Engineered botulinum neurotoxin B with improved efficacy for targeting human receptors
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Published in Nature communications (03.07.2017)
Published in Nature communications (03.07.2017)
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Augmentation of VAMP-catalytic activity of botulinum neurotoxin serotype B does not result in increased potency in physiological systems
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Published in PloS one (05.10.2017)
Published in PloS one (05.10.2017)
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Discovery and Structure–Activity Relationship of Potent and Selective Covalent Inhibitors of Transglutaminase 2 for Huntington’s Disease
Prime, Michael E, Andersen, Ole A, Barker, John J, Brooks, Mark A, Cheng, Robert K. Y, Toogood-Johnson, Ian, Courtney, Stephen M, Brookfield, Frederick A, Yarnold, Christopher J, Marston, Richard W, Johnson, Peter D, Johnsen, Siw F, Palfrey, Jordan J, Vaidya, Darshan, Erfan, Sayeh, Ichihara, Osamu, Felicetti, Brunella, Palan, Shilpa, Pedret-Dunn, Anna, Schaertl, Sabine, Sternberger, Ina, Ebneth, Andreas, Scheel, Andreas, Winkler, Dirk, Toledo-Sherman, Leticia, Beconi, Maria, Macdonald, Douglas, Muñoz-Sanjuan, Ignacio, Dominguez, Celia, Wityak, John
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Published in Journal of medicinal chemistry (09.02.2012)
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Non-Destructive Catalytic Inactivation of Novel Recombinant Botulinum Neurotoxin Type A Variants Facilitates Safe Mass Spectrometry Analysis, Outside of Containment
Palan, Shilpa, Mir, Imran, Martin, Nick Thorn, Ziomkiewicz, Iwona, Ehebauer, Matthias
Published in Toxicon (Oxford) (01.07.2022)
Published in Toxicon (Oxford) (01.07.2022)
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Botulinum neurotoxin B engineered for increased receptor affinity has improved clinical potential
Elliott, Mark, Favre-Guilmard, Christine, Liu, Sai Man, Maignel, Jacquie, Masuyer, Geoffrey, Beard, Matthew, Boone, Christopher, Carré, Denis, Kalinichev, Mikhail, Lezmi, Stephane, Mir, Imran, Nicoleau, Camille, Palan, Shilpa, Perier, Cindy, Raban, Elsa, Zhang, Sicai, Dong, Min, Stenmark, Pal, Krupp, Johannes
Published in Toxicon (Oxford) (01.12.2018)
Published in Toxicon (Oxford) (01.12.2018)
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Augmentation of the catalytic activity of Botulinum neurotoxin type B does not result in increased potency in physiologic systems
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Published in Toxicon (Oxford) (25.12.2016)
Published in Toxicon (Oxford) (25.12.2016)
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Rational modification of botulinum neurotoxin by directed scanning mutagenesis
Liu, Sai Man, Hackett, Gavin, Fonfria, Elena, Palan, Shilpa, Cornet, Sylvie, Lewandowska, Agnieszka, Donald, Sarah, Burgin, Dave, Sopp, Joshua, Hornby, Fraser, Marlin, Sandra, Perier, Cindy, Anderson, Dina
Published in Toxicon (Oxford) (25.12.2016)
Published in Toxicon (Oxford) (25.12.2016)
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Engineered botulinum neurotoxin B with improved binding to human receptors has enhanced efficacy in preclinical models
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Published in Science advances (01.01.2019)
Published in Science advances (01.01.2019)
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Published in Toxicon (Oxford) (01.01.2015)
Published in Toxicon (Oxford) (01.01.2015)
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Cheng, Robert, Felicetti, Brunella, Palan, Shilpa, Toogood‐Johnson, Ian, Scheich, Christoph, Barker, John, Whittaker, Mark, Hesterkamp, Thomas
Published in Protein science (01.01.2010)
Published in Protein science (01.01.2010)
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Year of Publication 26.06.2018
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Year of Publication 26.06.2018
Patent
Identification of Amino Acid Residues Critical for Aggregation of Human CC Chemokines Macrophage Inflammatory Protein (MIP)-1 alpha , MIP-1 beta , and RANTES: Characterization of Active Disaggregated Chemokine Variants
Czaplewski, L G, McKeating, J, Craven, C J, Higgins, L D, Appay, V, Brown, A, Dudgeon, T, Howard, LA, Meyers, T, Owen, J, Palan, SR, Tan, P, Wilson, G, Woods, N R, Heyworth, C M, Lord, B I, Brotherton, D, Christison, R, Craig, S, Cribbes, S, Edwards, R M, Evans, S J, Gilbert, R, Morgan, P, Randle, E, Schofield, N, Varley, P G, Fisher, J, Waltho, J P, Hunter, M G
Published in The Journal of biological chemistry (04.06.1999)
Published in The Journal of biological chemistry (04.06.1999)
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