Discovery of a piperazine urea based compound as a potent, selective, orally bioavailable melanocortin subtype-4 receptor partial agonist
Hong, Qingmei, Bakshi, Raman K., Palucki, Brenda L., Park, Min K., Ye, Zhixiong, He, Shuwen, Pollard, Patrick G., Sebhat, Iyassu K., Liu, Jian, Guo, Liangqin, Cashen, Doreen E., Martin, William J., Weinberg, David H., MacNeil, Tanya, Tang, Rui, Tamvakopoulos, Constantin, Peng, Qianping, Miller, Randy R., Stearns, Ralph A., Chen, Howard Y., Chen, Airu S., Strack, Alison M., Fong, Tung M., MacIntyre, D. Euan, Wyvratt, Matthew J., Nargund, Ravi P.
Published in Bioorganic & medicinal chemistry letters (15.04.2011)
Published in Bioorganic & medicinal chemistry letters (15.04.2011)
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Journal Article
Discovery of (2 S)- N-[(1 R)-2-[4-cyclohexyl-4-[[(1,1-dimethylethyl)amino]carbonyl]-1-piperidinyl]-1-[(4-fluorophenyl)methyl]-2-oxoethyl]-4-methyl-2-piperazinecarboxamide (MB243), a potent and selective melanocortin subtype-4 receptor agonist
Palucki, Brenda L., Park, Min K., Nargund, Ravi P., Ye, Zhixiong, Sebhat, Iyassu K., Pollard, Patrick G., Kalyani, Rubana N., Tang, Rui, MacNeil, Tanya, Weinberg, David H., Vongs, Aurawan, Rosenblum, Charles I., Doss, George A., Miller, Randall R., Stearns, Ralph A., Peng, Qianping, Tamvakopoulos, Constantin, McGowan, Erin, Martin, William J., Metzger, Joseph M., Shepherd, Cherrie A., Strack, Alison M., MacIntyre, D. Euan, Van der Ploeg, Lex H.T., Patchett, Arthur A.
Published in Bioorganic & medicinal chemistry letters (03.01.2005)
Published in Bioorganic & medicinal chemistry letters (03.01.2005)
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Journal Article
Discovery and activity of (1 R,4 S,6 R)- N-[(1 R)-2-[4-cyclohexyl-4-[[(1,1-dimethylethyl)amino]carbonyl]-1-piperidinyl]-1-[(4-fluorophenyl)methyl]-2-oxoethyl]-2-methyl-2-azabicyclo[2.2.2]octane-6-carboxamide (3, RY764), a potent and selective melanocortin subtype-4 receptor agonist
Ye, Zhixiong, Guo, Liangqin, Barakat, Khaled J., Pollard, Patrick G., Palucki, Brenda L., Sebhat, Iyassu K., Bakshi, Raman K., Tang, Rui, Kalyani, Rubana N., Vongs, Aurawan, Chen, Airu S., Chen, Howard Y., Rosenblum, Charles I., MacNeil, Tanya, Weinberg, David H., Peng, Qianping, Tamvakopoulos, Constantin, Miller, Randy R., Stearns, Ralph A., Cashen, Doreen E., Martin, William J., Metzger, Joseph M., Strack, Alison M., MacIntyre, D. Euan, Van der Ploeg, Lex H.T., Patchett, Arthur A., Wyvratt, Matthew J., Nargund, Ravi P.
Published in Bioorganic & medicinal chemistry letters (01.08.2005)
Published in Bioorganic & medicinal chemistry letters (01.08.2005)
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Journal Article
2-Piperazinecarboxamides as potent and selective melanocortin subtype-4 receptor agonists
Palucki, Brenda L., Park, Min K., Nargund, Ravi P., Tang, Rui, MacNeil, Tanya, Weinberg, David H., Vongs, Aurawan, Rosenblum, Charles I., Doss, George A., Miller, Randall R., Stearns, Ralph A., Peng, Qianping, Tamvakopoulos, Constantin, Van der Ploeg, Lex H.T., Patchett, Arthur A.
