Intracellular immune sensing promotes inflammation via gasdermin D–driven release of a lectin alarmin
Russo, Ashley J., Vasudevan, Swathy O., Méndez-Huergo, Santiago P., Kumari, Puja, Menoret, Antoine, Duduskar, Shivalee, Wang, Chengliang, Pérez Sáez, Juan M., Fettis, Margaret M., Li, Chuan, Liu, Renjie, Wanchoo, Arun, Chandiran, Karthik, Ruan, Jianbin, Vanaja, Sivapriya Kailasan, Bauer, Michael, Sponholz, Christoph, Hudalla, Gregory A., Vella, Anthony T., Zhou, Beiyan, Deshmukh, Sachin D., Rabinovich, Gabriel A., Rathinam, Vijay A.
Published in Nature immunology (01.02.2021)
Published in Nature immunology (01.02.2021)
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Journal Article
Circulating galectin-1 delineates response to bevacizumab in melanoma patients and reprograms endothelial cell biology
Bannoud, Nadia, Stupirski, Juan C, Cagnoni, Alejandro J, Hockl, Pablo F, Pérez Sáez, Juan M, García, P Alfredo, Mahmoud, Yamil D, Gambarte Tudela, Julián, Scheidegger, Marco A, Marshall, Andrea, Corrie, Pippa G, Middleton, Mark R, Mariño, Karina V, Girotti, M Romina, Croci, Diego O, Rabinovich, Gabriel A
Published in Proceedings of the National Academy of Sciences - PNAS (17.01.2023)
Published in Proceedings of the National Academy of Sciences - PNAS (17.01.2023)
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Journal Article
Characterization of a neutralizing anti-human galectin-1 monoclonal antibody with angioregulatory and immunomodulatory activities
Pérez Sáez, Juan M., Hockl, Pablo F., Cagnoni, Alejando J., Méndez Huergo, Santiago P., García, Pablo A., Gatto, Sabrina G., Cerliani, Juan P., Croci, Diego O., Rabinovich, Gabriel A.
Published in Angiogenesis (London) (01.02.2021)
Published in Angiogenesis (London) (01.02.2021)
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Journal Article
A proinflammatory stem cell niche drives myelofibrosis through a targetable galectin-1 axis
Li, Rong, Colombo, Michela, Wang, Guanlin, Rodriguez-Romera, Antonio, Benlabiod, Camelia, Jooss, Natalie J, O'Sullivan, Jennifer, Brierley, Charlotte K, Clark, Sally-Ann, Pérez Sáez, Juan M, Fernández, Pedro Aragón, Schoof, Erwin M, Porse, Bo, Meng, Yiran, Khan, Abdullah O, Wen, Sean, Dong, Pengwei, Zhou, Wenjiang, Sousos, Nikolaos, Murphy, Lauren, Clarke, Matthew, Olijnik, Aude-Anais, Wong, Zoë C, Karali, Christina Simoglou, Sirinukunwattana, Korsuk, Ryou, Hosuk, Norfo, Ruggiero, Cheng, Qian, Carrelha, Joana, Ren, Zemin, Thongjuea, Supat, Rathinam, Vijay A, Krishnan, Anandi, Royston, Daniel, Rabinovich, Gabriel A, Mead, Adam J, Psaila, Bethan
Published in Science translational medicine (09.10.2024)
Published in Science translational medicine (09.10.2024)
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Journal Article
A Dynamic Interplay of Circulating Extracellular Vesicles and Galectin-1 Reprograms Viral Latency during HIV-1 Infection
Rubione, Julia, Pérez, Paula S., Czernikier, Alejandro, Duette, Gabriel A., Pereyra Gerber, Federico Pehuen, Salido, Jimena, Fabiano, Martina P., Ghiglione, Yanina, Turk, Gabriela, Laufer, Natalia, Cagnoni, Alejandro J., Pérez Sáez, Juan M., Merlo, Joaquín P., Pascuale, Carla, Stupirski, Juan C., Sued, Omar, Varas-Godoy, Manuel, Lewin, Sharon R., Mariño, Karina V., Rabinovich, Gabriel A., Ostrowski, Matías
Published in mBio (30.08.2022)
Published in mBio (30.08.2022)
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Journal Article
