Cyclic Nucleotide Binding GAF Domains from Phosphodiesterases: Structural and Mechanistic Insights
Heikaus, Clemens C., Pandit, Jayvardhan, Klevit, Rachel E.
Published in Structure (London) (09.12.2009)
Published in Structure (London) (09.12.2009)
Get full text
Journal Article
Azetidine and Piperidine Carbamates as Efficient, Covalent Inhibitors of Monoacylglycerol Lipase
Butler, Christopher R., Beck, Elizabeth M., Harris, Anthony, Huang, Zhen, McAllister, Laura A., am Ende, Christopher W., Fennell, Kimberly, Foley, Timothy L., Fonseca, Kari, Hawrylik, Steven J., Johnson, Douglas S., Knafels, John D., Mente, Scot, Noell, G. Stephen, Pandit, Jayvardhan, Phillips, Tracy B., Piro, Justin R., Rogers, Bruce N., Samad, Tarek A., Wang, Jane, Wan, Shuangyi, Brodney, Michael A.
Published in Journal of medicinal chemistry (14.12.2017)
Published in Journal of medicinal chemistry (14.12.2017)
Get full text
Journal Article
Mechanism for the allosteric regulation of phosphodiesterase 2A deduced from the X-ray structure of a near full-length construct
Pandit, Jayvardhan, Forman, Michael D, Fennell, Kimberly F, Dillman, Keith S, Menniti, Frank S
Published in Proceedings of the National Academy of Sciences - PNAS (27.10.2009)
Published in Proceedings of the National Academy of Sciences - PNAS (27.10.2009)
Get full text
Journal Article
Allosteric modulators for the treatment of schizophrenia: targeting glutamatergic networks
Menniti, Frank S, Lindsley, Craig W, Conn, P Jeffrey, Pandit, Jayvardhan, Zagouras, Panayiotis, Volkmann, Robert A
Published in Current topics in medicinal chemistry (01.01.2013)
Published in Current topics in medicinal chemistry (01.01.2013)
Get more information
Journal Article
Design of Selective, ATP-Competitive Inhibitors of Akt
Freeman-Cook, Kevin D, Autry, Christopher, Borzillo, Gary, Gordon, Deborah, Barbacci-Tobin, Elsa, Bernardo, Vincent, Briere, David, Clark, Tracey, Corbett, Matthew, Jakubczak, John, Kakar, Shefali, Knauth, Elizabeth, Lippa, Blaise, Luzzio, Michael J, Mansour, Mahmoud, Martinelli, Gary, Marx, Matthew, Nelson, Kendra, Pandit, Jayvardhan, Rajamohan, Francis, Robinson, Shaughnessy, Subramanyam, Chakrapani, Wei, Liuqing, Wythes, Martin, Morris, Joel
Published in Journal of medicinal chemistry (24.06.2010)
Published in Journal of medicinal chemistry (24.06.2010)
Get full text
Journal Article
Discovery of a Series of 6,7-Dimethoxy-4-pyrrolidylquinazoline PDE10A Inhibitors
Chappie, Thomas A., Humphrey, John M., Allen, Martin P., Estep, Kimberly G., Fox, Carol B., Lebel, Lorraine A., Liras, Spiros, Marr, Eric S., Menniti, Frank S., Pandit, Jayvardhan, Schmidt, Christopher J., Tu, Meihua, Williams, Robert D., Yang, Feng V.
