the proteasome inhibitor bortezomib
Chen, Siquan, Blank, Jonathan L., Peters, Theodore, Liu, Jane, Rappoli, David M., Pickard, Michael D., Menon, Saurabh, Yu, Jie, Driscoll, Denise L., Lingaraj, Trupti, Burkhardt, Anne L., Chen, Wei, Sappal, Darshan S., Gray, Jesse, Garcia, Khristofer, Hales, Paul, Leroy, Patrick J., Ringeling, John, Rabino, Claudia, Spelman, James J., Morgenstern, Jay P., Lightcap, Eric S.
Published in Molecular cancer therapeutics (10.12.2009)
Published in Molecular cancer therapeutics (10.12.2009)
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