Search Results - "PALACHARLA RAGHAVA CHOUDARY" :: K.UTB vyhledávací portál | TBU Library Retrieval Portal

1-[2-(1-Cyclobutylpiperidin-4-yloxy)-6,7-dihydro-4H-thiazolo[5,4-c]pyridin-5-yl]propan-1-one: a Histamine H-3 Receptor Inverse Agonist with Efficacy in Animal Models of Cognition

1-[2-(1-Cyclobutylpiperidin-4-yloxy)-6,7-dihydro-4H-thiazolo[5,4-c]pyridin-5-yl]propan-1-one: a Histamine H-3 Receptor Inverse Agonist with Efficacy in Animal Models of Cognition

by Shinde, Anil Karbhari, Badange, Rajesh Kumar, Reballi, Veena, Achanta, Pramod Kumar, Bojja, Kumar, Manchineella, Sravanthi, Muddana, Nageswara Rao, Subramanian, Ramkumar, Palacharla, Raghava Choudary, Benade, Vijay, Jayarajan, Pradeep, Thentu, Jagadeesh Babu, Lingavarapu, Bujji Babu, Yarra, Sivasekhar, Kagita, Narendra, Doguparthi, Mallikarjuna Rao, Mohammed, Abdul Rasheed, Nirogi, Ramakrishna
Published in ChemMedChem (04.02.2022)

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Journal Article

1‐[2‐(1‐Cyclobutylpiperidin‐4‐yloxy)‐6,7‐dihydro‐4H‐thiazolo[5,4‐c]pyridin‐5‐yl]propan‐1‐one: a Histamine H3 Receptor Inverse Agonist with Efficacy in Animal Models of Cognition

1‐[2‐(1‐Cyclobutylpiperidin‐4‐yloxy)‐6,7‐dihydro‐4H‐thiazolo[5,4‐c]pyridin‐5‐yl]propan‐1‐one: a Histamine H3 Receptor Inverse Agonist with Efficacy in Animal Models of Cognition

by Shinde, Anil Karbhari, Badange, Rajesh Kumar, Reballi, Veena, Achanta, Pramod Kumar, Bojja, Kumar, Manchineella, Sravanthi, Rao Muddana, Nageswara, Subramanian, Ramkumar, Choudary Palacharla, Raghava, Benade, Vijay, Jayarajan, Pradeep, Thentu, Jagadeesh Babu, Lingavarapu, Bujji Babu, Yarra, Sivasekhar, Kagita, Narendra, Rao Doguparthi, Mallikarjuna, Mohammed, Abdul Rasheed, Nirogi, Ramakrishna
Published in ChemMedChem (04.02.2022)

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Inhibition of cytochrome P450 enzymes by saturated and unsaturated fatty acids in human liver microsomes, characterization of enzyme kinetics in the presence of bovine serum albumin (0.1 and 1.0% w/v) and in vitro – in vivo extrapolation of hepatic clearance

Inhibition of cytochrome P450 enzymes by saturated and unsaturated fatty acids in human liver microsomes, characterization of enzyme kinetics in the presence of bovine serum albumin (0.1 and 1.0% w/v) and in vitro – in vivo extrapolation of hepatic clearance

by Palacharla, Raghava Choudary, Uthukam, Venkatesham, Manoharan, Arunkumar, Ponnamaneni, Ranjith Kumar, Padala, Nagasurya Prakash, Boggavarapu, Rajesh Kumar, Bhyrapuneni, Gopinadh, Ajjala, Devender Reddy, Nirogi, Ramakrishna
Published in European journal of pharmaceutical sciences (01.04.2017)

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Journal Article

$Chemical inhibitors of CYP450 enzymes in liver microsomes: combining selectivity and unbound fractions to guide selection of appropriate concentration in phenotyping assays$

