Cryo-EM structures of inhibitory antibodies complexed with arginase 1 provide insight into mechanism of action
Palte, Rachel L, Juan, Veronica, Gomez-Llorente, Yacob, Bailly, Marc Andre, Chakravarthy, Kalyan, Chen, Xun, Cipriano, Daniel, Fayad, Ghassan N, Fayadat-Dilman, Laurence, Gathiaka, Symon, Greb, Heiko, Hall, Brian, Handa, Mas, Hsieh, Mark, Kofman, Esther, Lin, Heping, Miller, J Richard, Nguyen, Nhung, O'Neil, Jennifer, Shaheen, Hussam, Sterner, Eric, Strickland, Corey, Sun, Angie, Taremi, Shane, Scapin, Giovanna
Published in Communications biology (29.07.2021)
Published in Communications biology (29.07.2021)
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Author Correction: Cryo-EM structures of inhibitory antibodies complexed with arginase 1 provide insight into mechanism of action
Palte, Rachel L., Juan, Veronica, Gomez-Llorente, Yacob, Bailly, Marc Andre, Chakravarthy, Kalyan, Chen, Xun, Cipriano, Daniel, Fayad, Ghassan N., Fayadat-Dilman, Laurence, Gathiaka, Symon, Greb, Heiko, Hall, Brian, Handa, Mas, Hsieh, Mark, Kofman, Esther, Lin, Heping, Miller, J. Richard, Nguyen, Nhung, O’Neil, Jennifer, Shaheen, Hussam, Sterner, Eric, Strickland, Corey, Sun, Angie, Taremi, Shane, Scapin, Giovanna
Published in Communications biology (15.11.2021)
Published in Communications biology (15.11.2021)
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Journal Article
Design and synthesis of unprecedented 9- and 10-membered cyclonucleosides with PRMT5 inhibitory activity
Kawamura, Shuhei, Palte, Rachel L., Kim, Hai-Young, Saurí, Josep, Sondey, Christopher, Mansueto, My S., Altman, Michael D., Machacek, Michelle R.
Published in Bioorganic & medicinal chemistry (15.07.2022)
Published in Bioorganic & medicinal chemistry (15.07.2022)
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Discovery of non-boronic acid Arginase 1 inhibitors through virtual screening and biophysical methods
Gathiaka, Symon, Palte, Rachel L., So, Sung-Sau, Chai, Xiaomei, Richard Miller, J., Kuvelkar, Reshma, Wen, Xiujuan, Cifelli, Steven, Kreamer, Anthony, Liaw, Andy, McLaren, David G., Fischer, Christian
Published in Bioorganic & medicinal chemistry letters (15.03.2023)
Published in Bioorganic & medicinal chemistry letters (15.03.2023)
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Structure-Guided Discovery of Aminoquinazolines as Brain-Penetrant and Selective LRRK2 Inhibitors
Keylor, Mitchell H, Gulati, Anmol, Kattar, Solomon D, Johnson, Rebecca E, Chau, Ryan W, Margrey, Kaila A, Ardolino, Michael J, Zarate, Cayetana, Poremba, Kelsey E, Simov, Vladimir, Morriello, Gregori J, Acton, John J, Pio, Barbara, Yan, Xin, Palte, Rachel L, McMinn, Spencer E, Nogle, Lisa, Lesburg, Charles A, Adpressa, Donovon, Lin, Shishi, Neelamkavil, Santhosh, Liu, Ping, Su, Jing, Hegde, Laxminarayan G, Woodhouse, Janice D, Faltus, Robert, Xiong, Tina, Ciaccio, Paul J, Piesvaux, Jennifer, Otte, Karin M, Wood, Harold B, Kennedy, Matthew E, Bennett, David Jonathan, DiMauro, Erin F, Fell, Matthew J, Fuller, Peter H
Published in Journal of medicinal chemistry (13.01.2022)
Published in Journal of medicinal chemistry (13.01.2022)
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Development of a Flexible and Robust Synthesis of Tetrahydrofuro[3,4‑b]furan Nucleoside Analogues
Candito, David A, Ye, Yingchun, Quiroz, Ryan V, Reutershan, Michael H, Witter, David, Gadamsetty, Surendra B, Li, Hongming, Saurí, Josep, Schneider, Sebastian E, Lam, Yu-hong, Palte, Rachel L
Published in Journal of organic chemistry (02.04.2021)
Published in Journal of organic chemistry (02.04.2021)
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Discovery and Optimization of N‑Heteroaryl Indazole LRRK2 Inhibitors
Logan, Kaitlyn M., Kaplan, Will, Simov, Vladimir, Zhou, Hua, Li, Derun, Torres, Luis, Morriello, Gregori J., Acton, John J., Pio, Barbara, Chen, Yi-Heng, Keylor, Mitchell H., Johnson, Rebecca, Kattar, Solomon D., Chau, Ryan, Yan, Xin, Ardolino, Michael, Zarate, Cayetana, Otte, Karin M., Palte, Rachel L., Xiong, Tina, McMinn, Spencer E., Lin, Shishi, Neelamkavil, Santhosh F., Liu, Ping, Su, Jing, Hegde, Laxminarayan G., Woodhouse, Janice D., Moy, Lily Y., Ciaccio, Paul J., Piesvaux, Jennifer, Zebisch, Matthias, Henry, Clare, Barker, John, Wood, Harold B., Kennedy, Matthew E., DiMauro, Erin F., Fell, Matthew J., Fuller, Peter H.