An adipose tissue galectin controls endothelial cell function via preferential recognition of 3-fucosylated glycans
Maller, Sebastián M, Cagnoni, Alejandro J, Bannoud, Nadia, Sigaut, Lorena, Pérez Sáez, Juan M, Pietrasanta, Lía I, Yang, Ri-Yao, Liu, Fu-Tong, Croci, Diego O, Di Lella, Santiago, Sundblad, Victoria, Rabinovich, Gabriel A, Mariño, Karina V
Published in The FASEB journal (01.01.2020)
Published in The FASEB journal (01.01.2020)
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Journal Article
Exploring galectin interactions with human milk oligosaccharides and blood group antigens identifies BGA6 as a functional galectin-4 ligand
Cagnoni, Alejandro J., Massaro, Mora, Cutine, Anabela M., Gimeno, Ana, Pérez-Sáez, Juan M., Manselle Cocco, Montana N., Maller, Sebastián M., Di Lella, Santiago, Jiménez-Barbero, Jesús, Ardá, Ana, Rabinovich, Gabriel A., Mariño, Karina V.
Published in The Journal of biological chemistry (01.08.2024)
Published in The Journal of biological chemistry (01.08.2024)
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Journal Article
A C-type lectin from Bothrops jararacussu venom reprograms endothelial cell biology
Baudou, Federico G, Charó, Nancy L, Scheidegger, Marco A, Stupirski, Juan C, Pérez Sáez, Juan M, Troncoso, María F, Massaro, Mora, de Roodt, Adolfo R, De Marzi, Mauricio C, Schattner, Mirta, Rabinovich, Gabriel A
Published in Angiogenesis (London) (15.06.2024)
Published in Angiogenesis (London) (15.06.2024)
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Journal Article
Sex-dependent expression of galectin-1, a cardioprotective β-galactoside-binding lectin, in human calcific aortic stenosis
Jover, Eva, Martín-Núñez, Ernesto, Garaikoetxea, Mattie, Matilla, Lara, Blanco-Colio, Luis M, Pérez-Sáez, Juan M, Navarro, Adela, Fernández-Celis, Amaya, Gainza, Alicia, Álvarez, Virginia, Sádaba, Rafael, Tamayo, Ibai, Rabinovich, Gabriel A, Martín-Ventura, José L, López-Andrés, Natalia
Published in The FASEB journal (15.02.2024)
Published in The FASEB journal (15.02.2024)
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Journal Article
Glyco-nano-oncology: Novel therapeutic opportunities by combining small and sweet
Hockl, Pablo F., Wolosiuk, Alejandro, Pérez-Sáez, Juan M., Bordoni, Andrea V., Croci, Diego O., Toum-Terrones, Yamili, Soler-Illia, Galo J.A.A., Rabinovich, Gabriel A.
Published in Pharmacological research (01.07.2016)
Published in Pharmacological research (01.07.2016)
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Journal Article
Aryl hydrocarbon receptor activation leads to impairment of estrogen-driven chicken vitellogenin promoter activity in LMH cells
Bussmann, Ursula A., Pérez Sáez, Juan M., Bussmann, Leonardo E., Barañao, J. Lino
Published in Comparative biochemistry and physiology. Toxicology & pharmacology (01.03.2013)
Published in Comparative biochemistry and physiology. Toxicology & pharmacology (01.03.2013)
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Journal Article
Selective modifications of lactose and N-acetyllactosamine with sulfate and aromatic bulky groups unveil unique structural insights in galectin-1-ligand recognition
Massaro, Mora, Cagnoni, Alejandro J., Medrano, Francisco J., Pérez-Sáez, Juan M., Abdullayev, Shuay, Belkhadem, Karima, Mariño, Karina V., Romero, Antonio, Roy, René, Rabinovich, Gabriel A.
