Discovery of LNP1892: A Precision Calcimimetic for the Treatment of Secondary Hyperparathyroidism
Shukla, Manojkumar R., Sadasivam, Gayathri, Sarde, Ankush, Sayyed, Majid, Pachpute, Vipul, Phadtare, Ramesh, Walke, Navanath, Chaudhari, Vinod D., Loriya, Rajesh, Khan, Talha, Gote, Ganesh, Pawar, Chetan, Tryambake, Mahadeo, Mahajan, Nilesh, Gandhe, Amruta, Sabde, Sudeep, Pawar, Shashikant, Patil, Vinod, Modi, Dipak, Mehta, Maneesh, Nigade, Prashant, Modak, Vijay, Ghodke, Ravindra, Narasimham, Lakshmi, Bhonde, Mandar, Gundu, Jayasagar, Goel, Rajan, Shah, Chirag, Kulkarni, Sanjeev, Sharma, Sharad, Bakhle, Dhananjay, Kamboj, Rajender Kumar, Palle, Venkata P.
Published in Journal of medicinal chemistry (27.07.2023)
Published in Journal of medicinal chemistry (27.07.2023)
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Journal Article
Dual PI3Kδγ inhibition demonstrates potent anticancer effects in diffuse large B-cell lymphoma models: Discovery and preclinical characterization of LL-00084282
Verma, Mahip K., Samant, Charudatt, Kale, Ramesh, Patra, Sukanya, Mahajan, Nilesh, Gholve, Milind K., Marisetti, Ajitkumar, Sunkara, Brahmam, Naik, Aditya, Shingare, Manisha, Reddy, Madhusudhan, Bokare, Anand M., Akarte, Atul, Koul, Sarita, Nigade, Prashant B., Patil, Vinod B., Modi, Dipak, Ahirrao, Prajakta, Pawar, Shashikant, Kuldharan, Sandip, Dinchhana, Lal, Mehta, Maneesh, Gundu, Jayasagar, Jana, Nirmal, Vidhate, Prashant, Mahangare, Sachin Jaysing, Shukla, Manojkumar R., Goel, Rajan N., Bhonde, Mandar, Kamboj, Rajender Kumar, Palle, Venkata P.
Published in Biochemical and biophysical research communications (31.12.2022)
Published in Biochemical and biophysical research communications (31.12.2022)
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Journal Article
Discovery and pre-clinical characterization of a selective PI3Kδ inhibitor, LL-00071210 in rheumatoid arthritis
Kanoje, Vijay, Pandey, Dilip, Wagh, Akshaya, Patra, Sukanya, Kumar Marisetti, Ajit, Reddy, Madhusudhan, Samant, Charudatt, Mahajan, Nilesh, Gholve, Milind, Sabde, Sudeep, Trivedi, Sneha, Bhankhede, Trupti, Patil, Vinod, Nigade, Prashant, Modi, Dipak, Mehta, Maneesh, Ahirrao, Prajakta, Tota, Swathi, Nanda, Bidyut, Pawar, Shashikant, Polawar, Anuradha, Tamane, Kaustubh, Kuldharan, Sandip, Vishwase, Gururaj, Jana, Nirmal, Mahangare, Sachin J., Vidhate, Prashant, Lagad, Dipak, Gundu, Jayasagar, Phukan, Samiron, Shukla, Manojkumar, Narasimham, Lakshmi, Nemmani, Kumar V.S., Bhonde, Mandar, Sharma, Sharad, Kamboj, Rajender K., Palle, Venkata P.