Published in Journal of medicinal chemistry (25.01.2007)
Published in Journal of medicinal chemistry (25.01.2007)
Get full text
Journal Article
Synthesis and structure based optimization of novel Akt inhibitors
Lippa, Blaise, Pan, Gonghua, Corbett, Matthew, Li, Chao, Kauffman, Goss S., Pandit, Jayvardhan, Robinson, Shaughnessy, Wei, Liuqing, Kozina, Ekaterina, Marr, Eric S., Borzillo, Gary, Knauth, Elisabeth, Barbacci-Tobin, Elsa G., Vincent, Patrick, Troutman, Merin, Baker, Deborah, Rajamohan, Francis, Kakar, Shefali, Clark, Tracey, Morris, Joel
Published in Bioorganic & medicinal chemistry (01.06.2008)
Published in Bioorganic & medicinal chemistry (01.06.2008)
Get full text
Journal Article
Discovery of a Novel Class of Phosphodiesterase 10A Inhibitors and Identification of Clinical Candidate 2-[4-(1-Methyl-4-pyridin-4-yl-1H-pyrazol-3-yl)-phenoxymethyl]-quinoline (PF-2545920) for the Treatment of Schizophrenia † Coordinates of the PDE10A crystal structures have been deposited in the Protein Data Bank for compound 1 (3HQW), 2 (3HQY), 3 (3HQW) and 9 (3HR1)
Verhoest, Patrick R, Chapin, Douglas S, Corman, Michael, Fonseca, Kari, Harms, John F, Hou, Xinjun, Marr, Eric S, Menniti, Frank S, Nelson, Frederick, O’Connor, Rebecca, Pandit, Jayvardhan, Proulx-LaFrance, Caroline, Schmidt, Anne W, Schmidt, Christopher J, Suiciak, Judith A, Liras, Spiros
Published in Journal of medicinal chemistry (27.08.2009)
Published in Journal of medicinal chemistry (27.08.2009)
Get full text
Journal Article
Three-Dimensional Structure of Dimeric Human Recombinant Macrophage Colony-Stimulating Factor
Pandit, Jayvardhan, Bohm, Andrew, Jancarik, Jarmila, Halenbeck, Robert, Koths, Kirston, Kim, Sung-Hou
Published in Science (American Association for the Advancement of Science) (20.11.1992)
Published in Science (American Association for the Advancement of Science) (20.11.1992)
Get full text
Journal Article
Discovery of Cytotoxic Dolastatin 10 Analogues with N‑Terminal Modifications
Maderna, Andreas, Doroski, Matthew, Subramanyam, Chakrapani, Porte, Alexander, Leverett, Carolyn A, Vetelino, Beth C, Chen, Zecheng, Risley, Hud, Parris, Kevin, Pandit, Jayvardhan, Varghese, Alison H, Shanker, Suman, Song, Cynthia, Sukuru, Sai Chetan K, Farley, Kathleen A, Wagenaar, Melissa M, Shapiro, Michael J, Musto, Sylvia, Lam, My-Hanh, Loganzo, Frank, O’Donnell, Christopher J
Published in Journal of medicinal chemistry (26.12.2014)
Published in Journal of medicinal chemistry (26.12.2014)
Get full text
Journal Article
Discovery of PF-06835919: A Potent Inhibitor of Ketohexokinase (KHK) for the Treatment of Metabolic Disorders Driven by the Overconsumption of Fructose
Futatsugi, Kentaro, Smith, Aaron C, Tu, Meihua, Raymer, Brian, Ahn, Kay, Coffey, Steven B, Dowling, Matthew S, Fernando, Dilinie P, Gutierrez, Jemy A, Huard, Kim, Jasti, Jayasankar, Kalgutkar, Amit S, Knafels, John D, Pandit, Jayvardhan, Parris, Kevin D, Perez, Sylvie, Pfefferkorn, Jeffrey A, Price, David A, Ryder, Tim, Shavnya, Andre, Stock, Ingrid A, Tsai, Andy S, Tesz, Gregory J, Thuma, Benjamin A, Weng, Yan, Wisniewska, Hanna M, Xing, Gang, Zhou, Jun, Magee, Thomas V
Published in Journal of medicinal chemistry (25.11.2020)
Published in Journal of medicinal chemistry (25.11.2020)
Get full text
Journal Article
The three-dimensional structure of the ligand-binding domain of a wild-type bacterial chemotaxis receptor. Structural comparison to the cross-linked mutant forms and conformational changes upon ligand binding
YEH, J. I, BIEMANN, H.-P, JAYVARDHAN PANDIT, KOSHLAND, D. E, SUNG-HOU KIM
Published in The Journal of biological chemistry (05.05.1993)
