Site-Specific Antibody–Drug Conjugation through Glycoengineering
Zhou, Qun, Stefano, James E, Manning, Charlene, Kyazike, Josephine, Chen, Bo, Gianolio, Diego A, Park, Anna, Busch, Michelle, Bird, Julie, Zheng, Xiaoyang, Simonds-Mannes, Helene, Kim, Jennifer, Gregory, Rick C, Miller, Robert J, Brondyk, William H, Dhal, Pradeep K, Pan, Clark Q
Published in Bioconjugate chemistry (19.03.2014)
Published in Bioconjugate chemistry (19.03.2014)
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Engineering an anti-CD52 antibody for enhanced deamidation stability
Qiu, Huawei, Wei, Ronnie, Jaworski, Julie, Boudanova, Ekaterina, Hughes, Heather, VanPatten, Scott, Lund, Anders, Day, Jaime, Zhou, Yanfeng, McSherry, Tracey, Pan, Clark Q, Sendak, Rebecca
Published in mAbs (03.10.2019)
Published in mAbs (03.10.2019)
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Journal Article
Glycan Structure Determinants for Cation-Independent Mannose 6‑Phosphate Receptor Binding and Cellular Uptake of a Recombinant Protein
Zhou, Qun, Avila, Luis Z, Konowicz, Paul A, Harrahy, John, Finn, Patrick, Kim, Jennifer, Reardon, Michael R, Kyazike, Josephine, Brunyak, Elizabeth, Zheng, Xiaoyang, Patten, Scott M. Van, Miller, Robert J, Pan, Clark Q
Published in Bioconjugate chemistry (18.12.2013)
Published in Bioconjugate chemistry (18.12.2013)
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Journal Article
Antifibrotic effects of a tissue inhibitor of metalloproteinase‐1 antibody on established liver fibrosis in rats
Parsons, Christopher J., Bradford, Blair U., Pan, Clark Q., Cheung, Ellen, Schauer, Michael, Knorr, Andreas, Krebs, Barbara, Kraft, Sabine, Zahn, Stefan, Brocks, Bodo, Feirt, Nikki, Mei, Baisong, Cho, Myung‐Sam, Ramamoorthi, Roopa, Roldan, Greg, Ng, Paul, Lum, Peggy, Hirth‐Dietrich, Claudia, Tomkinson, Adrian, Brenner, David A.
Published in Hepatology (Baltimore, Md.) (01.11.2004)
Published in Hepatology (Baltimore, Md.) (01.11.2004)
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Design of a Long Acting Peptide Functioning as Both a Glucagon-like Peptide-1 Receptor Agonist and a Glucagon Receptor Antagonist
Pan, Clark Q., Buxton, Joanne M., Yung, Stephanie L., Tom, Irene, Yang, Ling, Chen, Hongxing, MacDougall, Margit, Bell, Andrea, Claus, Thomas H., Clairmont, Kevin B., Whelan, James P.
Published in The Journal of biological chemistry (05.05.2006)
Published in The Journal of biological chemistry (05.05.2006)
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Journal Article
Structure of the lipoprotein lipase–GPIHBP1 complex that mediates plasma triglyceride hydrolysis
Birrane, Gabriel, Beigneux, Anne P., Dwyer, Brian, Strack-Logue, Bettina, Kristensen, Kristian Kølby, Francone, Omar L., Fong, Loren G., Mertens, Haydyn D. T., Pan, Clark Q., Ploug, Michael, Young, Stephen G., Meiyappan, Muthuraman
Published in Proceedings of the National Academy of Sciences - PNAS (29.01.2019)
Published in Proceedings of the National Academy of Sciences - PNAS (29.01.2019)
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Journal Article
Dual-acting peptide with prolonged glucagon-like peptide-1 receptor agonist and glucagon receptor antagonist activity for the treatment of type 2 diabetes
Claus, Thomas H, Pan, Clark Q, Buxton, Joanne M, Yang, Ling, Reynolds, Jennifer C, Barucci, Nicole, Burns, Michael, Ortiz, Astrid A, Roczniak, Steve, Livingston, James N, Clairmont, Kevin B, Whelan, James P
Published in Journal of endocrinology (01.02.2007)
Published in Journal of endocrinology (01.02.2007)
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Journal Article
Engineering Novel VPAC2-Selective Agonists with Improved Stability and Glucose-Lowering Activity in Vivo
Pan, Clark Q, Li, Fugang, Tom, Irene, Wang, Wei, Dumas, Michael, Froland, Wayne, Yung, Stephanie L, Li, Yaxin, Roczniak, Steve, Claus, Thomas H, Wang, Y John, Whelan, James P
Published in The Journal of pharmacology and experimental therapeutics (01.02.2007)
Published in The Journal of pharmacology and experimental therapeutics (01.02.2007)
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Journal Article
Expression of human coagulation factor VIII in a human hybrid cell line, HKB11
Mei, Baisong, Chen, Yaoqi, Chen, Jianmin, Pan, Clark Q, Murphy, John E
Published in Molecular biotechnology (01.10.2006)
Published in Molecular biotechnology (01.10.2006)
