Discovery of an Oral Respiratory Syncytial Virus (RSV) Fusion Inhibitor (GS-5806) and Clinical Proof of Concept in a Human RSV Challenge Study
Mackman, Richard L, Sangi, Michael, Sperandio, David, Parrish, Jay P, Eisenberg, Eugene, Perron, Michel, Hui, Hon, Zhang, Lijun, Siegel, Dustin, Yang, Hai, Saunders, Oliver, Boojamra, Constantine, Lee, Gary, Samuel, Dharmaraj, Babaoglu, Kerim, Carey, Anne, Gilbert, Brian E, Piedra, Pedro A, Strickley, Robert, Iwata, Quynh, Hayes, Jaclyn, Stray, Kirsten, Kinkade, April, Theodore, Dorothy, Jordan, Robert, Desai, Manoj, Cihlar, Tomas
Published in Journal of medicinal chemistry (26.02.2015)
Published in Journal of medicinal chemistry (26.02.2015)
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Journal Article
Design, synthesis, and anti-HIV activity of 4′-modified carbocyclic nucleoside phosphonate reverse transcriptase inhibitors
Boojamra, Constantine G., Parrish, Jay P., Sperandio, David, Gao, Ying, Petrakovsky, Oleg V., Lee, Sharon K., Markevitch, David Y., Vela, Jennifer E., Laflamme, Genevieve, Chen, James M., Ray, Adrian S., Barron, Abraham C., Sparacino, Mark L., Desai, Manoj C., Kim, Choung U., Cihlar, Tomas, Mackman, Richard L.
Published in Bioorganic & medicinal chemistry (15.02.2009)
Published in Bioorganic & medicinal chemistry (15.02.2009)
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Journal Article
Evaluation of 2′-α-fluorine modified nucleoside phosphonates as potential inhibitors of HCV polymerase
Parrish, Jay P., Lee, Sharon K., Boojamra, Constantine G., Hui, Hon, Babusis, Darius, Brown, Brandon, Shih, I-hung, Feng, Joy Y., Ray, Adrian S., Mackman, Richard L.
Published in Bioorganic & medicinal chemistry letters (01.06.2013)
Published in Bioorganic & medicinal chemistry letters (01.06.2013)
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Journal Article
Oxidative dimerization: Pd(II) catalysis in the presence of oxygen using aqueous media
Parrish, Jay P., Jung, Young C., Floyd, Ryan J., Jung, Kyung Woon
Published in Tetrahedron letters (28.10.2002)
Published in Tetrahedron letters (28.10.2002)
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Journal Article
DNA Alkylation Properties of Yatakemycin
Parrish, Jay P, Kastrinsky, David B, Wolkenberg, Scott E, Igarashi, Yasuhiro, Boger, Dale L
Published in Journal of the American Chemical Society (10.09.2003)
Published in Journal of the American Chemical Society (10.09.2003)
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Synthesis and preliminary evaluation of duocarmycin analogues incorporating the 1,2,11,11a-tetrahydrocyclopropa[ c]naphtho[2,3- e]indol-4-one (CNI) and 1,2,11,11a-tetrahydrocyclopropa[ c]naphtho[1,2- e]indol-4-one ( iso-CNI) alkylation subunits
Gauss, Carla M., Hamasaki, Akiyuki, Parrish, Jay P., MacMillan, Karen S., Rayl, Thomas J., Hwang, Inkyu, Boger, Dale L.
Published in Tetrahedron (15.08.2009)
Published in Tetrahedron (15.08.2009)
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Journal Article
Establishing the Parabolic Relationship between Reactivity and Activity for Derivatives and Analogues of the Duocarmycin and CC-1065 Alkylation Subunits
Parrish, Jay P, Hughes, Terry V, Hwang, Inkyu, Boger, Dale L
Published in Journal of the American Chemical Society (14.01.2004)
Published in Journal of the American Chemical Society (14.01.2004)
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Journal Article
METHODS FOR TREATING FILOVIRIDAE VIRUS INFECTIONS
HUI HON CHUNG, JORDAN ROBERT, RAY ADRIAN S, SIEGEL DUSTIN, MACKMAN RICHARD L, PARRISH JAY P, DOERFFLER EDWARD, CHUN BYOUNG KWON, CLARKE MICHAEL O'NEIL HANRAHAN
Year of Publication 18.10.2022
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Year of Publication 18.10.2022
Patent
METHODS FOR TREATING FILOVIRIDAE VIRUS INFECTIONS
HUI HON CHUNG, JORDAN ROBERT, RAY ADRIAN S, SIEGEL DUSTIN, MACKMAN RICHARD L, PARRISH JAY P, DOERFFLER EDWARD, CHUN BYOUNG KWON, CLARKE MICHAEL O'NEIL HANRAHAN
Year of Publication 14.12.2021
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Year of Publication 14.12.2021
Patent
Establishment of substituent effects in the DNA binding subunit of CBI analogues of the duocarmycins and CC-1065
Parrish, Jay P., Kastrinsky, David B., Stauffer, Frederic, Hedrick, Michael P., Hwang, Inkyu, Boger, Dale L.
