In Vivo Biotransformation of the Fusion Protein Tetranectin-Apolipoprotein A1 Analyzed by Ligand-Binding Mass Spectrometry Combined with Quantitation by ELISA
Zell, Manfred, Husser, Christophe, Staack, Roland F, Jordan, Gregor, Richter, Wolfgang F, Schadt, Simone, Pähler, Axel
Published in Analytical chemistry (Washington) (06.12.2016)
Published in Analytical chemistry (Washington) (06.12.2016)
Get full text
Journal Article
Computational toxicology in drug development
Muster, Wolfgang, Breidenbach, Alexander, Fischer, Holger, Kirchner, Stephan, Müller, Lutz, Pähler, Axel
Published in Drug discovery today (01.04.2008)
Published in Drug discovery today (01.04.2008)
Get full text
Journal Article
Metabotropic Glutamate Receptor 5 Negative Allosteric Modulators: Discovery of 2‑Chloro-4-[1-(4-fluorophenyl)-2,5-dimethyl‑1H‑imidazol-4-ylethynyl]pyridine (Basimglurant, RO4917523), a Promising Novel Medicine for Psychiatric Diseases
Jaeschke, Georg, Kolczewski, Sabine, Spooren, Will, Vieira, Eric, Bitter-Stoll, Nadia, Boissin, Patrick, Borroni, Edilio, Büttelmann, Bernd, Ceccarelli, Simona, Clemann, Nicole, David, Beatrice, Funk, Christoph, Guba, Wolfgang, Harrison, Anthony, Hartung, Thomas, Honer, Michael, Huwyler, Jörg, Kuratli, Martin, Niederhauser, Urs, Pähler, Axel, Peters, Jens-Uwe, Petersen, Ann, Prinssen, Eric, Ricci, Antonio, Rueher, Daniel, Rueher, Marianne, Schneider, Manfred, Spurr, Paul, Stoll, Theodor, Tännler, Daniel, Wichmann, Jürgen, Porter, Richard H, Wettstein, Joseph G, Lindemann, Lothar
Published in Journal of medicinal chemistry (12.02.2015)
Published in Journal of medicinal chemistry (12.02.2015)
Get full text
Journal Article
Discovery and Characterization of 2‑Aminooxazolines as Highly Potent, Selective, and Orally Active TAAR1 Agonists
Galley, Guido, Beurier, Angélica, Décoret, Guillaume, Goergler, Annick, Hutter, Roman, Mohr, Susanne, Pähler, Axel, Schmid, Philipp, Türck, Dietrich, Unger, Robert, Zbinden, Katrin Groebke, Hoener, Marius C, Norcross, Roger D
Published in ACS medicinal chemistry letters (11.02.2016)
Published in ACS medicinal chemistry letters (11.02.2016)
Get full text
Journal Article
Sembragiline: A Novel, Selective Monoamine Oxidase Type B Inhibitor for the Treatment of Alzheimer’s Disease
Borroni, Edilio, Bohrmann, Bernd, Grueninger, Fiona, Prinssen, Eric, Nave, Stephane, Loetscher, Hansruedi, Chinta, Shankar J, Rajagopalan, Subramanian, Rane, Anand, Siddiqui, Almas, Ellenbroek, Bart, Messer, Juerg, Pähler, Axel, Andersen, Julie K, Wyler, Rene, Cesura, Andrea M
Published in The Journal of pharmacology and experimental therapeutics (01.09.2017)
Published in The Journal of pharmacology and experimental therapeutics (01.09.2017)
Get full text
Journal Article
Glutathione conjugates of 4-hydroxy-2( E)-nonenal as biomarkers of hepatic oxidative stress-induced lipid peroxidation in rats
Völkel, Wolfgang, Alvarez-Sánchez, Rubén, Weick, Idelette, Mally, Angela, Dekant, Wolfgang, Pähler, Axel
Published in Free radical biology & medicine (01.06.2005)
Published in Free radical biology & medicine (01.06.2005)
Get full text
Journal Article
Increased brain levels of 4-hydroxy-2-nonenal glutathione conjugates in severe Alzheimer's disease
Völkel, Wolfgang, Sicilia, Tina, Pähler, Axel, Gsell, W., Tatschner, Thomas, Jellinger, Kurt, Leblhuber, Friedrich, Riederer, Peter, Lutz, Werner K., Götz, Mario E.
