Discovery of LFF571: An Investigational Agent for Clostridium difficile Infection
LaMarche, Matthew J, Leeds, Jennifer A, Amaral, Adam, Brewer, Jason T, Bushell, Simon M, Deng, Gejing, Dewhurst, Janetta M, Ding, Jian, Dzink-Fox, JoAnne, Gamber, Gabriel, Jain, Akash, Lee, Kwangho, Lee, Lac, Lister, Troy, McKenney, David, Mullin, Steve, Osborne, Colin, Palestrant, Deborah, Patane, Michael A, Rann, Elin M, Sachdeva, Meena, Shao, Jian, Tiamfook, Stacey, Trzasko, Anna, Whitehead, Lewis, Yifru, Aregahegn, Yu, Donghui, Yan, Wanlin, Zhu, Qingming
Published in Journal of medicinal chemistry (08.03.2012)
Published in Journal of medicinal chemistry (08.03.2012)
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Journal Article
ACE2 X-Ray Structures Reveal a Large Hinge-bending Motion Important for Inhibitor Binding and Catalysis
Towler, Paul, Staker, Bart, Prasad, Sridhar G., Menon, Saurabh, Tang, Jin, Parsons, Thomas, Ryan, Dominic, Fisher, Martin, Williams, David, Dales, Natalie A., Patane, Michael A., Pantoliano, Michael W.
Published in Journal of molecular biology (23.04.2004)
Published in Journal of molecular biology (23.04.2004)
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Journal Article
Evaluation of Dexamethasone Phosphate Delivered by Ocular Iontophoresis for Treating Noninfectious Anterior Uveitis
Cohen, Amy E., MS, Assang, Carol, BA, Patane, Michael A., PhD, From, Stephen, BS, CA, Korenfeld, Michael, MD
Published in Ophthalmology (Rochester, Minn.) (2012)
Published in Ophthalmology (Rochester, Minn.) (2012)
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Journal Article
Trans-scleral iontophoretic delivery of low molecular weight therapeutics
Güngör, Sevgi, Delgado-Charro, M. Begoña, Ruiz-Perez, Begoña, Schubert, William, Isom, Phil, Moslemy, Peyman, Patane, Michael A., Guy, Richard H.
Published in Journal of controlled release (15.10.2010)
Published in Journal of controlled release (15.10.2010)
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Journal Article
Antibacterial and Solubility Optimization of Thiomuracin A
LaMarche, Matthew J, Leeds, Jennifer A, Brewer, Jason, Dean, Karl, Ding, Jian, Dzink-Fox, Joanne, Gamber, Gabe, Jain, Akash, Kerrigan, Ryan, Krastel, Philipp, Lee, Kwangho, Lombardo, Franco, McKenney, David, Neckermann, Georg, Osborne, Colin, Palestrant, Deborah, Patane, Michael A, Rann, Elin M, Robinson, Zachary, Schmitt, Esther, Stams, Travis, Tiamfook, Stacey, Yu, Donghui, Whitehead, Lewis
Published in Journal of medicinal chemistry (28.07.2016)
Published in Journal of medicinal chemistry (28.07.2016)
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Journal Article
Antibiotic Optimization and Chemical Structure Stabilization of Thiomuracin A
LaMarche, Matthew J, Leeds, Jennifer A, Dzink-Fox, Joanne, Gangl, Eric, Krastel, Philipp, Neckermann, Georg, Palestrant, Deborah, Patane, Michael A, Rann, Elin M, Tiamfook, Stacey, Yu, Donghui
Published in Journal of medicinal chemistry (09.08.2012)
Published in Journal of medicinal chemistry (09.08.2012)
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Journal Article
4-Aminothiazolyl analogs of GE2270 A: Design, synthesis and evaluation of imidazole analogs
LaMarche, Matthew J., Leeds, Jennifer A., Dzink-Fox, JoAnne, Mullin, Steve, Patane, Michael A., Rann, Elin M., Tiamfook, Stacey
Published in Bioorganic & medicinal chemistry letters (01.06.2011)
Published in Bioorganic & medicinal chemistry letters (01.06.2011)
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Journal Article
Substrate-Based Design of the First Class of Angiotensin-Converting Enzyme-Related Carboxypeptidase (ACE2) Inhibitors
Dales, Natalie A, Gould, Alexandra E, Brown, James A, Calderwood, Emily F, Guan, Bing, Minor, Charles A, Gavin, James M, Hales, Paul, Kaushik, Virendar K, Stewart, Michael, Tummino, Peter J, Vickers, Chad S, Ocain, Timothy D, Patane, Michael A
Published in Journal of the American Chemical Society (09.10.2002)
Published in Journal of the American Chemical Society (09.10.2002)
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Journal Article
Addressing hERG activity while maintaining favorable potency, selectivity and pharmacokinetic properties of PPARδ modulators
Lagu, Bharat, Senaiar, Ramesh S., Kluge, Arthur F., Mallesh, B., Ramakrishna, M., Bhat, Raveendra, Patane, Michael A.
