Targeting pleckstrin-2/Akt signaling reduces proliferation in myeloproliferative neoplasm models
Han, Xu, Mei, Yang, Mishra, Rama K, Bi, Honghao, Jain, Atul D, Schiltz, Gary E, Zhao, Baobing, Sukhanova, Madina, Wang, Pan, Grigorescu, Arabela A, Weber, Patricia C, Piwinski, John J, Prado, Miguel A, Paulo, Joao A, Stephens, Len, Anderson, Karen E, Abrams, Charles S, Yang, Jing, Ji, Peng
Published in The Journal of clinical investigation (15.03.2023)
Published in The Journal of clinical investigation (15.03.2023)
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Crystal structures of catalytic complexes of the oxidative DNA/RNA repair enzyme AlkB
Hunt, John F, Yu, Bomina, Edstrom, William C, Benach, Jordi, Hamuro, Yoshitomo, Weber, Patricia C, Gibney, Brian R
Published in Nature (16.02.2006)
Published in Nature (16.02.2006)
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Applications of calorimetric methods to drug discovery and the study of protein interactions
Weber, Patricia C, Salemme, F Raymond
Published in Current opinion in structural biology (01.02.2003)
Published in Current opinion in structural biology (01.02.2003)
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Structures of a minimal human CFTR first nucleotide-binding domain as a monomer, head-to-tail homodimer, and pathogenic mutant
Atwell, Shane, Brouillette, Christie G., Conners, Kris, Emtage, Spencer, Gheyi, Tarun, Guggino, William B., Hendle, Jorg, Hunt, John F., Lewis, Hal A., Lu, Frances, Protasevich, Irina I., Rodgers, Logan A., Romero, Rich, Wasserman, Stephen R., Weber, Patricia C., Wetmore, Diana, Zhang, Feiyu F., Zhao, Xun
Published in Protein engineering, design and selection (01.05.2010)
Published in Protein engineering, design and selection (01.05.2010)
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Microwave‐enhanced enzyme reaction for protein mapping by mass spectrometry: A new approach to protein digestion in minutes
Pramanik, Birendra N., Mirza, Urooj A., Ing, Yao Hain, Liu, Yan‐Hui, Bartner, Peter L., Weber, Patricia C., Bose, Ajay K.
Published in Protein science (01.11.2002)
Published in Protein science (01.11.2002)
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Discovery of the HCV NS3/4A Protease Inhibitor (1R,5S)-N-[3-Amino-1-(cyclobutylmethyl)-2,3-dioxopropyl]-3- [2(S)-[[[(1,1-dimethylethyl)amino]carbonyl]amino]-3,3-dimethyl-1-oxobutyl]- 6,6-dimethyl-3-azabicyclo[3.1.0]hexan-2(S)-carboxamide (Sch 503034) II. Key Steps in Structure-Based Optimization
Prongay, Andrew J, Guo, Zhuyan, Yao, Nanhua, Pichardo, John, Fischmann, Thierry, Strickland, Corey, Myers, Joseph, Weber, Patricia C, Beyer, Brian M, Ingram, Richard, Hong, Zhi, Prosise, Winifred W, Ramanathan, Lata, Taremi, S. Shane, Yarosh-Tomaine, Taisa, Zhang, Rumin, Senior, Mary, Yang, Rong-Sheng, Malcolm, Bruce, Arasappan, Ashok, Bennett, Frank, Bogen, Stephane L, Chen, Kevin, Jao, Edwin, Liu, Yi-Tsung, Lovey, Raymond G, Saksena, Anil K, Venkatraman, Srikanth, Girijavallabhan, Viyyoor, Njoroge, F. George, Madison, Vincent
Published in Journal of medicinal chemistry (17.05.2007)
Published in Journal of medicinal chemistry (17.05.2007)
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Journal Article
Structure of the hepatitis C virus RNA helicase domain
Yao, N, Hesson, T, Cable, M, Hong, Z, Kwong, A D, Le, H V, Weber, P C
Published in Nature structural biology (01.06.1997)
Published in Nature structural biology (01.06.1997)
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Journal Article
Structure-based design of selective, orally available salt-inducible kinase inhibitors that stimulate bone formation in mice
Sato, Tadatoshi, Andrade, Christian D Castro, Yoon, Sung-Hee, Zhao, Yingshe, Greenlee, William J, Weber, Patricia C, Viswanathan, Usha, Kulp, John, Brooks, Daniel J, Demay, Marie B, Bouxsein, Mary L, Mitlak, Bruce, Lanske, Beate, Wein, Marc N
Published in Proceedings of the National Academy of Sciences - PNAS (13.12.2022)
Published in Proceedings of the National Academy of Sciences - PNAS (13.12.2022)
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Structural characterization of nitric oxide synthase isoforms reveals striking active-site conservation