Chemical inhibitors of CYP450 enzymes in liver microsomes: combining selectivity and unbound fractions to guide selection of appropriate concentration in phenotyping assays

by Nirogi, Ramakrishna, Palacharla, Raghava Choudary, Uthukam, Venkatesham, Manoharan, Arunkumar, Srikakolapu, Surya Rao, Kalaikadhiban, Ilayaraja, Boggavarapu, Rajesh Kumar, Ponnamaneni, Ranjith Kumar, Ajjala, Devender Reddy, Bhyrapuneni, Gopinadh
Published in Xenobiotica (01.02.2015)

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Identification of a suitable and selective inhibitor towards aldehyde oxidase catalyzed reactions

Identification of a suitable and selective inhibitor towards aldehyde oxidase catalyzed reactions

by Nirogi, Ramakrishna, Kandikere, Vishwottam, Palacharla, Raghava Choudary, Bhyrapuneni, Gopinadh, Kanamarlapudi, Vijaya Bhargava, Ponnamaneni, Ranjith Kumar, Manoharan, Arun Kumar
Published in Xenobiotica (01.03.2014)

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Journal Article

LC–MS/MS method for the simultaneous quantification of artemether, dihydroartemisinin and lumefantrine in rabbit plasma and its application to a PK study

LC–MS/MS method for the simultaneous quantification of artemether, dihydroartemisinin and lumefantrine in rabbit plasma and its application to a PK study

by Padala, Nagasurya Prakash, Boggavarapu, Rajesh Kumar, Kunduru, Praveen, Palacharla, Raghava Choudary, Ajjala, Devender Reddy, Nirogi, Ramakrishna
Published in Drug metabolism and pharmacokinetics (01.01.2018)

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Sensitive LC–MS/MS method for quantification of vitamin B 12 in rat serum: Application to pharmacokinetic study

Sensitive LC–MS/MS method for quantification of vitamin B 12 in rat serum: Application to pharmacokinetic study

by Aleti, Raghupathi Reddy, Rayapati, Lakshmi Prasanna, Chunduru, Prathyusha, Palacharla, Raghava Choudary, Ajjala, Devender Reddy, Nirogi, Ramakrishna
Published in Drug metabolism and pharmacokinetics (01.01.2018)

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Journal Article

Effect of Dimethyl Sulfoxide on In Vitro Cytochrome P4501A2 Mediated Phenacetin O-Deethylation in Human Liver Microsomes

Effect of Dimethyl Sulfoxide on In Vitro Cytochrome P4501A2 Mediated Phenacetin O-Deethylation in Human Liver Microsomes

by NIROGI, Ramakrishna, KANDIKERE, Vishwottam, BHYRAPUNENI, Gopinadh, RANJITH KUMAR PONNAMANENI, RAGHAVA CHOUDARY PALACHARLA, MANOHARAN, Arunkumar
Published in Drug metabolism and disposition (01.11.2011)

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Journal Article

무스카린 M1 수용체 양성 알로스테릭 조절제로서 치환된 아자사이클

무스카린 M1 수용체 양성 알로스테릭 조절제로서 치환된 아자사이클

by NIROGI RAMAKRISHNA, SHINDE ANIL KARBHARI, MOHAMMED ABDUL RASHEED, PALACHARLA RAGHAVA CHOUDARY, BADANGE RAJESH KUMAR, JASTI VENKATESWARLU
Year of Publication 29.07.2020

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Patent

Discovery and Development of 3-(6-Chloropyridine-3-yloxymethyl)-2-azabicyclo[3.1.0]hexane Hydrochloride (SUVN-911): A Novel, Potent, Selective, and Orally Active Neuronal Nicotinic Acetylcholine alpha 4 beta 2 Receptor Antagonist for the Treatment of Depression

