Hypothalamic Fatty Acid Metabolism Mediates the Orexigenic Action of Ghrelin
López, Miguel, Lage, Ricardo, Saha, Asish K., Pérez-Tilve, Diego, Vázquez, María J., Varela, Luis, Sangiao-Alvarellos, Susana, Tovar, Sulay, Raghay, Kawtar, Rodríguez-Cuenca, Sergio, Deoliveira, Rosangela M., Castañeda, Tamara, Datta, Rakesh, Dong, Jesse Z., Culler, Michael, Sleeman, Mark W., Álvarez, Clara V., Gallego, Rosalía, Lelliott, Christopher J., Carling, David, Tschöp, Matthias H., Diéguez, Carlos, Vidal-Puig, Antonio
Published in Cell metabolism (01.05.2008)
Published in Cell metabolism (01.05.2008)
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Exendin-4 Potently Decreases Ghrelin Levels in Fasting Rats
Pérez-Tilve, Diego, González-Matías, Lucas, Alvarez-Crespo, Mayte, Leiras, Roberto, Tovar, Sulay, Diéguez, Carlos, Mallo, Federico
Published in Diabetes (New York, N.Y.) (01.01.2007)
Published in Diabetes (New York, N.Y.) (01.01.2007)
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GLP-1(7-36)-amide and Exendin-4 Stimulate the HPA Axis in Rodents and Humans
Gil-Lozano, Manuel, Pérez-Tilve, Diego, Alvarez-Crespo, Mayte, Martís, Aurelio, Fernandez, Ana M, Catalina, Pablo A. F, Gonzalez-Matias, Lucas C, Mallo, Federico
Published in Endocrinology (Philadelphia) (01.06.2010)
Published in Endocrinology (Philadelphia) (01.06.2010)
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Vertical Sleeve Gastrectomy Is Effective in Two Genetic Mouse Models of Glucagon-Like Peptide 1 Receptor Deficiency
WILSON-PÉREZ, Hilary E, CHAMBERS, Adam P, RYAN, Karen K, BAILING LI, SANDOVAL, Darleen A, STOFFERS, Doris, DRUCKER, Daniel J, PÉREZ-TILVE, Diego, SEELEY, Randy J
Published in Diabetes (New York, N.Y.) (01.07.2013)
Published in Diabetes (New York, N.Y.) (01.07.2013)
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Sleeve gastrectomy induces loss of weight and fat mass in obese rats, but does not affect leptin sensitivity
Stefater, Margaret A, Pérez-Tilve, Diego, Chambers, Adam P, Wilson-Pérez, Hilary E, Sandoval, Darleen A, Berger, José, Toure, Mouhamadoul, Tschöp, Matthias, Woods, Stephen C, Seeley, Randy J
Published in Gastroenterology (New York, N.Y. 1943) (01.06.2010)
Published in Gastroenterology (New York, N.Y. 1943) (01.06.2010)
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Journal Article
Ghrelin-induced adiposity is independent of orexigenic effects
Perez-Tilve, Diego, Heppner, Kristy, Kirchner, Henriette, Lockie, Sarah H, Woods, Stephen C, Smiley, David L, Tschöp, Matthias, Pfluger, Paul
Published in The FASEB journal (01.08.2011)
Published in The FASEB journal (01.08.2011)
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Journal Article
Exendin-4 increases blood glucose levels acutely in rats by activation of the sympathetic nervous system
Pérez-Tilve, Diego, González-Matías, Lucas, Aulinger, Benedikt A, Alvarez-Crespo, Mayte, Gil-Lozano, Manuel, Alvarez, Elias, Andrade-Olivie, Amalia M, Tschöp, Matthias H, D'Alessio, David A, Mallo, Federico
Published in American journal of physiology: endocrinology and metabolism (01.05.2010)
Published in American journal of physiology: endocrinology and metabolism (01.05.2010)
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A rationally designed monomeric peptide triagonist corrects obesity and diabetes in rodents
Finan, Brian, Yang, Bin, Ottaway, Nickki, Smiley, David L, Ma, Tao, Clemmensen, Christoffer, Chabenne, Joe, Zhang, Lianshan, Habegger, Kirk M, Fischer, Katrin, Campbell, Jonathan E, Sandoval, Darleen, Seeley, Randy J, Bleicher, Konrad, Uhles, Sabine, Riboulet, William, Funk, Jürgen, Hertel, Cornelia, Belli, Sara, Sebokova, Elena, Conde-Knape, Karin, Konkar, Anish, Drucker, Daniel J, Gelfanov, Vasily, Pfluger, Paul T, Müller, Timo D, Perez-Tilve, Diego, DiMarchi, Richard D, Tschöp, Matthias H
