Safety and immunogenicity of a SARS-CoV-2 Gamma variant RBD-based protein adjuvanted vaccine used as booster in healthy adults
Pasquevich, Karina A., Coria, Lorena M., Ceballos, Ana, Mazzitelli, Bianca, Rodriguez, Juan Manuel, Demaría, Agostina, Pueblas Castro, Celeste, Bruno, Laura, Saposnik, Lucas, Salvatori, Melina, Varese, Augusto, González, Soledad, González Martínez, Veronica V., Geffner, Jorge, Álvarez, Diego, Feleder, Ethel, Halabe, Karina, Perez Lera, Pablo E., de Oca, Federico Montes, Vega, Julio C., Lombardo, Mónica, Yerino, Gustavo A., Fló, Juan, Cassataro, Juliana
Published in Nature communications (28.07.2023)
Published in Nature communications (28.07.2023)
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A Gamma-adapted subunit vaccine induces broadly neutralizing antibodies against SARS-CoV-2 variants and protects mice from infection
Coria, Lorena M., Rodriguez, Juan Manuel, Demaria, Agostina, Bruno, Laura A., Medrano, Mayra Rios, Castro, Celeste Pueblas, Castro, Eliana F., Del Priore, Sabrina A., Hernando Insua, Andres C., Kaufmann, Ingrid G., Saposnik, Lucas M., Stone, William B., Prado, Lineia, Notaro, Ulises S., Amweg, Ayelen N., Diaz, Pablo U., Avaro, Martin, Ortega, Hugo, Ceballos, Ana, Krum, Valeria, Zurvarra, Francisco M., Sidabra, Johanna E., Drehe, Ignacio, Baqué, Jonathan A., Li Causi, Mariana, De Nichilo, Analia V., Payes, Cristian J., Southard, Teresa, Vega, Julio C., Auguste, Albert J., Álvarez, Diego E., Flo, Juan M., Pasquevich, Karina A., Cassataro, Juliana
Published in Nature communications (02.02.2024)
Published in Nature communications (02.02.2024)
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A Novel Bacterial Protease Inhibitor Adjuvant in RBD-Based COVID-19 Vaccine Formulations Containing Alum Increases Neutralizing Antibodies, Specific Germinal Center B Cells and Confers Protection Against SARS-CoV-2 Infection in Mice
Coria, Lorena M, Saposnik, Lucas M, Pueblas Castro, Celeste, Castro, Eliana F, Bruno, Laura A, Stone, William B, Pérez, Paula S, Darriba, Maria Laura, Chemes, Lucia B, Alcain, Julieta, Mazzitelli, Ignacio, Varese, Augusto, Salvatori, Melina, Auguste, Albert J, Álvarez, Diego E, Pasquevich, Karina A, Cassataro, Juliana
Published in Frontiers in immunology (28.02.2022)
Published in Frontiers in immunology (28.02.2022)
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Immunization with Recombinant Brucella Species Outer Membrane Protein Omp16 or Omp19 in Adjuvant Induces Specific CD4⁺ and CD8⁺ T Cells as Well as Systemic and Oral Protection against Brucella abortus Infection
Pasquevich, Karina A, Estein, Silvia M, Samartino, Clara García, Zwerdling, Astrid, Coria, Lorena M, Barrionuevo, Paula, Fossati, Carlos A, Giambartolomei, Guillermo H, Cassataro, Juliana
Published in Infection and Immunity (01.01.2009)
Published in Infection and Immunity (01.01.2009)
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An oral vaccine based on U-Omp19 induces protection against B. abortus mucosal challenge by inducing an adaptive IL-17 immune response in mice
Pasquevich, Karina A, Ibañez, Andrés E, Coria, Lorena M, García Samartino, Clara, Estein, Silvia M, Zwerdling, Astrid, Barrionuevo, Paula, Oliveira, Fernanda S, Seither, Christine, Warzecha, Heribert, Oliveira, Sergio C, Giambartolomei, Guillermo H, Cassataro, Juliana
Published in PloS one (14.01.2011)
Published in PloS one (14.01.2011)
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Omp19 Enables Brucella abortus to Evade the Antimicrobial Activity From Host's Proteolytic Defense System
