Intestinal microbiota signatures of clinical response and immune-related adverse events in melanoma patients treated with anti-PD-1
McCulloch, John A., Davar, Diwakar, Rodrigues, Richard R., Badger, Jonathan H., Fang, Jennifer R., Cole, Alicia M., Balaji, Ascharya K., Vetizou, Marie, Prescott, Stephanie M., Fernandes, Miriam R., Costa, Raquel G. F., Yuan, Wuxing, Salcedo, Rosalba, Bahadiroglu, Erol, Roy, Soumen, DeBlasio, Richelle N., Morrison, Robert M., Chauvin, Joe-Marc, Ding, Quanquan, Zidi, Bochra, Lowin, Ava, Chakka, Saranya, Gao, Wentao, Pagliano, Ornella, Ernst, Scarlett J., Rose, Amy, Newman, Nolan K., Morgun, Andrey, Zarour, Hassane M., Trinchieri, Giorgio, Dzutsev, Amiran K.
Published in Nature medicine (01.03.2022)
Published in Nature medicine (01.03.2022)
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303 Phase II trial of neoadjuvant nivolumab (Nivo) and intra-tumoral (IT) CMP-001 in high-risk resectable melanoma (Neo-C-Nivo): final results
Davar, Diwakar, Karunamurthy, Arivarasan, Hartman, Douglas, DeBlasio, Richelle, Chauvin, Joe-Marc, Ding, Quanquan, Pagliano, Ornella, Rose, Amy, Kirkwood, John, Zarour, Hassane
Published in Journal for immunotherapy of cancer (01.11.2020)
Published in Journal for immunotherapy of cancer (01.11.2020)
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Journal Article
TIGIT and PD-1 impair tumor antigen-specific CD8⁺ T cells in melanoma patients
Chauvin, Joe-Marc, Pagliano, Ornella, Fourcade, Julien, Sun, Zhaojun, Wang, Hong, Sander, Cindy, Kirkwood, John M, Chen, Tseng-hui Timothy, Maurer, Mark, Korman, Alan J, Zarour, Hassane M
Published in The Journal of clinical investigation (01.05.2015)
Published in The Journal of clinical investigation (01.05.2015)
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Journal Article
Fecal microbiota transplant overcomes resistance to anti-PD-1 therapy in melanoma patients
Davar, Diwakar, Dzutsev, Amiran K, McCulloch, John A, Rodrigues, Richard R, Chauvin, Joe-Marc, Morrison, Robert M, Deblasio, Richelle N, Menna, Carmine, Ding, Quanquan, Pagliano, Ornella, Zidi, Bochra, Zhang, Shuowen, Badger, Jonathan H, Vetizou, Marie, Cole, Alicia M, Fernandes, Miriam R, Prescott, Stephanie, Costa, Raquel G F, Balaji, Ascharya K, Morgun, Andrey, Vujkovic-Cvijin, Ivan, Wang, Hong, Borhani, Amir A, Schwartz, Marc B, Dubner, Howard M, Ernst, Scarlett J, Rose, Amy, Najjar, Yana G, Belkaid, Yasmine, Kirkwood, John M, Trinchieri, Giorgio, Zarour, Hassane M
Published in Science (American Association for the Advancement of Science) (05.02.2021)
Published in Science (American Association for the Advancement of Science) (05.02.2021)
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Journal Article
IL15 Stimulation with TIGIT Blockade Reverses CD155-mediated NK-Cell Dysfunction in Melanoma
Chauvin, Joe-Marc, Ka, Mignane, Pagliano, Ornella, Menna, Carmine, Ding, Quanquan, DeBlasio, Richelle, Sanders, Cindy, Hou, Jiajie, Li, Xian-Yang, Ferrone, Soldano, Davar, Diwakar, Kirkwood, John M, Johnston, Robert J, Korman, Alan J, Smyth, Mark J, Zarour, Hassane M
Published in Clinical cancer research (15.10.2020)
Published in Clinical cancer research (15.10.2020)
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CD8+ T Cells Specific for Tumor Antigens Can Be Rendered Dysfunctional by the Tumor Microenvironment through Upregulation of the Inhibitory Receptors BTLA and PD-1
FOURCADE, Julien, ZHAOJUN SUN, PAGLIANO, Ornella, GUILLAUME, Philippe, LUESCHER, Immanuel F, SANDER, Cindy, KIRKWOOD, John M, OLIVE, Daniel, KUCHROO, Vijay, ZAROUR, Hassane M
Published in Cancer research (Chicago, Ill.) (15.02.2012)
Published in Cancer research (Chicago, Ill.) (15.02.2012)
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PD-1 and Tim-3 Regulate the Expansion of Tumor Antigen-Specific CD8+ T Cells Induced by Melanoma Vaccines
FOURCADE, Julien, ZHAOJUN SUN, HONG WANG, GUILLAUME, Philippe, LUESCHER, Immanuel F, KRIEG, Arthur, ANDERSON, Ana C, KUCHROO, Vijay K, ZAROUR, Hassane M, PAGLIANO, Ornella, CHAUVIN, Joe-Marc, SANDER, Cindy, JANJIC, Bratislav, TARHINI, Ahmad A, TAWBI, Hussein A, KIRKWOOD, John M, MOSCHOS, Stergios