Published in European journal of pharmacology (15.07.2022)
Published in European journal of pharmacology (15.07.2022)
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Journal Article
Discovery and Characterization of Potent Pan-Genotypic HCV NS5A Inhibitors Containing Novel Tricyclic Central Core Leading to Clinical Candidate
Ramdas, Vidya, Talwar, Rashmi, Banerjee, Moloy, Joshi, Advait Arun, Das, Amit Kumar, Walke, Deepak Sahebrao, Borhade, Prashant, Dhayagude, Usha, Loriya, Rajesh, Gote, Ganesh, Bommakanti, Apparao, Sivaram, Aruna, Agarwal, Gautam, Goswami, Arnab, Nigade, Prashant, Mehta, Maneesh, Patil, Vinod, Modi, Dipak, Kumar, Hemant, Mallurwar, Sadanand, Dash, Amruta, Modi, Falguni, Kuldharan, Sandip, Srivastava, Pratima, Singh, Minakshi, Narasimham, Lakshmi, Gundu, Jayasagar, Sharma, Sharad, Kamboj, Rajender Kumar, Palle, Venkata P
Published in Journal of medicinal chemistry (12.12.2019)
Published in Journal of medicinal chemistry (12.12.2019)
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Journal Article
Discovery of Novel, Potent, Brain-Permeable, and Orally Efficacious Positive Allosteric Modulator of α7 Nicotinic Acetylcholine Receptor [4-(5-(4-Chlorophenyl)-4-methyl-2-propionylthiophen-3-yl)benzenesulfonamide]: Structure–Activity Relationship and Preclinical Characterization
Sinha, Neelima, Karche, Navnath P, Verma, Mahip Kalyan, Walunj, Sameer S, Nigade, Prashant B, Jana, Gourhari, Kurhade, Sanjay P, Hajare, Anil K, Tilekar, Ajay R, Jadhav, Ganesh R, Thube, Baban R, Shaikh, Javed S, Balgude, Sudhakar, Singh, Lairikyengbam Bikramjit, Mahimane, Vijaya, Adurkar, Shridhar K, Hatnapure, Girish, Raje, Firoj, Bhosale, Yogesh, Bhanage, Dnyaneshwar, Sachchidanand, Sachchidanand, Dixit, Ruchi, Gupta, Rajesh, Bokare, Anand M, Dandekar, Manoj, Bharne, Ashish, Chatterjee, Manavi, Desai, Sagar, Koul, Sarita, Modi, Dipak, Mehta, Maneesh, Patil, Vinod, Singh, Minakshi, Gundu, Jayasagar, Goel, Rajan N, Shah, Chirag, Sharma, Sharad, Bakhle, Dhananjay, Kamboj, Rajender Kumar, Palle, Venkata P
Published in Journal of medicinal chemistry (13.02.2020)
Published in Journal of medicinal chemistry (13.02.2020)
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Journal Article
Discovery of a Potent and Selective PI3Kδ Inhibitor ( S )-2,4-Diamino-6-((1-(7-fluoro-1-(4-fluorophenyl)-4-oxo-3-phenyl-4 H -quinolizin-2-yl)ethyl)amino)pyrimidine-5-carbonitrile with Improved Pharmacokinetic Profile and Superior Efficacy in Hematological Cancer Models
Shukla, Manojkumar R, Patra, Sukanya, Verma, Mahip, Sadasivam, Gayathri, Jana, Nirmal, Mahangare, Sachin J, Vidhate, Prashant, Lagad, Dipak, Tarage, Anand, Cheemala, Murthy, Kulkarni, Chaitanya, Bhagwat, Shankar, Chaudhari, Vinod D, Sayyed, Majid, Pachpute, Vipul, Phadtare, Ramesh, Gole, Gopal, Phukan, Samiron, Sunkara, Brahmam, Samant, Charudatt, Shingare, Manisha, Naik, Aditya, Trivedi, Sneha, Marisetti, Ajit Kumar, Reddy, Madhusudhan, Gholve, Milind, Mahajan, Nilesh, Sabde, Sudeep, Patil, Vinod, Modi, Dipak, Mehta, Maneesh, Nigade, Prashant, Tamane, Kaustubh, Tota, Swati, Goyal, Hemant, Volam, Harish, Pawar, Shashikant, Ahirrao, Prajakta, Dinchhana, Lal, Mallurwar, Sadanand, Akarte, Atul, Bokare, Anand, Kanhere, Rupesh, Reddy, Neetinkumar, Koul, Sarita, Dandekar, Manoj, Singh, Minakshi, Bernstein, Peter R, Narasimham, Lakshmi, Bhonde, Mandar, Gundu, Jayasagar, Goel, Rajan, Kulkarni, Sanjeev, Sharma, Sharad, Kamboj, Rajender Kumar, Palle, Venkata P
Published in Journal of medicinal chemistry (10.12.2020)
Published in Journal of medicinal chemistry (10.12.2020)
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Journal Article
LL-00066471, a novel positive allosteric modulator of α7 nicotinic acetylcholine receptor ameliorates cognitive and sensorimotor gating deficits in animal models: Discovery and preclinical characterization
Verma, Mahip K., Goel, Rajan N., Bokare, Anand M., Dandekar, Manoj P., Koul, Sarita, Desai, Sagar, Tota, Santoshkumar, Singh, Nilendra, Nigade, Prashant B., Patil, Vinod B., Modi, Dipak, Mehta, Maneesh, Gundu, Jayasagar, Walunj, Sameer S., Karche, Navnath P., Sinha, Neelima, Kamboj, Rajender K., Palle, Venkata P.
