Discovery of Milvexian, a High-Affinity, Orally Bioavailable Inhibitor of Factor XIa in Clinical Studies for Antithrombotic Therapy
Dilger, Andrew K, Pabbisetty, Kumar B, Corte, James R, De Lucca, Indawati, Fang, Tianan, Yang, Wu, Pinto, Donald J. P, Wang, Yufeng, Zhu, Yeheng, Mathur, Arvind, Li, Jianqing, Hou, Xiaoping, Smith, Daniel, Sun, Dawn, Zhang, Huiping, Krishnananthan, Subramaniam, Wu, Dauh-Rurng, Myers, Joseph E, Sheriff, Steven, Rossi, Karen A, Chacko, Silvi, Zheng, Joanna J, Galella, Michael A, Ziemba, Theresa, Dierks, Elizabeth A, Bozarth, Jeffrey M, Wu, Yiming, Crain, Earl, Wong, Pancras C, Luettgen, Joseph M, Wexler, Ruth R, Ewing, William R
Published in Journal of medicinal chemistry (10.02.2022)
Published in Journal of medicinal chemistry (10.02.2022)
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Discovery of a High Affinity, Orally Bioavailable Macrocyclic FXIa Inhibitor with Antithrombotic Activity in Preclinical Species
Yang, Wu, Wang, Yufeng, Lai, Amy, Clark, Charles G, Corte, James R, Fang, Tianan, Gilligan, Paul J, Jeon, Yoon, Pabbisetty, Kumar B, Rampulla, Richard A, Mathur, Arvind, Kaspady, Mahammed, Neithnadka, Premsai Rai, Arumugam, Arunachalam, Raju, Sivashankaran, Rossi, Karen A, Myers, Joseph E, Sheriff, Steven, Lou, Zhen, Zheng, Joanna J, Chacko, Silvi A, Bozarth, Jeffrey M, Wu, Yiming, Crain, Earl J, Wong, Pancras C, Seiffert, Dietmar A, Luettgen, Joseph M, Lam, Patrick Y. S, Wexler, Ruth R, Ewing, William R
Published in Journal of medicinal chemistry (09.07.2020)
Published in Journal of medicinal chemistry (09.07.2020)
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Journal Article
Novel phenylalanine derived diamides as Factor XIa inhibitors
Smith, Leon M., Orwat, Michael J., Hu, Zilun, Han, Wei, Wang, Cailan, Rossi, Karen A., Gilligan, Paul J., Pabbisetty, Kumar B., Osuna, Honey, Corte, James R., Rendina, Alan R., Luettgen, Joseph M., Wong, Pancras C., Narayanan, Ranga, Harper, Timothy W., Bozarth, Jeffrey M., Crain, Earl J., Wei, Anzhi, Ramamurthy, Vidhyashankar, Morin, Paul E., Xin, Baomin, Zheng, Joanna, Seiffert, Dietmar A., Quan, Mimi L., Lam, Patrick Y.S., Wexler, Ruth R., Pinto, Donald J.P.
Published in Bioorganic & medicinal chemistry letters (15.01.2016)
Published in Bioorganic & medicinal chemistry letters (15.01.2016)
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Journal Article
Discovery of a Potent Parenterally Administered Factor XIa Inhibitor with Hydroxyquinolin-2(1H)‑one as the P2′ Moiety
Hu, Zilun, Wong, Pancras C, Gilligan, Paul J, Han, Wei, Pabbisetty, Kumar B, Bozarth, Jeffrey M, Crain, Earl J, Harper, Timothy, Luettgen, Joseph M, Myers, Joseph E, Ramamurthy, Vidhyashankar, Rossi, Karen A, Sheriff, Steven, Watson, Carol A, Wei, Anzi, Zheng, Joanna J, Seiffert, Dietmar A, Wexler, Ruth R, Quan, Mimi L
Published in ACS medicinal chemistry letters (14.05.2015)
Published in ACS medicinal chemistry letters (14.05.2015)
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Journal Article
Kinetic analysis of the binding of monomeric and dimeric ephrins to Eph receptors: Correlation to function in a growth cone collapse assay
Pabbisetty, Kumar B., Yue, Xin, Li, Chen, Himanen, Juha‐Pekka, Zhou, Renping, Nikolov, Dimitar B., Hu, Longqin
Published in Protein science (01.03.2007)
Published in Protein science (01.03.2007)
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Journal Article
Chemoselective deprotection of N-Boc group in amino acids and peptides by bismuth(III) trichloride
Navath, Raghavendra S., Pabbisetty, Kumar B., Hu, Longqin
Published in Tetrahedron letters (01.01.2006)
Published in Tetrahedron letters (01.01.2006)
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Journal Article
A concise, stereoselective and scalable synthesis of optically pure (3R,4R)-1-benzyl- and (3R,4R)-1-Boc-3-methyl-4-aminopiperidines
Hazra, Sunit, Kangune, Ankit, Pawar, Govind, Karmakar, Ananta, Pabbisetty, Kumar B., Mortensen, Deborah S., Dodd, Dharmpal S., Li, Jianqing, Mathur, Arvind, Gupta, Anuradha, Nimje, Roshan Y.
