EVT‐701 is a novel selective and safe mitochondrial complex 1 inhibitor with potent anti‐tumor activity in models of solid cancers
Luna Yolba, Raquel, Visentin, Virgile, Hervé, Caroline, Chiche, Johanna, Ricci, Jean‐Ehrland, Méneyrol, Jérôme, Paillasse, Michaël R., Alet, Nathalie
Published in Pharmacology research & perspectives (01.10.2021)
Published in Pharmacology research & perspectives (01.10.2021)
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Journal Article
Dendrogenin A and B two new steroidal alkaloids increasing neural responsiveness in the deafened guinea pig
Fransson, Anette, de Medina, Philippe, Paillasse, Michaël R, Silvente-Poirot, Sandrine, Poirot, Marc, Ulfendahl, Mats
Published in Frontiers in aging neuroscience (24.07.2015)
Published in Frontiers in aging neuroscience (24.07.2015)
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Journal Article
Exosomes account for vesicle-mediated transcellular transport of activatable phospholipases and prostaglandins[S]
Subra, Caroline, Grand, David, Laulagnier, Karine, Stella, Alexandre, Lambeau, Gérard, Paillasse, Michael, De Medina, Philippe, Monsarrat, Bernard, Perret, Bertrand, Silvente-Poirot, Sandrine, Poirot, Marc, Record, Michel
Published in Journal of lipid research (01.08.2010)
Published in Journal of lipid research (01.08.2010)
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Journal Article
Identification and pharmacological characterization of cholesterol-5,6-epoxide hydrolase as a target for tamoxifen and AEBS ligands
de Medina, Philippe, Paillasse, Michael R., Segala, Gregory, Poirot, Marc, Silvente-Poirot, Sandrine, Mangelsdorf, David J.
Published in Proceedings of the National Academy of Sciences - PNAS (27.07.2010)
Published in Proceedings of the National Academy of Sciences - PNAS (27.07.2010)
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Journal Article
5,6-Epoxy-cholesterols contribute to the anticancer pharmacology of Tamoxifen in breast cancer cells
Segala, Gregory, de Medina, Philippe, Iuliano, Luigi, Zerbinati, Chiara, Paillasse, Michael R., Noguer, Emmanuel, Dalenc, Florence, Payré, Bruno, Jordan, V. Craig, Record, Michel, Silvente-Poirot, Sandrine, Poirot, Marc
Published in Biochemical pharmacology (01.07.2013)
Published in Biochemical pharmacology (01.07.2013)
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Journal Article
Dendrogenin A arises from cholesterol and histamine metabolism and shows cell differentiation and anti-tumour properties
de Medina, Philippe, Paillasse, Michael R., Segala, Gregory, Voisin, Maud, Mhamdi, Loubna, Dalenc, Florence, Lacroix-Triki, Magali, Filleron, Thomas, Pont, Frederic, Saati, Talal Al, Morisseau, Christophe, Hammock, Bruce D., Silvente-Poirot, Sandrine, Poirot, Marc
Published in Nature communications (2013)
Published in Nature communications (2013)
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Journal Article
Disrupting Mitochondrial Electron Transfer Chain Complex I Decreases Immune Checkpoints in Murine and Human Acute Myeloid Leukemic Cells
Luna-Yolba, Raquel, Marmoiton, Justine, Gigo, Véronique, Marechal, Xavier, Boet, Emeline, Sahal, Ambrine, Alet, Nathalie, Abramovich, Ifat, Gottlieb, Eyal, Visentin, Virgile, Paillasse, Michael R, Sarry, Jean-Emmanuel
Published in Cancers (13.07.2021)
Published in Cancers (13.07.2021)
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Journal Article
Targeting cholesterol homeostasis to fight hearing loss: a new perspective
Malgrange, Brigitte, Varela-Nieto, Isabel, de Medina, Philippe, Paillasse, Michael R
Published in Frontiers in aging neuroscience (2015)
Published in Frontiers in aging neuroscience (2015)
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Journal Article
Web Resource
Signaling through cholesterol esterification: a new pathway for the cholecystokinin 2 receptor involved in cell growth and invasion
Paillasse, Michael R., de Medina, Philippe, Amouroux, Guillaume, Mhamdi, Loubna, Poirot, Marc, Silvente-Poirot, Sandrine
Published in Journal of lipid research (01.11.2009)
Published in Journal of lipid research (01.11.2009)
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Journal Article
Synthesis of New Alkylaminooxysterols with Potent Cell Differentiating Activities: Identification of Leads for the Treatment of Cancer and Neurodegenerative Diseases