Published in European journal of pharmacology (15.01.2021)
Published in European journal of pharmacology (15.01.2021)
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Journal Article
Design and synthesis of novel xanthine derivatives as potent and selective A2B adenosine receptor antagonists for the treatment of chronic inflammatory airway diseases
Basu, Sujay, Barawkar, Dinesh A., Ramdas, Vidya, Patel, Meena, Waman, Yogesh, Panmand, Anil, Kumar, Santosh, Thorat, Sachin, Naykodi, Minakshi, Goswami, Arnab, Reddy, B. Srinivasa, Prasad, Vandna, Chaturvedi, Sandhya, Quraishi, Azfar, Menon, Suraj, Paliwal, Shalini, Kulkarni, Abhay, Karande, Vikas, Ghosh, Indraneel, Mustafa, Syed, De, Siddhartha, Jain, Vaibhav, Banerjee, Ena Ray, Rouduri, Sreekanth R., Palle, Venkata P., Chugh, Anita, Mookhtiar, Kasim A.
Published in European journal of medicinal chemistry (07.07.2017)
Published in European journal of medicinal chemistry (07.07.2017)
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Journal Article
Discovery of a Potent and Selective PI3Kδ Inhibitor (S)‑2,4-Diamino-6-((1-(7-fluoro-1-(4-fluorophenyl)-4-oxo-3-phenyl‑4H‑quinolizin-2-yl)ethyl)amino)pyrimidine-5-carbonitrile with Improved Pharmacokinetic Profile and Superior Efficacy in Hematological Cancer Models
Shukla, Manojkumar R, Patra, Sukanya, Verma, Mahip, Sadasivam, Gayathri, Jana, Nirmal, Mahangare, Sachin J, Vidhate, Prashant, Lagad, Dipak, Tarage, Anand, Cheemala, Murthy, Kulkarni, Chaitanya, Bhagwat, Shankar, Chaudhari, Vinod D, Sayyed, Majid, Pachpute, Vipul, Phadtare, Ramesh, Gole, Gopal, Phukan, Samiron, Sunkara, Brahmam, Samant, Charudatt, Shingare, Manisha, Naik, Aditya, Trivedi, Sneha, Marisetti, Ajit Kumar, Reddy, Madhusudhan, Gholve, Milind, Mahajan, Nilesh, Sabde, Sudeep, Patil, Vinod, Modi, Dipak, Mehta, Maneesh, Nigade, Prashant, Tamane, Kaustubh, Tota, Swati, Goyal, Hemant, Volam, Harish, Pawar, Shashikant, Ahirrao, Prajakta, Dinchhana, Lal, Mallurwar, Sadanand, Akarte, Atul, Bokare, Anand, Kanhere, Rupesh, Reddy, Neetinkumar, Koul, Sarita, Dandekar, Manoj, Singh, Minakshi, Bernstein, Peter R, Narasimham, Lakshmi, Bhonde, Mandar, Gundu, Jayasagar, Goel, Rajan, Kulkarni, Sanjeev, Sharma, Sharad, Kamboj, Rajender Kumar, Palle, Venkata P
Published in Journal of medicinal chemistry (10.12.2020)
Published in Journal of medicinal chemistry (10.12.2020)
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Journal Article