Published in Bioorganic & medicinal chemistry (15.08.2003)
Published in Bioorganic & medicinal chemistry (15.08.2003)
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Journal Article
COMPOUNDS AND METHODS FOR ANTIVIRAL TREATMENT
HUI HON CHUNG, SIEGEL DUSTIN, MACKMAN RICHARD L, PARRISH JAY P, SPERANDIO DAVID, YANG HAI, SANGI MICHAEL
Year of Publication 29.04.2020
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Year of Publication 29.04.2020
Patent
Synthesis and evaluation of N-aryl and N-alkenyl CBI derivatives
Parrish, Jay P., Trzupek, John D., Hughes, Terry V., Hwang, Inkyu, Boger, Dale L.
Published in Bioorganic & medicinal chemistry (15.11.2004)
Published in Bioorganic & medicinal chemistry (15.11.2004)
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Journal Article
METHODS AND COMPOUNDS FOR TREATING PARAMYXOVIRIDAE VIRUS INFECTIONS
RAY ADRIAN S, THEODORE DOROTHY AGNES, MACKMAN RICHARD L, PARRISH JAY P
Year of Publication 05.02.2018
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Year of Publication 05.02.2018
Patent
Synthesis and Evaluation of Duocarmycin and CC-1065 Analogues Incorporating the 1,2,9,9a-Tetrahydrocyclopropa[c]benz[e]-3-azaindol-4-one (CBA) Alkylation Subunit
Parrish, Jay P, Kastrinsky, David B, Hwang, Inkyu, Boger, Dale L
Published in Journal of organic chemistry (14.11.2003)
Published in Journal of organic chemistry (14.11.2003)
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Journal Article
METHODS FOR TREATING FILOVIRIDAE VIRUS INFECTIONS
HUI HON CHUNG, JORDAN ROBERT, RAY ADRIAN S, SIEGEL DUSTIN, MACKMAN RICHARD L, PARRISH JAY P, DOERFFLER EDWARD, CHUN BYOUNG KWON, CLARKE MICHAEL O'NEIL HANRAHAN
Year of Publication 16.06.2017
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Year of Publication 16.06.2017
Patent
METHODS FOR TREATING FILOVIRIDAE VIRUS INFECTIONS
HUI HON CHUNG, JORDAN ROBERT, RAY ADRIAN S, SIEGEL DUSTIN, CHUN, BYOUNG KWON, MACKMAN RICHARD L, PARRISH JAY P, DOERFFLER EDWARD, CLARKE MICHAEL O'NEIL HANRAHAN
Year of Publication 14.06.2017
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Year of Publication 14.06.2017
Patent
ANTIVIRAL COMPOUNDS
SQUIRES NEIL, WATKINS WILLIAM J, CHO AESOP, DESAI MANOJ C, BACON ELIZABETH M, KRYGOWSKI EVAN S, SCHROEDER SCOTT D, LIU QI, TSE WINSTON C, SAUGIER JOSEPH H, XU LIANHONG, LAZERWITH SCOTT E, KATO DARRYL, PYUN HYUNG JUNG, MISH MICHAEL R, TRENKLE JAMES D, CLARKE MICHAEL O'NEIL HANRAHAN, PHILLIPS BARTON W, GUO HONGYAN, KELLAR TERRY, SUN JIANYU, KIRSCHBERG THORSTEN A, LINK JOHN O, COTTELL JEROMY J, VIVIAN RANDALL W, CANALES EDA, TAYLOR JAMES, MACKMAN RICHARD, LIU HONGTAO, CHOU CHIEN HUNG, VENKATARAMANI CHANDRASEKAR, MITCHELL MICHAEL L, JIN HAOLUN, METOBO SAMUEL E, YANG ZHENG YU, PARRISH JAY P, KIM CHOUNG U, MCFADDEN RYAN, GRAUPE MICHAEL, SHENG XIAONING, HALCOMB RANDALL L
Year of Publication 31.01.2020
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Year of Publication 31.01.2020
Patent