Published in Neurochemistry international (01.06.2006)
Published in Neurochemistry international (01.06.2006)
Get full text
Journal Article
In vivo and in vitro characterization of ethyl methanesulfonate pharmacokinetics in animals and in human
Lavé, Thierry, Birnböck, Herbert, Götschi, Andreas, Ramp, Thomas, Pähler, Axel
Published in Toxicology letters (12.11.2009)
Published in Toxicology letters (12.11.2009)
Get full text
Journal Article
LC–MS/MS methods for the detection of isoprostanes (iPF 2α-III and 8,12- iso-iPF 2α-VI) as biomarkers of CCl 4-induced oxidative damage to hepatic tissue
Sicilia, Tina, Mally, Angela, Schauer, Ute, Pähler, Axel, Völkel, Wolfgang
Published in Journal of chromatography. B, Analytical technologies in the biomedical and life sciences (2008)
Published in Journal of chromatography. B, Analytical technologies in the biomedical and life sciences (2008)
Get full text
Journal Article
Profiling of dalcetrapib metabolites in human plasma by accelerator mass spectrometry and investigation of the free phenothiol by derivatisation with methylacrylate
Husser, Christophe, Pähler, Axel, Seymour, Mark, Kuhlmann, Olaf, Schadt, Simone, Zell, Manfred
Published in Journal of pharmaceutical and biomedical analysis (15.04.2018)
Published in Journal of pharmaceutical and biomedical analysis (15.04.2018)
Get full text
Journal Article
Post-acquisition analysis of untargeted accurate mass quadrupole time-of-flight MSE data for multiple collision-induced neutral losses and fragment ions of glutathione conjugates
Brink, Andreas, Fontaine, Fabien, Marschmann, Michaela, Steinhuber, Bernd, Cece, Esra Nurten, Zamora, Ismael, Pähler, Axel
Published in Rapid communications in mass spectrometry (30.12.2014)
Published in Rapid communications in mass spectrometry (30.12.2014)
Get full text
Journal Article
Quantitative profiling of prostaglandins as oxidative stress biomarkers in vitro and in vivo by negative ion online solid phase extraction – Liquid chromatography–tandem mass spectrometry
Teppner, Marieke, Zell, Manfred, Husser, Christophe, Ernst, Beat, Pähler, Axel
Published in Analytical biochemistry (01.04.2016)
Published in Analytical biochemistry (01.04.2016)
Get full text
Journal Article
RO6807936 as a novel positron emission tomography (PET) radiotracer for in vitro and in vivo visualization and quantification of beta‐site amyloid precursor protein cleaving enzyme (BACE1) in the rodent and baboon brain
Honer, Michael, Polara, Alessandra, Kuwabara, Hiroto, Jacobsen, Helmut, Pähler, Axel, Hartung, Thomas, Caruso, Antonello, Esterhazy, Daria, Stoffel, Markus, Dannals, Robert F., Wong, Dean F., Borroni, Edilio, Gobbi, Luca C.
Published in Journal of labelled compounds & radiopharmaceuticals (01.07.2023)
Published in Journal of labelled compounds & radiopharmaceuticals (01.07.2023)
Get full text
Journal Article
Software-aided cytochrome P450 reaction phenotyping and kinetic analysis in early drug discovery
Cece-Esencan, Esra Nurten, Fontaine, Fabien, Plasencia, Guillem, Teppner, Marieke, Brink, Andreas, Pähler, Axel, Zamora, Ismael
Published in Rapid communications in mass spectrometry (30.01.2016)
Published in Rapid communications in mass spectrometry (30.01.2016)
Get full text
Journal Article
Meeting report of the 3rd European Biotransformation Workshop
Walles, Markus, Pähler, Axel, Isin, Emre M., Ahlqvist, Marie M.
Published in Xenobiotica (01.02.2023)
Published in Xenobiotica (01.02.2023)
Get full text
Journal Article
Rapid Detection and Identification of N-Acetyl- L-Cysteine Thioethers Using Constant Neutral Loss and Theoretical Multiple Reaction Monitoring Combined with Enhanced Product-Ion Scans on a Linear Ion Trap Mass Spectrometer
Scholz, Karoline, Dekant, Wolfgang, Völkel, Wolfgang, Pähler, Axel
Published in Journal of the American Society for Mass Spectrometry (01.12.2005)
Published in Journal of the American Society for Mass Spectrometry (01.12.2005)
Get full text
Journal Article