Discovery of a Novel Potent and Selective Calcium Release-Activated Calcium Channel Inhibitor: 2,6-Difluoro‑N‑(2′-methyl-3′-(4-methyl-5-oxo-4,5-dihydro-1,3,4-oxadiazol-2-yl)-[1,1′-biphenyl]-4-yl)benzamide. Structure–Activity Relationship and Preclinical Characterization
Khedkar, Nilesh Raghunath, Irlapatti, Nageswara Rao, Dadke, Disha, Kanoje, Vijay, Shaikh, Zubair, Karche, Vijay, Shinde, Vikas, Deshmukh, Gokul, Patil, Amit, Jachak, Santosh, Phukan, Samiron, Kizhakinagath, Praveenkumar Anidil, Gholve, Milind, Bhankhede, Trupti, Daler, Jagadeesh, Nemade, Harshal Narendra, Budhe, Sagar, Pareek, Himani, Yeshodharan, Rajesh, Gupta, Rajesh, Kalia, Anil, Pandey, Dilip, Wagh, Akshaya, Kumar, Swaroop, Patil, Vinod, Modi, Dipak, Sharma, Nidhi, Ahirrao, Prajakta, Mehta, Maneesh, Kumar, Hemant, Nigade, Prashant, Tamane, Kaustubh, Mallurwar, Sadanand, Kuldharan, Sandip, Pawar, Shashikant, Vishwase, Gururaj, Bokan, Sanjay, Singh, Minakshi, Naik, Kumar, Ingawale, Sachin, Shankar, Rajesh, Kamalakannan, Prabakaran, Venugopal, Spinvin, George, Shaji K, Padiya, Kamlesh J, Nemmani, Kumar V. S, Gundu, Jaysagar, Bhonde, Mandar, Narasimham, Lakshmi, Sindkhedkar, Milind, Shah, Chirag, Sinha, Neelima, Sharma, Sharad, Bakhle, Dhananjay, Kamboj, Rajender Kumar, Palle, Venkata P
Published in Journal of medicinal chemistry (09.12.2021)
Published in Journal of medicinal chemistry (09.12.2021)
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Journal Article
Discovery of isoquinolinone and naphthyridinone-based inhibitors of poly(ADP-ribose) polymerase-1 (PARP1) as anticancer agents: Structure activity relationship and preclinical characterization
Karche, Navnath P., Bhonde, Mandar, Sinha, Neelima, Jana, Gourhari, Kukreja, Gagan, Kurhade, Sanjay P., Jagdale, Arun R., Tilekar, Ajay R., Hajare, Anil K., Jadhav, Ganesh R., Gupta, Nishant R., Limaye, Rohan, Khedkar, Nilesh, Thube, Baban R., Shaikh, Javed S., Rao Irlapati, Nageswara, Phukan, Samiron, Gole, Gopal, Bommakanti, Apparao, Khanwalkar, Harshal, Pawar, Yogesh, Kale, Ramesh, Kumar, Rakesh, Gupta, Rajesh, Praveen Kumar, V.R., Wahid, Saif, Francis, Albi, Bhat, Tariq, Kamble, Nivrutti, Patil, Vinod, Nigade, Prashant B., Modi, Dipak, Pawar, Shashikant, Naidu, Sneha, Volam, Harish, Pagdala, Vamsi, Mallurwar, Sadanand, Goyal, Hemant, Bora, Pushpak, Ahirrao, Prajakta, Singh, Minakshi, Kamalakannan, Prabhakaran, Naik, Kumar Ram, Kumar, Pradipta, Powar, Rajendra G., Shankar, Rajesh B., Bernstein, Peter R., Gundu, Jayasagar, Nemmani, Kumar, Narasimham, Lakshmi, George, Kochumalayil Shaji, Sharma, Sharad, Bakhle, Dhananjay, Kamboj, Rajender Kumar, Palle, Venkata P.