Published in Journal of medicinal chemistry (26.09.2024)
Published in Journal of medicinal chemistry (26.09.2024)
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The Discovery of Two Novel Classes of 5,5-Bicyclic Nucleoside-Derived PRMT5 Inhibitors for the Treatment of Cancer
Quiroz, Ryan V, Reutershan, Michael H, Schneider, Sebastian E, Sloman, David, Lacey, Brian M, Swalm, Brooke M, Yeung, Charles S, Gibeau, Craig, Spellman, Daniel S, Rankic, Danica A, Chen, Dapeng, Witter, David, Linn, Doug, Munsell, Erik, Feng, Guo, Xu, Haiyan, Hughes, Jonathan M. E, Lim, Jongwon, Saurí, Josep, Geddes, Kristin, Wan, Murray, Mansueto, My Sam, Follmer, Nicole E, Fier, Patrick S, Siliphaivanh, Phieng, Daublain, Pierre, Palte, Rachel L, Hayes, Robert P, Lee, Sandra, Kawamura, Shuhei, Silverman, Steven, Sanyal, Sulagna, Henderson, Timothy J, Ye, Yingchun, Gao, Yuanwei, Nicholson, Benjamin, Machacek, Michelle R
Published in Journal of medicinal chemistry (08.04.2021)
Published in Journal of medicinal chemistry (08.04.2021)
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Discovery of MK-1468: A Potent, Kinome-Selective, Brain-Penetrant Amidoisoquinoline LRRK2 Inhibitor for the Potential Treatment of Parkinson’s Disease
Kattar, Solomon D., Gulati, Anmol, Margrey, Kaila A., Keylor, Mitchell H., Ardolino, Michael, Yan, Xin, Johnson, Rebecca, Palte, Rachel L., McMinn, Spencer E., Nogle, Lisa, Su, Jing, Xiao, Dong, Piesvaux, Jennifer, Lee, Susi, Hegde, Laxminarayan G., Woodhouse, Janice D., Faltus, Robert, Moy, Lily Y., Xiong, Tina, Ciaccio, Paul J., Pearson, Kara, Patel, Mayankbhai, Otte, Karin M., Leyns, Cheryl E.G., Kennedy, Matthew E., Bennett, David Jonathan, DiMauro, Erin F., Fell, Matthew J., Fuller, Peter H.
