Structure-based drug design enables conversion of a DFG-in binding CSF-1R kinase inhibitor to a DFG-out binding mode
Meyers, Marvin J., Pelc, Matthew, Kamtekar, Satwik, Day, Jacqueline, Poda, Gennadiy I., Hall, Molly K., Michener, Marshall L., Reitz, Beverly A., Mathis, Karl J., Pierce, Betsy S., Parikh, Mihir D., Mischke, Deborah A., Long, Scott A., Parlow, John J., Anderson, David R., Thorarensen, Atli
Published in Bioorganic & medicinal chemistry letters (01.03.2010)
Published in Bioorganic & medicinal chemistry letters (01.03.2010)
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Design, Parallel Synthesis, and Crystal Structures of Pyrazinone Antithrombotics as Selective Inhibitors of the Tissue Factor VIIa Complex
Parlow, John J, Case, Brenda L, Dice, Thomas A, Fenton, Ricky L, Hayes, Michael J, Jones, Darin E, Neumann, William L, Wood, Rhonda S, Lachance, Rhonda M, Girard, Thomas J, Nicholson, Nancy S, Clare, Michael, Stegeman, Roderick A, Stevens, Anna M, Stallings, William C, Kurumbail, Ravi G, South, Michael S
Published in Journal of medicinal chemistry (11.09.2003)
Published in Journal of medicinal chemistry (11.09.2003)
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Pharmacological Interruption of Acute Thrombus Formation with Minimal Hemorrhagic Complications by a Small Molecule Tissue Factor/Factor VIIa Inhibitor: Comparison to Factor Xa and Thrombin Inhibition in a Nonhuman Primate Thrombosis Model
Suleymanov, Osman D, Szalony, James A, Salyers, Anita K, LaChance, Rhonda M, Parlow, John J, South, Michael S, Wood, Rhonda S, Nicholson, Nancy S
Published in The Journal of pharmacology and experimental therapeutics (01.09.2003)
Published in The Journal of pharmacology and experimental therapeutics (01.09.2003)
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Piperazinyl-glutamate-pyridines as potent orally bioavailable P2Y12 antagonists for inhibition of platelet aggregation
PARLOW, John J, BURNEY, Mary W, WOERNDLE, Rhonda S, ENNIS, Michael D, CASE, Brenda L, GIRARD, Thomas J, HALL, Kerri A, HIEBSCH, Ronald R, HUFF, Rita M, LACHANCE, Rhonda M, MISCHKE, Deborah A, RAPP, Stephen R
Published in Bioorganic & medicinal chemistry letters (15.08.2009)
Published in Bioorganic & medicinal chemistry letters (15.08.2009)
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Journal Article
Piperazinyl-glutamate-pyrimidines as potent P2Y12 antagonists for inhibition of platelet aggregation
PARLOW, John J, BURNEY, Mary W, WOERNDLE, Rhonda S, ENNIS, Michael D, CASE, Brenda L, GIRARD, Thomas J, HALL, Kerri A, HIEBSCH, Ronald R, HUFF, Rita M, LACHANCE, Rhonda M, MISCHKE, Deborah A, RAPP, Stephen R
Published in Bioorganic & medicinal chemistry letters (01.11.2009)
Published in Bioorganic & medicinal chemistry letters (01.11.2009)
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Part II: Piperazinyl-glutamate-pyridines as potent orally bioavailable P2Y12 antagonists for inhibition of platelet aggregation
PARLOW, John J, BURNEY, Mary W, RAPP, Stephen R, WOERNDLE, Rhonda S, ENNIS, Michael D, CASE, Brenda L, GIRARD, Thomas J, HALL, Kerri A, HARRIS, Peter K, HIEBSCH, Ronald R, HUFF, Rita M, LACHANCE, Rhonda M, MISCHKE, Deborah A
Published in Bioorganic & medicinal chemistry letters (15.02.2010)
Published in Bioorganic & medicinal chemistry letters (15.02.2010)
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Utility of Complementary Molecular Reactivity and Molecular Recognition (CMR/R) Technology and Polymer-Supported Reagents in the Solution-Phase Synthesis of Heterocyclic Carboxamides