Published in Bioorganic & medicinal chemistry (15.12.2020)
Published in Bioorganic & medicinal chemistry (15.12.2020)
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Journal Article
Magtrieve (TM) (CrO2) and MnO2 mediated oxidation of aldoximes: studying the reaction course
Bhosale, Sandeep, Kurhade, Santosh, Vyas, Samir, Palle, Venkata P., Bhuniya, Debnath
Published in Tetrahedron (11.12.2010)
Published in Tetrahedron (11.12.2010)
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Journal Article
Modifications of flexible nonyl chain and nucleobase head group of (+)-erythro-9-(2′s-hydroxy-3′s-nonyl)adenine [(+)-EHNA] as adenosine deaminase inhibitors
Kandalkar, Sachin R., Ramaiah, Parimi Atchuta, Joshi, Manoj, Wavhal, Atul, Waman, Yogesh, Raje, Amol A., Tambe, Ashwini, Ansari, Shariq, De, Siddhartha, Palle, Venkata P., Mookhtiar, Kasim A., Deshpande, Anil M., Barawkar, Dinesh A.
Published in Bioorganic & medicinal chemistry (15.10.2017)
Published in Bioorganic & medicinal chemistry (15.10.2017)
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Journal Article
Discovery of Potent, Selective, and State-Dependent Na V 1.7 Inhibitors with Robust Oral Efficacy in Pain Models: Structure-Activity Relationship and Optimization of Chroman and Indane Aryl Sulfonamides
Ramdas, Vidya, Talwar, Rashmi, Kanoje, Vijay, Loriya, Rajesh M, Banerjee, Moloy, Patil, Pradeep, Joshi, Advait Arun, Datrange, Laxmikant, Das, Amit Kumar, Walke, Deepak Sahebrao, Kalhapure, Vaibhav, Khan, Talha, Gote, Ganesh, Dhayagude, Usha, Deshpande, Shreyas, Shaikh, Javed, Chaure, Ganesh, Pal, Ravindra R, Parkale, Santosh, Suravase, Sachin, Bhoskar, Smita, Gupta, Rajesh V, Kalia, Anil, Yeshodharan, Rajesh, Azhar, Mahammad, Daler, Jagadeesh, Mali, Vinod, Sharma, Geetika, Kishore, Amitesh, Vyawahare, Rupali, Agarwal, Gautam, Pareek, Himani, Budhe, Sagar, Nayak, Arun, Warude, Dnyaneshwar, Gupta, Praveen Kumar, Joshi, Parag, Joshi, Sneha, Darekar, Sagar, Pandey, Dilip, Wagh, Akshaya, Nigade, Prashant B, Mehta, Maneesh, Patil, Vinod, Modi, Dipak, Pawar, Shashikant, Verma, Mahip, Singh, Minakshi, Das, Sudipto, Gundu, Jayasagar, Nemmani, Kumar, Bock, Mark G, Sharma, Sharad, Bakhle, Dhananjay, Kamboj, Rajender Kumar, Palle, Venkata P
Published in Journal of medicinal chemistry (11.06.2020)
Published in Journal of medicinal chemistry (11.06.2020)
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Journal Article
Design, Synthesis of Novel, Potent, Selective, Orally Bioavailable Adenosine A2A Receptor Antagonists and Their Biological Evaluation
Basu, Sujay, Barawkar, Dinesh A, Thorat, Sachin, Shejul, Yogesh D, Patel, Meena, Naykodi, Minakshi, Jain, Vaibhav, Salve, Yogesh, Prasad, Vandna, Chaudhary, Sumit, Ghosh, Indraneel, Bhat, Ganesh, Quraishi, Azfar, Patil, Harish, Ansari, Shariq, Menon, Suraj, Unadkat, Vishal, Thakare, Rhishikesh, Seervi, Madhav S, Meru, Ashwinkumar V, De, Siddhartha, Bhamidipati, Ravi K, Rouduri, Sreekanth R, Palle, Venkata P, Chug, Anita, Mookhtiar, Kasim A
Published in Journal of medicinal chemistry (26.01.2017)
Published in Journal of medicinal chemistry (26.01.2017)
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Journal Article
Discovery of a potent and selective small molecule hGPR91 antagonist
