HDP-101, an Anti-BCMA Antibody-Drug Conjugate, Safely Delivers Amanitin to Induce Cell Death in Proliferating and Resting Multiple Myeloma Cells
Figueroa-Vazquez, Vianihuini, Ko, Jonathan, Breunig, Christian, Baumann, Anja, Giesen, Nicola, Pálfi, Anikó, Müller, Christoph, Lutz, Christian, Hechler, Torsten, Kulke, Michael, Müller-Tidow, Carsten, Krämer, Alwin, Goldschmidt, Hartmut, Pahl, Andreas, Raab, Marc S
Published in Molecular cancer therapeutics (01.02.2021)
Published in Molecular cancer therapeutics (01.02.2021)
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Journal Article
A three component mix of thioredoxin-L2 antigens elicits broadly neutralizing responses against oncogenic human papillomaviruses
Seitz, Hanna, Canali, Elena, Ribeiro-Müller, Lis, Pàlfi, Anikó, Bolchi, Angelo, Tommasino, Massimo, Ottonello, Simone, Müller, Martin
Published in Vaccine (07.05.2014)
Published in Vaccine (07.05.2014)
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Journal Article
Abstract 237: Preclinical evaluation of anti-HER2 Antibody Targeted Amanitin Conjugates (ATACs) on HER2low breast cancer with chromosome 17p deletion
Breunig, Christian, Pálfi, Anikó, Kulke, Michael, Lutz, Christian, Müller, Christoph, Hechler, Torsten, Pahl, Andreas
Published in Cancer research (Chicago, Ill.) (01.07.2019)
Published in Cancer research (Chicago, Ill.) (01.07.2019)
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Journal Article
Abstract 740: Preclinical evaluation of an anti-PSMA antibody-targeted amanitin conjugate (ATAC)
Pálfi, Anikó, Breunig, Christian, Hechler, Torsten, Müller, Christoph, Lutz, Christian, Pahl, Andreas, Kulke, Michael
Published in Cancer research (Chicago, Ill.) (01.07.2018)
Published in Cancer research (Chicago, Ill.) (01.07.2018)
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Journal Article
Abstract 735: SAR of amanitin and optimization of linker-amanitin derivatives for solid tumors
Kulke, Michael, Pálfi, Anikó, Müller, Christoph, Simon, Werner, Werner-Simon, Susanne, Lutz, Christian, Hechler, Torsten, Pahl, Andreas
Published in Cancer research (Chicago, Ill.) (01.07.2018)
Published in Cancer research (Chicago, Ill.) (01.07.2018)
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Journal Article
Abstract 2636: Amanitin-based ADCs targeting Guanylyl cyclase C (GCC) as novel therapeutic modality for treatment of colorectal cancer
Braun, Alexandra, Pelz, Andreas, Ebeling, Franziska, Decker, Kristin, Pálfi, Anikó, Kulke, Michael, Pahl, Andreas, Hechler, Torsten
Published in Cancer research (Chicago, Ill.) (04.04.2023)
Published in Cancer research (Chicago, Ill.) (04.04.2023)
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Journal Article
Abstract 1523: Subcutaneous dosing of amatoxin-based ADCs increases the therapeutic index
Decker, Kristin, Vranic, Marija, Schmitt, Marisa, Dranova, Irina, Pálfi, Anikó, Hechler, Torsten, Pahl, Andreas, Kulke, Michael
Published in Cancer research (Chicago, Ill.) (04.04.2023)
Published in Cancer research (Chicago, Ill.) (04.04.2023)
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Journal Article
Abstract 1865: HDP-102 - a CD37-targeting Amanitin-based-ADC for the treatment of NHL - non-clinical data package
Neuberth, Sarah-Jane, Decker, Kristin, Orlik, Christian, Dranova, Irina, Pálfi, Anikó, Hechler, Torsten, Pahl, Andreas, Kulke, Michael
Published in Cancer research (Chicago, Ill.) (22.03.2024)
Published in Cancer research (Chicago, Ill.) (22.03.2024)
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Journal Article
Abstract 1754: Amatoxin-based antibody-drug conjugates induce immunogenic cell death and improve the anti-tumor efficacy of immune checkpoint inhibitors in humanized mouse models
Orlik, Christian, Ebeling, Franziska, Decker, Kristin, Dranova, Irina, Pálfi, Anikó, Mueller, Christoph, Hechler, Torsten, Pahl, Andreas, Kulke, Michael
Published in Cancer research (Chicago, Ill.) (15.06.2022)
Published in Cancer research (Chicago, Ill.) (15.06.2022)
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Journal Article