Published in Journal of medicinal chemistry (09.11.2023)
Published in Journal of medicinal chemistry (09.11.2023)
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Allosteric Modulation of Protein Arginine Methyltransferase 5 (PRMT5)
Palte, Rachel L, Schneider, Sebastian E, Altman, Michael D, Hayes, Robert P, Kawamura, Shuhei, Lacey, Brian M, Mansueto, My Sam, Reutershan, Michael, Siliphaivanh, Phieng, Sondey, Christopher, Xu, Haiyan, Xu, Zangwei, Ye, Yingchun, Machacek, Michelle R
Published in ACS medicinal chemistry letters (10.09.2020)
Published in ACS medicinal chemistry letters (10.09.2020)
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Discovery and Optimization of Potent, Selective, and Brain-Penetrant 1‑Heteroaryl‑1H‑Indazole LRRK2 Kinase Inhibitors for the Treatment of Parkinson’s Disease
Candito, David A., Simov, Vladimir, Gulati, Anmol, Kattar, Solomon, Chau, Ryan W., Lapointe, Blair T., Methot, Joey L., DeMong, Duane E., Graham, Thomas H., Kurukulasuriya, Ravi, Keylor, Mitchell H., Tong, Ling, Morriello, Gregori J., Acton, John J., Pio, Barbara, Liu, Weiguo, Scott, Jack D., Ardolino, Michael J., Martinot, Theodore A., Maddess, Matthew L., Yan, Xin, Gunaydin, Hakan, Palte, Rachel L., McMinn, Spencer E., Nogle, Lisa, Yu, Hongshi, Minnihan, Ellen C., Lesburg, Charles A., Liu, Ping, Su, Jing, Hegde, Laxminarayan G., Moy, Lily Y., Woodhouse, Janice D., Faltus, Robert, Xiong, Tina, Ciaccio, Paul, Piesvaux, Jennifer A., Otte, Karin M., Kennedy, Matthew E., Bennett, David Jonathan, DiMauro, Erin F., Fell, Matthew J., Neelamkavil, Santhosh, Wood, Harold B., Fuller, Peter H., Ellis, J. Michael
Published in Journal of medicinal chemistry (22.12.2022)
Published in Journal of medicinal chemistry (22.12.2022)
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Journal Article
Discovery and Optimization of Potent, Selective, and Brain-Penetrant 1-Heteroaryl-1 H -Indazole LRRK2 Kinase Inhibitors for the Treatment of Parkinson's Disease
Candito, David A, Simov, Vladimir, Gulati, Anmol, Kattar, Solomon, Chau, Ryan W, Lapointe, Blair T, Methot, Joey L, DeMong, Duane E, Graham, Thomas H, Kurukulasuriya, Ravi, Keylor, Mitchell H, Tong, Ling, Morriello, Gregori J, Acton, John J, Pio, Barbara, Liu, Weiguo, Scott, Jack D, Ardolino, Michael J, Martinot, Theodore A, Maddess, Matthew L, Yan, Xin, Gunaydin, Hakan, Palte, Rachel L, McMinn, Spencer E, Nogle, Lisa, Yu, Hongshi, Minnihan, Ellen C, Lesburg, Charles A, Liu, Ping, Su, Jing, Hegde, Laxminarayan G, Moy, Lily Y, Woodhouse, Janice D, Faltus, Robert, Xiong, Tina, Ciaccio, Paul, Piesvaux, Jennifer A, Otte, Karin M, Kennedy, Matthew E, Bennett, David Jonathan, DiMauro, Erin F, Fell, Matthew J, Neelamkavil, Santhosh, Wood, Harold B, Fuller, Peter H, Ellis, J Michael
Published in Journal of medicinal chemistry (22.12.2022)
Published in Journal of medicinal chemistry (22.12.2022)
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Structure-Based Discovery of Proline-Derived Arginase Inhibitors with Improved Oral Bioavailability for Immuno-Oncology
Lu, Min, Zhang, Hongjun, Li, Derun, Childers, Matthew, Pu, Qinglin, Palte, Rachel L, Gathiaka, Symon, Lyons, Thomas W, Palani, Anandan, Fan, Peter W, Spacciapoli, Peter, Miller, J. Richard, Cho, Hyelim, Cheng, Mangeng, Chakravarthy, Kalyan, O’Neil, Jennifer, Eangoor, Padmanabhan, Beard, Adam, Kim, Hai-Young, Saurí, Josep, Gunaydin, Hakan, Sloman, David L, Siliphaivanh, Phieng, Cumming, Jared, Fischer, Christian
Published in ACS medicinal chemistry letters (09.09.2021)
Published in ACS medicinal chemistry letters (09.09.2021)
