A Novel Class of Nonpeptidic Biaryl Inhibitors of Human Cathepsin K
Robichaud, Joël, Oballa, Renata, Prasit, Peppi, Falgueyret, Jean-Pierre, Percival, M. David, Wesolowski, Gregg, Rodan, Sevgi B, Kimmel, Donald, Johnson, Colena, Bryant, Cliff, Venkatraman, Shankar, Setti, Eduardo, Mendonca, Rohan, Palmer, James T
Published in Journal of medicinal chemistry (14.08.2003)
Published in Journal of medicinal chemistry (14.08.2003)
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Journal Article
VEGF antagonism reduces edema formation and tissue damage after ischemia/reperfusion injury in the mouse brain
van Bruggen, N, Thibodeaux, H, Palmer, J T, Lee, W P, Fu, L, Cairns, B, Tumas, D, Gerlai, R, Williams, S P, van Lookeren Campagne, M, Ferrara, N
Published in The Journal of clinical investigation (01.12.1999)
Published in The Journal of clinical investigation (01.12.1999)
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Journal Article
Trifluoroethylamines as amide isosteres in inhibitors of cathepsin K
Black, W. Cameron, Bayly, Christopher I., Davis, Dana E., Desmarais, Sylvie, Falgueyret, Jean-Pierre, Léger, Serge, Li, Chun Sing, Massé, Frédéric, McKay, Daniel J., Palmer, James T., Percival, M. David, Robichaud, Joël, Tsou, Nancy, Zamboni, Robert
Published in Bioorganic & medicinal chemistry letters (01.11.2005)
Published in Bioorganic & medicinal chemistry letters (01.11.2005)
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Journal Article
Design and synthesis of tri-ring P-3 benzamide-containing aminonitriles as potent, selective, orally effective inhibitors of cathepsin K
Palmer, JT, Bryant, C, Wang, DX, Davis, DE, Setti, EL, Rydzewski, RM, Venkatraman, S, Tian, ZQ, Burrill, LC, Mendonca, RV, Springman, E, McCarter, J, Chung, T, Cheung, H, Janc, JW, McGrath, M, Somoza, Enriquez, P, Yu, ZW, Strickley, RM, Liu, L, Venuti, MC, Percival, MD, Falgueyret, JP, Prasit, P, Oballa, R, Riendeau, D, Young, RN, Wesolowski, G, Rodan, SB, Johnson, C, Kimmel, DB, Rodan, G
Published in Journal of medicinal chemistry (01.12.2005)
Published in Journal of medicinal chemistry (01.12.2005)
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Journal Article
Keto-1,3,4-oxadiazoles as cathepsin K inhibitors
Palmer, James T., Hirschbein, Bernard L., Cheung, Harry, McCarter, John, Janc, James W., Yu, Z. Walter, Wesolowski, Gregg
Published in Bioorganic & medicinal chemistry letters (01.06.2006)
Published in Bioorganic & medicinal chemistry letters (01.06.2006)
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Journal Article
Vinyl Sulfones as Mechanism-Based Cysteine Protease Inhibitors
Palmer, James T, Rasnick, David, Klaus, Jeffrey L, Bromme, Dieter
Published in Journal of medicinal chemistry (01.08.1995)
Published in Journal of medicinal chemistry (01.08.1995)
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Journal Article
Cathepsin S activity regulates antigen presentation and immunity
Riese, R J, Mitchell, R N, Villadangos, J A, Shi, G P, Palmer, J T, Karp, E R, De Sanctis, G T, Ploegh, H L, Chapman, H A
Published in The Journal of clinical investigation (01.06.1998)
Published in The Journal of clinical investigation (01.06.1998)
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Journal Article
Evidence for a Protective Role of Metallothionein-1 in Focal Cerebral Ischemia
Menno van Lookeren Campagne, Thibodeaux, Harold, van Bruggen, Nick, Cairns, Belinda, Gerlal, Robert, Palmer, James T., Williams, Simon P., Lowe, David G.
