Demonstrating In-Cell Target Engagement Using a Pirin Protein Degradation Probe (CCT367766)
Chessum, Nicola E. A, Sharp, Swee Y, Caldwell, John J, Pasqua, A. Elisa, Wilding, Birgit, Colombano, Giampiero, Collins, Ian, Ozer, Bugra, Richards, Meirion, Rowlands, Martin, Stubbs, Mark, Burke, Rosemary, McAndrew, P. Craig, Clarke, Paul A, Workman, Paul, Cheeseman, Matthew D, Jones, Keith
Published in Journal of medicinal chemistry (08.02.2018)
Published in Journal of medicinal chemistry (08.02.2018)
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Journal Article
HSF1 Pathway Inhibitor Clinical Candidate (CCT361814/NXP800) Developed from a Phenotypic Screen as a Potential Treatment for Refractory Ovarian Cancer and Other Malignancies
Pasqua, A. Elisa, Sharp, Swee Y., Chessum, Nicola E. A., Hayes, Angela, Pellegrino, Loredana, Tucker, Michael J., Miah, Asadh, Wilding, Birgit, Evans, Lindsay E., Rye, Carl S., Mok, N. Yi, Liu, Manjuan, Henley, Alan T., Gowan, Sharon, De Billy, Emmanuel, te Poele, Robert, Powers, Marissa, Eccles, Suzanne A., Clarke, Paul A., Raynaud, Florence I., Workman, Paul, Jones, Keith, Cheeseman, Matthew D.
Published in Journal of medicinal chemistry (27.04.2023)
Published in Journal of medicinal chemistry (27.04.2023)
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Investigating the phosphinic acid tripeptide mimetic DG013A as a tool compound inhibitor of the M1-aminopeptidase ERAP1
Wilding, Birgit, Pasqua, A. Elisa, E. A. Chessum, Nicola, Pierrat, Olivier A., Hahner, Tamas, Tomlin, Kathy, Shehu, Erald, Burke, Rosemary, Richards, G. Meirion, Whitton, Bradleigh, Arwert, Esther N., Thapaliya, Arjun, Salimraj, Ramya, van Montfort, Rob, Skawinska, Agi, Hayes, Angela, Raynaud, Florence, Chopra, Rajesh, Jones, Keith, Newton, Gary, Cheeseman, Matthew D.
Published in Bioorganic & medicinal chemistry letters (15.06.2021)
Published in Bioorganic & medicinal chemistry letters (15.06.2021)
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Discovery of a Chemical Probe Bisamide (CCT251236): An Orally Bioavailable Efficacious Pirin Ligand from a Heat Shock Transcription Factor 1 (HSF1) Phenotypic Screen
Cheeseman, Matthew D, Chessum, Nicola E. A, Rye, Carl S, Pasqua, A. Elisa, Tucker, Michael J, Wilding, Birgit, Evans, Lindsay E, Lepri, Susan, Richards, Meirion, Sharp, Swee Y, Ali, Salyha, Rowlands, Martin, O’Fee, Lisa, Miah, Asadh, Hayes, Angela, Henley, Alan T, Powers, Marissa, te Poele, Robert, De Billy, Emmanuel, Pellegrino, Loredana, Raynaud, Florence, Burke, Rosemary, van Montfort, Rob L. M, Eccles, Suzanne A, Workman, Paul, Jones, Keith
Published in Journal of medicinal chemistry (12.01.2017)
Published in Journal of medicinal chemistry (12.01.2017)
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Privileged Structures and Polypharmacology within and between Protein Families
Meyers, Joshua, Chessum, Nicola E. A, Ali, Salyha, Mok, N. Yi, Wilding, Birgit, Pasqua, A. Elisa, Rowlands, Martin, Tucker, Michael J, Evans, Lindsay E, Rye, Carl S, O’Fee, Lisa, Le Bihan, Yann-Vaï, Burke, Rosemary, Carter, Michael, Workman, Paul, Blagg, Julian, Brown, Nathan, van Montfort, Rob L. M, Jones, Keith, Cheeseman, Matthew D
Published in ACS medicinal chemistry letters (13.12.2018)
Published in ACS medicinal chemistry letters (13.12.2018)
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Abstract 2976: Confirmation of in-cell target engagement using the proteolysis targeting chimeras (PROTACs) against pirin
Sharp, Swee Y., Chessum, Nicola E., Caldwell, John J., Powers, Marissa V., Pasqua, A Elisa, Wilding, Birgit, Collins, Ian, Ozer, Bugra, Rowlands, Martin, Stubbs, Mark, Burke, Rosemary, Montfort, Rob L. van, Cheeseman, Matthew D., Clarke, Paul A., Workman, Paul, Jones, Keith
Published in Cancer research (Chicago, Ill.) (01.07.2018)
Published in Cancer research (Chicago, Ill.) (01.07.2018)
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Abstract LB-304: Discovery of chemical probe CCT251236: An orally bioavailable efficacious pirin ligand from an HSF1 phenotypic screen
Cheeseman, Matthew D., Chessum, Nicola E., Rye, Carl S., Pasqua, Elisa A., Tucker, Michael J., Wilding, Birgit, Evans, Lindsay E., Lepri, Susan, Richards, Meirion, Sharp, Swee Y., Ali, Salyha, Rowlands, Martin, O'Fee, Lisa, Miah, Asadh, Hayes, Angela, Henley, Alan T., Powers, Marissa, Poele, Robert te, Billy, Emmanuel De, Pellegrino, Loredana, Raynaud, Florence, Burke, Rosemary, Montfort, Robert L. van, Eccles, Suzanne A., Jones, Keith, Workman, Paul
Published in Cancer research (Chicago, Ill.) (01.07.2017)
Published in Cancer research (Chicago, Ill.) (01.07.2017)
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