Fluorine Scanning by Nonselective Fluorination: Enhancing Raf/MEK Inhibition while Keeping Physicochemical Properties
Hyohdoh, Ikumi, Furuichi, Noriyuki, Aoki, Toshihiro, Itezono, Yoshiko, Shirai, Haruyoshi, Ozawa, Sawako, Watanabe, Fumio, Matsushita, Masayuki, Sakaitani, Masahiro, Ho, Pil-Su, Takanashi, Kenji, Harada, Naoki, Tomii, Yasushi, Yoshinari, Kiyoshi, Ori, Kazutomo, Tabo, Mitsuyasu, Aoki, Yuko, Shimma, Nobuo, Iikura, Hitoshi
Published in ACS medicinal chemistry letters (14.11.2013)
Published in ACS medicinal chemistry letters (14.11.2013)
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Optimizing the Physicochemical Properties of Raf/MEK Inhibitors by Nitrogen Scanning
Aoki, Toshihiro, Hyohdoh, Ikumi, Furuichi, Noriyuki, Ozawa, Sawako, Watanabe, Fumio, Matsushita, Masayuki, Sakaitani, Masahiro, Morikami, Kenji, Takanashi, Kenji, Harada, Naoki, Tomii, Yasushi, Shiraki, Koji, Furumoto, Kentaro, Tabo, Mitsuyasu, Yoshinari, Kiyoshi, Ori, Kazutomo, Aoki, Yuko, Shimma, Nobuo, Iikura, Hitoshi
Published in ACS medicinal chemistry letters (10.04.2014)
Published in ACS medicinal chemistry letters (10.04.2014)
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The sulfamide moiety affords higher inhibitory activity and oral bioavailability to a series of coumarin dual selective RAF/MEK inhibitors
Aoki, Toshihiro, Hyohdoh, Ikumi, Furuichi, Noriyuki, Ozawa, Sawako, Watanabe, Fumio, Matsushita, Masayuki, Sakaitani, Masahiro, Ori, Kazutomo, Takanashi, Kenji, Harada, Naoki, Tomii, Yasushi, Tabo, Mitsuyasu, Yoshinari, Kiyoshi, Aoki, Yuko, Shimma, Nobuo, Iikura, Hitoshi
Published in Bioorganic & medicinal chemistry letters (01.12.2013)
Published in Bioorganic & medicinal chemistry letters (01.12.2013)
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Abstract 2789: Discovery of a novel specific MEK and Raf inhibitor, CH5126766 (RO5126766), hit to lead study of a unique scaffold for kinase inhibitor to a clinical compound
Iikura, Hitoshi, Aoki, Toshihiro, Hyoudoh, Ikumi, Furuichi, Noriyuki, Watanabe, Fumio, Ozawa, Sawako, Sakaidani, Masahiro, Matsushita, Masayuki, Shimma, Nobuo, Harada, Naoki, Tomii, Yasushi, Aoki, Yuko, Takanashi, Kenji
Published in Cancer research (Chicago, Ill.) (15.04.2011)
Published in Cancer research (Chicago, Ill.) (15.04.2011)
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water soluble prodrug of a novel camptothecin analog is efficacious against breast cancer resistance protein-expressing tumor xenografts
Endo, Mika, Miwa, Masanori, Ura, Masako, Tanimura, Hiromi, Taniguchi, Kenji, Miyazaki, Yoko, Ohwada, Jun, Tsukazaki, Masao, Niizuma, Satoshi, Murata, Takeshi, Ozawa, Sawako, Suda, Hitomi, Ogawa, Kotaro, Nanba, Eitaro, Nagao, Shunsuke, Shimma, Nobuo, Yamada-Okabe, Hisafumi
Published in Cancer chemotherapy and pharmacology (2010)
Published in Cancer chemotherapy and pharmacology (2010)
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Synthesis of new camptothecin analogs with improved antitumor activities
NIIZUMA, Satoshi, TSUKAZAKI, Masao, YOSHINARI, Kiyoshi, ENDO, Mika, URA, Masako, TANIMURA, Hiromi, MIYAZAKI, Yoko, TAKASUKA, Tsuyoshi, KAWASHIMA, Akira, NANBA, Eitaro, NAKANO, Kounosuke, OGAWA, Kotaro, SUDA, Hitomi, KOBAYASHI, Kazuko, OKABE, Hisafumi, UMEDA, Isao, SHIMMA, Nobuo, MURATA, Takeshi, OHWADA, Jun, OZAWA, Sawako, FUKUDA, Hiroshi, MURASAKI, Chikako, KOHCHI, Masami, MORIKAMI, Kenji
Published in Bioorganic & medicinal chemistry letters (01.04.2009)
Published in Bioorganic & medicinal chemistry letters (01.04.2009)
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Synthesis and biological activities of a pH-dependently activated water-soluble prodrug of a novel hexacyclic camptothecin analog
