Discovery of a Novel Mode of Protein Kinase Inhibition Characterized by the Mechanism of Inhibition of Human Mesenchymal-epithelial Transition Factor (c-Met) Protein Autophosphorylation by ARQ 197
Eathiraj, Sudharshan, Palma, Rocio, Volckova, Erika, Hirschi, Marscha, France, Dennis S., Ashwell, Mark A., Chan, Thomas C.K.
Published in The Journal of biological chemistry (10.06.2011)
Published in The Journal of biological chemistry (10.06.2011)
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Journal Article
Discovery and Optimization of a Series of 3-(3-Phenyl-3H-imidazo[4,5-b]pyridin-2-yl)pyridin-2-amines: Orally Bioavailable, Selective, and Potent ATP-Independent Akt Inhibitors
Ashwell, Mark A, Lapierre, Jean-Marc, Brassard, Christopher, Bresciano, Karen, Bull, Cathy, Cornell-Kennon, Susan, Eathiraj, Sudharshan, France, Dennis S, Hall, Terence, Hill, Jason, Kelleher, Eoin, Khanapurkar, Sampada, Kizer, Darin, Koerner, Steffi, Link, Jeff, Liu, Yanbin, Makhija, Sapna, Moussa, Magdi, Namdev, Nivedita, Nguyen, Khanh, Nicewonger, Robert, Palma, Rocio, Szwaya, Jeff, Tandon, Manish, Uppalapati, Uma, Vensel, David, Volak, Laurie P, Volckova, Erika, Westlund, Neil, Wu, Hui, Yang, Rui-Yang, Chan, Thomas C. K
Published in Journal of medicinal chemistry (14.06.2012)
Published in Journal of medicinal chemistry (14.06.2012)
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Adsorption of cobalt by using inorganic components of sediment samples from water bodies
Montes de Oca-Palma, Rocío, Solache-Ríos, Marcos, Jiménez-Reyes, Melania, García-Sánchez, José Juan, Almazán-Sánchez, Perla Tatiana
Published in International journal of sediment research (01.08.2021)
Published in International journal of sediment research (01.08.2021)
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Journal Article
Synthesis and Antioxidant Activity of Alkyl Nitroderivatives of Hydroxytyrosol
Gallardo, Elena, Palma-Valdés, Rocío, Sarriá, Beatriz, Gallardo, Irene, de la Cruz, José P, Bravo, Laura, Mateos, Raquel, Espartero, José L
Published in Molecules (Basel, Switzerland) (18.05.2016)
Published in Molecules (Basel, Switzerland) (18.05.2016)
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Journal Article
Success Rate of Apical Surgeries Performed in a Postgraduate Endodontic Fellowship. A Retrospective Observational Study
Claudia Milena Roa Flórez, Laura María Espinosa Giraldo, Ivonne Rocio Palma Motta, María Alejandra Castillo Delgado, Luis Alberto López Pérez, Julieta Bermúdez Alarcón, Jaime Rodrigo Rivera Barrero
Published in Revista Cubana de estomatologia (01.05.2024)
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Published in Revista Cubana de estomatologia (01.05.2024)
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A novel mode of protein kinase inhibition exploiting hydrophobic motifs of autoinhibited kinases: discovery of ATP-independent inhibitors of fibroblast growth factor receptor
Eathiraj, Sudharshan, Palma, Rocio, Hirschi, Marscha, Volckova, Erika, Nakuci, Enkeleda, Castro, Jennifer, Chen, Chang-Rung, Chan, Thomas C K, France, Dennis S, Ashwell, Mark A
Published in The Journal of biological chemistry (10.06.2011)
Published in The Journal of biological chemistry (10.06.2011)
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Journal Article
Abstract 2914: Creation of a novel biochemical and biophysical assay suite to enable the identification of inhibitors targeting inactive kinases
France, Dennis S., Chen, Chang-Rung, Volckova, Erika, Eathiraj, Sudharshan, Cornell-Kennon, Susan, Huang, Li, McSweeney, Denise, Szwaya, Jeffrey, Palma, Rocio, Ashwell, Mark A., Chan, Thomas C.k.