Discovery and Development of 3-(6-Chloropyridine-3-yloxymethyl)-2-azabicyclo[3.1.0]hexane Hydrochloride (SUVN-911): A Novel, Potent, Selective, and Orally Active Neuronal Nicotinic Acetylcholine alpha 4 beta 2 Receptor Antagonist for the Treatment of Depression

by Nirogi, Ramakrishna, Mohammed, Abdul Rasheed, Shinde, Anil K., Ravella, Srinivasa Rao, Bogaraju, Narsimha, Subramanian, Ramkumar, Mekala, Venkat Reddy, Palacharla, Raghava Choudary, Muddana, Nageswararao, Thentu, Jagadeesh Babu, Bhyrapuneni, Gopinadh, Abraham, Renny, Jasti, Venkat
Published in Journal of medicinal chemistry (26.03.2020)

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Journal Article

Discovery and Development of 1-[(2-Bromophenyl)sulfony1]-5methoxy-3-[(4-methyl-1-piperazinyl)methy1]-1H-indole Dimesylate Monohydrate (SUVN-502): A Novel, Potent, Selective and Orally Active Serotonin 6 (5-HT6) Receptor Antagonist for Potential Treatment of Alzheimer's Disease

Discovery and Development of 1-[(2-Bromophenyl)sulfony1]-5methoxy-3-[(4-methyl-1-piperazinyl)methy1]-1H-indole Dimesylate Monohydrate (SUVN-502): A Novel, Potent, Selective and Orally Active Serotonin 6 (5-HT6) Receptor Antagonist for Potential Treatment of Alzheimer's Disease

by Nirogi, Ramakrishna, Shinde, Anil, Kambhampati, Rama Sastry, Mohammed, Abdul Rasheed, Saraf, Sangram Keshari, Mohammed, Abdul Rasheed, Saraf, Sangram Keshari, Badange, Rajesh Kumar, Bandyala, Thrinath Reddy, Bhatta, Venugopalarao, Bojja, Kumar, Reballi, Veena, Subramanian, Ramkumar, Benade, Vijay, Palacharla, Raghava Choudary, Bhyrapuneni, Gopinadh, Jayarajan, Pradeep, Goyal, Vinod, Jasti, Venkat
Published in Journal of medicinal chemistry (09.03.2017)

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Journal Article

Synthesis, Structure–Activity Relationships, and Preclinical Evaluation of Heteroaromatic Amides and 1,3,4-Oxadiazole Derivatives as 5‑HT4 Receptor Partial Agonists

Synthesis, Structure–Activity Relationships, and Preclinical Evaluation of Heteroaromatic Amides and 1,3,4-Oxadiazole Derivatives as 5‑HT4 Receptor Partial Agonists

by Nirogi, Ramakrishna, Mohammed, Abdul Rasheed, Shinde, Anil K, Gagginapally, Shankar Reddy, Kancharla, Durga Malleshwari, Middekadi, Vanaja Reddy, Bogaraju, Narsimha, Ravella, Srinivasa Rao, Singh, Pooja, Birangal, Sumit Raosaheb, Subramanian, Ramkumar, Palacharla, Raghava Choudary, Benade, Vijay, Muddana, Nageswararao, Jayarajan, Pradeep
Published in Journal of medicinal chemistry (14.06.2018)

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Journal Article

Quantitative in vitro phenotyping and prediction of drug interaction potential of CYP2B6 substrates as victims

Quantitative in vitro phenotyping and prediction of drug interaction potential of CYP2B6 substrates as victims

by Palacharla, Raghava Choudary, Nirogi, Ramakrishna, Uthukam, Venkatesham, Manoharan, Arunkumar, Ponnamaneni, Ranjith Kumar, Kalaikadhiban, Ilayaraja
Published in Xenobiotica (03.07.2018)

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Journal Article

Discovery and Development of N-[4-(1-Cyclobutylpiperidin-4-yloxy)phenyl]-2-(morpholin-4-yl)acetamide Dihydrochloride (SUVN-G3031): A Novel, Potent, Selective, and Orally Active Histamine H-3 Receptor Inverse Agonist with Robust Wake-Promoting Activity