Ohwada, Jun, Ozawa, Sawako, Kohchi, Masami, Fukuda, Hiroshi, Murasaki, Chikako, Suda, Hitomi, Murata, Takeshi, Niizuma, Satoshi, Tsukazaki, Masao, Ori, Kazutomo, Yoshinari, Kiyoshi, Itezono, Yoshiko, Endo, Mika, Ura, Masako, Tanimura, Hiromi, Miyazaki, Yoko, Kawashima, Akira, Nagao, Shunsuke, Namba, Eitarou, Ogawa, Koutarou, Kobayashi, Kazuko, Okabe, Hisafumi, Umeda, Isao, Shimma, Nobuo
Published in Bioorganic & medicinal chemistry letters (15.05.2009)
Published in Bioorganic & medicinal chemistry letters (15.05.2009)
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A water soluble prodrug of a novel camptothecin analog is efficacious against breast cancer resistance protein-expressing tumor xenografts
ENDO, Mika, MIWA, Masanori, OZAWA, Sawako, SUDA, Hitomi, OGAWA, Kotaro, NANBA, Eitaro, NAGAO, Shunsuke, SHIMMA, Nobuo, YAMADA-OKABE, Hisafumi, URA, Masako, TANIMURA, Hiromi, TANIGUCHI, Kenji, MIYAZAKI, Yoko, OHWADA, Jun, TSUKAZAKI, Masao, NIIZUMA, Satoshi, MURATA, Takeshi
Published in Cancer chemotherapy and pharmacology (2010)
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Published in Cancer chemotherapy and pharmacology (2010)
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HETEROARYLPHENYLUREA DERIVATIVE
SHIMMA, NOBUO, TSUKAGUCHI, TOSHIYUKI, ISHII, NOBUYA, OZAWA, SAWAKO, MORIKAMI, KENJI, MIZUGUCHI, EISAKU, OIKAWA, NOBUHIRO
Year of Publication 01.09.2005
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Year of Publication 01.09.2005
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P27 PROTEIN INDUCER
IIKURA HITOSHI, FURUICHI NORIYUKI, WATANABE FUMIO, SAKAITANI MASAHIRO, OZAWA SAWAKO, MATSUSHITA MASAYUKI, HYOUDOH IKUMI, TAKANASHI KENJI, HO, PIL SU, TOMII YASUSHI, SAKAI TOSHIYUKI, AOKI TOSHIHIRO, HARADA NAOKI
Year of Publication 26.04.2010
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Year of Publication 26.04.2010
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TAKANASHI, KENJI, OZAWA, SAWAKO, SAKAI, TOSHIYUKI, HYOUDOH, IKUMI, FURUICHI, NORIYUKI, IIKURA, HITOSHI, TOMII, YASUSHI, HARADA, NAOKI, WATANABE, FUMIO, SAKAITANI, MASAHIRO, AOKI, TOSHIHIRO, MATSUSHITA, MASAYUKI, HO, PIL-SU
Year of Publication 29.01.2009
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Year of Publication 29.01.2009
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MULTIKINASE INHIBITOR
SHIMMA, NOBUO, TSUKAGUCHI, TOSHIYUKI, TAMAKI, YASUHIRO, ISHII, NOBUYA, OZAWA, SAWAKO, WATANABE, FUMIO, MORIKAMI, KENJI, MIZUGUCHI, EISAKU, EBIIKE, HIROSATO, OIKAWA, NOBUHIRO, TAKAHASHI, HIDENORI
Year of Publication 15.02.2007
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Year of Publication 15.02.2007
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NOVEL COUMARIN DERIVATIVE HAVING ANTITUMOR ACTIVITY
TOMII, YASUSHI, TAKANASHI, KENJI, HARADA, NAOKI, OZAWA, SAWAKO, WATANABE, FUMIO, SAKAITANI, MASAHIRO, HYOUDOH, IKUMI, FURUICHI, NORIYUKI, IIKURA, HITOSHI, AOKI, TOSHIHIRO, MATSUSHITA, MASAYUKI, HO, PIL-SU
Year of Publication 16.08.2007
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Year of Publication 16.08.2007
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Design and synthesis of 10-oxo derivative of N-cyclopropylmethyl (−)-6β-acetylthiodihydro-normorphine, a potentially κ-selective opioid receptor ligand
Sagara, Takeshi, Ozawa, Sawako, Kushiyama, Emi, Koike, Katsuo, Takayanagi, Issei, Kanematsu, Ken
Published in Bioorganic & medicinal chemistry letters (20.07.1995)
Published in Bioorganic & medicinal chemistry letters (20.07.1995)
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Nye kumarinderivater med antitumoraktivitet
Sakaitani, Masahiro, Furuichi, Noriyuki, Hyoudoh, Ikumi, Iikura, Hitoshi, Matsushita, Masayuki, Harada, Naoki, Tomii, Yasushi, Takanashi, Kenji, Watanabe, Fumio, Ozawa, Sawako, Aoki, Toshihiro, Ho, Pil-Su
Year of Publication 13.11.2017
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Year of Publication 13.11.2017
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