Published in Cancer research (Chicago, Ill.) (15.04.2012)
Published in Cancer research (Chicago, Ill.) (15.04.2012)
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Journal Article
SUBSTITUTED IMIDAZOPYRIDINYL-AMINOPYRIDINE COMPOUNDS
ISOYAMA TAKESHI, HILL JASON, VENSEL DAVID, KOERNER STEFFI, BRASSARD CHRIS, YOSHIDA KENICHI, ASHWELL MARK A, MATSUDA AKIHISA, PALMA ROCIO, IIMURA SHIN, YAMAZAKI TAKANORI, FILIKOV ANTON, NAMDEV NIVEDITA, LAPIERRE JEAN MARC, TANDON MANISH, NICEWONGER ROBERT, KITAMURA TAKAHIRO, LIU YANBIN
Year of Publication 13.02.2019
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Year of Publication 13.02.2019
Patent
Abstract A230: Discovery and characterization of ARQ 092, an ATP-independent, potent and selective inhibitor of AKT kinases
Chan, Thomas C.K., Lapierre, Jean-Marc, Ashwell, Mark A., France, Dennis S., Chen, Chang-Rung, Cornell-Kennon, Susan, Bull, Cathy, Eathiraj, Sudhi, Palma, Rocio, Liu, Yanbin, Makhija, Sapna, Waghorne, Carol, Savage, Ron, Fujiwara, Kosaku
Published in Molecular cancer therapeutics (12.11.2011)
Published in Molecular cancer therapeutics (12.11.2011)
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Journal Article
Abstract LB-1: Discovery and optimization of orally bioavailable, selective and potent ATP-independent Akt inhibitors
Chan, Thomas C.K., Ashwell, Mark A., Lapierre, Jean-Marc, Brassard, Christopher, Bull, Cathy, Cornell-Kennon, Susan, Eathiraj, Sudharshan, France, Dennis S., Hill, Jason, Koerner, Steffi, Kelleher, Eoin, Kizer, Darin, Liu, Yanbin, Link, Jeff, Makhija, Sapna, Moussa, Magdi, Namdev, Nivedita, Nicewonger, Robert, Uppalapati, Uma, Palma, Rocio, Szwaya, Jeff, Tandon, Manish, Vensel, David, Volak, Laurie, Volckova, Erika, Westland, Neil, Wu, Hui, Yang, Rui-Yang
Published in Cancer research (Chicago, Ill.) (15.04.2012)
Published in Cancer research (Chicago, Ill.) (15.04.2012)
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Journal Article
Abstract 3905: Synthesis and structure activity relationship of substituted N,6-diphenyl-5,6-dihydrobenzo[h]quinazolin-2-amine as inhibitors of fibroblast growth factor receptors (FGFR)
Ali, Syed M., Brassard, Chris, Dalton, Audra, Kizer, Darin, Lapierre, Jean-Marc, Liu, Yanbin, Moussa, Magdi, Palma, Rocio, Tandon, Manish, Vensel, David, Volckova, Erika, Wang, Jianqiang, Westlund, Neil, Wu, Hui, Yang, Rui-Yang, Bates, Craig, Bhavsar, Mayank, Bull, Cathy, Eathiraj, Sudharshan, Nicewonger, Robert, Savage, Ron, Waghorne, Carol, Castro, Jennifer, Nakuci, Enkeleda, Chen, Chang-Rung, France, Dennis S., Chan, Thomas C.K., Ashwell, Mark A.
Published in Cancer research (Chicago, Ill.) (15.04.2012)
Published in Cancer research (Chicago, Ill.) (15.04.2012)
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Journal Article
A Novel Mode of Protein Kinase Inhibition Exploiting Hydrophobic Motifs of Autoinhibited Kinases
Eathiraj, Sudharshan, Palma, Rocio, Hirschi, Marscha, Volckova, Erika, Nakuci, Enkeleda, Castro, Jennifer, Chen, Chang-Rung, Chan, Thomas C.K., France, Dennis S., Ashwell, Mark A.
Published in The Journal of biological chemistry (31.12.2011)
Published in The Journal of biological chemistry (31.12.2011)
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Journal Article
Abstract A139: Discovery and biological profiling of potent fibroblast growth factor receptor (FGFR) kinase inhibitors derived from in silico design with in vivo antitumor activity against FGFR2-dependent human tumors
Chen, Chang-Rung, Ali, Syed, Palma, Rocio, Eathiraj, Sudharshan, Bates, Craig, Bhavsar, Mayank, Brassard, Chris, Brown, Jennifer O., Bull, Cathy, Huang, Li, Kizer, Darin, Liu, Yanbin, McSweeney, Denise, Moussa, Magdi, Nakuci, Enkeleda, Tandon, Manish, Vensel, Dave, Volckova, Erika, Wang, Jianqiang, Westlund, Neil, Wu, Hui, Yang, Rui-Yang, France, Dennis S., Ashwell, Mark A., Chan, Thomas C.K
Published in Molecular cancer therapeutics (10.12.2009)
Published in Molecular cancer therapeutics (10.12.2009)
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Journal Article
SUBSTITUTED IMIDAZOPYRIDINYL-AMINOPYRIDINE COMPOUNDS
ISOYAMA TAKESHI, HILL JASON, VENSEL DAVID, KOERNER STEFFI, BRASSARD CHRIS, YOSHIDA KENICHI, ASHWELL MARK A, MATSUDA AKIHISA, PALMA ROCIO, IIMURA SHIN, YAMAZAKI TAKANORI, FILIKOV ANTON, NAMDEV NIVEDITA, LAPIERRE JEAN MARC, TANDON MANISH, NICEWONGER ROBERT, KITAMURA TAKAHIRO, LIU YANBIN
Year of Publication 03.04.2014
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Year of Publication 03.04.2014
Patent
The design and preparation of metabolically protected new arylpiperazine 5-HT1A ligands
TANDON, Manish, O'DONNELL, Mary-Margaret, PORTE, Alex, VENSEL, David, DONGLAI YANG, PALMA, Rocio, BERESFORD, Alan, ASHWELL, Mark A
Published in Bioorganic & medicinal chemistry letters (05.04.2004)
Published in Bioorganic & medicinal chemistry letters (05.04.2004)
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Journal Article
SUBSTITUTED 5,6-DIHYDRO-6-PHENYLBENZO[F]ISOQUINOLIN-2-AMINE COMPOUNDS
ASHWELL MARK, VENSEL DAVID, WESTLUND NEIL, PALMA ROCIO, YANG RUI YANG, NAMDEV NIVEDITA, LAPIERRE JEAN MARC, TANDON MANISH, EATHIRAJ SUDHARSHAN, KELLEHER EUGENE, ALI SYED M, LIU YANBIN, WU HUI
Year of Publication 08.09.2011
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Year of Publication 08.09.2011
Patent