Bhuniya, Debnath, Umrani, Dhananjay, Dave, Bhavesh, Salunke, Deepak, Kukreja, Gagan, Gundu, Jayasagar, Naykodi, Minakshi, Shaikh, Nadim S., Shitole, Prasad, Kurhade, Santosh, De, Siddhartha, Majumdar, Sreemita, Reddy, Srinivasa B., Tambe, Suhas, Shejul, Yogesh, Chugh, Anita, Palle, Venkata P., Mookhtiar, Kasim A., Cully, Doris, Vacca, Joseph, Chakravarty, Prasun K., Nargund, Ravi P., Wright, Samuel D., Graziano, Michael P., Singh, Sheo B., Roy, Sophie, Cai, Tian-Quan
Published in Bioorganic & medicinal chemistry letters (15.06.2011)
Published in Bioorganic & medicinal chemistry letters (15.06.2011)
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Journal Article
Discovery of liver-directed glucokinase activator having anti-hyperglycemic effect without hypoglycemia
Deshpande, Anil M., Bhuniya, Debnath, De, Siddhartha, Dave, Bhavesh, Vyavahare, Vinod P., Kurhade, Santosh H., Kandalkar, Sachin R., Naik, Keshav P., Kobal, Balasaheb S., Kaduskar, Rahul D., Basu, Sujay, Jain, Vaibhav, Patil, Pratima, Chaturvedi Joshi, Sandhya, Bhat, Ganesh, Raje, Amol A., Reddy, Satyanarayana, Gundu, Jayasagar, Madgula, Vamsi, Tambe, Suhas, Shitole, Prasad, Umrani, Dhananjay, Chugh, Anita, Palle, Venkata P., Mookhtiar, Kasim A.
Published in European journal of medicinal chemistry (16.06.2017)
Published in European journal of medicinal chemistry (16.06.2017)
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Journal Article
Design and synthesis of novel xanthine derivatives as potent and selective A 2B adenosine receptor antagonists for the treatment of chronic inflammatory airway diseases
Basu, Sujay, Barawkar, Dinesh A, Ramdas, Vidya, Patel, Meena, Waman, Yogesh, Panmand, Anil, Kumar, Santosh, Thorat, Sachin, Naykodi, Minakshi, Goswami, Arnab, Reddy, B Srinivasa, Prasad, Vandna, Chaturvedi, Sandhya, Quraishi, Azfar, Menon, Suraj, Paliwal, Shalini, Kulkarni, Abhay, Karande, Vikas, Ghosh, Indraneel, Mustafa, Syed, De, Siddhartha, Jain, Vaibhav, Banerjee, Ena Ray, Rouduri, Sreekanth R, Palle, Venkata P, Chugh, Anita, Mookhtiar, Kasim A
Published in European journal of medicinal chemistry (07.07.2017)
Published in European journal of medicinal chemistry (07.07.2017)
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Journal Article
Design, Synthesis of Novel, Potent, Selective, Orally Bioavailable Adenosine A 2A Receptor Antagonists and Their Biological Evaluation
Basu, Sujay, Barawkar, Dinesh A, Thorat, Sachin, Shejul, Yogesh D, Patel, Meena, Naykodi, Minakshi, Jain, Vaibhav, Salve, Yogesh, Prasad, Vandna, Chaudhary, Sumit, Ghosh, Indraneel, Bhat, Ganesh, Quraishi, Azfar, Patil, Harish, Ansari, Shariq, Menon, Suraj, Unadkat, Vishal, Thakare, Rhishikesh, Seervi, Madhav S, Meru, Ashwinkumar V, De, Siddhartha, Bhamidipati, Ravi K, Rouduri, Sreekanth R, Palle, Venkata P, Chug, Anita, Mookhtiar, Kasim A
Published in Journal of medicinal chemistry (26.01.2017)
Published in Journal of medicinal chemistry (26.01.2017)
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Journal Article
Discovery of novel and potent heterocyclic carboxylic acid derivatives as protein tyrosine phosphatase 1B inhibitors
Basu, Sujay, Prasad, Uppuleti Viplava, Barawkar, Dinesh A., De, Siddhartha, Palle, Venkata P., Menon, Suraj, Patel, Meena, Thorat, Sachin, Singh, Umesh P., Sarma, Koushik Das, Waman, Yogesh, Niranjan, Sanjay, Pathade, Vishal, Gaur, Ashwani, Reddy, Satyanarayana, Ansari, Shariq
Published in Bioorganic & medicinal chemistry letters (15.04.2012)
Published in Bioorganic & medicinal chemistry letters (15.04.2012)
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