Published in Proceedings of the National Academy of Sciences - PNAS (26.10.1999)
Published in Proceedings of the National Academy of Sciences - PNAS (26.10.1999)
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Journal Article
Peptidyl vinyl sulphones: a new class of potent and selective cysteine protease inhibitors: S2P2 specificity of human cathepsin O2 in comparison with cathepsins S and L
Brömme, D, Klaus, J L, Okamoto, K, Rasnick, D, Palmer, J T
Published in Biochemical journal (01.04.1996)
Published in Biochemical journal (01.04.1996)
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Journal Article
β-Substituted Cyclohexanecarboxamide: A Nonpeptidic Framework for the Design of Potent Inhibitors of Cathepsin K
Crane, Sheldon N, Black, W. Cameron, Palmer, James T, Davis, Dana E, Setti, Eduardo, Robichaud, Joel, Paquet, Julie, Oballa, Renata M, Bayly, Christopher I, McKay, Daniel J, Somoza, John R, Chauret, Natalie, Seto, Carmai, Scheigetz, John, Wesolowski, Greg, Massé, Frederic, Desmarais, Sylvie, Ouellet, Marc
Published in Journal of medicinal chemistry (09.02.2006)
Published in Journal of medicinal chemistry (09.02.2006)
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Journal Article
Peptide Ketobenzoxazole Inhibitors Bound to Cathepsin K
McGrath, Mary E, Sprengeler, Paul A, Hill, Craig M, Martichonok, Valeri, Cheung, Harry, Somoza, John R, Palmer, James T, Janc, James W
Published in Biochemistry (Easton) (30.12.2003)
Published in Biochemistry (Easton) (30.12.2003)
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Journal Article
Design and synthesis of selective keto-1,2,4-oxadiazole-based tryptase inhibitors
Palmer, James T., Rydzewski, Robert M., Mendonca, Rohan V., Sperandio, David, Spencer, Jeffrey R., Hirschbein, Bernard L., Lohman, Julia, Beltman, Jeri, Nguyen, Margaret, Liu, Liang
Published in Bioorganic & medicinal chemistry letters (01.07.2006)
Published in Bioorganic & medicinal chemistry letters (01.07.2006)
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Journal Article
Antimalarial effects of vinyl sulfone cysteine proteinase inhibitors
ROSENTHAL, P. J, OLSON, J. E, LEE, G. K, PALMER, J. T, KLAUS, J. L, RASNICK, D
Published in Antimicrobial Agents and Chemotherapy (01.07.1996)
Published in Antimicrobial Agents and Chemotherapy (01.07.1996)
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Journal Article
Localization of Rat Cathepsin K in Osteoclasts and Resorption Pits: Inhibition of Bone Resorption and Cathepsin K-Activity by Peptidyl Vinyl Sulfones
Xia, L., Kilb, J., Wex, H., Li, Z., Lipyansky, A., Breuil, V., Stein, L., Palmer, J.T., Dempster, D.W., Brömme, D.
Published in Biological chemistry (01.06.1999)
Published in Biological chemistry (01.06.1999)
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Journal Article
Crystal Structure of Human Cathepsin V
Somoza, John R, Zhan, Hangjun, Bowman, Krista K, Yu, Lily, Mortara, Kyle D, Palmer, James T, Clark, James M, McGrath, Mary E
Published in Biochemistry (Easton) (17.10.2000)
Published in Biochemistry (Easton) (17.10.2000)
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Journal Article
High-Resolution Functional Magnetic Resonance Imaging of the Rat Brain: Mapping Changes in Cerebral Blood Volume Using Iron Oxide Contrast Media
van Bruggen, Nicholas, Busch, Elmar, Palmer, James T., Williams, Simon-Peter, de Crespigny, Alexander J.
Published in Journal of cerebral blood flow and metabolism (01.11.1998)
Published in Journal of cerebral blood flow and metabolism (01.11.1998)
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Journal Article
Crystal structure of human cathepsin S
Mcgrath, Mary E., Palmer, James T., Brömme, Ddeter, Somoza, John R.
Published in Protein science (01.06.1998)
Published in Protein science (01.06.1998)
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Journal Article
Expression of human cathepsin K in Pichia pastoris and preliminary crystallographic studies of an inhibitor complex
Linnevers, Christopher J., Mcgrath, Mary E., Armstrong, Andy, Mistry, Firoz R., Barnes, Michael G., Klaus, Jeffrey L., Palmer, James T., Katz, Bradley A., Brömme, Dieter
Published in Protein science (01.04.1997)
Published in Protein science (01.04.1997)
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Journal Article