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Discovery and Optimization of Rationally Designed Bicyclic Inhibitors of Human Arginase to Enhance Cancer Immunotherapy
Mitcheltree, Matthew J, Li, Derun, Achab, Abdelghani, Beard, Adam, Chakravarthy, Kalyan, Cheng, Mangeng, Cho, Hyelim, Eangoor, Padmanabhan, Fan, Peter, Gathiaka, Symon, Kim, Hai-Young, Lesburg, Charles A, Lyons, Thomas W, Martinot, Theodore A, Miller, J. Richard, McMinn, Spencer, O’Neil, Jennifer, Palani, Anandan, Palte, Rachel L, Saurí, Josep, Sloman, David L, Zhang, Hongjun, Cumming, Jared N, Fischer, Christian
Published in ACS medicinal chemistry letters (09.04.2020)
Published in ACS medicinal chemistry letters (09.04.2020)
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Comprehensive Strategies to Bicyclic Prolines: Applications in the Synthesis of Potent Arginase Inhibitors
Li, Derun, Zhang, Hongjun, Lyons, Thomas W, Lu, Min, Achab, Abdelghani, Pu, Qinglin, Childers, Matthew, Mitcheltree, Matthew J, Wang, Jialiang, Martinot, Theodore A, McMinn, Spencer E, Sloman, David L, Palani, Anandan, Beard, Adam, Nogle, Lisa, Gathiaka, Symon, Saurí, Josep, Kim, Hai-Young, Adpressa, Donovon, Spacciapoli, Peter, Miller, J. Richard, Palte, Rachel L, Lesburg, Charles A, Cumming, Jared, Fischer, Christian
Published in ACS medicinal chemistry letters (11.11.2021)
Published in ACS medicinal chemistry letters (11.11.2021)
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Discovery of N‑(Indazol-3-yl)piperidine-4-carboxylic Acids as RORγt Allosteric Inhibitors for Autoimmune Diseases
Zhang, Hongjun, Lapointe, Blair T, Anthony, Neville, Azevedo, Rita, Cals, Jos, Correll, Craig C, Daniels, Matthew, Deshmukh, Sujal, van Eenenaam, Hans, Ferguson, Heidi, Hegde, Laxminarayan G, Karstens, Willem Jan, Maclean, John, Miller, J. Richard, Moy, Lily Y, Simov, Vladimir, Nagpal, Sunil, Oubrie, Arthur, Palte, Rachel L, Parthasarathy, Gopal, Sciammetta, Nunzio, van der Stelt, Mario, Woodhouse, Janice D, Trotter, B. Wesley, Barr, Kenneth
Published in ACS medicinal chemistry letters (13.02.2020)
Published in ACS medicinal chemistry letters (13.02.2020)
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ARGINASE 1 BINDERS FOR INHIBITING ARGINASE 1 ACTIVITY
FAYADAT-DILMAN, Laurence, BAILLY, Marc Andre, PALTE, Rachel, L, CHAKRAVARTHY, Kalyan, KOFMAN, Esther, O'NEIL, Jennifer, E, FAYAD, Ghassan Najib, SCAPIN, Giovanna, HANDA, Masahisa, TAREMI, Shahriar Shane
Year of Publication 04.10.2023
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Year of Publication 04.10.2023
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ARGINASE INHIBITORS AND METHODS OF USE
Lu, Min, Gathiaka, Symon, Li, Derun, Fischer, Christian, Palani, Anandan, Zhang, Hongjun, Achab, Abdelghani Abe, Childers, Matthew L, Sloman, David L, Pu, Qinglin, Palte, Rachel L
Year of Publication 04.05.2023
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Year of Publication 04.05.2023
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ARGINASE INHIBITORS AND METHODS OF USE
LU, Min, PALANI, Anandan, PALTE, Rachel, L, ACHAB, Abdelghani Abe, CHILDERS, Matthew, L, ZHANG, Hongjun, PU, Qinglin, FISCHER, Christian, GATHIAKA, Symon, LI, Derun, SLOMAN, David, L
Year of Publication 24.01.2024
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Year of Publication 24.01.2024
Patent
ARGINASE INHIBITORS AND METHODS OF USE
Lu, Min, Mitcheltree, Matthew J, Gathiaka, Symon, Cumming, Jared N, Li, Derun, Palani, Anandan, Zhang, Hongjun, Achab, Abdelghani Abe, Childers, Matthew L, Lesburg, Charles A, Palte, Rachel L
Year of Publication 24.02.2022
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Year of Publication 24.02.2022
Patent