Published in Cancer research (Chicago, Ill.) (15.02.2014)
Published in Cancer research (Chicago, Ill.) (15.02.2014)
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Journal Article
Phase Ib/II Study of Pembrolizumab and Pegylated-Interferon Alfa-2b in Advanced Melanoma
Davar, Diwakar, Wang, Hong, Chauvin, Joe-Marc, Pagliano, Ornella, Fourcade, Julien J, Ka, Mignane, Menna, Carmine, Rose, Amy, Sander, Cindy, Borhani, Amir A, Karunamurthy, Arivarasan, Tarhini, Ahmad A, Tawbi, Hussein A, Zhao, Qing, Moreno, Blanca H, Ebbinghaus, Scott, Ibrahim, Nageatte, Kirkwood, John M, Zarour, Hassane M
Published in Journal of clinical oncology (10.12.2018)
Published in Journal of clinical oncology (10.12.2018)
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Journal Article
Abstract P5-04-28: Targeting TIGIT and PD-1 in triple negative breast cancer
Pandey, Apurva Kumari, Chauvin, Joe Marc, Brufsky, Adam, Pagliano, Ornella, Ka, Mignane, Menna, Carmine, McAuliffe, Priscilla, Zarour, Hassane
Published in Cancer research (Chicago, Ill.) (15.02.2020)
Published in Cancer research (Chicago, Ill.) (15.02.2020)
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Journal Article
CD226 opposes TIGIT to disrupt Tregs in melanoma
Fourcade, Julien, Sun, Zhaojun, Chauvin, Joe-Marc, Ka, Mignane, Davar, Diwakar, Pagliano, Ornella, Wang, Hong, Saada, Sofiane, Menna, Carmine, Amin, Rada, Sander, Cindy, Kirkwood, John M, Korman, Alan J, Zarour, Hassane M
Published in JCI insight (26.07.2018)
Published in JCI insight (26.07.2018)
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Journal Article
Abstract IA02: Next targets for immune checkpoint blockade in melanoma
Chauvin, Joe-Marc, Ka, Mignane, Pagliano, Ornella, Foucade, Julien, Menna, Carmine, Davar, Diwakar, Kirkwood, John, Kuchroo, Vijay, Anderson, Ana, Korman, Alan, Zarour, Hassane
Published in Cancer research (Chicago, Ill.) (01.10.2020)
Published in Cancer research (Chicago, Ill.) (01.10.2020)
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Journal Article
Tim-3 mediates T cell trogocytosis to limit antitumor immunity
Pagliano, Ornella, Morrison, Robert M, Chauvin, Joe-Marc, Banerjee, Hridesh, Davar, Diwakar, Ding, Quanquan, Tanegashima, Tokiyoshi, Gao, Wentao, Chakka, Saranya R, DeBlasio, Richelle, Lowin, Ava, Kara, Kevin, Ka, Mignane, Zidi, Bochra, Amin, Rada, Raphael, Itay, Zhang, Shuowen, Watkins, Simon C, Sander, Cindy, Kirkwood, John M, Bosenberg, Marcus, Anderson, Ana C, Kuchroo, Vijay K, Kane, Lawrence P, Korman, Alan J, Rajpal, Arvind, West, Sean M, Han, Minhua, Bee, Christine, Deng, Xiaodi, Schebye, Xiao Min, Strop, Pavel, Zarour, Hassane M
Published in The Journal of clinical investigation (01.05.2022)
Published in The Journal of clinical investigation (01.05.2022)
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Journal Article
Neoadjuvant vidutolimod and nivolumab in high-risk resectable melanoma: A prospective phase II trial
Davar, Diwakar, Morrison, Robert M., Dzutsev, Amiran K., Karunamurthy, Arivarasan, Chauvin, Joe-Marc, Amatore, Florent, Deutsch, Julie S., Das Neves, Rodrigo X., Rodrigues, Richard R., McCulloch, John A., Wang, Hong, Hartman, Douglas J., Badger, Jonathan H., Fernandes, Miriam R., Bai, Yulong, Sun, Jie, Cole, Alicia M., Aggarwal, Poonam, Fang, Jennifer R., Deitrick, Christopher, Bao, Riyue, Duvvuri, Umamaheswar, Sridharan, Shaum S., Kim, Seungwon W., A. Choudry, Haroon, Holtzman, Matthew P., Pingpank, James F., O'Toole, James Patrick, DeBlasio, Richelle, Jin, Yang, Ding, Quanquan, Gao, Wentao, Groetsch, Christopher, Pagliano, Ornella, Rose, Amy, Urban, Corey, Singh, Jagjit, Divarkar, Prajan, Mauro, David, Bobilev, Dmitri, Wooldridge, James, Krieg, Arthur M., Fury, Matthew G., Whiteaker, Jeffrey R., Zhao, Lei, Paulovich, Amanda G., Najjar, Yana G., Luke, Jason J., Kirkwood, John M., Taube, Janis M., Park, Hyun Jung, Trinchieri, Giorgio, Zarour, Hassane M.