Pasquevich, Karina A, Carabajal, Marianela V, Guaimas, Francisco F, Bruno, Laura, Roset, Mara S, Coria, Lorena M, Rey Serrantes, Diego A, Comerci, Diego J, Cassataro, Juliana
Published in Frontiers in immunology (26.06.2019)
Published in Frontiers in immunology (26.06.2019)
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Depletion of dendritic cells enhances innate anti-bacterial host defense through modulation of phagocyte homeostasis
Autenrieth, Stella E, Warnke, Philipp, Wabnitz, Guido H, Lucero Estrada, Cecilia, Pasquevich, Karina A, Drechsler, Doreen, Günter, Manina, Hochweller, Kristin, Novakovic, Ana, Beer-Hammer, Sandra, Samstag, Yvonne, Hämmerling, Günter J, Garbi, Natalio, Autenrieth, Ingo B
Published in PLoS pathogens (01.02.2012)
Published in PLoS pathogens (01.02.2012)
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A disordered region retains the full protease inhibitor activity and the capacity to induce CD8+ T cells in vivo of the oral vaccine adjuvant U-Omp19
Laura Darriba, M., Castro, Celeste Pueblas, Coria, Lorena M., Bruno, Laura, Laura Cerutti, M., Otero, Lisandro H., Chemes, Lucía B., Rasia, Rodolfo M., Klinke, Sebastián, Cassataro, Juliana, Pasquevich, Karina A.
Published in Computational and structural biotechnology journal (2022)
Published in Computational and structural biotechnology journal (2022)
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Brucella abortus Inhibits Major Histocompatibility Complex Class II Expression and Antigen Processing through Interleukin-6 Secretion via Toll-Like Receptor 2
Barrionuevo, Paula, Cassataro, Juliana, Delpino, M. Victoria, Zwerdling, Astrid, Pasquevich, Karina A, Samartino, Clara García, Wallach, Jorge C, Fossati, Carlos A, Giambartolomei, Guillermo H
Published in Infection and Immunity (01.01.2008)
Published in Infection and Immunity (01.01.2008)
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Vaccination with the Recombinant Brucella Outer Membrane Protein 31 or a Derived 27-Amino-Acid Synthetic Peptide Elicits a CD4+ T Helper 1 Response That Protects against Brucella melitensis Infection
CASSATARO, Juliana, ESTEIN, Silvia M, PASQUEVICH, Karina A, VELIKOVSKY, Carlos A, DE LA BARRERA, Silvia, BOWDEN, Raul, FOSSATI, Carlos A, GIAMBARTOLOMEI, Guillermo H
Published in Infection and Immunity (01.12.2005)
Published in Infection and Immunity (01.12.2005)
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A DNA Vaccine Coding for the Brucella Outer Membrane Protein 31 Confers Protection against B. melitensis and B. ovis Infection by Eliciting a Specific Cytotoxic Response
CASSATARO, Juliana, VELIKOVSKY, Carlos A, DE LA BARRERA, Silvia, ESTEIN, Silvia M, BRUNO, Laura, BOWDEN, Raul, PASQUEVICH, Karina A, FOSSATI, Carlos A, GIAMBARTOLOMEI, Guillermo H
Published in Infection and Immunity (01.10.2005)
Published in Infection and Immunity (01.10.2005)
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Unlipidated outer membrane protein Omp16 (U-Omp16) from Brucella spp. as nasal adjuvant induces a Th1 immune response and modulates the Th2 allergic response to cow's milk proteins
Ibañez, Andrés E, Smaldini, Paola, Coria, Lorena M, Delpino, María V, Pacífico, Lucila G G, Oliveira, Sergio C, Risso, Gabriela S, Pasquevich, Karina A, Fossati, Carlos Alberto, Giambartolomei, Guillermo H, Docena, Guillermo H, Cassataro, Juliana
Published in PloS one (05.07.2013)
Published in PloS one (05.07.2013)
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Stability Studies of the Vaccine Adjuvant U-Omp19
Darriba, M. Laura, Cerutti, María L., Bruno, Laura, Cassataro, Juliana, Pasquevich, Karina A.
