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PARP Inhibitors in Ovarian Cancer
Mittica, Gloria, Ghisoni, Eleonora, Giannone, Gaia, Genta, Sofia, Aglietta, Massimo, Sapino, Anna, Valabrega, Giorgio
Published in Recent patents on anti-cancer drug discovery (01.01.2018)
Published in Recent patents on anti-cancer drug discovery (01.01.2018)
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Weight Loss Is Associated With Increased NAD+/SIRT1 Expression But Reduced PARP Activity in White Adipose Tissue
Rappou, Elisabeth, Jukarainen, Sakari, Rinnankoski-Tuikka, Rita, Kaye, Sanna, Heinonen, Sini, Hakkarainen, Antti, Lundbom, Jesper, Lundbom, Nina, Saunavaara, Virva, Rissanen, Aila, Virtanen, Kirsi A., Pirinen, Eija, Pietiläinen, Kirsi H.
Published in The journal of clinical endocrinology and metabolism (01.03.2016)
Published in The journal of clinical endocrinology and metabolism (01.03.2016)
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Parent-Metabolite Pharmacokinetic Modeling and Pharmacodynamics of Veliparib (ABT-888), a PARP Inhibitor, in Patients With BRCA 1/2-Mutated Cancer or PARP-Sensitive Tumor Types
Niu, Jing, Scheuerell, Christie, Mehrotra, Shailly, Karan, Sharon, Puhalla, Shannon, Kiesel, Brian F, Ji, Jiuping, Chu, Edward, Gopalakrishnan, Mathangi, Ivaturi, Vijay, Gobburu, Jogarao, Beumer, Jan H
Published in Journal of clinical pharmacology (01.08.2017)
Published in Journal of clinical pharmacology (01.08.2017)
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PARP inhibition protects against alcoholic and non-alcoholic steatohepatitis
Mukhopadhyay, Partha, Horváth, Béla, Rajesh, Mohanraj, Varga, Zoltán V., Gariani, Karim, Ryu, Dongryeol, Cao, Zongxian, Holovac, Eileen, Park, Ogyi, Zhou, Zhou, Xu, Ming-Jiang, Wang, Wei, Godlewski, Grzegorz, Paloczi, Janos, Nemeth, Balazs Tamas, Persidsky, Yuri, Liaudet, Lucas, Haskó, György, Bai, Peter, Boulares, A. Hamid, Auwerx, Johan, Gao, Bin, Pacher, Pal
Published in Journal of hepatology (01.03.2017)
Published in Journal of hepatology (01.03.2017)
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Effects of food and ethnicity on the pharmacokinetics of venadaparib, a next-generation PARP inhibitor, in healthy Korean, Caucasian, and Chinese male subjects
Kim, Hyun Chul, Yang, Eunsol, Lee, Soyoung, Oh, Jaeseong, Lee, Myongjae, Lee, ChaeEun, Ha, Kyoung Soo, Lee, Won Sik, Jang, In-Jin, Yu, Kyung-Sang
Published in Investigational new drugs (01.02.2024)
Published in Investigational new drugs (01.02.2024)
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PARP is activated at stalled forks to mediate Mre11-dependent replication restart and recombination
Bryant, Helen E, Petermann, Eva, Schultz, Niklas, Jemth, Ann-Sofie, Loseva, Olga, Issaeva, Natalia, Johansson, Fredrik, Fernandez, Serena, McGlynn, Peter, Helleday, Thomas
Published in The EMBO journal (02.09.2009)
Published in The EMBO journal (02.09.2009)
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[18F]FluorThanatrace ([18F]FTT) PET Imaging of PARP-Inhibitor Drug-Target Engagement as a Biomarker of Response in Ovarian Cancer, a Pilot Study
Pantel, Austin R., Gitto, Sarah B., Makvandi, Mehran, Kim, Hyoung, Medvedv, Sergey, Weeks, Joanna K., Torigian, Drew A., Hsieh, Chia-Ju, Ferman, Benjamin, Latif, Nawar A., Tanyi, Janos L., Martin, Lainie P., Lanzo, Shannon M., Liu, Fang, Cao, Quy, Mills, Gordon B., Doot, Robert K., Mankoff, David A., Mach, Robert H., Lin, Lilie L., Simpkins, Fiona
Published in Clinical cancer research (14.04.2023)
Published in Clinical cancer research (14.04.2023)
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Stabilization of mutant BRCA1 protein confers PARP inhibitor and platinum resistance
Johnson, Neil, Johnson, Shawn F., Yao, Wei, Li, Yu-Chen, Choi, Young-Eun, Bernhardy, Andrea J., Wang, Yifan, Capelletti, Marzia, Sarosiek, Kristopher A., Moreau, Lisa A., Chowdhury, Dipanjan, Wickramanayake, Anneka, Harrell, Maria I., Liu, Joyce F., D'Andrea, Alan D., Miron, Alexander, Swisher, Elizabeth M., Shapiro, Geoffrey I.