Published in Cancer cell (11.11.2024)
Published in Cancer cell (11.11.2024)
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Journal Article
IL-15 stimulation with TIGIT blockade reverses CD155-mediated NK cell dysfunction in melanoma
Chauvin, Joe-Marc, Ka, Mignane, Pagliano, Ornella, Menna, Carmine, Ding, Quanquan, DeBlasio, Richelle, Sanders, Cindy, Hou, Jiajie, Li, Xian-Yang, Ferrone, Soldano, Davar, Diwakar, Kirkwood, John M., Johnston, Robert, Korman, Alan J., Smyth, Mark J., Zarour, Hassane M.
Published in Clinical cancer research (26.06.2020)
Published in Clinical cancer research (26.06.2020)
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Journal Article
Abstract LB062: Efficacy of Responder-derived Fecal Microbiota Transplant (R-FMT) and Pembrolizumab in Anti-PD-1 Refractory Patients with Advanced Melanoma
Davar, Diwakar, Dzutsev, Amiran, McCulloch, John A., Rodrigues, Richard R., Chauvin, Joe-Marc, Morrison, Robert M., Deblasio, Richelle N., Menna, Carmine, Ding, Quanquan, Pagliano, Ornella, Zidi, Bochra, Zhang, Shuowen, Badger, Jonathan H., Vetizou, Marie, Cole, Alicia M., Fernandes, Miriam R., Prescott, Stephanie, Costa, Raquel G., Balaji, Ascharya K., Morgun, Andrey, Vujkovic-Cvijin, Ivan, Wang, Hong, Borhani, Amir A., Schwartz, Marc B., Dubner, Howard M., Ernst, Scarlett J., Rose, Amy, Najjar, Yana G., Belkaid, Yasmine, Kirkwood, John M., Trinchieri, Giorgio, Zarour, Hassane M.
Published in Cancer research (Chicago, Ill.) (01.07.2021)
Published in Cancer research (Chicago, Ill.) (01.07.2021)
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Journal Article
Abstract 4046: Interleukin-10 and programmed death-1 cooperate to regulate tumor antigen-specific CD8+ T cells in melanoma patients
Sun, Zhaojun, Fourcade, Julien, Pagliano, Ornella, Chauvin, Joe-Marc, Sander, Cindy, Kirkwood, John M., Zarour, Hassane M.
Published in Cancer research (Chicago, Ill.) (01.08.2015)
Published in Cancer research (Chicago, Ill.) (01.08.2015)
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Journal Article
Abstract 459: Targeting TIGIT and PD-1 to increase the expansion and function of tumor antigen-specific CD8+ T cells in melanoma patients
Chauvin, Joe-Marc, Pagliano, Ornella, Fourcade, Julien, Sun, Zhaojun, Sanders, Cindy, Kirkwood, John M., Chen, Tseng-hui T., Maurer, Mark, Korman, Alan, Zarour, Hassane
Published in Cancer research (Chicago, Ill.) (01.08.2015)
Published in Cancer research (Chicago, Ill.) (01.08.2015)
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Journal Article
Study of anti-PD-1 antibody pembrolizumab and pegylated-interferon alfa-2b (Peg-IFN) for advanced melanoma
Zarour, Hassane M., Tawbi, Hussein, Tarhini, Ahmad A., Wang, Hong, Sander, Cindy, Rose, Amy, Fourcade, Julien J., Chauvin, Joe-Marc, Sun, Zhaojun, Pagliano, Ornella, Kirkwood, John M.
Published in Journal of clinical oncology (20.05.2015)
Published in Journal of clinical oncology (20.05.2015)
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Journal Article