Published in Tetrahedron (07.11.2024)
Published in Tetrahedron (07.11.2024)
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Journal Article
Macrocyclic compounds with heterocyclic P2 'groups as factor XIA inhibitors
DE LUCCA INDAWATI, PABBISETTY KUMAR B, WEXLER RUTH R, FANG TIANAN, WANG YUFENG, ZHU YEHENG, ORWAT MICHAEL J, DILGER ANDREW K, PINTO DONALD J P, EWING WILLIAM R, CORTE JAMES R, YANG WU
Year of Publication 03.11.2023
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Year of Publication 03.11.2023
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DIHYDROPYRIDONE P1 AS FACTOR XIA INHIBITORS
Ewing, William R, Dilger, Andrew K, Pabbisetty, Kumar B, Wang, Yufeng, Smith, Leon M, Fang, Tianan, Pinto, Donald J.P. Pinto, Gilligan, Paul J, Corte, James R, Yang, Wu
Year of Publication 02.06.2017
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Year of Publication 02.06.2017
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Dihydropyridone P1 as factor XIa inhibitors
Ewing, William R, Dilger, Andrew K, Pabbisetty, Kumar B, Wang, Yufeng, Pinto, Donald J. P, Fang, Tianan, Smith, II, Leon M, Gilligan, Paul J, Corte, James R, Yang, Wu
Year of Publication 24.04.2018
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Year of Publication 24.04.2018
Patent
PYRIMIDINONES AS FACTOR XIA INHIBITORS
Ewing, William R, Pabbisetty, Kumar B, Wang, Yufeng, Fang, Tianan, Corte, James R, Yang, Wu, Orwat, Michael J, Dilger, Andrew K, Smith II, Leon M, De Lucca, Indawati, Wexler, Ruth R, Pinto, Donald J.P, Zhu, Yeheng
Year of Publication 23.02.2018
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Year of Publication 23.02.2018
Patent
DIHYDROPYRIDONE P1 AS FACTOR XIA INHIBITORS
GILLIGAN, Paul, J, PINTO, Donald, J.P., Pinto, YANG, Wu, CORTE, James, R, SMITH II, Leon, M, PABBISETTY, Kumar, B, EWING, William, R, WANG, Yufeng, FANG, Tianan, DILGER, Andrew, K
Year of Publication 30.10.2017
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Year of Publication 30.10.2017
Patent
DIHYDROPYRIDONE P1 AS FACTOR XIA INHIBITORS
FANG, TIANAN, PINTO, DONALD, J.P., PINTO, EWING, WILLIAM, R, SMITH II, LEON, M, CORTE, JAMES, R, PABBISETTY, KUMAR, B, DILGER, ANDREW, K, GILLIGAN, PAUL, J, YANG, WU, WANG, YUFENG
Year of Publication 29.09.2017
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Year of Publication 29.09.2017
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DIHYDROPYRIDONE P1 AS FACTOR XIA INHIBITORS
PABBISETTY KUMAR B, SMITH II LEON M, WANG YUFENG, FANG TIANAN, PINTO DONALD J.P. PINTO, DILGER ANDREW K, EWING WILLIAM R, YANG WU, CORTE JAMES R, GILLIGAN PAUL J
Year of Publication 31.08.2017
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Year of Publication 31.08.2017
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DIHYDROPYRIDON-P1 SOM FAKTOR XIA-HÆMMERE
GILLIGAN, Paul, J, PINTO, Donald, J.P., Pinto, YANG, Wu, CORTE, James, R, SMITH II, Leon, M, PABBISETTY, Kumar, B, EWING, William, R, WANG, Yufeng, FANG, Tianan, DILGER, Andrew, K
Year of Publication 06.06.2017
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Year of Publication 06.06.2017
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DIHYDROPYRIDONE P1 AS FACTOR XIA INHIBITORS
YUFENG WANG, DONALD J.P. PINTO PINTO, JAMES R. CORTE, PAUL J. GILLIGAN, KUMAR B. PABBISETTY, TIANAN FANG, LEON M. SMITH II, WU YANG, WILLIAM R. EWING, ANDREW K. DILGER
Year of Publication 03.05.2017
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Year of Publication 03.05.2017
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DIHYDROPYRIDONE P1 AS FACTOR XIA INHIBITORS
WANG Yufeng, YANG Wu, PABBISETTY Kumar B, GILLIGAN Paul J, PINTO Donald J.P. Pinto, DILGER Andrew K, CORTE James R, FANG Tianan, EWING William R, SMITH II Leon M
Year of Publication 26.04.2017
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Year of Publication 26.04.2017
Patent
DIHYDROPYRIDONE P1 AS FACTOR XIA INHIBITORS
GILLIGAN, Paul, J, PINTO, Donald, J.P., Pinto, YANG, Wu, CORTE, James, R, SMITH II, Leon, M, PABBISETTY, Kumar, B, EWING, William, R, WANG, Yufeng, FANG, Tianan, DILGER, Andrew, K
Year of Publication 25.04.2017
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Year of Publication 25.04.2017
Patent
DIHYDROPYRIDONE P1 AS FACTOR XIA INHIBITORS
GILLIGAN, Paul, J, PINTO, Donald, J.P., Pinto, YANG, Wu, CORTE, James, R, SMITH II, Leon, M, PABBISETTY, Kumar, B, EWING, William, R, WANG, Yufeng, FANG, Tianan, DILGER, Andrew, K
Year of Publication 22.02.2017
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Year of Publication 22.02.2017
Patent
DIHYDROPYRIDONE P1 AS FACTOR XIA INHIBITORS
Fang Tianan, Pinto Donald J.P, Smith, II Leon M, Ewing William R, Yang Wu, Dilger Andrew K, Pabbisetty Kumar B, Wang Yufeng, Corte James R, Gilligan Paul J
Year of Publication 24.11.2016
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Year of Publication 24.11.2016
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