Intracrine Regulation of Estrogen and Other Sex Steroid Levels in Endometrium and Non-gynecological Tissues; Pathology, Physiology, and Drug Discovery
Konings, Gonda, Brentjens, Linda, Delvoux, Bert, Linnanen, Tero, Cornel, Karlijn, Koskimies, Pasi, Bongers, Marlies, Kruitwagen, Roy, Xanthoulea, Sofia, Romano, Andrea
Published in Frontiers in pharmacology (19.09.2018)
Published in Frontiers in pharmacology (19.09.2018)
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Overexpression of Human Estrogen Biosynthetic Enzyme Hydroxysteroid (17beta) Dehydrogenase Type 1 Induces Adenomyosis-like Phenotype in Transgenic Mice
Heinosalo, Taija, Rytkönen, Kalle T, Saarinen, Niina, Järvensivu, Päivi, Damdimopoulou, Pauliina, Strauss, Leena, Orasniemi, Satu, Horshauge, Petricia, Gabriel, Michael, Koskimies, Pasi, Ohlsson, Claes, Kronqvist, Pauliina, Poutanen, Matti
Published in International journal of molecular sciences (27.04.2022)
Published in International journal of molecular sciences (27.04.2022)
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Blocking oestradiol synthesis pathways with potent and selective coumarin derivatives
Niinivehmas, Sanna, Postila, Pekka A., Rauhamäki, Sanna, Manivannan, Elangovan, Kortet, Sami, Ahinko, Mira, Huuskonen, Pasi, Nyberg, Niina, Koskimies, Pasi, Lätti, Sakari, Multamäki, Elina, Juvonen, Risto O., Raunio, Hannu, Pasanen, Markku, Huuskonen, Juhani, Pentikäinen, Olli T.
Published in Journal of enzyme inhibition and medicinal chemistry (01.01.2018)
Published in Journal of enzyme inhibition and medicinal chemistry (01.01.2018)
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Structure-Activity Relationship Analysis of 3-Phenylcoumarin-Based Monoamine Oxidase B Inhibitors
Rauhamäki, Sanna, Postila, Pekka A, Niinivehmas, Sanna, Kortet, Sami, Schildt, Emmi, Pasanen, Mira, Manivannan, Elangovan, Ahinko, Mira, Koskimies, Pasi, Nyberg, Niina, Huuskonen, Pasi, Multamäki, Elina, Pasanen, Markku, Juvonen, Risto O, Raunio, Hannu, Huuskonen, Juhani, Pentikäinen, Olli T
Published in Frontiers in chemistry (02.03.2018)
Published in Frontiers in chemistry (02.03.2018)
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Development of an Image-Guided Orthotopic Xenograft Mouse Model of Endometrial Cancer with Controllable Estrogen Exposure
Konings, Gonda Fj, Saarinen, Niina, Delvoux, Bert, Kooreman, Loes, Koskimies, Pasi, Krakstad, Camilla, Fasmer, Kristine E, Haldorsen, Ingfrid S, Zaffagnini, Amina, Häkkinen, Merja R, Auriola, Seppo, Dubois, Ludwig, Lieuwes, Natasja, Verhaegen, Frank, Schyns, Lotte Ejr, Kruitwagen, Roy Fpm, Xanthoulea, Sofia, Romano, Andrea
Published in International journal of molecular sciences (28.08.2018)
Published in International journal of molecular sciences (28.08.2018)
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Screening of some anti-androgenic endocrine disruptors using a recombinant cell-based in vitro bioassay
Roy, Partha, Salminen, Heli, Koskimies, Pasi, Simola, Janne, Smeds, Annika, Saukko, Pekka, Huhtaniemi, Ilpo T
Published in The Journal of steroid biochemistry and molecular biology (01.02.2004)
Published in The Journal of steroid biochemistry and molecular biology (01.02.2004)
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Serum hydroxysteroid (17beta) dehydrogenase 1 concentration in pregnant women correlates with pregnancy-associated plasma protein A but does not serve as an independent marker for preeclampsia
Heinosalo, Taija, Saarinen, Niina, Biehl, Alexander, Rytkönen, Kalle T, Villa, Pia M, Juhila, Juuso, Koskimies, Pasi, Laiho, Asta, Hämäläinen, Esa, Kajantie, Eero, Räikkönen, Katri, Elo, Laura L, Laivuori, Hannele, Poutanen, Matti
Published in Biology of reproduction (15.08.2024)
Published in Biology of reproduction (15.08.2024)
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Abstract 2931: Pharmacological inhibition of 17β-hydroxysteroid dehydrogenase impairs endometrial cancer growth in an orthotopic xenograft mouse model
Xanthoulea, Sofia, Konings, Gonda, Saarinen, Niina, Delvoux, Bert, Kooreman, Loes, Koskimies, Pasi, Häkkinen, Merja, Auriola, Seppo, d'Avanzo, Elisabetta, Walid, Youssef, Verhaegen, Frank, Lieuwes, Natasja, Caiment, Florian, Kruitwagen, Roy, Romano, Andrea
