Immunogenomics of Colorectal Cancer Response to Checkpoint Blockade: Analysis of the KEYNOTE 177 Trial and Validation Cohorts
Bortolomeazzi, Michele, Keddar, Mohamed Reda, Montorsi, Lucia, Acha-Sagredo, Amelia, Benedetti, Lorena, Temelkovski, Damjan, Choi, Subin, Petrov, Nedyalko, Todd, Katrina, Wai, Patty, Kohl, Johannes, Denner, Tamara, Nye, Emma, Goldstone, Robert, Ward, Sophia, Wilson, Gareth A., Al Bakir, Maise, Swanton, Charles, John, Susan, Miles, James, Larijani, Banafshe, Kunene, Victoria, Fontana, Elisa, Arkenau, Hendrik-Tobias, Parker, Peter J., Rodriguez-Justo, Manuel, Shiu, Kai-Keen, Spencer, Jo, Ciccarelli, Francesca D.
Published in Gastroenterology (New York, N.Y. 1943) (01.10.2021)
Published in Gastroenterology (New York, N.Y. 1943) (01.10.2021)
Get full text
Journal Article
Receptor tyrosine kinase c-Met controls the cytoskeleton from different endosomes via different pathways
Ménard, Ludovic, Parker, Peter J., Kermorgant, Stéphanie
Published in Nature communications (19.05.2014)
Published in Nature communications (19.05.2014)
Get full text
Journal Article
PKC and the control of localized signal dynamics
Parker, Peter J, Rosse, Carine, Linch, Mark, Kermorgant, Stéphanie, Cameron, Angus J. M, Boeckeler, Katrina
Published in Nature reviews. Molecular cell biology (01.02.2010)
Published in Nature reviews. Molecular cell biology (01.02.2010)
Get full text
Journal Article
EGFR oligomerization organizes kinase-active dimers into competent signalling platforms
Needham, Sarah R., Roberts, Selene K., Arkhipov, Anton, Mysore, Venkatesh P., Tynan, Christopher J., Zanetti-Domingues, Laura C., Kim, Eric T., Losasso, Valeria, Korovesis, Dimitrios, Hirsch, Michael, Rolfe, Daniel J., Clarke, David T., Winn, Martyn D., Lajevardipour, Alireza, Clayton, Andrew H. A., Pike, Linda J., Perani, Michela, Parker, Peter J., Shan, Yibing, Shaw, David E., Martin-Fernandez, Marisa L.
Published in Nature communications (31.10.2016)
Published in Nature communications (31.10.2016)
Get full text
Journal Article
14-3-3 Proteins Interact with a Hybrid Prenyl-Phosphorylation Motif to Inhibit G Proteins
Riou, Philippe, Kjær, Svend, Garg, Ritu, Purkiss, Andrew, George, Roger, Cain, Robert J., Bineva, Ganka, Reymond, Nicolas, McColl, Brad, Thompson, Andrew J., O’Reilly, Nicola, McDonald, Neil Q., Parker, Peter J., Ridley, Anne J.
Published in Cell (25.04.2013)
Published in Cell (25.04.2013)
Get full text
Journal Article
Beta 1-integrin–c-Met cooperation reveals an inside-in survival signalling on autophagy-related endomembranes
Barrow-McGee, Rachel, Kishi, Naoki, Joffre, Carine, Ménard, Ludovic, Hervieu, Alexia, Bakhouche, Bakhouche A., Noval, Alejandro J., Mai, Anja, Guzmán, Camilo, Robbez-Masson, Luisa, Iturrioz, Xavier, Hulit, James, Brennan, Caroline H., Hart, Ian R., Parker, Peter J., Ivaska, Johanna, Kermorgant, Stéphanie
Published in Nature communications (23.06.2016)
Published in Nature communications (23.06.2016)
Get full text
Journal Article
A genetically-encoded crosslinker screen identifies SERBP1 as a PKCε substrate influencing translation and cell division
Martini, Silvia, Davis, Khalil, Faraway, Rupert, Elze, Lisa, Lockwood, Nicola, Jones, Andrew, Xie, Xiao, McDonald, Neil Q., Mann, David J., Armstrong, Alan, Ule, Jernej, Parker, Peter J.