HDP-101: Preclinical evaluation of a novel anti-BCMA antibody drug conjugates in multiple myeloma
Pahl, Andreas, Ko, Jonathan, Breunig, Christian, Figueroa, Vianiuhini, Lehners, Nicola, Baumann, Anja, Pálfi, Anikó, Mueller, Christoph, Lutz, Christian, Hechler, Torsten, Kulke, Michael, Mueller-Tidow, Carsten, Goldschmidt, Hartmut, Raab, Marc
Published in Journal of clinical oncology (20.05.2018)
Published in Journal of clinical oncology (20.05.2018)
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Journal Article
ETx-22: a novel nectin-4-directed antibody drug conjugate, demonstrates safety and potent antitumor activity in low nectin-4 expressing tumors
Lopez, Marc, Crompot, Emerence, Josselin, Emmanuelle, Farina, Anne, Rubis, Marion, Castellano, Remy, Fares, Joanna, Wehbe, Maria, Collette, Yves, Charafe-Jauffret, Emmanuelle, Blanchin, Stéphanie, Romagne, Francois, Pálfi, Anikó, Hechler, Torsten, Pahl, Andreas, Azim, Hatem A, Lhospice, Florence, Mamessier, Emilie, Bertucci, François, Elands, Jack, Preville, Xavier, Olive, Daniel
Published in Cancer research communications (23.10.2024)
Published in Cancer research communications (23.10.2024)
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Journal Article
AMANITIN ANTIBODY CONJUGATES
LUTZ, Christian, MÜLLER, Christoph, KULKE, Michael, PÁLFI, Anikó, HECHLER, Torsten, PAHL, Andreas, SIMON, Werner
Year of Publication 09.10.2024
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Year of Publication 09.10.2024
Patent
Amanitin antibody conjugates
Pálfi, Anikó, Pahl, Andreas, Lutz, Christian, Müller, Christoph, Kulke, Michael, Hechler, Torsten, Simon, Werner
Year of Publication 11.07.2024
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Year of Publication 11.07.2024
Patent
Abstract 1761: Treatment with antibody-targeted amanitin conjugates induces tolerability in preclinical models without triggering tolerance
Decker, Kristin, Schmitt, Marisa, Araman, Can, Ebeling, Franziska, Dranova, Irina, Hechler, Torsten, Pálfí, Anikó, Pahl, Andreas, Kulke, Michael
Published in Cancer research (Chicago, Ill.) (15.06.2022)
Published in Cancer research (Chicago, Ill.) (15.06.2022)
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Journal Article
AMANITIN ANTIBODY CONJUGATES
Torsten HECHLER, Christian LUTZ, Anikó PÁLFI, Werner SIMON, Andreas PAHL, Michael KULKE, Christoph MÜLLER
Year of Publication 30.08.2023
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Year of Publication 30.08.2023
Patent
Preclinical Evaluation of Hdp-101, a Novel Anti-BCMA Antibody-Drug Conjugate, in Multiple Myeloma
Ko, Jonathan, Breunig, Christian, Figueroa, Vianiuhini, Lehners, Nicola, Baumann, Anja, Pálfi, Aniko, Müller, Christoph, Lutz, Christian, Hechler, Torsten, Kulke, Michael, Müller-Tidow, Carsten, Goldschmidt, Hartmut, Pahl, Andreas, Raab, Marc S
Published in Blood (08.12.2017)
Published in Blood (08.12.2017)
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Journal Article
Amanitin antibody conjugates
Pálfi, Anikó, Pahl, Andreas, Lutz, Christian, Müller, Christoph, Kulke, Michael, Hechler, Torsten, Simon, Werner
Year of Publication 20.09.2022
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Year of Publication 20.09.2022
Patent
AMANITIN ANTIBODY CONJUGATES
Pálfi, Anikó, Pahl, Andreas, Lutz, Christian, Müller, Christoph, Kulke, Michael, Hechler, Torsten, Simon, Werner
Year of Publication 31.10.2019
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Year of Publication 31.10.2019
Patent
AMANITIN ANTIBODY CONJUGATES
LUTZ, Christian, MÜLLER, Christoph, KULKE, Michael, PÁLFI, Anikó, HECHLER, Torsten, PAHL, Andreas, SIMON, Werner
Year of Publication 30.10.2019
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Year of Publication 30.10.2019
Patent
Amanitin antibody conjugates
Pálfi, Anikó, Pahl, Andreas, Lutz, Christian, Müller, Christoph, Kulke, Michael, Hechler, Torsten, Simon, Werner
Year of Publication 13.06.2019
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Year of Publication 13.06.2019
Patent