Selectively Modulating Conformational States of USP7 Catalytic Domain for Activation
Özen, Ayşegül, Rougé, Lionel, Bashore, Charlene, Hearn, Brian R., Skelton, Nicholas J., Dueber, Erin C.
Published in Structure (London) (02.01.2018)
Published in Structure (London) (02.01.2018)
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Journal Article
HIV-1 protease-substrate coevolution in nelfinavir resistance
Kolli, Madhavi, Ozen, Ayşegül, Kurt-Yilmaz, Nese, Schiffer, Celia A
Published in Journal of virology (01.07.2014)
Published in Journal of virology (01.07.2014)
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Journal Article
Context Surrounding Processing Sites Is Crucial in Determining Cleavage Rate of a Subset of Processing Sites in HIV-1 Gag and Gag-Pro-Pol Polyprotein Precursors by Viral Protease
Lee, Sook-Kyung, Potempa, Marc, Kolli, Madhavi, Özen, Ayşegül, Schiffer, Celia A., Swanstrom, Ronald
Published in The Journal of biological chemistry (13.04.2012)
Published in The Journal of biological chemistry (13.04.2012)
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Journal Article
The molecular basis of drug resistance against hepatitis C virus NS3/4A protease inhibitors
Romano, Keith P, Ali, Akbar, Aydin, Cihan, Soumana, Djade, Ozen, Ayşegül, Deveau, Laura M, Silver, Casey, Cao, Hong, Newton, Alicia, Petropoulos, Christos J, Huang, Wei, Schiffer, Celia A
Published in PLoS pathogens (01.07.2012)
Published in PLoS pathogens (01.07.2012)
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Journal Article
Drug‐resistant HIV‐1 protease regains functional dynamics through cleavage site coevolution
Özer, Nevra, Özen, Ayşegül, Schiffer, Celia A., Haliloğlu, Türkan
Published in Evolutionary applications (01.02.2015)
Published in Evolutionary applications (01.02.2015)
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Journal Article
Molecular Basis for Drug Resistance in HIV-1 Protease
Ali, Akbar, Bandaranayake, Rajintha M, Cai, Yufeng, King, Nancy M, Kolli, Madhavi, Mittal, Seema, Murzycki, Jennifer F, Nalam, Madhavi N L, Nalivaika, Ellen A, Ozen, Ayşegül, Prabu-Jeyabalan, Moses M, Thayer, Kelly, Schiffer, Celia A
Published in Viruses (01.11.2010)
Published in Viruses (01.11.2010)
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Journal Article
Book Review
Discovery of BLU-945, a Reversible, Potent, and Wild-Type-Sparing Next-Generation EGFR Mutant Inhibitor for Treatment-Resistant Non-Small-Cell Lung Cancer
Eno, Meredith S., Brubaker, Jason D., Campbell, John E., De Savi, Chris, Guzi, Timothy J., Williams, Brett D., Wilson, Douglas, Wilson, Kevin, Brooijmans, Natasja, Kim, Joseph, Özen, Ayşegül, Perola, Emanuele, Hsieh, John, Brown, Victoria, Fetalvero, Kristina, Garner, Andrew, Zhang, Zhuo, Stevison, Faith, Woessner, Rich, Singh, Jatinder, Timsit, Yoav, Kinkema, Caitlin, Medendorp, Clare, Lee, Christopher, Albayya, Faris, Zalutskaya, Alena, Schalm, Stefanie, Dineen, Thomas A.
