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Published in Cancer cell (13.08.2018)
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Sensitivity to splicing modulation of BCL2 family genes defines cancer therapeutic strategies for splicing modulators
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Splicing modulators act at the branch point adenosine binding pocket defined by the PHF5A–SF3b complex
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Published in Nature communications (25.05.2017)
Published in Nature communications (25.05.2017)
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Parkin-deficient Mice Exhibit Nigrostriatal Deficits but Not Loss of Dopaminergic Neurons
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Published in The Journal of biological chemistry (31.10.2003)
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A striatal-enriched intronic GPCR modulates huntingtin levels and toxicity
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Intrinsic resistance of neural stem cells to toxic metabolites may make them well suited for cell non‐autonomous disorders: evidence from a mouse model of Krabbe leukodystrophy
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Published in Journal of neurochemistry (01.06.2006)
Published in Journal of neurochemistry (01.06.2006)
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Nitric oxide directly activates calcium-dependent potassium channels in vascular smooth muscle
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Published in Nature (London) (28.04.1994)
Published in Nature (London) (28.04.1994)
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Huntingtin cleavage product A forms in neurons and is reduced by gamma-secretase inhibitors
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Published in Molecular neurodegeneration (14.12.2010)
Published in Molecular neurodegeneration (14.12.2010)
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Modulation of splicing catalysis for therapeutic targeting of leukemia with mutations in genes encoding spliceosomal proteins
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Palacino, James, Swalley, Susanne E, Song, Cheng, Cheung, Atwood K, Shu, Lei, Zhang, Xiaolu, Van Hoosear, Mailin, Shin, Youngah, Chin, Donovan N, Keller, Caroline Gubser, Beibel, Martin, Renaud, Nicole A, Smith, Thomas M, Salcius, Michael, Shi, Xiaoying, Hild, Marc, Servais, Rebecca, Jain, Monish, Deng, Lin, Bullock, Caroline, McLellan, Michael, Schuierer, Sven, Murphy, Leo, Blommers, Marcel J J, Blaustein, Cecile, Berenshteyn, Frada, Lacoste, Arnaud, Thomas, Jason R, Roma, Guglielmo, Michaud, Gregory A, Tseng, Brian S, Porter, Jeffery A, Myer, Vic E, Tallarico, John A, Hamann, Lawrence G, Curtis, Daniel, Fishman, Mark C, Dietrich, William F, Dales, Natalie A, Sivasankaran, Rajeev
Published in Nature chemical biology (01.07.2015)
Published in Nature chemical biology (01.07.2015)
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Identification of NUB1 as a suppressor of mutant Huntingtin toxicity via enhanced protein clearance
Lu, Boxun, Al-Ramahi, Ismael, Valencia, Antonio, Wang, Qiong, Berenshteyn, Frada, Yang, Haidi, Gallego-Flores, Tatiana, Ichcho, Salah, Lacoste, Arnaud, Hild, Marc, DiFiglia, Marian, Botas, Juan, Palacino, James
Published in Nature neuroscience (01.05.2013)
Published in Nature neuroscience (01.05.2013)
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A phase 1, first-in-human, open label, escalation and expansion study of ORM-5029, a highly potent GSPT1 degrader targeting HER2, in patients with HER2-expressing advanced solid tumors
Hurvitz, Sara A., Hamilton, Erika P., Spira, Alexander I., Pohlmann, Paula R, Giordano, Antonio, Clifton, Katherine, Anderson, Barry Douglas, Dutta, Sujoy, Mangipudi, Umesh, Saini, Shikha, Palacino, James, Karunaratne, Tina, Greensmith, Dennise, Christensen, Olaf, Wilks, Sharon
Published in Journal of clinical oncology (01.06.2023)
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Yu, Shenliang, Liang, Yijian, Palacino, James, Difiglia, Marian, Lu, Boxun
Published in Trends in pharmacological sciences (Regular ed.) (01.02.2014)
Published in Trends in pharmacological sciences (Regular ed.) (01.02.2014)
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ORM-6151: A First-in-Class, Anti-CD33 Antibody-Enabled GSPT1 Degrader for AML
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Published in Blood (15.11.2022)
Published in Blood (15.11.2022)
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Aldose reductase inhibition restores endothelial cell function in diabetic rabbit aorta
Tesfamariam, B, Palacino, J J, Weisbrod, R M, Cohen, R A
Published in Journal of cardiovascular pharmacology (01.02.1993)
Published in Journal of cardiovascular pharmacology (01.02.1993)
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Abstract 383: Survey of spliceosome gene mutations and associated splicing defects across 33 cancer types
Seiler, Michael, Peng, Shouyong, Agrawal, Anant, Tsai, Jennifer, Palacino, James, Buonamici, Silvia, Yu, Lihua
Published in Cancer research (Chicago, Ill.) (01.07.2017)
Published in Cancer research (Chicago, Ill.) (01.07.2017)
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