Published in Bioorganic & medicinal chemistry (30.10.2023)
Published in Bioorganic & medicinal chemistry (30.10.2023)
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Journal Article
Untangling Galectin-Mediated Circuits that Control Hypoxia-Driven Angiogenesis
Bannoud, Nadia, García, P Alfredo, Gambarte-Tudela, Julian, Sundblad, Victoria, Cagnoni, Alejandro J, Bach, Camila A, Pérez Saez, Juan M, Blidner, Ada G, Maller, Sebastián M, Mariño, Karina V, Salatino, Mariana, Cerliani, Juan P, Rabinovich, Gabriel A, Croci, Diego O
Published in Methods in molecular biology (Clifton, N.J.) (2022)
Published in Methods in molecular biology (Clifton, N.J.) (2022)
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Journal Article
Galectin-7 reprograms skin carcinogenesis by fostering innate immune evasive programs
Pinto, Nicolás A., Abba, Martín C., Laporte, Lorena, Pérez Sáez, Juan M., Blidner, Ada G., Torres, Nicolás I., Morales, Rosa M., Gatto, Sabrina G., Bach, Camila A., Veigas, Florencia, García Rivello, Hernán J., Song, Peng, Frederiksen, Jane H., Rasmussen, Lene Juel, Poirier, Francoise, Croci, Diego O., Sundblad, Victoria, Rabinovich, Gabriel A., Cerliani, Juan P.
Published in Cell death and differentiation (01.04.2023)
Published in Cell death and differentiation (01.04.2023)
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Journal Article
Galectin-1 prevents pathological vascular remodeling in atherosclerosis and abdominal aortic aneurysm
Roldán-Montero, Raquel, Pérez-Sáez, Juan M, Cerro-Pardo, Isabel, Oller, Jorge, Martinez-Lopez, Diego, Nuñez, Estefania, Maller, Sebastian M, Gutierrez-Muñoz, Carmen, Mendez-Barbero, Nerea, Escola-Gil, Joan C, Michel, Jean-Baptiste, Mittelbrunn, Maria, Vázquez, Jesús, Blanco-Colio, Luis M, Rabinovich, Gabriel A, Martin-Ventura, Jose L
Published in Science advances (18.03.2022)
Published in Science advances (18.03.2022)
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Journal Article
Control of intestinal inflammation by glycosylation-dependent lectin-driven immunoregulatory circuits
Morosi, Luciano G., Cutine, Anabela M., Cagnoni, Alejandro J., Manselle-Cocco, Montana N., Croci, Diego O., Merlo, Joaquín P., Morales, Rosa M., May, María, Pérez-Sáez, Juan M., Girotti, María R., Méndez-Huergo, Santiago P., Pucci, Betiana, Gil, Aníbal H., Huernos, Sergio P., Docena, Guillermo H., Sambuelli, Alicia M., Toscano, Marta A., Rabinovich, Gabriel A., Mariño, Karina V.
Published in Science advances (01.06.2021)
Published in Science advances (01.06.2021)
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Journal Article
Abstract 2261: Deciphering cross-resistance mechanisms associated to targeted therapies and immunotherapy in BRAFmutmelanoma: The role of tumor-associated macrophages and galectin-1
Veigas, Florencia, Mahmoud, Yamil Damian, Merlo, Joaquin P., Cocco, Montana Manselle, Massaro, Mora, Gatto, Sabrina, Morales, Rosa, Girotti, Maria R., Perez-Saez, Juan M., Rabinovich, Gabriel A.
Published in Cancer research (Chicago, Ill.) (04.04.2023)
Published in Cancer research (Chicago, Ill.) (04.04.2023)
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