Published in Nature medicine (01.01.2015)
Published in Nature medicine (01.01.2015)
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Reappraisal of GIP Pharmacology for Metabolic Diseases
Finan, Brian, Müller, Timo D, Clemmensen, Christoffer, Perez-Tilve, Diego, DiMarchi, Richard D, Tschöp, Matthias H
Published in Trends in molecular medicine (01.05.2016)
Published in Trends in molecular medicine (01.05.2016)
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Optimized GIP analogs promote body weight lowering in mice through GIPR agonism not antagonism
Mroz, Piotr A., Finan, Brian, Gelfanov, Vasily, Yang, Bin, Tschöp, Matthias H., DiMarchi, Richard D., Perez-Tilve, Diego
Published in Molecular metabolism (Germany) (01.02.2019)
Published in Molecular metabolism (Germany) (01.02.2019)
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Diet-Induced Obese Mice Retain Endogenous Leptin Action
Ottaway, Nickki, Mahbod, Parinaz, Rivero, Belen, Norman, Lee Ann, Gertler, Arieh, D’Alessio, David A., Perez-Tilve, Diego
Published in Cell metabolism (02.06.2015)
Published in Cell metabolism (02.06.2015)
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Hormones and diet, but not body weight, control hypothalamic microglial activity
Gao, Yuanqing, Ottaway, Nickki, Schriever, Sonja C., Legutko, Beata, García-Cáceres, Cristina, de la Fuente, Esther, Mergen, Clarita, Bour, Susanne, Thaler, Joshua P., Seeley, Randy J., Filosa, Jessica, Stern, Javier E., Perez-Tilve, Diego, Schwartz, Michael W., Tschöp, Matthias H., Yi, Chun-Xia
Published in Glia (01.01.2014)
Published in Glia (01.01.2014)
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Direct Control of Brown Adipose Tissue Thermogenesis by Central Nervous System Glucagon-Like Peptide-1 Receptor Signaling
LOCKIE, Sarah H, HEPPNER, Kristy M, RAHMOUNI, Kamal, OLDFIELD, Brian J, TSCHÖP, Matthias H, PEREZ-TILVE, Diego, CHAUDHARY, Nilika, CHABENNE, Joseph R, MORGAN, Donald A, VEYRAT-DUREBEX, Christelle, ANANTHAKRISHNAN, Gayathri, ROHNER-JEANRENAUD, Françoise, DRUCKER, Daniel J, DIMARCHI, Richard
Published in Diabetes (New York, N.Y.) (01.11.2012)
Published in Diabetes (New York, N.Y.) (01.11.2012)
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Next generation GLP-1/GIP/glucagon triple agonists normalize body weight in obese mice
Knerr, Patrick J., Mowery, Stephanie A., Douros, Jonathan D., Premdjee, Bhavesh, Hjøllund, Karina Rahr, He, Yantao, Kruse Hansen, Ann Maria, Olsen, Anette K., Perez-Tilve, Diego, DiMarchi, Richard D., Finan, Brian
Published in Molecular metabolism (Germany) (01.09.2022)
Published in Molecular metabolism (Germany) (01.09.2022)
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Fibroblast Growth Factor 21 Mediates Specific Glucagon Actions
HABEGGER, Kirk M, STEMMER, Kerstin, KRISHNA, Radha, ARAFAT, Ayman M, KONKAR, Anish, BELLI, Sara, KAPPS, Martin, WOODS, Stephen C, HOFMANN, Susanna M, D'ALESSIO, David, PFLUGER, Paul T, PEREZ-TILVE, Diego, CHENG, Christine, SEELEY, Randy J, KONISHI, Morichika, ITOH, Nobuyujki, KHARITONENKOV, Alexei, SPRANGER, Joachim, DIMARCHI, Richard D, TSCHÖP, Matthias H, MÜLLER, Timo D, HEPPNER, Kristy M, OTTAWAY, Nickki, HOLLAND, Jenna, HEMBREE, Jazzminn L, SMILEY, David, GELFANOV, Vasily
Published in Diabetes (New York, N.Y.) (01.05.2013)
Published in Diabetes (New York, N.Y.) (01.05.2013)
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Synaptic input organization of the melanocortin system predicts diet-induced hypothalamic reactive gliosis and obesity
Horvath, Tamas L., Sarman, Beatrix, García-Cáceres, Cristina, Enriori, Pablo J., Sotonyi, Peter, Shanabrough, Marya, Borok, Erzsebet, Argente, Jesus, Chowen, Julie A., Perez-Tilve, Diego, Pfluger, Paul T., Brönneke, Hella S., Levin, Barry E., Diano, Sabrina, Cowley, Michael A., Tschöp, Matthias H., Friedman, Jeffrey M.
