Selective Type IV Phosphodiesterase Inhibitors as Antiasthmatic Agents. The Syntheses and Biological Activities of 3-(Cyclopentyloxy)-4-methoxybenzamides and Analogs
Ashton, Michael J, Cook, David C, Fenton, Garry, Karlsson, Jan-Anders, Palfreyman, Malcolm N, Raeburn, David, Ratcliffe, Andrew J, Souness, John E, Thurairatnam, Suga, Vicker, Nigel
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Published in Journal of medicinal chemistry (01.05.1994)
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Synthesis and biological activity of trans-(.+-.)-N-methyl-2-(3-pyridyl)-2-tetrahydrothiopyrancarbothioamide 1-oxide (RP 49356) and analogs: a new class of potassium channel opener
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Published in Journal of medicinal chemistry (01.10.1992)
Published in Journal of medicinal chemistry (01.10.1992)
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Studies related to cyclopentanoid natural products. Part 1. Preparation of (4RS)- and (4R)-4-hydroxy-2-hydroxymethylcyclopent-2-en-1-one; a versatile synthetic intermediate
Elliott, John D., Hetmanski, Michael, Stoodley, Richard J., Palfreyman, Malcolm N.
Published in Journal of the Chemical Society, Perkin Transactions 1 (1981)
Published in Journal of the Chemical Society, Perkin Transactions 1 (1981)
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Studies related to cyclopentanoid natural products. Part 2. An improved route to (4R)-4-hydroxy-2-hydroxymethylcyclopent-2-en-1-one and its O-substituted derivatives
Elliott, John D., Kelson, Andrew B., Purcell, Neil, Stoodley, Richard J., Palfreyman, Malcolm N.
Published in Journal of the Chemical Society, Perkin Transactions 1 (1983)
Published in Journal of the Chemical Society, Perkin Transactions 1 (1983)
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Syntheses and biological activities of potent potassium channel openers derived from (.+-.)-2-oxo-1-pyridin-3-yl-cyclohexanecarbothioic acid methylamide: new potassium channel openers
Brown, Thomas J, Chapman, Robert F, Mason, Jonathan S, Palfreyman, Malcolm N, Vicker, Nigel, Walsh, Roger J. A
Published in Journal of medicinal chemistry (28.05.1993)
Published in Journal of medicinal chemistry (28.05.1993)
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Evidence that cyclic AMP phosphodiesterase inhibitors suppress TNFα generation from human monocytes by interacting with a ‘low‐affinity’ phosphodiesterase 4 conformer
Souness, John E., Griffin, Miriam, Maslen, Christopher, Ebsworth, Karen, Scott, Lisa C., Pollock, Kenneth, Palfreyman, Malcolm N., Karlsson, Jan‐Anders
Published in British journal of pharmacology (01.06.1996)
Published in British journal of pharmacology (01.06.1996)
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Suppression of eosinophil function by RP 73401, a potent and selective inhibitor of cyclic AMP‐specific phosphodiesterase: comparison with rolipram
Soilness, John E., Maslen, Christopher, Webber, Stephen, Foster, Martyn, Raeburn, David, Palfreyman, Malcolm N., Ashton, Michael J., Karlsson, Jan‐Anders
Published in British journal of pharmacology (01.05.1995)
Published in British journal of pharmacology (01.05.1995)
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4-Hydroxy-2-hydroxymethylcyclopent-2-en-1-one: a versatile intermediate for the synthesis of cyclopentanoid natural products
Elliott, John D., Hetmanski, Michael, Stoodley, Richard J., Palfreyman, Malcolm N.
Published in Journal of the Chemical Society. Chemical communications (1980)
Published in Journal of the Chemical Society. Chemical communications (1980)
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