Published in Bioorganic & medicinal chemistry letters (15.04.2005)
Published in Bioorganic & medicinal chemistry letters (15.04.2005)
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Journal Article
Spiro(indoline-3,4'-piperidine) growth hormone secretagogues as ghrelin mimetics
PALUCKI, Brenda L, FEIGHNER, Scott D, PONG, Sheng-Shung, MCKEE, Karen Kulju, HRENIUK, Donna L, TAN, Carina, HOWARD, Andrew D, VAN DER PLOEG, Lex H. Y, PATCHETT, Arthur A, NARGUND, Ravi P
Published in Bioorganic & medicinal chemistry letters (23.07.2001)
Published in Bioorganic & medicinal chemistry letters (23.07.2001)
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Journal Article
Discovery of (2S)-N-[(1R)-2-[4-cyclohexyl-4-[[(1,1-dimethylethyl)-amino]carbonyl]-1-piperidin yl]-1-[(4-fluorophenyl)methyl]-2-oxoethyl]-4-methyl-2-piperazinecarboxamide (MB243), a potent and selective melanocortin subtype-4 receptor agonist
PALUCKI, Brenda L, PARK, Min K, VONGS, Aurawan, ROSENBLUM, Charles I, DOSS, George A, MILLER, Randall R, STEARNS, Ralph A, QIANPING PENG, TAMVAKOPOULOS, Constantin, MCGOWAN, Erin, MARTIN, William J, METZGER, Joseph M, NARGUND, Ravi P, SHEPHERD, Cherrie A, STRACK, Alison M, MACINTYRE, D. Euan, VAN DER PLOEG, Lex H. T, PATCHETT, Arthur A, ZHIXIONG YE, SEBHAT, Iyassu K, POLLARD, Patrick G, KALYANI, Rubana N, RUI TANG, MACNEIL, Tanya, WEINBERG, David H
Published in Bioorganic & medicinal chemistry letters (2005)
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Published in Bioorganic & medicinal chemistry letters (2005)
Journal Article
Piperazine urea derivatives as melanocortin-4 receptor agonists
YE ZHIXIONG, PALUCKI BRENDA L, PARK MIN K, BAKSHI RAMAN KUMAR, NARGUND RAVI P
Year of Publication 19.08.2008
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Year of Publication 19.08.2008
Patent
Piperazine urea derivatives as melanocortin-4 receptor agonists
Bakshi, Raman Kumar, Nargund, Ravi P, Palucki, Brenda L, Park, Min K, Ye, Zhixiong
Year of Publication 19.08.2008
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Year of Publication 19.08.2008
Patent
SUBSTITUTED PIPERIDINES AS MELANOCORTIN RECEPTOR AGONISTS
PARK, MIN K, PALUCKI, BRENDA L, LAI, YINGJIE, YE, ZHIXIONG, POLLARD, PATRICK G, SEBHAT, IYASSU K, GUO, LIANGQIN, NARGUND, RAVI P, BARAKAT, KHALED J
Year of Publication 26.01.2010
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Year of Publication 26.01.2010
Patent
PIPERAZINE UREA DERIVATIVES AS MELANOCORTIN-4 RECEPTOR AGONISTS
YE, ZHIXIONG, BAKSHI, RAMAN KUMAR, PARK, MIN, K, NARGUND, RAVI, P, PALUCKI, BRENDA, L
Year of Publication 26.07.2006
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Year of Publication 26.07.2006
Patent
Piperazine urea derivatives as melanocortin-4 receptor agonists
BAKSHI RAMAN K, YE ZHIXIONG, PALUCKI BRENDA L, PARK MIN K, NARGUND RAVI P
Year of Publication 23.02.2006
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Year of Publication 23.02.2006
Patent