Published in Journal of medicinal chemistry (28.07.2022)
Published in Journal of medicinal chemistry (28.07.2022)
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Journal Article
Abstract A086: NST-628 is a novel molecular glue that inhibits signaling and pathway reactivation in oncogenic RAS-MAPK cancers
Quade, Bradley, Ryan, Meagan, Swalm, Brooke, Cohen, Steven, Fang, Zhong, Ozen, Aysegul, Huang, Xin, Dar, Arvin C, Han, Yongxin, Hoeflich, Klaus P, Hagel, Margit, Hale, Michael
Published in Molecular cancer therapeutics (01.12.2023)
Published in Molecular cancer therapeutics (01.12.2023)
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Journal Article
Abstract LB-020: Characterization of a novel BRAF in-frame deletion reveals a distinct mutational activating mechanism for oncogenic kinases
Foster, Scott, Ozen, Aysegul, Whalen, Dan, Song, Kyung, Hatzivassiliou, Georgia, Hymowitz, Sarah, Skelton, Nick, Malek, Shiva
Published in Cancer research (Chicago, Ill.) (01.08.2015)
Published in Cancer research (Chicago, Ill.) (01.08.2015)
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Journal Article
Abstract ND10: NST-628 is a novel, potent, fully brain-penetrant MAPK pathway molecular glue that inhibits RAS- and RAF-driven cancers
Ryan, Meagan B., Quade, Bradley, Schenk, Natasha, Fang, Zhong, Zingg, Marshall, Cohen, Steven E., Li, Chun, Swalm, Brooke M., Ozen, Aysegul, Ye, Chaoyang, Ritorto, Maria Stella, Huang, Xin, Dar, Arvin C., Han, Yongxin, Hale, Michael, Hagel, Margit, Hoeflich, Klaus P.
Published in Cancer research (Chicago, Ill.) (05.04.2024)
Published in Cancer research (Chicago, Ill.) (05.04.2024)
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Journal Article
Evaluating the Substrate-Envelope Hypothesis: Structural Analysis of Novel HIV-1 Protease Inhibitors Designed To Be Robust against Drug Resistance
NALAM, Madhavi N. L, ALI, Akbar, RANA, Tariq M, SCHIFFER, Celia A, ALTMAN, Michael D, KIRAN KUMAR REDDY, G. S, CHELLAPPAN, Sripriya, KAIRYS, Visvaldas, ZEN, Ayşegül Ö, HONG CAO, GILSON, Michael K, TIDOR, Bruce
Published in Journal of Virology (01.05.2010)
Published in Journal of Virology (01.05.2010)
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Journal Article
Clusters of isoleucine, leucine, and valine side chains define cores of stability in high‐energy states of globular proteins: Sequence determinants of structure and stability
Kathuria, Sagar V., Chan, Yvonne H., Nobrega, R. Paul, Özen, Ayşegül, Matthews, C. Robert
Published in Protein science (01.03.2016)
Published in Protein science (01.03.2016)
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Journal Article
Activation Mechanism of Oncogenic Deletion Mutations in BRAF, EGFR, and HER2
Foster, Scott A., Whalen, Daniel M., Özen, Ayşegül, Wongchenko, Matthew J., Yin, JianPing, Yen, Ivana, Schaefer, Gabriele, Mayfield, John D., Chmielecki, Juliann, Stephens, Philip J., Albacker, Lee A., Yan, Yibing, Song, Kyung, Hatzivassiliou, Georgia, Eigenbrot, Charles, Yu, Christine, Shaw, Andrey S., Manning, Gerard, Skelton, Nicholas J., Hymowitz, Sarah G., Malek, Shiva
Published in Cancer cell (11.04.2016)
Published in Cancer cell (11.04.2016)
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Journal Article
Machine Learning ADME Models in Practice: Four Guidelines from a Successful Lead Optimization Case Study
Rich, Alexander S., Chan, Yvonne H., Birnbaum, Benjamin, Haider, Kamran, Haimson, Joshua, Hale, Michael, Han, Yongxin, Hickman, William, Hoeflich, Klaus P., Ortwine, Daniel, Özen, Ayşegül, Belanger, David B.
Published in ACS medicinal chemistry letters (08.08.2024)
Published in ACS medicinal chemistry letters (08.08.2024)
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Journal Article
EGFR의 돌연변이체 형태의 억제제
CAMPBELL JOHN EMMERSON, OZEN AYSEGUL, WILSON DOUGLAS, PEROLA EMANUELE, ENO MEREDITH SUZANNE, DE SAVI CHRISTOPHER, DINEEN THOMAS A, BRUBAKER JASON D, KIM JOSEPH L, WILLIAMS BRETT D, WILSON KEVIN J, BROOIJMANS NATASJA
Year of Publication 09.01.2023
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Year of Publication 09.01.2023
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