Published in Proceedings of the National Academy of Sciences - PNAS (17.08.2010)
Published in Proceedings of the National Academy of Sciences - PNAS (17.08.2010)
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A new glucagon and GLP-1 co-agonist eliminates obesity in rodents
DiMarchi, Richard, Day, Jonathan W, Ottaway, Nickki, Patterson, James T, Gelfanov, Vasily, Smiley, David, Gidda, Jas, Findeisen, Hannes, Bruemmer, Dennis, Drucker, Daniel J, Chaudhary, Nilika, Holland, Jenna, Hembree, Jazzminn, Abplanalp, William, Grant, Erin, Ruehl, Jennifer, Wilson, Hilary, Kirchner, Henriette, Lockie, Sarah Haas, Hofmann, Susanna, Woods, Stephen C, Nogueiras, Ruben, Pfluger, Paul T, Perez-Tilve, Diego, Tschöp, Matthias H
Published in Nature chemical biology (01.10.2009)
Published in Nature chemical biology (01.10.2009)
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Journal Article
Both acyl and des-acyl ghrelin regulate adiposity and glucose metabolism via central nervous system ghrelin receptors
Heppner, Kristy M, Piechowski, Carolin L, Müller, Anne, Ottaway, Nickki, Sisley, Stephanie, Smiley, David L, Habegger, Kirk M, Pfluger, Paul T, Dimarchi, Richard, Biebermann, Heike, Tschöp, Matthias H, Sandoval, Darleen A, Perez-Tilve, Diego
Published in Diabetes (New York, N.Y.) (01.01.2014)
Published in Diabetes (New York, N.Y.) (01.01.2014)
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Hypothalamic leptin action is mediated by histone deacetylase 5
Kabra, Dhiraj G, Pfuhlmann, Katrin, García-Cáceres, Cristina, Schriever, Sonja C, Casquero García, Veronica, Kebede, Adam Fiseha, Fuente-Martin, Esther, Trivedi, Chitrang, Heppner, Kristy, Uhlenhaut, N Henriette, Legutko, Beata, Kabra, Uma D, Gao, Yuanqing, Yi, Chun-Xia, Quarta, Carmelo, Clemmensen, Christoffer, Finan, Brian, Müller, Timo D, Meyer, Carola W, Paez-Pereda, Marcelo, Stemmer, Kerstin, Woods, Stephen C, Perez-Tilve, Diego, Schneider, Robert, Olson, Eric N, Tschöp, Matthias H, Pfluger, Paul T
Published in Nature communications (29.02.2016)
Published in Nature communications (29.02.2016)
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The central melanocortin system directly controls peripheral lipid metabolism
Nogueiras, Ruben, Wiedmer, Petra, Perez-Tilve, Diego, Veyrat-Durebex, Christelle, Keogh, Julia M, Sutton, Gregory M, Pfluger, Paul T, Castaneda, Tamara R, Neschen, Susanne, Hofmann, Susanna M, Howles, Philip N, Morgan, Donald A, Benoit, Stephen C, Szanto, Ildiko, Schrott, Brigitte, Schürmann, Annette, Joost, Hans-Georg, Hammond, Craig, Hui, David Y, Woods, Stephen C, Rahmouni, Kamal, Butler, Andrew A, Farooqi, I Sadaf, O'Rahilly, Stephen, Rohner-Jeanrenaud, Françoise, Tschöp, Matthias H
Published in The Journal of clinical investigation (01.11.2007)
Published in The Journal of clinical investigation (01.11.2007)
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