de Medina, Philippe, Paillasse, Michael R, Payré, Bruno, Silvente-Poirot, Sandrine, Poirot, Marc
Published in Journal of medicinal chemistry (10.12.2009)
Published in Journal of medicinal chemistry (10.12.2009)
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Journal Article
Auraptene is an inhibitor of cholesterol esterification and a modulator of estrogen receptors
de Medina, Philippe, Genovese, Salvatore, Paillasse, Michael R, Mazaheri, Mahta, Caze-Subra, Stephanie, Bystricky, Kerstin, Curini, Massimo, Silvente-Poirot, Sandrine, Epifano, Francesco, Poirot, Marc
Published in Molecular pharmacology (01.11.2010)
Published in Molecular pharmacology (01.11.2010)
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Journal Article
Importance of cholesterol and oxysterols metabolism in the pharmacology of tamoxifen and other AEBS ligands
de Medina, Philippe, Paillasse, Michael R., Ségala, Gregory, Khallouki, Farid, Brillouet, Severine, Dalenc, Florence, Courbon, Frederic, Record, Michel, Poirot, Marc, Silvente-Poirot, Sandrine
Published in Chemistry and physics of lipids (01.09.2011)
Published in Chemistry and physics of lipids (01.09.2011)
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Journal Article
1515 Gene edited iPSC-derived macrophages (iMACs) show increased phagocytosis in pre-clinical tumor models
Haake, Kathrin, Mirenda, Michela, Bernard, Quentin, Hublitz, Philip, Gouxette, Lucie, Briscadieu, Martin, Scheinpflug, Philine, Singh, Garima, Hinkelmann, Alica, Schneider, Tanja, Epstein, Michael, Esquerré, Michael, Holtzinger, Audrey, Sommermeyer, Daniel, Paillasse, Michael, Scheel, Andreas, Dangl, Markus, Braun, Monika, Wagner, Nadja
Published in Journal for immunotherapy of cancer (01.11.2023)
Published in Journal for immunotherapy of cancer (01.11.2023)
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Journal Article
Targeting Tumor Angiogenesis with the Selective VEGFR-3 Inhibitor EVT801 in Combination with Cancer Immunotherapy
Paillasse, Michael R, Esquerré, Michael, Bertrand, Florie A, Poussereau-Pomié, Céline, Pichery, Mélanie, Visentin, Virgile, Gueguen-Dorbes, Geneviève, Gaujarengues, Florence, Barron, Pauline, Badet, Gaelle, Briaux, Anne, Ancey, Pierre-Benoit, Sibrac, David, Erdociain, Eric, Özcelik, Dennis, Meneyrol, Jérôme, Martin, Valérie, Gomez-Brouchet, Anne, Selves, Janik, Rochaix, Philippe, Battistella, Maxime, Lebbé, Céleste, Delord, Jean-Pierre, Dol-Gleizes, Frédérique, Bono, Françoise, Blanc, Isabelle, Alam, Antoine, Hunneyball, Ian, Whittaker, Mark, Fons, Pierre
Published in Cancer research communications (01.11.2022)
Published in Cancer research communications (01.11.2022)
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Journal Article
Technical note: Hapten synthesis, antibody production and development of an enzyme-linked immunosorbent assay for detection of the natural steroidal alkaloid Dendrogenin A
de Medina, Philippe, Paillasse, Michael R., Segala, Gregory, Al Saati, Talal, Boyes, Jeannine, Delsol, Georges, Allal, Cuider, Marsili, Sabrina, Silvente-Poirot, Sandrine, Poirot, Marc
Published in Biochimie (01.03.2013)
Published in Biochimie (01.03.2013)
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Journal Article
Abstract 1731: EXS21546, a non-CNS penetrant A2AR-selective antagonist for anti-cancer immunotherapy
Payne, Andrew, Fons, Pierre, Alt, Isabella, van Ham, Joost, Taubert, Christina, Bell, Andy, Versluys, Stephanie, Bertrand, Florie, Visentin, Virgile, Mirey, Emilie, Pelissier, Emilie, Paillasse, Michael, Pagliarusco, Sabrina, Vladimer, Gregory, Whittaker, Mark
Published in Cancer research (Chicago, Ill.) (01.07.2021)
Published in Cancer research (Chicago, Ill.) (01.07.2021)
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Journal Article
Abstract 4079: EVT801: a selective VEGFR3 inhibitor with the potential for combination with immune-checkpoint therapies, preclinical evidences and plans for first-in-human evaluation
Fons, Pierre, Esquerre, Michael, Paillasse, Michael, Visentin, Virgile, Dol, Frederique, Meneyrol, Jerome, Badet, Gaelle, Cogo, Eric, Vidaud, Lionel, Alam, Antoine, Blanc, Isabelle, Bono, Francoise, Lisztwan, Joanna, Poublanc, Muriel, Filleron, Thomas, Hunneyball, Ian, Delord, Jean-Pierre, Whittaker, Mark
Published in Cancer research (Chicago, Ill.) (01.07.2019)
Published in Cancer research (Chicago, Ill.) (01.07.2019)
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