Targeted anti-mitotic therapies: can we improve on tubulin agents?
Jackson, Jeffrey R, Patrick, Denis R, Dar, Mohammed M, Huang, Pearl S
Published in Nature reviews. Cancer (01.02.2007)
Published in Nature reviews. Cancer (01.02.2007)
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Demonstration of a genetic therapeutic index for tumors expressing oncogenic BRAF by the kinase inhibitor SB-590885
KING, Alastair J, PATRICK, Denis R, HUGGER, Erin, LIFU WANG, KARRETH, Florian, LOUGHEED, Julie C, LEE, Jae, CHAU, David, STOUT, Thomas J, MAY, Earl W, ROMINGER, Cynthia M, SCHABER, Michael D, BATORSKY, Roberta S, LUSONG LUO, LAKDAWALA, Ami S, ADAMS, Jerry L, CONTRACTOR, Rooja G, SMALLEY, Keiran S. M, HERLYN, Meenhard, MORRISSEY, Michael M, TUVESON, David A, HUANG, Pearl S, HO, Maureen L, DO, Hieu T, SHU YUN ZHANG, KUMAR, Rakesh, RUSNAK, David W, TAKLE, Andrew K, WILSON, David M
Published in Cancer research (Chicago, Ill.) (01.12.2006)
Published in Cancer research (Chicago, Ill.) (01.12.2006)
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Discovery of GSK1070916, a Potent and Selective Inhibitor of Aurora B/C Kinase
Adams, Nicholas D, Adams, Jerry L, Burgess, Joelle L, Chaudhari, Amita M, Copeland, Robert A, Donatelli, Carla A, Drewry, David H, Fisher, Kelly E, Hamajima, Toshihiro, Hardwicke, Mary Ann, Huffman, William F, Koretke-Brown, Kristin K, Lai, Zhihong V, McDonald, Octerloney B, Nakamura, Hiroko, Newlander, Ken A, Oleykowski, Catherine A, Parrish, Cynthia A, Patrick, Denis R, Plant, Ramona, Sarpong, Martha A, Sasaki, Kosuke, Schmidt, Stanley J, Silva, Domingos J, Sutton, David, Tang, Jun, Thompson, Christine S, Tummino, Peter J, Wang, Jamin C, Xiang, Hong, Yang, Jingsong, Dhanak, Dashyant
Published in Journal of medicinal chemistry (27.05.2010)
Published in Journal of medicinal chemistry (27.05.2010)
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Evolutionary relationships of Aurora kinases: implications for model organism studies and the development of anti-cancer drugs
Brown, James R, Koretke, Kristin K, Birkeland, Marian L, Sanseau, Philippe, Patrick, Denis R
Published in BMC evolutionary biology (12.10.2004)
Published in BMC evolutionary biology (12.10.2004)
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Orally active 4-amino-5-diarylurea-furo[2,3- d]pyrimidine derivatives as anti-angiogenic agent inhibiting VEGFR2 and Tie-2
Miyazaki, Yasushi, Tang, Jun, Maeda, Yutaka, Nakano, Masato, Wang, Liping, Nolte, Robert T., Sato, Hideyuki, Sugai, Masaki, Okamoto, Yuji, Truesdale, Anne T., Hassler, Daniel F., Nartey, Eldridge N., Patrick, Denis R., Ho, Maureen L., Ozawa, Kazunori
Published in Bioorganic & medicinal chemistry letters (15.03.2007)
Published in Bioorganic & medicinal chemistry letters (15.03.2007)
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Immobilized metal-ion affinity chromatography of recombinant Fab protein OPG C11 in the presence of EDTA–Mg(II)
Xiang, Hui, Wynn, Richard, Nguyen, Lien-Hanh T, Ross, O.Harold, Ahrens, Douglas P, O’Neil, Karyn T, Hollis, Gregory F, Patrick, Denis R
Published in Journal of Chromatography A (29.11.2002)
Published in Journal of Chromatography A (29.11.2002)
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Transcription Factor E2F Binds DNA as a Heterodimer
Huber, Hans E., Edwards, Gwynneth, Goodhart, Paula J., Patrick, Denis R., Huang, Pearl S., Ivey-Hoyle, Mona, Barnett, Stanley F., Oliff, Allen, Heimbrook, David C.