Fischmann, Thierry O, Hruza, Alan, Niu, Xiao Da, Fossetta, James D, Lunn, Charles A, Dolphin, Edward, Prongay, Andrew J, Reichert, Paul, Lundell, Daniel J, Narula, Satwant K, Weber, Patricia C
Published in Nature structural biology (01.03.1999)
Published in Nature structural biology (01.03.1999)
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Conserved C-Terminal Threonine of Hepatitis C Virus NS3 Regulates Autoproteolysis and Prevents Product Inhibition
Wang, Wenyan, Lahser, Frederick C, Yi, MinKyung, Wright-Minogue, Jacquelyn, Xia, Ellen, Weber, Patricia C, Lemon, Stanley M, Malcolm, Bruce A
Published in Journal of Virology (01.01.2004)
Published in Journal of Virology (01.01.2004)
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Protein Farnesyltransferase Inhibitors Exhibit Potent Antimalarial Activity
Nallan, Laxman, Bauer, Kevin D, Bendale, Pravin, Rivas, Kasey, Yokoyama, Kohei, Hornéy, Carolyn P, Pendyala, Prakash Rao, Floyd, David, Lombardo, Louis J, Williams, David K, Hamilton, Andrew, Sebti, Said, Windsor, William T, Weber, Patricia C, Buckner, Frederick S, Chakrabarti, Debopam, Gelb, Michael H, Van Voorhis, Wesley C
Published in Journal of medicinal chemistry (02.06.2005)
Published in Journal of medicinal chemistry (02.06.2005)
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Serine Protease of Hepatitis C Virus Expressed in Insect Cells as the NS3/4A Complex
Sali, Dasa Lipovsek, Ingram, Richard, Wendel, Michele, Gupta, Divya, McNemar, Charles, Tsarbopoulos, Anthony, Chen, Janice W, Hong, Zhi, Chase, Robert, Risano, Christine, Zhang, Rumin, Yao, Nanhua, Kwong, Ann D, Ramanathan, Lata, Le, Hung V, Weber, Patricia C
Published in Biochemistry (Easton) (10.03.1998)
Published in Biochemistry (Easton) (10.03.1998)
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Thermodynamic and Structural Analysis of Phosphotyrosine Polypeptide Binding to Grb2-SH2
McNemar, Charles, Snow, Mark E, Windsor, William T, Prongay, Andrew, Mui, Philip, Zhang, Rumin, Durkin, James, Le, Hung V, Weber, Patricia C
Published in Biochemistry (Easton) (19.08.1997)
Published in Biochemistry (Easton) (19.08.1997)
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Crystal Structure of Farnesyl Protein Transferase Complexed with a CaaX Peptide and Farnesyl Diphosphate Analogue
Strickland, Corey L, Windsor, William T, Syto, Rosalinda, Wang, Lynn, Bond, Richard, Wu, Zhen, Schwartz, Jeffrey, Le, Hung V, Beese, Lorena S, Weber, Patricia C
Published in Biochemistry (Easton) (24.11.1998)
Published in Biochemistry (Easton) (24.11.1998)
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Protein Crystal Growth in Microgravity
DeLucas, Lawrence J., Smith, Craig D., Smith, H. Wilson, Vijay-Kumar, Senadhi, Senadhi, Shobha E., Ealick, Steven E., Carter, Daniel C., Snyder, Robert S., Weber, Patricia C., Salemme, F. Raymond, Ohlendorf, D. H., Einspahr, H. M., Clancy, L. L., Navia, Manuel A., McKeever, Brian M., Nagabhushan, T. L., Nelson, George, McPherson, A., Koszelak, S., Taylor, G., Stammers, D., Powell, K., Darby, G., Bugg, Charles E.
Published in Science (American Association for the Advancement of Science) (03.11.1989)
Published in Science (American Association for the Advancement of Science) (03.11.1989)
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Crystal structure of the RNA-dependent RNA polymerase from hepatitis C virus reveals a fully encircled active site
Weber, Patricia C, Lesburg, Charles A, Cable, Michael B, Ferrari, Eric, Hong, Zhi, Mannarino, Anthony F
Published in Nature structural biology (01.10.1999)
Published in Nature structural biology (01.10.1999)
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Rational Design of Potent, Bioavailable, Nonpeptide Cyclic Ureas as HIV Protease Inhibitors
Patrick Y. S. Lam, Jahdav, Prabhakar K., Eyermann, Charles J., Hodge, C. Nicholas, Ru, Yu, Bacheler, Lee T., Meek, James L., Otto, Michael J., Rayner, Marlene M., Wong, Y. Nancy, Chang, Chong-Hwan, Weber, Patricia C., Jackson, David A., Sharpe, Thomas R., Erickson-Viitanen, Susan
Published in Science (American Association for the Advancement of Science) (21.01.1994)
Published in Science (American Association for the Advancement of Science) (21.01.1994)
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