NADPH oxidase links endoplasmic reticulum stress, oxidative stress, and PKR activation to induce apoptosis
Li, Gang, Scull, Christopher, Ozcan, Lale, Tabas, Ira
Published in The Journal of cell biology (13.12.2010)
Published in The Journal of cell biology (13.12.2010)
Get full text
Journal Article
Chemical Chaperones Reduce ER Stress and Restore Glucose Homeostasis in a Mouse Model of Type 2 Diabetes
Özcan, Umut, Yilmaz, Erkan, Özcan, Lale, Furuhashi, Masato, Vaillancourt, Eric, Smith, Ross O, Görgün, Cem Z, Hotamisligil, Gökhan S
Published in Science (American Association for the Advancement of Science) (25.08.2006)
Published in Science (American Association for the Advancement of Science) (25.08.2006)
Get full text
Journal Article
Hepatocyte-secreted DPP4 in obesity promotes adipose inflammation and insulin resistance
Ghorpade, Devram S, Ozcan, Lale, Zheng, Ze, Nicoloro, Sarah M, Shen, Yuefei, Chen, Emily, Blüher, Matthias, Czech, Michael P, Tabas, Ira
Published in Nature (London) (29.03.2018)
Published in Nature (London) (29.03.2018)
Get full text
Journal Article
Endoplasmic Reticulum Stress Plays a Central Role in Development of Leptin Resistance
Ozcan, Lale, Ergin, Ayse Seda, Lu, Allen, Chung, Jason, Sarkar, Sumit, Nie, Duyu, Myers, Martin G., Ozcan, Umut
Published in Cell metabolism (07.01.2009)
Published in Cell metabolism (07.01.2009)
Get full text
Journal Article
Hepatic Glucagon Signaling Regulates PCSK9 and Low-Density Lipoprotein Cholesterol
Spolitu, Stefano, Okamoto, Haruka, Dai, Wen, Zadroga, John A, Wittchen, Erika S, Gromada, Jesper, Ozcan, Lale
Published in Circulation research (04.01.2019)
Published in Circulation research (04.01.2019)
Get full text
Journal Article
Loss of the Tuberous Sclerosis Complex Tumor Suppressors Triggers the Unfolded Protein Response to Regulate Insulin Signaling and Apoptosis
Ozcan, Umut, Ozcan, Lale, Yilmaz, Erkan, Düvel, Katrin, Sahin, Mustafa, Manning, Brendan D., Hotamisligil, Gökhan S.
Published in Molecular cell (14.03.2008)
Published in Molecular cell (14.03.2008)
Get full text
Journal Article
Adipocyte CAMK2 deficiency improves obesity-associated glucose intolerance
Dai, Wen, Choubey, Mayank, Patel, Sonal, Singer, Harold A., Ozcan, Lale
Published in Molecular metabolism (Germany) (01.11.2021)
Published in Molecular metabolism (Germany) (01.11.2021)
Get full text
Journal Article
Calcium Signaling through CaMKII Regulates Hepatic Glucose Production in Fasting and Obesity
Ozcan, Lale, Wong, Catherine C.L., Li, Gang, Xu, Tao, Pajvani, Utpal, Park, Sung Kyu Robin, Wronska, Anetta, Chen, Bi-Xing, Marks, Andrew R., Fukamizu, Akiyoshi, Backs, Johannes, Singer, Harold A., Yates, John R., Accili, Domenico, Tabas, Ira
Published in Cell metabolism (02.05.2012)
Published in Cell metabolism (02.05.2012)
Get full text
Journal Article
An ATF6-tPA pathway in hepatocytes contributes to systemic fibrinolysis and is repressed by DACH1
Zheng, Ze, Nayak, Lalitha, Wang, Wei, Yurdagul, Arif, Wang, Xiaobo, Cai, Bishuang, Lapping, Stephanie, Ozcan, Lale, Ramakrishnan, Rajasekhar, Pestell, Richard G., Jain, Mukesh K., Tabas, Ira
Published in Blood (14.02.2019)
Published in Blood (14.02.2019)
Get full text
Journal Article
Allosteric MAPKAPK2 inhibitors improve plaque stability in advanced atherosclerosis
Ozcan, Lale, Kasikara, Canan, Yurdagul, Jr, Arif, Kuriakose, George, Hubbard, Brian, Serrano-Wu, Michael H, Tabas, Ira
Published in PloS one (13.05.2021)
Published in PloS one (13.05.2021)
Get full text
Journal Article
Common therapeutic targets in cardiometabolic disease
Fredman, Gabrielle, Ozcan, Lale, Tabas, Ira
Published in Science translational medicine (04.06.2014)
Published in Science translational medicine (04.06.2014)
Get more information
Journal Article
Hepatocyte DACH1 Is Increased in Obesity via Nuclear Exclusion of HDAC4 and Promotes Hepatic Insulin Resistance
Ozcan, Lale, Ghorpade, Devram S., Zheng, Ze, de Souza, Jane Cristina, Chen, Ke, Bessler, Marc, Bagloo, Melissa, Schrope, Beth, Pestell, Richard, Tabas, Ira
Published in Cell reports (Cambridge) (07.06.2016)
Published in Cell reports (Cambridge) (07.06.2016)
Get full text
Journal Article
A Hepatocyte FOXN3-α Cell Glucagon Axis Regulates Fasting Glucose
Karanth, Santhosh, Adams, J.D., Serrano, Maria de los Angeles, Quittner-Strom, Ezekiel B., Simcox, Judith, Villanueva, Claudio J., Ozcan, Lale, Holland, William L., Yost, H. Joseph, Vella, Adrian, Schlegel, Amnon
Published in Cell reports (Cambridge) (10.07.2018)
Published in Cell reports (Cambridge) (10.07.2018)
Get full text
Journal Article
Resolvin D1 limits 5-lipoxygenase nuclear localization and leukotriene B₄ synthesis by inhibiting a calcium-activated kinase pathway
Fredman, Gabrielle, Ozcan, Lale, Spolitu, Stefano, Hellmann, Jason, Spite, Matthew, Backs, Johannes, Tabas, Ira
Published in Proceedings of the National Academy of Sciences - PNAS (07.10.2014)
Published in Proceedings of the National Academy of Sciences - PNAS (07.10.2014)
Get full text
Journal Article