Blocking the human common beta subunit of the GM-CSF, IL-5 and IL-3 receptors markedly reduces hyperinflammation in ARDS models
Wang, Hao, Tumes, Damon J., Hercus, Timothy R., Yip, K. H., Aloe, Christian, Vlahos, Ross, Lopez, Angel F., Wilson, Nick, Owczarek, Catherine M., Bozinovski, Steven
Published in Cell death & disease (10.02.2022)
Published in Cell death & disease (10.02.2022)
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Evaluation of Phage Display Biopanning Strategies for the Selection of Anti-Cell Surface Receptor Antibodies
Panagides, Nadya, Zacchi, Lucia F., De Souza, Mitchell J., Morales, Rodrigo A. V., Karnowski, Alexander, Liddament, Mark T., Owczarek, Catherine M., Mahler, Stephen M., Panousis, Con, Jones, Martina L., Fercher, Christian
Published in International journal of molecular sciences (01.08.2022)
Published in International journal of molecular sciences (01.08.2022)
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Mining the Plasma Cell Transcriptome for Novel Cell Surface Proteins
Trezise, Stephanie, Karnowski, Alexander, Fedele, Pasquale L, Mithraprabhu, Sridurga, Liao, Yang, D'Costa, Kathy, Kueh, Andrew J, Hardy, Matthew P, Owczarek, Catherine M, Herold, Marco J, Spencer, Andrew, Shi, Wei, Willis, Simon N, Nutt, Stephen L, Corcoran, Lynn M
Published in International journal of molecular sciences (24.07.2018)
Published in International journal of molecular sciences (24.07.2018)
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Dual Mechanism of Interleukin-3 Receptor Blockade by an Anti-Cancer Antibody
Broughton, Sophie E., Hercus, Timothy R., Hardy, Matthew P., McClure, Barbara J., Nero, Tracy L., Dottore, Mara, Huynh, Huy, Braley, Hal, Barry, Emma F., Kan, Winnie L., Dhagat, Urmi, Scotney, Pierre, Hartman, Dallas, Busfield, Samantha J., Owczarek, Catherine M., Nash, Andrew D., Wilson, Nicholas J., Parker, Michael W., Lopez, Angel F.
Published in Cell reports (Cambridge) (24.07.2014)
Published in Cell reports (Cambridge) (24.07.2014)
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EphA4 receptor tyrosine kinase is a modulator of onset and disease severity of experimental autoimmune encephalomyelitis (EAE)
Munro, Kathryn M, Dixon, Kirsty J, Gresle, Melissa M, Jonas, Anna, Kemper, Dennis, Doherty, William, Fabri, Louis J, Owczarek, Catherine M, Pearse, Martin, Boyd, Andrew W, Kilpatrick, Trevor J, Butzkueven, Helmut, Turnley, Ann M
Published in PloS one (04.02.2013)
Published in PloS one (04.02.2013)
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Translating the biology of β common receptor-engaging cytokines into clinical medicine
Pant, Harshita, Hercus, Timothy R., Tumes, Damon J., Yip, Kwok Ho, Parker, Michael W., Owczarek, Catherine M., Lopez, Angel F., Huston, David P.
Published in Journal of allergy and clinical immunology (01.02.2023)
Published in Journal of allergy and clinical immunology (01.02.2023)
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Targeting the human βc receptor inhibits inflammatory myeloid cells and lung injury caused by acute cigarette smoke exposure
Fung, Nok Him, Wang, Hao, Vlahos, Ross, Wilson, Nick, Lopez, Angel F., Owczarek, Catherine M., Bozinovski, Steven
Published in Respirology (Carlton, Vic.) (01.08.2022)
Published in Respirology (Carlton, Vic.) (01.08.2022)
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The soluble murine type I interferon receptor Ifnar-2 is present in serum, is independently regulated, and has both agonistic and antagonistic properties
Hardy, Matthew P., Owczarek, Catherine M., Trajanovska, Suzana, Liu, Xiang, Kola, Ismail, Hertzog, Paul J.
Published in Blood (15.01.2001)
Published in Blood (15.01.2001)
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Targeting the Human βc Receptor Inhibits Contact Dermatitis in a Transgenic Mouse Model
Yip, Kwok Ho, McKenzie, Duncan, Ramshaw, Hayley S., Chao, Jessica, McClure, Barbara J., Raquet, Elmar, Kraushaar, Timo, Röder, Joachim, Maxwell, Mhairi, Alhamdoosh, Monther, Hammet, Andrew, Fong, Jia Hong, Zeglinski, Kathleen, Monaghan, Katherine, Pant, Harshita, Grimbaldeston, Michele A., Vairo, Gino, Wilson, Nicholas J., Owczarek, Catherine M., Hercus, Timothy R., Lopez, Angel F., Tumes, Damon J.