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Journal Article
Impact of cysteine variants on the structure, activity, and stability of recombinant human α‐galactosidase A
Qiu, Huawei, Honey, Denise M., Kingsbury, Jonathan S., Park, Anna, Boudanova, Ekaterina, Wei, Ronnie R., Pan, Clark Q., Edmunds, Tim
Published in Protein science (01.09.2015)
Published in Protein science (01.09.2015)
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Journal Article
Generation of Highly Selective VPAC2 Receptor Agonists by High Throughput Mutagenesis of Vasoactive Intestinal Peptide and Pituitary Adenylate Cyclase-activating Peptide
Yung, Stephanie L, Dela Cruz, Fernando, Hamren, Sarah, Zhu, Jian, Tsutsumi, Manami, Bloom, James W, Caudle, Margaret, Roczniak, Steve, Todd, Tracey, Lemoine, Lynn, MacDougall, Margit, Shanafelt, Armen B, Pan, Clark Q
Published in The Journal of biological chemistry (21.03.2003)
Published in The Journal of biological chemistry (21.03.2003)
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Structures of a pan‐specific antagonist antibody complexed to different isoforms of TGFβ reveal structural plasticity of antibody–antigen interactions
Moulin, Aaron, Mathieu, Magali, Lawrence, Catherine, Bigelow, Russell, Levine, Mark, Hamel, Christine, Marquette, Jean‐Piere, Parc, Josiane, Loux, Christophe, Ferrari, Paul, Capdevila, Cecile, Dumas, Jacques, Dumas, Bruno, Rak, Alexey, Bird, Julie, Qiu, Huawei, Pan, Clark Q., Edmunds, Tim, Wei, Ronnie R.
Published in Protein science (01.12.2014)
Published in Protein science (01.12.2014)
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Journal Article
Strategies for Neoglycan Conjugation to Human Acid α-Glucosidase
Zhou, Qun, Stefano, James E, Harrahy, John, Finn, Patrick, Avila, Luis, Kyazike, Josephine, Wei, Ronnie, Van Patten, Scott M, Gotschall, Russell, Zheng, Xiaoyang, Zhu, Yunxiang, Edmunds, Tim, Pan, Clark Q
Published in Bioconjugate chemistry (20.04.2011)
Published in Bioconjugate chemistry (20.04.2011)
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Journal Article
Site-Specific PEGylation of Human Thyroid Stimulating Hormone to Prolong Duration of Action
Qiu, Huawei, Boudanova, Ekaterina, Park, Anna, Bird, Julie J, Honey, Denise M, Zarazinski, Christine, Greene, Ben, Kingsbury, Jonathan S, Boucher, Susan, Pollock, Julie, McPherson, John M, Pan, Clark Q
Published in Bioconjugate chemistry (20.03.2013)
Published in Bioconjugate chemistry (20.03.2013)
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Journal Article
Carbohydrate-Mediated Polyethylene Glycol Conjugation of TSH Improves Its Pharmacological Properties
Park, Anna, Honey, Denise M, Hou, Lihui, Bird, Julie J, Zarazinski, Christine, Searles, Michelle, Braithwaite, Christian, Kingsbury, Jonathan S, Kyazike, Josephine, Culm-Merdek, Kerry, Greene, Ben, Stefano, James E, Qiu, Huawei, McPherson, John M, Pan, Clark Q
Published in Endocrinology (Philadelphia) (01.03.2013)
Published in Endocrinology (Philadelphia) (01.03.2013)
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Journal Article
High-Affinity VEGF Antagonists by Oligomerization of a Minimal Sequence VEGF-Binding Domain
Stefano, James E, Bird, Julie, Kyazike, Josephine, Cheng, Anthony Wai-Ming, Boudanova, Ekaterina, Dwyer, Markryan, Hou, Lihui, Qiu, Huawei, Matthews, Gloria, O’Callaghan, Michael, Pan, Clark Q
Published in Bioconjugate chemistry (19.12.2012)
Published in Bioconjugate chemistry (19.12.2012)
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Journal Article
Cloning and characterization of an actin-resistant DNase I-like endonuclease secreted by macrophages
Baron, Will F, Pan, Clark Q, Spencer, Steven A, Ryan, Anne M, Lazarus, Robert A, Baker, Kevin P
Published in Gene (30.07.1998)
Published in Gene (30.07.1998)
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Journal Article
A potent and highly selective VPAC2 agonist enhances glucose-induced insulin release and glucose disposal: A potential therapy for type 2 diabetes
TSUTSUMI, Manami, CLAUS, Thomas H, HAMREN, Sarah, LIVINGSTON, James N, PAN, Clark Q, YIN LIANG, YAXIN LI, LING YANG, JIAN ZHU, DELA CRUZ, Fernando, XIANBU PENG, HONGXING CHEN, YUNG, Stephanie L
Published in Diabetes (New York, N.Y.) (01.05.2002)
Published in Diabetes (New York, N.Y.) (01.05.2002)
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