Published in Proceedings of the National Academy of Sciences - PNAS (15.10.2013)
Published in Proceedings of the National Academy of Sciences - PNAS (15.10.2013)
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A PARP1 PROTAC as a novel strategy against PARP inhibitor resistance via promotion of ferroptosis in p53-positive breast cancer
Li, Ge, Lin, Shan-shan, Yu, Ze-lei, Wu, Xin-hua, Liu, Jing-wen, Tu, Gui-hui, Liu, Quan-yu, Tang, Yuan-ling, Jiang, Qing-na, Xu, Jian-hua, Huang, Qing-ling, Wu, Li-xian
Published in Biochemical pharmacology (01.12.2022)
Published in Biochemical pharmacology (01.12.2022)
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Advances in the Treatment of Ovarian Cancer Using PARP Inhibitors and the Underlying Mechanism of Resistance
Wang, Ling, Wang, Qi, Xu, Yangchun, Cui, Manhua, Han, Liying
Published in Current drug targets (01.01.2020)
Published in Current drug targets (01.01.2020)
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The PARP inhibitor, olaparib, depletes the ovarian reserve in mice: implications for fertility preservation
Winship, Amy L, Griffiths, Meaghan, Lliberos Requesens, Carolina, Sarma, Urooza, Phillips, Kelly-Anne, Hutt, Karla J
Published in Human reproduction (Oxford) (01.08.2020)
Published in Human reproduction (Oxford) (01.08.2020)
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BRCA1 intronic Alu elements drive gene rearrangements and PARP inhibitor resistance
Wang, Yifan, Bernhardy, Andrea J., Nacson, Joseph, Krais, John J., Tan, Yin-Fei, Nicolas, Emmanuelle, Radke, Marc R., Handorf, Elizabeth, Llop-Guevara, Alba, Balmaña, Judith, Swisher, Elizabeth M., Serra, Violeta, Peri, Suraj, Johnson, Neil
Published in Nature communications (11.12.2019)
Published in Nature communications (11.12.2019)
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The efficacy and adverse effects of PARP inhibitor combined with chemotherapy compared with chemotherapy alone in the treatment of cancer patient: A protocol for systematic review
Zhao, Suyue, Fang, Tao, Yao, Li, Zheng, Ying, Zhang, Ling, Zhu, Kexiang
Published in Medicine (Baltimore) (06.11.2020)
Published in Medicine (Baltimore) (06.11.2020)
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A Population Pharmacokinetic Meta‐Analysis of Veliparib, a PARP Inhibitor, Across Phase 1/2/3 Trials in Cancer Patients
Stodtmann, Sven, Nuthalapati, Silpa, Eckert, Doerthe, Kasichayanula, Sreeneeranj, Joshi, Rujuta, Bach, Bruce A., Mensing, Sven, Menon, Rajeev, Xiong, Hao
Published in Journal of clinical pharmacology (01.09.2021)
Published in Journal of clinical pharmacology (01.09.2021)
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Effect of food on the pharmacokinetics and safety profiles of a new PARP inhibitor fuzuloparib capsules in healthy volunteers
Du, Pengfei, Long, Yao, Wang, Minhui, Huang, Yunzhe, Wang, Yaqin, Chen, Xinyan, Lin, Yuhong, Wu, Jianbang, Shen, Jie, Jia, Yuanwei
Published in Cancer chemotherapy and pharmacology (01.08.2024)
Published in Cancer chemotherapy and pharmacology (01.08.2024)
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PARPs, PAR and NAD Metabolism and Their Inhibitors in Cancer
Year of Publication 2023
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Survey on implementation of molecular testing in ovarian cancer and PARP inhibitor: a national North-Eastern German Society of Gynecologic Oncology/Young Academy of Gynecologic Oncology/Arbeitsgemeinschaft Gynäkologische Onkologie intergroup analysis
Nguyen-Sträuli, Bich Doan, Baum, Joanna, Meyer-Wilmes, Philipp, Kreklau, Anne, Buschmann, Christina, El Ouardi, Nabila, Fotopoulou, Christina, Hummel, Michael, Chekerov, Radoslav, Braicu, Elena, Sehouli, Jalid, Pietzner, Klaus
Published in International journal of gynecological cancer (01.10.2022)
Published in International journal of gynecological cancer (01.10.2022)
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Anti-tumour and radiosensitising effects of PARP inhibitor on cervical cancer xenografts
Xue, Qin, Enyang, Wang, Tingting, Gong, Xiaolin, Ma, Qipeng, Ma, Song, Gao
Published in Journal of obstetrics and gynaecology (01.12.2023)
Published in Journal of obstetrics and gynaecology (01.12.2023)
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Modulation of Poly ADP Ribose Polymerase (PARP) Levels and Activity by Alcohol Binge-Like Drinking in Male Mice
Vallerini, Gian Paolo, Cheng, You-Hong, Chase, Kayla A., Sharma, Rajiv P., Kusumo, Handojo, Khakhkhar, Shivani, Feinstein, Douglas L., Guizzetti, Marina, Gavin, David P.
Published in Neuroscience (10.11.2020)
Published in Neuroscience (10.11.2020)
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