Published in Cancer research (Chicago, Ill.) (01.07.2021)
Published in Cancer research (Chicago, Ill.) (01.07.2021)
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Inhibition of Type 1 17β-Hydroxysteroid Dehydrogenase Impairs the Synthesis of 17β-Estradiol in Endometriosis Lesions
Delvoux, Bert, D'Hooghe, Thomas, Kyama, Cleophas, Koskimies, Pasi, Hermans, Rob J. J, Dunselman, Gerard A, Romano, Andrea
Published in The journal of clinical endocrinology and metabolism (01.01.2014)
Published in The journal of clinical endocrinology and metabolism (01.01.2014)
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Pharmacological inhibition of 17β-hydroxysteroid dehydrogenase impairs human endometrial cancer growth in an orthotopic xenograft mouse model
Xanthoulea, Sofia, Konings, Gonda F.J., Saarinen, Niina, Delvoux, Bert, Kooreman, Loes F.S., Koskimies, Pasi, Häkkinen, Merja R., Auriola, Seppo, D'Avanzo, Elisabetta, Walid, Youssef, Verhaegen, Frank, Lieuwes, Natasja G., Caiment, Florian, Kruitwagen, Roy, Romano, Andrea
Published in Cancer letters (28.06.2021)
Published in Cancer letters (28.06.2021)
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HSD17B1 expression enhances estrogen signaling stimulated by the low active estrone, evidenced by an estrogen responsive element-driven reporter gene in vivo
Järvensivu, Päivi, Saloniemi-Heinonen, Taija, Awosanya, Michael, Koskimies, Pasi, Saarinen, Niina, Poutanen, Matti
Published in Chemico-biological interactions (05.06.2015)
Published in Chemico-biological interactions (05.06.2015)
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Blocking 17β‐hydroxysteroid dehydrogenase type 1 in endometrial cancer: a potential novel endocrine therapeutic approach
Konings, Gonda FJ, Cornel, Karlijn MC, Xanthoulea, Sofia, Delvoux, Bert, Skowron, Margaretha A, Kooreman, Loes, Koskimies, Pasi, Krakstad, Camilla, Salvesen, Helga B, van Kuijk, Kim, Schrooders, Yannick JM, Vooijs, Marc, Groot, Arjan J, Bongers, Marlies Y, Kruitwagen, Roy FPM, Romano, Andrea
Published in The Journal of pathology (01.02.2018)
Published in The Journal of pathology (01.02.2018)
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Single-dose and steady-state pharmacokinetics of ospemifene, a selective estrogen receptor modulator, in postmenopausal women
Koskimies, Pasi, Turunen, Jari, Lammintausta, Risto, Scheinin, Mika
Published in International journal of clinical pharmacology and therapeutics (01.11.2013)
Published in International journal of clinical pharmacology and therapeutics (01.11.2013)
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Blocking 17[beta]-hydroxysteroid dehydrogenase type 1 in endometrial cancer: a potential novel endocrine therapeutic approach
Konings, Gonda FJ, Cornel, Karlijn MC, Xanthoulea, Sofia, Delvoux, Bert, Skowron, Margaretha A, Kooreman, Loes, Koskimies, Pasi, Krakstad, Camilla, Salvesen, Helga B, van Kuijk, Kim, Schrooders, Yannick JM, Vooijs, Marc, Groot, Arjan J, Bongers, Marlies Y, Kruitwagen, Roy FPM, Romano, Andrea
Published in The Journal of pathology (01.02.2018)
Published in The Journal of pathology (01.02.2018)
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Synthesis and Biological Evaluation of 17β-Hydroxysteroid Dehydrogenase Type 1 (17β-HSD1) Inhibitors Based on a Thieno[2,3-d]pyrimidin-4(3H)-one Core
Lilienkampf, Annamaria, Karkola, Sampo, Alho-Richmond, Sari, Koskimies, Pasi, Johansson, Nina, Huhtinen, Kaisa, Vihko, Kimmo, Wähälä, Kristiina
Published in Journal of medicinal chemistry (12.11.2009)
Published in Journal of medicinal chemistry (12.11.2009)
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Novel Hydroxysteroid (17β) Dehydrogenase 1 Inhibitors Reverse Estrogen-Induced Endometrial Hyperplasia in Transgenic Mice
Saloniemi, Taija, Järvensivu, Päivi, Koskimies, Pasi, Jokela, Heli, Lamminen, Tarja, Ghaem-Maghami, Sadaf, Dina, Roberto, Damdimopoulou, Pauliina, Mäkelä, Sari, Perheentupa, Antti, Kujari, Harry, Brosens, Jan, Poutanen, Matti
Published in The American journal of pathology (01.03.2010)
Published in The American journal of pathology (01.03.2010)
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