Antibacterial activity of quinoxalines, quinazolines, and 1,5-naphthyridines
Parhi, Ajit K., Zhang, Yongzheng, Saionz, Kurt W., Pradhan, Padmanava, Kaul, Malvika, Trivedi, Kalkal, Pilch, Daniel S., LaVoie, Edmond J.
Published in Bioorganic & medicinal chemistry letters (01.09.2013)
Published in Bioorganic & medicinal chemistry letters (01.09.2013)
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Journal Article
Combining the FtsZ-Targeting Prodrug TXA709 and the Cephalosporin Cefdinir Confers Synergy and Reduces the Frequency of Resistance in Methicillin-Resistant Staphylococcus aureus
Kaul, Malvika, Mark, Lilly, Parhi, Ajit K, LaVoie, Edmond J, Pilch, Daniel S
Published in Antimicrobial agents and chemotherapy (01.07.2016)
Published in Antimicrobial agents and chemotherapy (01.07.2016)
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Journal Article
Evaluation of 2,6-difluoro-3-(oxazol-2-ylmethoxy)benzamide chemotypes as Gram-negative FtsZ inhibitors
Rosado-Lugo, Jesus D., Sun, Yangsheng, Banerjee, Anamika, Cao, Yanlu, Datta, Pratik, Zhang, Yongzheng, Yuan, Yi, Parhi, Ajit K.
Published in Journal of antibiotics (01.07.2022)
Published in Journal of antibiotics (01.07.2022)
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Journal Article
Structural Flexibility of an Inhibitor Overcomes Drug Resistance Mutations in Staphylococcus aureus FtsZ
Fujita, Junso, Maeda, Yoko, Mizohata, Eiichi, Inoue, Tsuyoshi, Kaul, Malvika, Parhi, Ajit K, LaVoie, Edmond J, Pilch, Daniel S, Matsumura, Hiroyoshi
Published in ACS chemical biology (21.07.2017)
Published in ACS chemical biology (21.07.2017)
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Journal Article
An FtsZ-Targeting Prodrug with Oral Antistaphylococcal Efficacy In Vivo
KAUL, Malvika, MARK, Lilly, YONGZHENG ZHANG, PARHI, Ajit K, LAVOIE, Edmond J, PILCH, Daniel S
Published in Antimicrobial Agents and Chemotherapy (01.12.2013)
Published in Antimicrobial Agents and Chemotherapy (01.12.2013)
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Journal Article
Crystallographic Fragment Screening and Structure-Based Optimization Yields a New Class of Influenza Endonuclease Inhibitors
Bauman, Joseph D, Patel, Disha, Baker, Steven F, Vijayan, R. S. K, Xiang, Amy, Parhi, Ajit K, Martínez-Sobrido, Luis, LaVoie, Edmond J, Das, Kalyan, Arnold, Eddy
Published in ACS chemical biology (15.11.2013)
Published in ACS chemical biology (15.11.2013)
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Journal Article
Pharmacokinetics and in vivo antistaphylococcal efficacy of TXY541, a 1-methylpiperidine-4-carboxamide prodrug of PC190723
Kaul, Malvika, Mark, Lilly, Zhang, Yongzheng, Parhi, Ajit K., LaVoie, Edmond J., Pilch, Daniel S.
Published in Biochemical pharmacology (15.12.2013)
Published in Biochemical pharmacology (15.12.2013)
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Journal Article
Evaluation of a Conformationally Constrained Indole Carboxamide as a Potential Efflux Pump Inhibitor in Pseudomonas aeruginosa
Zhang, Yongzheng, Rosado-Lugo, Jesus D, Datta, Pratik, Sun, Yangsheng, Cao, Yanlu, Banerjee, Anamika, Yuan, Yi, Parhi, Ajit K
Published in Antibiotics (Basel) (26.05.2022)
Published in Antibiotics (Basel) (26.05.2022)
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Journal Article
TXH11106: A Third-Generation MreB Inhibitor with Enhanced Activity against a Broad Range of Gram-Negative Bacterial Pathogens
Bryan, Eric J, Sagong, Hye Yeon, Parhi, Ajit K, Grier, Mark C, Roberge, Jacques Y, LaVoie, Edmond J, Pilch, Daniel S
Published in Antibiotics (Basel) (20.05.2022)
Published in Antibiotics (Basel) (20.05.2022)
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Journal Article
Evaluation of Heterocyclic Carboxamides as Potential Efflux Pump Inhibitors in Pseudomonas aeruginosa
Yuan, Yi, Rosado-Lugo, Jesus D, Zhang, Yongzheng, Datta, Pratik, Sun, Yangsheng, Cao, Yanlu, Banerjee, Anamika, Parhi, Ajit K
Published in Antibiotics (Basel) (28.12.2021)
Published in Antibiotics (Basel) (28.12.2021)
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Journal Article
Enterococcal and streptococcal resistance to PC190723 and related compounds: Molecular insights from a FtsZ mutational analysis
Kaul, Malvika, Zhang, Yongzheng, Parhi, Ajit K., LaVoie, Edmond J., Tuske, Steve, Arnold, Eddy, Kerrigan, John E., Pilch, Daniel S.
Published in Biochimie (01.10.2013)
Published in Biochimie (01.10.2013)
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Journal Article
TXA709, an FtsZ-Targeting Benzamide Prodrug with Improved Pharmacokinetics and Enhanced In Vivo Efficacy against Methicillin-Resistant Staphylococcus aureus
Kaul, Malvika, Mark, Lilly, Zhang, Yongzheng, Parhi, Ajit K, Lyu, Yi Lisa, Pawlak, Joan, Saravolatz, Stephanie, Saravolatz, Louis D, Weinstein, Melvin P, LaVoie, Edmond J, Pilch, Daniel S
Published in Antimicrobial agents and chemotherapy (01.08.2015)
Published in Antimicrobial agents and chemotherapy (01.08.2015)
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Journal Article
β-Lactam Antibiotics with a High Affinity for PBP2 Act Synergistically with the FtsZ-Targeting Agent TXA707 against Methicillin-Resistant Staphylococcus aureus
Ferrer-González, Edgar, Kaul, Malvika, Parhi, Ajit K, LaVoie, Edmond J, Pilch, Daniel S
Published in Antimicrobial agents and chemotherapy (01.09.2017)
Published in Antimicrobial agents and chemotherapy (01.09.2017)
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Journal Article
A Bactericidal Guanidinomethyl Biaryl That Alters the Dynamics of Bacterial FtsZ Polymerization
Kaul, Malvika, Parhi, Ajit K, Zhang, Yongzheng, LaVoie, Edmond J, Tuske, Steve, Arnold, Eddy, Kerrigan, John E, Pilch, Daniel S
Published in Journal of medicinal chemistry (26.11.2012)
Published in Journal of medicinal chemistry (26.11.2012)
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Journal Article
Novel MreB inhibitors with antibacterial activity against Gram (-) bacteria
Sagong, Hye Yeon, Rosado-Lugo, Jesus D., Bryan, Eric J., Ferrer-González, Edgar, Wang, Yiling, Cao, Yanlu, Parhi, Ajit K., Pilch, Daniel S., LaVoie, Edmond J.
Published in Medicinal chemistry research (01.10.2022)
Published in Medicinal chemistry research (01.10.2022)
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Journal Article
Synthesis of fluorescent probes based on stilbenes and diphenylacetylenes targeting β-amyloid plaques
Parhi, Ajit K., Kung, Mei-Ping, Ploessl, Karl, Kung, Hank F.
Published in Tetrahedron letters (01.01.2008)
Published in Tetrahedron letters (01.01.2008)
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Journal Article