Comprehensive behavioral and molecular characterization of a new knock-in mouse model of Huntington's disease: zQ175
Menalled, Liliana B, Kudwa, Andrea E, Miller, Sam, Fitzpatrick, Jon, Watson-Johnson, Judy, Keating, Nicole, Ruiz, Melinda, Mushlin, Richard, Alosio, William, McConnell, Kristi, Connor, David, Murphy, Carol, Oakeshott, Steve, Kwan, Mei, Beltran, Jose, Ghavami, Afshin, Brunner, Dani, Park, Larry C, Ramboz, Sylvie, Howland, David
Published in PloS one (20.12.2012)
Published in PloS one (20.12.2012)
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Characterization of neurophysiological and behavioral changes, MRI brain volumetry and 1H MRS in zQ175 knock-in mouse model of Huntington's disease
Heikkinen, Taneli, Lehtimäki, Kimmo, Vartiainen, Nina, Puoliväli, Jukka, Hendricks, Susan J, Glaser, Jack R, Bradaia, Amyaouch, Wadel, Kristian, Touller, Chrystelle, Kontkanen, Outi, Yrjänheikki, Juha M, Buisson, Bruno, Howland, David, Beaumont, Vahri, Munoz-Sanjuan, Ignacio, Park, Larry C
Published in PloS one (20.12.2012)
Published in PloS one (20.12.2012)
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Rapid and robust patterns of spontaneous locomotor deficits in mouse models of Huntington's disease
Heikkinen, Taneli, Bragge, Timo, Bhattarai, Niina, Parkkari, Teija, Puoliväli, Jukka, Kontkanen, Outi, Sweeney, Patrick, Park, Larry C, Munoz-Sanjuan, Ignacio
Published in PloS one (28.12.2020)
Published in PloS one (28.12.2020)
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Age- and sex-related changes in cortical and striatal nitric oxide synthase in the Q175 mouse model of Huntington's disease
Padovan-Neto, Fernando E., Jurkowski, Lauren, Murray, Conor, Stutzmann, Grace E., Kwan, Mei, Ghavami, Afshin, Beaumont, Vahri, Park, Larry C., West, Anthony R.
Published in Nitric oxide (01.02.2019)
Published in Nitric oxide (01.02.2019)
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Impaired Performance of the Q175 Mouse Model of Huntington's Disease in the Touch Screen Paired Associates Learning Task
Piiponniemi, Tuukka O, Parkkari, Teija, Heikkinen, Taneli, Puoliväli, Jukka, Park, Larry C, Cachope, Roger, Kopanitsa, Maksym V
Published in Frontiers in behavioral neuroscience (02.10.2018)
Published in Frontiers in behavioral neuroscience (02.10.2018)
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Improved synthesis of [18F] fallypride and characterization of a Huntington’s disease mouse model, zQ175DN KI, using longitudinal PET imaging of D2/D3 receptors
Huhtala, Tuulia, Poutiainen, Pekka, Rytkönen, Jussi, Lehtimäki, Kimmo, Parkkari, Teija, Kasanen, Iiris, Airaksinen, Anu J., Koivula, Teija, Sweeney, Patrick, Kontkanen, Outi, Wityak, John, Dominiquez, Celia, Park, Larry C.
Published in EJNMMI radiopharmacy and chemistry (05.08.2019)
Published in EJNMMI radiopharmacy and chemistry (05.08.2019)
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Nuclear factor (erythroid-derived 2)-like 2 (NRF2) drug discovery: Biochemical toolbox to develop NRF2 activators by reversible binding of Kelch-like ECH-associated protein 1 (KEAP1)
Bresciani, Alberto, Missineo, Antonino, Gallo, Mariana, Cerretani, Mauro, Fezzardi, Paola, Tomei, Licia, Cicero, Daniel Oscar, Altamura, Sergio, Santoprete, Alessia, Ingenito, Raffaele, Bianchi, Elisabetta, Pacifici, Robert, Dominguez, Celia, Munoz-Sanjuan, Ignacio, Harper, Steven, Toledo-Sherman, Leticia, Park, Larry C.
Published in Archives of biochemistry and biophysics (01.10.2017)
Published in Archives of biochemistry and biophysics (01.10.2017)
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Abnormalities in the Tricarboxylic Acid Cycle in Huntington Disease and in a Huntington Disease Mouse Model
Naseri, Nima N., Xu, Hui, Bonica, Joseph, Vonsattel, Jean Paul G., Cortes, Etty P., Park, Larry C., Arjomand, Jamshid, Gibson, Gary E.