Parlow, John J, Mischke, Deborah A, Woodard, Scott S
Published in Journal of organic chemistry (22.08.1997)
Published in Journal of organic chemistry (22.08.1997)
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Chemical Library Purification Strategies Based on Principles of Complementary Molecular Reactivity and Molecular Recognition
Flynn, Daniel L, Crich, Joyce Z, Devraj, Rajesh V, Hockerman, Susan L, Parlow, John J, South, Michael S, Woodard, Scott
Published in Journal of the American Chemical Society (28.05.1997)
Published in Journal of the American Chemical Society (28.05.1997)
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Synthesis and Crystal Structures of Substituted Benzenes and Benzoquinones as Tissue Factor VIIa Inhibitors
Parlow, John J, Stevens, Anna M, Stegeman, Roderick A, Stallings, William C, Kurumbail, Ravi G, South, Michael S
Published in Journal of medicinal chemistry (25.09.2003)
Published in Journal of medicinal chemistry (25.09.2003)
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Journal Article
Structure-based drug design of pyrazinone antithrombotics as selective inhibitors of the tissue factor VIIa complex
South, Michael S., Case, Brenda L., Wood, Rhonda S., Jones, Darin E., Hayes, Michael J., Girard, Thomas J., Lachance, Rhonda M., Nicholson, Nancy S., Clare, Michael, Stevens, Anna M., Stegeman, Roderick A., Stallings, William C., Kurumbail, Ravi G., Parlow, John J.
Published in Bioorganic & medicinal chemistry letters (21.07.2003)
Published in Bioorganic & medicinal chemistry letters (21.07.2003)
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Journal Article
Synthesis and X-ray crystal structures of substituted fluorobenzene and benzoquinone inhibitors of the tissue Factor VIIa complex
PARLOW, John J, KURUMBAIL, Ravi G, STEGEMAN, Roderick A, STEVENS, Anna M, STALLINGS, William C, SOUTH, Michael S
Published in Bioorganic & medicinal chemistry letters (03.11.2003)
Published in Bioorganic & medicinal chemistry letters (03.11.2003)
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Journal Article
Polymer-Assisted Solution-Phase Library Synthesis and Crystal Structure of α-Ketothiazoles as Tissue Factor VIIa Inhibitors
Parlow, John J, Dice, Thomas A, Lachance, Rhonda M, Girard, Thomas J, Stevens, Anna M, Stegeman, Roderick A, Stallings, William C, Kurumbail, Ravi G, South, Michael S
Published in Journal of medicinal chemistry (11.09.2003)
Published in Journal of medicinal chemistry (11.09.2003)
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Journal Article
Polymer-Assisted solution-Phase (PASP) parallel synthesis of an α-Ketothiazole library as tissue factor VIIa inhibitors
South, Michael S, Dice, Thomas A, Girard, Thomas J, Lachance, Rhonda M, Stevens, Anna M, Stegeman, Roderick A, Stallings, William C, Kurumbail, Ravi G, Parlow, John J
Published in Bioorganic & medicinal chemistry letters (21.07.2003)
Published in Bioorganic & medicinal chemistry letters (21.07.2003)
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Journal Article
Administration of a small molecule tissue factor/Factor VIIa inhibitor in a non-human primate thrombosis model of venous thrombosis: effects on thrombus formation and bleeding time
Szalony, James A, Suleymanov, Osman D, Salyers, Anita K, Panzer-Knodle, Susan G, Blom, Jason D, LaChance, Rhonda M, Case, Brenda L, Parlow, John J, South, Michael S, Wood, Rhonda S, Nicholson, Nancy S
Published in Thrombosis research (2003)
Published in Thrombosis research (2003)
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