Published in Bioorganic & medicinal chemistry letters (15.02.2020)
Published in Bioorganic & medicinal chemistry letters (15.02.2020)
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Journal Article
Novel highly selective peroxisome proliferator-activated receptor δ (PPARδ) modulators with pharmacokinetic properties suitable for once-daily oral dosing
Lagu, Bharat, Kluge, Arthur F., Fredenburg, Ross A., Tozzo, Effie, Senaiar, Ramesh S., Jaleel, Mahaboobi, Panigrahi, Sunil K., Tiwari, Nirbhay K., Krishnamurthy, Narasimha R., Takahashi, Taisuke, Patane, Michael A.
Published in Bioorganic & medicinal chemistry letters (01.12.2017)
Published in Bioorganic & medicinal chemistry letters (01.12.2017)
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Journal Article
Highly selective peroxisome proliferator-activated receptor δ (PPARδ) modulator demonstrates improved safety profile compared to GW501516
Lagu, Bharat, Kluge, Arthur F., Goddeeris, Matthew M., Tozzo, Effie, Fredenburg, Ross A., Chellur, Shekar, Senaiar, Ramesh S., Jaleel, Mahaboobi, Babu, D. Ravi Krishna, Tiwari, Nirbhay K., Takahashi, Taisuke, Patane, Michael A.
Published in Bioorganic & medicinal chemistry letters (01.02.2018)
Published in Bioorganic & medicinal chemistry letters (01.02.2018)
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Journal Article
4-Aminothiazolyl Analogues of GE2270 A: Antibacterial Lead Finding
LaMarche, Matthew J, Leeds, Jennifer A, Dzink-Fox, JoAnne, Gunderson, Karl, Krastel, Philipp, Memmert, Klaus, Patane, Michael A, Rann, Elin M, Schmitt, Esther, Tiamfook, Stacey, Wang, Bing
Published in Journal of medicinal chemistry (14.04.2011)
Published in Journal of medicinal chemistry (14.04.2011)
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Journal Article
Synthesis and biological evaluation of imidazole-based small molecule antagonists of the melanocortin 4 receptor (MC4-R)
MARSILJE, Thomas H, ROSES, Jonathan B, DANIELS, J. Scott, PING LI, LIJUN WU, PATANE, Michael A, CLAIBORNE, Christopher F, CALDERWOOD, Emily F, STROUD, Stephen G, FORSYTH, Nancy E, BLACKBURN, Christopher, YOWE, David L, MIAO, Wenyan, DRABIC, Stacey V, BOHANE, Marie D
Published in Bioorganic & medicinal chemistry letters (16.07.2004)
Published in Bioorganic & medicinal chemistry letters (16.07.2004)
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Journal Article
Selective PPARδ Modulators Improve Mitochondrial Function: Potential Treatment for Duchenne Muscular Dystrophy (DMD)
Lagu, Bharat, Kluge, Arthur F, Tozzo, Effie, Fredenburg, Ross, Bell, Eric L, Goddeeris, Matthew M, Dwyer, Peter, Basinski, Andrew, Senaiar, Ramesh S, Jaleel, Mahaboobi, Tiwari, Nirbhay Kumar, Panigrahi, Sunil K, Krishnamurthy, Narasimha Rao, Takahashi, Taisuke, Patane, Michael A
Published in ACS medicinal chemistry letters (13.09.2018)
Published in ACS medicinal chemistry letters (13.09.2018)
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Journal Article
Identification and structure–activity relationships of a new series of Melanocortin-4 receptor antagonists
Vos, Tricia J., Balani, Suresh, Blackburn, Christopher, Chau, Ryan W., Danca, M. Diana, Drabic, Stacey V., Farrer, Cheryl A., Patane, Michael A., Stroud, Stephen G., Yowe, David L., Claiborne, Christopher F.