Published in The Journal of biological chemistry (05.05.1993)
Get full text
Journal Article
Discovery of a Novel Class of Phosphodiesterase 10A Inhibitors and Identification of Clinical Candidate 2-[4-(1-Methyl-4-pyridin-4-yl-1H-pyrazol-3-yl)-phenoxymethyl]-quinoline (PF-2545920) for the Treatment of Schizophrenia
Verhoest, Patrick R., Chapin, Douglas S., Corman, Michael, Fonseca, Kari, Harms, John F., Hou, Xinjun, Marr, Eric S., Menniti, Frank S., Nelson, Frederick, O'Connor, Rebecca, Pandit, Jayvardhan, Proulx-LaFrance, Caroline, Schmidt, Anne W., Schmidt, Christopher J., Suiciak, Judith A., Liras, Spiros
Published in Journal of medicinal chemistry (27.08.2009)
Published in Journal of medicinal chemistry (27.08.2009)
Get full text
Journal Article
Discovery of Potent and Selective Periphery-Restricted Quinazoline Inhibitors of the Cyclic Nucleotide Phosphodiesterase PDE1
Humphrey, John M, Movsesian, Matthew, am Ende, Christopher W, Becker, Stacey L, Chappie, Thomas A, Jenkinson, Stephen, Liras, Jennifer L, Liras, Spiros, Orozco, Christine, Pandit, Jayvardhan, Vajdos, Felix F, Vandeput, Fabrice, Yang, Eddie, Menniti, Frank S
Published in Journal of medicinal chemistry (24.05.2018)
Published in Journal of medicinal chemistry (24.05.2018)
Get full text
Journal Article
Discovery of Trifluoromethyl Glycol Carbamates as Potent and Selective Covalent Monoacylglycerol Lipase (MAGL) Inhibitors for Treatment of Neuroinflammation
McAllister, Laura A, Butler, Christopher R, Mente, Scot, O’Neil, Steven V, Fonseca, Kari R, Piro, Justin R, Cianfrogna, Julie A, Foley, Timothy L, Gilbert, Adam M, Harris, Anthony R, Helal, Christopher J, Johnson, Douglas S, Montgomery, Justin I, Nason, Deane M, Noell, Stephen, Pandit, Jayvardhan, Rogers, Bruce N, Samad, Tarek A, Shaffer, Christopher L, da Silva, Rafael G, Uccello, Daniel P, Webb, Damien, Brodney, Michael A
Published in Journal of medicinal chemistry (12.04.2018)
Published in Journal of medicinal chemistry (12.04.2018)
Get full text
Journal Article
Utilizing Structures of CYP2D6 and BACE1 Complexes To Reduce Risk of Drug–Drug Interactions with a Novel Series of Centrally Efficacious BACE1 Inhibitors
Brodney, Michael A, Beck, Elizabeth M, Butler, Christopher R, Barreiro, Gabriela, Johnson, Eric F, Riddell, David, Parris, Kevin, Nolan, Charles E, Fan, Ying, Atchison, Kevin, Gonzales, Cathleen, Robshaw, Ashley E, Doran, Shawn D, Bundesmann, Mark W, Buzon, Leanne, Dutra, Jason, Henegar, Kevin, LaChapelle, Erik, Hou, Xinjun, Rogers, Bruce N, Pandit, Jayvardhan, Lira, Ricardo, Martinez-Alsina, Luis, Mikochik, Peter, Murray, John C, Ogilvie, Kevin, Price, Loren, Sakya, Subas M, Yu, Aijia, Zhang, Yong, O’Neill, Brian T
Published in Journal of medicinal chemistry (09.04.2015)
Published in Journal of medicinal chemistry (09.04.2015)
Get full text
Journal Article
Mechanism for the allosteric regulation of phosphodiesterase 2A deduced from the X-ray structure of a near full-length construct
Pandit, Jayvardhan, Forman, Michael D., Fennell, Kimberly F., Dillman, Keith S., Menniti, Frank S.
Published in Proceedings of the National Academy of Sciences - PNAS (18.06.2015)
Published in Proceedings of the National Academy of Sciences - PNAS (18.06.2015)
Get full text
Journal Article
Crystal Structure of Human Squalene Synthase
Pandit, Jayvardhan, Danley, Dennis E., Schulte, Gayle K., Mazzalupo, Stacy, Pauly, Thomas A., Hayward, Cheryl M., Hamanaka, Ernest S., Thompson, John F., Harwood, H. James
Published in The Journal of biological chemistry (29.09.2000)
Published in The Journal of biological chemistry (29.09.2000)
Get full text
Journal Article