Discovery and Development of N-[4-(1-Cyclobutylpiperidin-4-yloxy)phenyl]-2-(morpholin-4-yl)acetamide Dihydrochloride (SUVN-G3031): A Novel, Potent, Selective, and Orally Active Histamine H-3 Receptor Inverse Agonist with Robust Wake-Promoting Activity

by Nirogi, Ramakrishna, Shinde, Anil, Mohammed, Abdul Rasheed, Badange, Rajesh Kumar, Reballi, Veena, Bandyala, Thrinath Reddy, Saraf, Sangram Keshari, Bojja, Kumar, Manchineella, Sravanthi, Achanta, Pramod Kumar, Kandukuri, Kiran Kumar, Subramanian, Ramkumar, Benade, Vijay, Palacharla, Raghava Choudary, Jayarajan, Pradeep, Pandey, Santoshkumar, Jasti, Venkat
Published in Journal of medicinal chemistry (14.02.2019)

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Journal Article

Discovery and Preclinical Characterization of Usmarapride (SUVN-D4010): A Potent, Selective 5‑HT4 Receptor Partial Agonist for the Treatment of Cognitive Deficits Associated with Alzheimer’s Disease

Discovery and Preclinical Characterization of Usmarapride (SUVN-D4010): A Potent, Selective 5‑HT4 Receptor Partial Agonist for the Treatment of Cognitive Deficits Associated with Alzheimer’s Disease

by Nirogi, Ramakrishna, Mohammed, Abdul Rasheed, Shinde, Anil Karbhari, Gagginapally, Shankar Reddy, Kancharla, Durga Malleshwari, Ravella, Srinivasa Rao, Bogaraju, Narsimha, Middekadi, Vanaja Reddy, Subramanian, Ramkumar, Palacharla, Raghava Choudary, Benade, Vijay, Muddana, Nageswararao, Abraham, Renny, Medapati, Rajesh Babu, Thentu, Jagadeesh Babu, Mekala, Venkat Reddy, Petlu, Surendra, Lingavarapu, Bujji Babu, Yarra, Sivasekhar, Kagita, Narendra, Goyal, Vinod Kumar, Pandey, Santosh Kumar, Jasti, Venkat
Published in Journal of medicinal chemistry (12.08.2021)

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Journal Article

Synthesis, Structure-Activity Relationships, and Preclinical Evaluation of Heteroaromatic Amides and 1,3,4-Oxadiazole Derivatives as 5-HT 4 Receptor Partial Agonists

Synthesis, Structure-Activity Relationships, and Preclinical Evaluation of Heteroaromatic Amides and 1,3,4-Oxadiazole Derivatives as 5-HT 4 Receptor Partial Agonists

by Nirogi, Ramakrishna, Mohammed, Abdul Rasheed, Shinde, Anil K, Gagginapally, Shankar Reddy, Kancharla, Durga Malleshwari, Middekadi, Vanaja Reddy, Bogaraju, Narsimha, Ravella, Srinivasa Rao, Singh, Pooja, Birangal, Sumit Raosaheb, Subramanian, Ramkumar, Palacharla, Raghava Choudary, Benade, Vijay, Muddana, Nageswararao, Jayarajan, Pradeep
Published in Journal of medicinal chemistry (14.06.2018)

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Journal Article

Discovery and Development of 3‑(6-Chloropyridine-3-yloxymethyl)-2-azabicyclo[3.1.0]hexane Hydrochloride (SUVN-911): A Novel, Potent, Selective, and Orally Active Neuronal Nicotinic Acetylcholine α4β2 Receptor Antagonist for the Treatment of Depression

