Cdc-Like Kinases (CLKs): Biology, Chemical Probes, and Therapeutic Potential
Martín Moyano, Paula, Němec, Václav, Paruch, Kamil
Published in International journal of molecular sciences (13.10.2020)
Published in International journal of molecular sciences (13.10.2020)
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Dinaciclib (SCH 727965), a novel and potent cyclin-dependent kinase inhibitor
Parry, David, Guzi, Timothy, Shanahan, Frances, Davis, Nicole, Prabhavalkar, Deepa, Wiswell, Derek, Seghezzi, Wolfgang, Paruch, Kamil, Dwyer, Michael P, Doll, Ronald, Nomeir, Amin, Windsor, William, Fischmann, Thierry, Wang, Yaolin, Oft, Martin, Chen, Taiying, Kirschmeier, Paul, Lees, Emma M
Published in Molecular cancer therapeutics (01.08.2010)
Published in Molecular cancer therapeutics (01.08.2010)
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Impact of the access tunnel engineering on catalysis is strictly ligand‐specific
Kaushik, Shubhangi, Marques, Sérgio M., Khirsariya, Prashant, Paruch, Kamil, Libichova, Lenka, Brezovsky, Jan, Prokop, Zbynek, Chaloupkova, Radka, Damborsky, Jiri
Published in The FEBS journal (01.04.2018)
Published in The FEBS journal (01.04.2018)
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BRCA1 or CDK12 loss sensitizes cells to CHK1 inhibitors
Paculová, Hana, Kramara, Juraj, Šimečková, Šárka, Fedr, Radek, Souček, Karel, Hylse, Ondřej, Paruch, Kamil, Svoboda, Marek, Mistrík, Martin, Kohoutek, Jiří
Published in Tumor biology (01.10.2017)
Published in Tumor biology (01.10.2017)
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Targeting the replication checkpoint using SCH 900776, a potent and functionally selective CHK1 inhibitor identified via high content screening
Guzi, Timothy J, Paruch, Kamil, Dwyer, Michael P, Labroli, Marc, Shanahan, Frances, Davis, Nicole, Taricani, Lorena, Wiswell, Derek, Seghezzi, Wolfgang, Penaflor, Ervin, Bhagwat, Bhagyashree, Wang, Wei, Gu, Danling, Hsieh, Yunsheng, Lee, Suining, Liu, Ming, Parry, David
Published in Molecular cancer therapeutics (01.04.2011)
Published in Molecular cancer therapeutics (01.04.2011)
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Novel CHK1 inhibitor MU380 exhibits significant single-agent activity in TP53-mutated chronic lymphocytic leukemia cells
Boudny, Miroslav, Zemanova, Jana, Khirsariya, Prashant, Borsky, Marek, Verner, Jan, Cerna, Jana, Oltova, Alexandra, Seda, Vaclav, Mraz, Marek, Jaros, Josef, Jaskova, Zuzana, Spunarova, Michaela, Brychtova, Yvona, Soucek, Karel, Drapela, Stanislav, Kasparkova, Marie, Mayer, Jiri, Paruch, Kamil, Trbusek, Martin
Published in Haematologica (Roma) (01.12.2019)
Published in Haematologica (Roma) (01.12.2019)
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Chk1 Inhibitor SCH900776 Effectively Potentiates the Cytotoxic Effects of Platinum-Based Chemotherapeutic Drugs in Human Colon Cancer Cells
Herůdková, Jarmila, Paruch, Kamil, Khirsariya, Prashant, Souček, Karel, Krkoška, Martin, Vondálová Blanářová, Olga, Sova, Petr, Kozubík, Alois, Hyršlová Vaculová, Alena
Published in Neoplasia (New York, N.Y.) (01.10.2017)
Published in Neoplasia (New York, N.Y.) (01.10.2017)
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A Concise Synthesis of Forskolin
Hylse, Ondřej, Maier, Lukáš, Kučera, Roman, Perečko, Tomáš, Svobodová, Aneta, Kubala, Lukáš, Paruch, Kamil, Švenda, Jakub
Published in Angewandte Chemie International Edition (02.10.2017)
Published in Angewandte Chemie International Edition (02.10.2017)
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Characterization of an RNA binding protein interactome reveals a context-specific post-transcriptional landscape of MYC-amplified medulloblastoma
Kameda-Smith, Michelle M., Zhu, Helen, Luo, En-Ching, Suk, Yujin, Xella, Agata, Yee, Brian, Chokshi, Chirayu, Xing, Sansi, Tan, Frederick, Fox, Raymond G., Adile, Ashley A., Bakhshinyan, David, Brown, Kevin, Gwynne, William D., Subapanditha, Minomi, Miletic, Petar, Picard, Daniel, Burns, Ian, Moffat, Jason, Paruch, Kamil, Fleming, Adam, Hope, Kristin, Provias, John P., Remke, Marc, Lu, Yu, Reya, Tannishtha, Venugopal, Chitra, Reimand, Jüri, Wechsler-Reya, Robert J., Yeo, Gene W., Singh, Sheila K.
Published in Nature communications (06.12.2022)
Published in Nature communications (06.12.2022)
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Author Correction: Characterization of an RNA binding protein interactome reveals a context-specific post-transcriptional landscape of MYC-amplified medulloblastoma
Kameda-Smith, Michelle M., Zhu, Helen, Luo, En-Ching, Suk, Yujin, Xella, Agata, Yee, Brian, Chokshi, Chirayu, Xing, Sansi, Tan, Frederick, Fox, Raymond G., Adile, Ashley A., Bakhshinyan, David, Brown, Kevin, Gwynne, William D., Subapanditha, Minomi, Miletic, Petar, Picard, Daniel, Burns, Ian, Moffat, Jason, Paruch, Kamil, Fleming, Adam, Hope, Kristin, Provias, John P., Remke, Marc, Lu, Yu, Reya, Tannishtha, Venugopal, Chitra, Reimand, Jüri, Wechsler-Reya, Robert J., Yeo, Gene W., Singh, Sheila K.