Published in Journal of neuropathology and experimental neurology (01.06.2015)
Published in Journal of neuropathology and experimental neurology (01.06.2015)
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The novel KMO inhibitor CHDI-340246 leads to a restoration of electrophysiological alterations in mouse models of Huntington's disease
Beaumont, Vahri, Mrzljak, Ladislav, Dijkman, Ulrike, Freije, Robert, Heins, Mariette, Rassoulpour, Arash, Tombaugh, Geoffrey, Gelman, Simon, Bradaia, Amyaouch, Steidl, Esther, Gleyzes, Melanie, Heikkinen, Taneli, Lehtimäki, Kimmo, Puoliväli, Jukka, Kontkanen, Outi, Javier, Robyn M., Neagoe, Ioana, Deisemann, Heike, Winkler, Dirk, Ebneth, Andreas, Khetarpal, Vinod, Toledo-Sherman, Leticia, Dominguez, Celia, Park, Larry C., Munoz-Sanjuan, Ignacio
Published in Experimental neurology (01.08.2016)
Published in Experimental neurology (01.08.2016)
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HDinHD: A Rich Data Portal for Huntington’s Disease Research
Aaronson, Jeff, Beaumont, Vahri, Blevins, Richard A., Andreeva, Viktoria, Murasheva, Irina, Shneyderman, Anastasia, Armah, Kabenla, Gill, Rob, Chen, Jian, Rosinski, Jim, Park, Larry C., Coppola, Giovanni, Munoz-Sanjuan, Ignacio, Vogt, Thomas F.
Published in Journal of Huntington's disease (01.01.2021)
Published in Journal of Huntington's disease (01.01.2021)
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Induction of Nitric Oxide Synthase and Microglial Responses Precede Selective Cell Death Induced by Chronic Impairment of Oxidative Metabolism
Calingasan, Noel Y., Park, Larry C.H., Calo, Leonard L., Trifiletti, Rosario R., Gandy, Samuel E., Gibson, Gary E.
Published in The American journal of pathology (01.08.1998)
Published in The American journal of pathology (01.08.1998)
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Transcriptional Assessment of Striatal mRNAs as Valid Biomarkers of Disease Progression in Three Mouse Models of Huntington’s Disease
Ghavami, Afshin, Olsen, Michael, Kwan, Mei, Beltran, Jose, Shea, John, Ramboz, Sylvie, Duan, Wenzhen, Lavery, Daniel, Howland, David, Park, Larry C.
Published in Journal of Huntington's disease (01.01.2020)
Published in Journal of Huntington's disease (01.01.2020)
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Cognitive Training at a Young Age Attenuates Deficits in the zQ175 Mouse Model of HD
Curtin, Paul C P, Farrar, Andrew M, Oakeshott, Stephen, Sutphen, Jane, Berger, Jason, Mazzella, Matthew, Cox, Kimberly, He, Dansha, Alosio, William, Park, Larry C, Howland, David, Brunner, Daniela
Published in Frontiers in behavioral neuroscience (11.01.2016)
Published in Frontiers in behavioral neuroscience (11.01.2016)
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Blockade of Tetrahydrobiopterin Synthesis Protects Neurons after Transient Forebrain Ischemia in Rat: A Novel Role for the Cofactor
Cho, Sunghee, Volpe, Bruce T, Bae, Youngmee, Hwang, Onyou, Choi, Hyun J, Gal, Judit, Park, Larry C. H, Chu, Chung K, Du, Jinfa, Joh, Tong H
Published in The Journal of neuroscience (01.02.1999)
Published in The Journal of neuroscience (01.02.1999)
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Cognitive Deficits in Transgenic and Knock-in HTT Mice Parallel those in Huntington's Disease
Farrar, Andrew M., Murphy, Carol A., Paterson, Neil E., Oakeshott, Stephen, He, Dansha, Alosio, William, McConnell, Kristi, Menalled, Liliana B., Ramboz, Sylvie, Park, Larry C., Howland, David, Brunner, Dani
Published in Journal of Huntington's disease (2014)
Published in Journal of Huntington's disease (2014)
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Metabolic Impairment Induces Oxidative Stress, Compromises Inflammatory Responses, and Inactivates a Key Mitochondrial Enzyme in Microglia
Park, Larry C. H., Zhang, Hui, Sheu, Kwan‐Fu Rex, Calingasan, Noel Y., Kristal, Bruce S., Gordon Lindsay, J., Gibson, Gary E.
Published in Journal of neurochemistry (01.05.1999)
Published in Journal of neurochemistry (01.05.1999)
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Therapeutic Efficacy of FEx-022 in Protecting the Kidneys during Ischemia-Reperfusion Injury: TH-PO041
Kim, Sung ki, Kim, Jayoung, Stiles, Wesley Robert, Lee, Hee Young, Park, Kyung Ho, Park, Larry C., Kang, Min-Woong, Choi, Hak Soo
Published in Journal of the American Society of Nephrology (01.10.2024)
Published in Journal of the American Society of Nephrology (01.10.2024)
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Oxidative Stress and a Key Metabolic Enzyme in Alzheimer Brains, Cultured Cells, and an Animal Model of Chronic Oxidative Deficits
GIBSON, GARY E., PARK, LARRY C. H., ZHANG, HUI, SORBI, SANDRO, CALINGASAN, NOEL Y.
Published in Annals of the New York Academy of Sciences (01.01.1999)
Published in Annals of the New York Academy of Sciences (01.01.1999)
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