Discovery and Development of 3‑(6-Chloropyridine-3-yloxymethyl)-2-azabicyclo[3.1.0]hexane Hydrochloride (SUVN-911): A Novel, Potent, Selective, and Orally Active Neuronal Nicotinic Acetylcholine α4β2 Receptor Antagonist for the Treatment of Depression

by Nirogi, Ramakrishna, Mohammed, Abdul Rasheed, Shinde, Anil K, Ravella, Srinivasa Rao, Bogaraju, Narsimha, Subramanian, Ramkumar, Mekala, Venkat Reddy, Palacharla, Raghava Choudary, Muddana, Nageswararao, Thentu, Jagadeesh Babu, Bhyrapuneni, Gopinadh, Abraham, Renny, Jasti, Venkat
Published in Journal of medicinal chemistry (26.03.2020)

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Journal Article

Discovery and Preclinical Characterization of Usmarapride (SUVN-D4010): A Potent, Selective 5-HT 4 Receptor Partial Agonist for the Treatment of Cognitive Deficits Associated with Alzheimer’s Disease

Discovery and Preclinical Characterization of Usmarapride (SUVN-D4010): A Potent, Selective 5-HT 4 Receptor Partial Agonist for the Treatment of Cognitive Deficits Associated with Alzheimer’s Disease

by Nirogi, Ramakrishna, Mohammed, Abdul Rasheed, Shinde, Anil Karbhari, Gagginapally, Shankar Reddy, Kancharla, Durga Malleshwari, Ravella, Srinivasa Rao, Bogaraju, Narsimha, Middekadi, Vanaja Reddy, Subramanian, Ramkumar, Palacharla, Raghava Choudary, Benade, Vijay, Muddana, Nageswararao, Abraham, Renny, Medapati, Rajesh Babu, Thentu, Jagadeesh Babu, Mekala, Venkat Reddy, Petlu, Surendra, Lingavarapu, Bujji Babu, Yarra, Sivasekhar, Kagita, Narendra, Goyal, Vinod Kumar, Pandey, Santosh Kumar, Jasti, Venkat
Published in Journal of medicinal chemistry (12.08.2021)

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Journal Article

Methoxsalen as an in vitro phenotyping tool in comparison with 1-aminobenzotriazole

Methoxsalen as an in vitro phenotyping tool in comparison with 1-aminobenzotriazole

by Palacharla, Raghava Choudary, Molgara, Parusharamulu, Panthangi, Hanumanth Rao, Boggavarapu, Rajesh Kumar, Manoharan, Arun Kumar, Ponnamaneni, Ranjith Kumar, Ajjala, Devender Reddy, Nirogi, Ramakrishna
Published in Xenobiotica (01.02.2019)

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Journal Article

Discovery and Development of 1‑[(2-Bromophenyl)sulfonyl]-5-methoxy-3-[(4-methyl-1-piperazinyl)methyl]‑1H‑indole Dimesylate Monohydrate (SUVN-502): A Novel, Potent, Selective and Orally Active Serotonin 6 (5-HT6) Receptor Antagonist for Potential Treatment of Alzheimer’s Disease

Discovery and Development of 1‑[(2-Bromophenyl)sulfonyl]-5-methoxy-3-[(4-methyl-1-piperazinyl)methyl]‑1H‑indole Dimesylate Monohydrate (SUVN-502): A Novel, Potent, Selective and Orally Active Serotonin 6 (5-HT6) Receptor Antagonist for Potential Treatment of Alzheimer’s Disease

by Nirogi, Ramakrishna, Shinde, Anil, Kambhampati, Rama Sastry, Mohammed, Abdul Rasheed, Saraf, Sangram Keshari, Badange, Rajesh kumar, Bandyala, Thrinath Reddy, Bhatta, Venugopalarao, Bojja, Kumar, Reballi, Veena, Subramanian, Ramkumar, Benade, Vijay, Palacharla, Raghava Choudary, Bhyrapuneni, Gopinadh, Jayarajan, Pradeep, Goyal, Vinod, Jasti, Venkat
Published in Journal of medicinal chemistry (09.03.2017)

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Journal Article