Published in Proceedings of the National Academy of Sciences - PNAS (15.04.1993)
Published in Proceedings of the National Academy of Sciences - PNAS (15.04.1993)
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Large-scale purification of active platelet integrin glycoprotein IIb–IIIa
Hillman, Milton C, Zolotarjova, Nina I, Patrick, Denis R, McCabe, Denise D, Shen, Keqiang, Corman, Jeanne I, Billheimer, Jeffrey T, Seiffert, Dietmar A, Hollis, Gregory F, Wynn, Richard
Published in Protein expression and purification (01.08.2002)
Published in Protein expression and purification (01.08.2002)
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Resorcylic Acid Lactones. Naturally Occurring Potent and Sclective Inbibitors
ZHAO, ANNIE, LEE, SEOK H., MOIENA, MARINA, JENKINS, ROSALIND G., PATRICK, DENIS R., HUBER, HANS E., GOETZ, MICHAEL A., HENSENS, OTTO D., ZINK, DEBORAH L., VILELLA, DOLORES, DOMBROWSKI, ANNE W., LINGHAM, RUSSELL B., HUANG, LEEYUAN
Published in Journal of antibiotics (1999)
Published in Journal of antibiotics (1999)
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Resorcylic Acid Lactones: Naturally Occurring Potent and Selective Inhibitors of MEK
ZHAO, ANNIE, LEE, SEOK H., MOIENA, MARINA, JENKINS, ROSALIND G., PATRICK, DENIS R., HUBER, HANS E., GOETZ, MICHAEL A., HENSENS, OTTO D., ZINK, DEBORAH L., VILELLA, DOLORES, DOMBROWSKI, ANNE W., LINGHAM, RUSSELL B., HUANG, LEEYUAN
Published in Journal of antibiotics (01.12.1999)
Published in Journal of antibiotics (01.12.1999)
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Protein domains governing interactions between E2F, the retinoblastoma gene product, and human papillomavirus type 16 E7 protein
HUANG, P. S, PATRICK, D. R, EDWARDS, G, GOODHARDT, P. J, HUBER, H. E, MILES, L, GARSKY, V. M, OLIFF, A, HEIMBROOK, D. C
Published in Molecular and Cellular Biology (01.02.1993)
Published in Molecular and Cellular Biology (01.02.1993)
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Identification of HPV-16 E7 peptides that are potent antagonists of E7 binding to the retinoblastoma suppressor protein
JONES, R. E, WEGRZYN, R. J, PATRICK, D. R, BALISHIN, N. L, VUOCOLO, G. A, RIEMEN, M. W, DEFEO-JONES, D, GARSKY, V. M, HEIMBROOK, D. C, OLIFF, A
Published in The Journal of biological chemistry (05.08.1990)
Published in The Journal of biological chemistry (05.08.1990)
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Transforming Growth Factor α-Pseudomonas Exotoxin Fusion Protein Prolongs Survival of Nude Mice Bearing Tumor Xenografts
Heimbrook, David C., Stirdivant, Steven M., Ahern, Janet D., Balishin, Nancy L., Patrick, Denis R., Edwards, Gwynneth M., Defeo-Jones, Deborah, FitzGerald, David J., Pastan, Ira, Oliff, Allen
Published in Proceedings of the National Academy of Sciences - PNAS (01.06.1990)
Published in Proceedings of the National Academy of Sciences - PNAS (01.06.1990)
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Characterization of functional HPV-16 E7 protein produced in Escherichia coli
Patrick, D R, Zhang, K, Defeo-Jones, D, Vuocolo, G R, Maigetter, R Z, Sardana, M K, Oliff, A, Heimbrook, D C
Published in The Journal of biological chemistry (05.04.1992)
Published in The Journal of biological chemistry (05.04.1992)
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Protein Domains Governing Interactions Between E2F, the Retinoblastoma Gene Product, and Human Papillomavirus type 16 E7 Protein
Huang, Pearl S., Patrick, Denis R., Edwards, Gwynneth, Goodhart, Paula J., Huber, Hans E., Miles, Lynette, Garsky, Victor M., Oliff, Allen, Heimbrook, David C.
Published in Molecular and cellular biology (01.02.1993)
Published in Molecular and cellular biology (01.02.1993)
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Human Papillomavirus Type 16 E7 Protein Inhibits DNA Binding by the Retinoblastoma Gene Product
Stirdivant, Steven M., Huber, Hans E., Patrick, Denis R., Defeo-Jones, Deborah, Mcavoy, Elizabeth M., Garsky, Victor M., Oliff, Allen, Heimbrook, David C.
Published in Molecular and cellular biology (01.05.1992)
Published in Molecular and cellular biology (01.05.1992)
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