Published in Nature communications (10.01.2023)
Published in Nature communications (10.01.2023)
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The CHK1 inhibitor MU380 significantly increases the sensitivity of human docetaxel‐resistant prostate cancer cells to gemcitabine through the induction of mitotic catastrophe
Drápela, Stanislav, Khirsariya, Prashant, Weerden, Wytske M., Fedr, Radek, Suchánková, Tereza, Búzová, Diana, Červený, Jan, Hampl, Aleš, Puhr, Martin, Watson, William R., Culig, Zoran, Krejčí, Lumír, Paruch, Kamil, Souček, Karel
Published in Molecular oncology (01.10.2020)
Published in Molecular oncology (01.10.2020)
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Synthesis and Profiling of a Novel Potent Selective Inhibitor of CHK1 Kinase Possessing Unusual N-trifluoromethylpyrazole Pharmacophore Resistant to Metabolic N-dealkylation
Samadder, Pounami, Suchánková, Tereza, Hylse, Ondřej, Khirsariya, Prashant, Nikulenkov, Fedor, Drápela, Stanislav, Straková, Nicol, Vaňhara, Petr, Vašíčková, Kateřina, Kolářová, Hana, Binó, Lucia, Bittová, Miroslava, Ovesná, Petra, Kollár, Peter, Fedr, Radek, Ešner, Milan, Jaroš, Josef, Hampl, Aleš, Krejčí, Lumír, Paruch, Kamil, Souček, Karel
Published in Molecular cancer therapeutics (01.09.2017)
Published in Molecular cancer therapeutics (01.09.2017)
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Site-Specific Analysis of Protein Hydration Based on Unnatural Amino Acid Fluorescence
Amaro, Mariana, Brezovský, Jan, Kováčová, Silvia, Sýkora, Jan, Bednář, David, Němec, Václav, Lišková, Veronika, Kurumbang, Nagendra Prasad, Beerens, Koen, Chaloupková, Radka, Paruch, Kamil, Hof, Martin, Damborský, Jiří
Published in Journal of the American Chemical Society (22.04.2015)
Published in Journal of the American Chemical Society (22.04.2015)
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Discovery of pyrazolo[1,5-a]pyrimidine-based CHK1 inhibitors: A template-based approach—Part 1
Dwyer, Michael P., Paruch, Kamil, Labroli, Marc, Alvarez, Carmen, Keertikar, Kerry M., Poker, Cory, Rossman, Randall, Fischmann, Thierry O., Duca, Jose S., Madison, Vincent, Parry, David, Davis, Nicole, Seghezzi, Wolfgang, Wiswell, Derek, Guzi, Timothy J.
Published in Bioorganic & medicinal chemistry letters (01.01.2011)
Published in Bioorganic & medicinal chemistry letters (01.01.2011)
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Discovery of pyrazolo[1,5-a]pyrimidine-based CHK1 inhibitors: A template-based approach—Part 2
Labroli, Marc, Paruch, Kamil, Dwyer, Michael P., Alvarez, Carmen, Keertikar, Kartik, Poker, Cory, Rossman, Randall, Duca, Jose S., Fischmann, Thierry O., Madison, Vincent, Parry, David, Davis, Nicole, Seghezzi, Wolfgang, Wiswell, Derek, Guzi, Timothy J.
Published in Bioorganic & medicinal chemistry letters (01.01.2011)
Published in Bioorganic & medicinal chemistry letters (01.01.2011)
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Quantum mechanical scoring: structural and energetic insights into cyclin-dependent kinase 2 inhibition by pyrazolo[1,5-a]pyrimidines
Brahmkshatriya, Pathik S, Dobeš, Petr, Fanfrlik, Jindrich, Rezáç, Jan, Paruch, Kamil, Bronowska, Agnieszka, Lepšík, Martin, Hobza, Pavel
Published in Current computer-aided drug design (01.03.2013)
Published in Current computer-aided drug design (01.03.2013)
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Structure-guided discovery of cyclin-dependent kinase inhibitors
Fischmann, Thierry O., Hruza, Alan, Duca, José S., Ramanathan, Lata, Mayhood, Todd, Windsor, William T., Le, Hung V., Guzi, Timothy J., Dwyer, Michael P., Paruch, Kamil, Doll, Ronald J., Lees, Emma, Parry, David, Seghezzi, Wolfgang, Madison, Vincent
Published in Biopolymers (01.05.2008)
Published in Biopolymers (01.05.2008)
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Preparation of 3,4-Substituted-5-Aminopyrazoles and 4‑Substituted-2-Aminothiazoles
Havel, Stepan, Khirsariya, Prashant, Akavaram, Naresh, Paruch, Kamil, Carbain, Benoit
Published in Journal of organic chemistry (21.12.2018)
Published in Journal of organic chemistry (21.12.2018)
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First Friedel−Crafts Diacylation of a Phenanthrene as the Basis for an Efficient Synthesis of Nonracemic [7]Helicenes
Paruch, Kamil, Katz, Thomas J, Incarvito, Christopher, Lam, Kin-Chung, Rhatigan, Brian, Rheingold, Arnold L
Published in Journal of organic chemistry (03.11.2000)
Published in Journal of organic chemistry (03.11.2000)
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