Published in Journal of investigative dermatology (01.04.2022)
Published in Journal of investigative dermatology (01.04.2022)
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Sialylation-dependent pharmacokinetics and differential complement pathway inhibition are hallmarks of CR1 activity in vivo
Wymann, Sandra, Mischnik, Marcel, Leong, David, Ghosh, Subhajit, Tan, Xiahui, Cao, Helen, Kuehnemuth, Benjamin, Powers, Glenn A, Halder, Partho, de Souza, Mitchell J, James, Hannah S, Tomasetig, Vesna, Lind, Holger, Rossato, Paolo, Owczarek, Catherine M, Ow, Saw Yen, Dower, Steven K, Baz Morelli, Adriana, Rowe, Tony, Hardy, Matthew P
Published in Biochemical journal (13.05.2022)
Published in Biochemical journal (13.05.2022)
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Modular Platform for the Development of Recombinant Hemoglobin Scavenger Biotherapeutics
Buzzi, Raphael M, Owczarek, Catherine M, Akeret, Kevin, Tester, Andrea, Pereira, Natasha, Butcher, Rebecca, Brügger-Verdon, Valérie, Hardy, Matthew P, Illi, Marlies, Wassmer, Andreas, Vallelian, Florence, Humar, Rok, Hugelshofer, Michael, Buehler, Paul W, Gentinetta, Thomas, Schaer, Dominik J
Published in Molecular pharmaceutics (02.08.2021)
Published in Molecular pharmaceutics (02.08.2021)
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An Optimized Hepatitis C Virus E2 Glycoprotein Core Adopts a Functional Homodimer That Efficiently Blocks Virus Entry
McCaffrey, Kathleen, Boo, Irene, Owczarek, Catherine M, Hardy, Matthew P, Perugini, Matthew A, Fabri, Louis, Scotney, Pierre, Poumbourios, Pantelis, Drummer, Heidi E
Published in Journal of virology (01.03.2017)
Published in Journal of virology (01.03.2017)
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Journal Article
Glycoproteomic measurement of site-specific polysialylation
Pelingon, Ruby, Pegg, Cassandra L., Zacchi, Lucia F., Phung, Toan K., Howard, Christopher B., Xu, Ping, Hardy, Matthew P., Owczarek, Catherine M., Schulz, Benjamin L.
Published in Analytical biochemistry (01.05.2020)
Published in Analytical biochemistry (01.05.2020)
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Journal Article
Anti‐βc mAb CSL311 inhibits human nasal polyp pathophysiology in a humanized mouse xenograft model
Yip, Kwok Ho, Wilson, Nicholas J., Pant, Harshita, Brown, Christopher L., Busfield, Samantha, Ng, Milica, Alhamdoosh, Monther, Woodman, Naomi, Schembri, Mark, Tumes, Damon J., Vairo, Gino, Lopez, Angel F., Nash, Andrew D., Wilson, Michael J., Grimbaldeston, Michele A., Owczarek, Catherine M.
Published in Allergy (Copenhagen) (01.02.2020)
Published in Allergy (Copenhagen) (01.02.2020)
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Journal Article
Role of the β Common (βc) Family of Cytokines in Health and Disease
Hercus, Timothy R, Kan, Winnie L T, Broughton, Sophie E, Tvorogov, Denis, Ramshaw, Hayley S, Sandow, Jarrod J, Nero, Tracy L, Dhagat, Urmi, Thompson, Emma J, Shing, Karen S Cheung Tung, McKenzie, Duncan R, Wilson, Nicholas J, Owczarek, Catherine M, Vairo, Gino, Nash, Andrew D, Tergaonkar, Vinay, Hughes, Timothy, Ekert, Paul G, Samuel, Michael S, Bonder, Claudine S, Grimbaldeston, Michele A, Parker, Michael W, Lopez, Angel F
Published in Cold Spring Harbor perspectives in biology (01.06.2018)
Published in Cold Spring Harbor perspectives in biology (01.06.2018)
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Soluble IFN receptor potentiates in vivo type I IFN signaling and exacerbates TLR4-mediated septic shock
Samarajiwa, Shamith A, Mangan, Niamh E, Hardy, Matthew P, Najdovska, Meri, Dubach, Daphne, Braniff, Susie-Jane, Owczarek, Catherine M, Hertzog, Paul J
Published in The Journal of immunology (1950) (01.05.2014)
Published in The Journal of immunology (1950) (01.05.2014)
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Journal Article
CSL311, a novel, potent, therapeutic monoclonal antibody for the treatment of diseases mediated by the common β chain of the IL-3, GM-CSF and IL-5 receptors
Panousis, Con, Dhagat, Urmi, Edwards, Kirsten M, Rayzman, Veronika, Hardy, Matthew P, Braley, Hal, Gauvreau, Gail M, Hercus, Timothy R, Smith, Steven, Sehmi, Roma, McMillan, Laura, Dottore, Mara, McClure, Barbara J, Fabri, Louis J, Vairo, Gino, Lopez, Angel F, Parker, Michael W, Nash, Andrew D, Wilson, Nicholas J, Wilson, Michael J, Owczarek, Catherine M
Published in mAbs (02.04.2016)
Published in mAbs (02.04.2016)
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SOCS1 is a critical inhibitor of interferon gamma signaling and prevents the potentially fatal neonatal actions of this cytokine
Alexander, W S, Starr, R, Fenner, J E, Scott, C L, Handman, E, Sprigg, N S, Corbin, J E, Cornish, A L, Darwiche, R, Owczarek, C M, Kay, T W, Nicola, N A, Hertzog, P J, Metcalf, D, Hilton, D J
Published in Cell (03.09.1999)
Published in Cell (03.09.1999)
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Identification of potent antagonist antibodies against mouse IL-13Rα1 using novel bioassays
Edwards, Kirsten M., Huynh, Huy, Prasad, Ranjeeta, McDonald, Anne, Hardy, Matthew P., Scotney, Pierre, Owczarek, Catherine M., Busfield, Samantha J., Panousis, Con, Wilson, Nicholas J.
Published in Journal of immunological methods (01.05.2014)
Published in Journal of immunological methods (01.05.2014)
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