Published in Nature communications (26.11.2021)
Published in Nature communications (26.11.2021)
Get full text
Journal Article
The late endosome is essential for mTORC1 signaling
Flinn, Rory J, Yan, Ying, Goswami, Sumanta, Parker, Peter J, Backer, Jonathan M
Published in Molecular biology of the cell (01.03.2010)
Published in Molecular biology of the cell (01.03.2010)
Get full text
Journal Article
Regulatory domain selectivity in the cell-type specific PKN-dependence of cell migration
Lachmann, Sylvie, Jevons, Amy, De Rycker, Manu, Casamassima, Adele, Radtke, Simone, Collazos, Alejandra, Parker, Peter J
Published in PloS one (06.07.2011)
Published in PloS one (06.07.2011)
Get full text
Journal Article
The architecture of EGFR’s basal complexes reveals autoinhibition mechanisms in dimers and oligomers
Zanetti-Domingues, Laura C., Korovesis, Dimitrios, Needham, Sarah R., Tynan, Christopher J., Sagawa, Shiori, Roberts, Selene K., Kuzmanic, Antonija, Ortiz-Zapater, Elena, Jain, Purvi, Roovers, Rob C., Lajevardipour, Alireza, van Bergen en Henegouwen, Paul M. P., Santis, George, Clayton, Andrew H. A., Clarke, David T., Gervasio, Francesco L., Shan, Yibing, Shaw, David E., Rolfe, Daniel J., Parker, Peter J., Martin-Fernandez, Marisa L.
Published in Nature communications (18.10.2018)
Published in Nature communications (18.10.2018)
Get full text
Journal Article
A class I PI3K signalling network regulates primary cilia disassembly in normal physiology and disease
Conduit, Sarah E., Pearce, Wayne, Bhamra, Amandeep, Bilanges, Benoit, Bozal-Basterra, Laura, Foukas, Lazaros C., Cobbaut, Mathias, Castillo, Sandra D., Danesh, Mohammad Amin, Adil, Mahreen, Carracedo, Arkaitz, Graupera, Mariona, McDonald, Neil Q., Parker, Peter J., Cutillas, Pedro R., Surinova, Silvia, Vanhaesebroeck, Bart
Published in Nature communications (21.08.2024)
Published in Nature communications (21.08.2024)
Get full text
Journal Article
aPKC Inhibition by Par3 CR3 Flanking Regions Controls Substrate Access and Underpins Apical-Junctional Polarization
Soriano, Erika V., Ivanova, Marina E., Fletcher, Georgina, Riou, Philippe, Knowles, Philip P., Barnouin, Karin, Purkiss, Andrew, Kostelecky, Brenda, Saiu, Peter, Linch, Mark, Elbediwy, Ahmed, Kjær, Svend, O’Reilly, Nicola, Snijders, Ambrosius P., Parker, Peter J., Thompson, Barry J., McDonald, Neil Q.
Published in Developmental cell (22.08.2016)
Published in Developmental cell (22.08.2016)
Get full text
Journal Article
Drug-resistant EGFR mutations promote lung cancer by stabilizing interfaces in ligand-free kinase-active EGFR oligomers
Iyer, R. Sumanth, Needham, Sarah R., Galdadas, Ioannis, Davis, Benjamin M., Roberts, Selene K., Man, Rico C. H., Zanetti-Domingues, Laura C., Clarke, David T., Fruhwirth, Gilbert O., Parker, Peter J., Rolfe, Daniel J., Gervasio, Francesco L., Martin-Fernandez, Marisa L.
Published in Nature communications (19.03.2024)
Published in Nature communications (19.03.2024)
Get full text
Journal Article
A selective PIKfyve inhibitor blocks PtdIns(3,5)P2 production and disrupts endomembrane transport and retroviral budding
Jefferies, Harold B J, Cooke, Frank T, Jat, Parmjit, Boucheron, Christine, Koizumi, Tomonobu, Hayakawa, Masahiko, Kaizawa, Hiroyuki, Ohishi, Takahide, Workman, Paul, Waterfield, Michael D, Parker, Peter J
Published in EMBO reports (01.02.2008)
Published in EMBO reports (01.02.2008)
Get full text
Journal Article
Chromosomal Instability Selects Gene Copy-Number Variants Encoding Core Regulators of Proliferation in ER+ Breast Cancer
ENDESFELDER, David, BURRELL, Rebecca A, KANU, Nnennaya, McGRANAHAN, Nicholas, HOWELL, Mike, PARKER, Peter J, DOWNWARD, Julian, SWANTON, Charles, KSCHISCHO, Maik
Published in Cancer research (Chicago, Ill.) (01.09.2014)
Published in Cancer research (Chicago, Ill.) (01.09.2014)
Get full text
Journal Article
Control of MT1-MMP transport by atypical PKC during breast-cancer progression
Rossé, Carine, Lodillinsky, Catalina, Fuhrmann, Laetitia, Nourieh, Maya, Monteiro, Pedro, Irondelle, Marie, Lagoutte, Emilie, Vacher, Sophie, Waharte, François, Paul-Gilloteaux, Perrine, Romao, Maryse, Sengmanivong, Lucie, Linch, Mark, van Lint, Johan, Raposo, Graça, Vincent-Salomon, Anne, Bièche, Ivan, Parker, Peter J., Chavrier, Philippe
Published in Proceedings of the National Academy of Sciences - PNAS (06.05.2014)
Published in Proceedings of the National Academy of Sciences - PNAS (06.05.2014)
Get full text
Journal Article