Published in Bioorganic & medicinal chemistry letters (15.04.2006)
Published in Bioorganic & medicinal chemistry letters (15.04.2006)
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Journal Article
Author Correction: Discovery of a selective catalytic p300/CBP inhibitor that targets lineage-specific tumours
Lasko, Loren M., Jakob, Clarissa G., Edalji, Rohinton P., Qiu, Wei, Montgomery, Debra, Digiammarino, Enrico L., Hansen, T. Matt, Risi, Roberto M., Frey, Robin, Manaves, Vlasios, Shaw, Bailin, Algire, Mikkel, Hessler, Paul, Lam, Lloyd T., Uziel, Tamar, Faivre, Emily, Ferguson, Debra, Buchanan, Fritz G., Martin, Ruth L., Torrent, Maricel, Chiang, Gary G., Karukurichi, Kannan, Langston, J. William, Weinert, Brian T., Choudhary, Chunaram, de Vries, Peter, Kluge, Arthur F., Patane, Michael A., Van Drie, John H., Wang, Ce, McElligott, David, Kesicki, Edward A., Marmorstein, Ronen, Sun, Chaohong, Cole, Philip A., Rosenberg, Saul H., Michaelides, Michael R., Lai, Albert, Bromberg, Kenneth D.
Published in Nature (London) (01.06.2018)
Published in Nature (London) (01.06.2018)
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Journal Article
Evaluation of ocular and general safety following repeated dosing of dexamethasone phosphate delivered by transscleral iontophoresis in rabbits
Patane, Michael A, Schubert, William, Sanford, Thomas, Gee, Raymond, Burgos, Melissa, Isom, William P, Ruiz-Perez, Begona
Published in Journal of ocular pharmacology and therapeutics (01.10.2013)
Published in Journal of ocular pharmacology and therapeutics (01.10.2013)
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Journal Article
Antibacterial Optimization of 4-Aminothiazolyl Analogues of the Natural Product GE2270 A: Identification of the Cycloalkylcarboxylic Acids
LaMarche, Matthew J, Leeds, Jennifer A, Amaral, Kerri, Brewer, Jason T, Bushell, Simon M, Dewhurst, Janetta M, Dzink-Fox, JoAnne, Gangl, Eric, Goldovitz, Julie, Jain, Akash, Mullin, Steve, Neckermann, Georg, Osborne, Colin, Palestrant, Deborah, Patane, Michael A, Rann, Elin M, Sachdeva, Meena, Shao, Jian, Tiamfook, Stacey, Whitehead, Lewis, Yu, Donghui
Published in Journal of medicinal chemistry (08.12.2011)
Published in Journal of medicinal chemistry (08.12.2011)
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Journal Article
Correction to “Selective PPARδ Modulators Improve Mitochondrial Function: Potential Treatment for Duchenne Muscular Dystrophy (DMD)”
Lagu, Bharat, Kluge, Arthur F, Tozzo, Effie, Fredenburg, Ross, Bell, Eric L, Goddeeris, Matthew M, Dwyer, Peter, Basinski, Andrew, Senaiar, Ramesh S, Jaleel, Mahaboobi, Tiwari, Nirbhay Kumar, Panigrahi, Sunil K, Krishnamurthy, Narasimha Rao, Takahashi, Taisuke, Patane, Michael A
Published in ACS medicinal chemistry letters (13.06.2019)
Published in ACS medicinal chemistry letters (13.06.2019)
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Journal Article
Ocular iontophoresis of EGP-437 (dexamethasone phosphate) in dry eye patients: results of a randomized clinical trial
Patane, Michael A, Cohen, Amy, From, Stephen, Torkildsen, Gail, Welch, Donna, Ousler, 3rd, George W
Published in Clinical ophthalmology (Auckland, N.Z.) (01.01.2011)
Published in Clinical ophthalmology (Auckland, N.Z.) (01.01.2011)
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