Published in Journal of pharmaceutical sciences (01.02.2021)
Published in Journal of pharmaceutical sciences (01.02.2021)
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Journal Article
U-Omp19 from Brucella abortus increases dmLT immunogenicity and improves protection against Escherichia coli heat-labile toxin (LT) oral challenge
Coria, Lorena M., Martinez, Franco L., Bruno, Laura A., Pasquevich, Karina A., Cassataro, Juliana
Published in Vaccine (06.07.2020)
Published in Vaccine (06.07.2020)
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Oral co-administration of a bacterial protease inhibitor in the vaccine formulation increases antigen delivery at the intestinal epithelial barrier
Coria, Lorena M., Risso, Gabriela S., Guaimas, Francisco F., Ferrero, Mariana C., Bruno, Laura, Pasquevich, Karina A., Cassataro, Juliana
Published in Journal of controlled release (10.01.2019)
Published in Journal of controlled release (10.01.2019)
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Journal Article
A Brucella spp. Protease Inhibitor Limits Antigen Lysosomal Proteolysis, Increases Cross-Presentation, and Enhances CD8+ T Cell Responses
Coria, Lorena M, Ibañez, Andrés E, Tkach, Mercedes, Sabbione, Florencia, Bruno, Laura, Carabajal, Marianela V, Berguer, Paula M, Barrionuevo, Paula, Schillaci, Roxana, Trevani, Analía S, Giambartolomei, Guillermo H, Pasquevich, Karina A, Cassataro, Juliana
Published in The Journal of immunology (1950) (15.05.2016)
Published in The Journal of immunology (1950) (15.05.2016)
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RomA, A Periplasmic Protein Involved in the Synthesis of the Lipopolysaccharide, Tunes Down the Inflammatory Response Triggered by Brucella
Valguarnera, Ezequiel, Spera, Juan M, Czibener, Cecilia, Fulgenzi, Fabiana R, Casabuono, Adriana C, Altabe, Silvia G, Pasquevich, Karina A, Guaimas, Francisco, Cassataro, Juliana, Couto, Alicia S, Ugalde, Juan E
Published in The Journal of infectious diseases (28.03.2018)
Published in The Journal of infectious diseases (28.03.2018)
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Innate immune system favors emergency monopoiesis at the expense of DC‐differentiation to control systemic bacterial infection in mice
Pasquevich, Karina A., Bieber, Kristin, Günter, Manina, Grauer, Matthias, Pötz, Oliver, Schleicher, Ulrike, Biedermann, Tilo, Beer‐Hammer, Sandra, Bühring, Hans‐Jörg, Rammensee, Hans‐Georg, Zender, Lars, Autenrieth, Ingo B., Lengerke, Claudia, Autenrieth, Stella E.
Published in European journal of immunology (01.10.2015)
Published in European journal of immunology (01.10.2015)
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The protein moiety of Brucella abortus outer membrane protein 16 is a new bacterial pathogen-associated molecular pattern that activates dendritic cells in vivo, induces a Th1 immune response, and is a promising self-adjuvanting vaccine against systemic and oral acquired brucellosis
Pasquevich, Karina A, García Samartino, Clara, Coria, Lorena M, Estein, Silvia M, Zwerdling, Astrid, Ibañez, Andrés E, Barrionuevo, Paula, Oliveira, Fernanda Souza de, Carvalho, Natalia Barbosa, Borkowski, Julia, Oliveira, Sergio Costa, Warzecha, Heribert, Giambartolomei, Guillermo H, Cassataro, Juliana
Published in The Journal of immunology (1950) (01.05.2010)
Published in The Journal of immunology (1950) (01.05.2010)
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