Antibody-mediated phagocytosis contributes to the anti-tumor activity of the therapeutic antibody daratumumab in lymphoma and multiple myeloma
Overdijk, Marije B, Verploegen, Sandra, Bögels, Marijn, van Egmond, Marjolein, van Bueren, Jeroen J Lammerts, Mutis, Tuna, Groen, Richard WJ, Breij, Esther, Martens, Anton CM, Bleeker, Wim K, Parren, Paul WHI
Published in mAbs (04.03.2015)
Published in mAbs (04.03.2015)
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Potent Preclinical Efficacy of DuoHexaBody‐CD37 in B‐Cell Malignancies
Horst, Hilma J., Oostindie, Simone C., Cillessen, Saskia. A. G. M., Gelderloos, Anne T., Overdijk, Marije B., Nijhof, Inger. S., Zweegman, Sonja, Chamuleau, Martine E. D., Breij, Esther C. W., Mutis, Tuna
Published in HemaSphere (01.01.2021)
Published in HemaSphere (01.01.2021)
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Journal Article
N-cadherin-mediated interaction with multiple myeloma cells inhibits osteoblast differentiation
GROEN, Richard W. J, DE ROOIJ, Martin F. M, JOSE KERSTEN, Marie, PALS, Steven T, SPAARGAREN, Marcel, KOCEMBA, Kinga A, REIJMERS, Rogier M, DE HAAN-KRAMER, Anneke, OVERDIJK, Marije B, AALDERS, Linda, ROZEMULLER, Henk, MARTENS, Anton C. M, LEIF BERGSAGEL, P
Published in Haematologica (Roma) (01.11.2011)
Published in Haematologica (Roma) (01.11.2011)
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Journal Article
The Therapeutic CD38 Monoclonal Antibody Daratumumab Induces Programmed Cell Death via Fcγ Receptor-Mediated Cross-Linking
Overdijk, Marije B, Jansen, J H Marco, Nederend, Maaike, Lammerts van Bueren, Jeroen J, Groen, Richard W J, Parren, Paul W H I, Leusen, Jeanette H W, Boross, Peter
Published in The Journal of immunology (1950) (01.08.2016)
Published in The Journal of immunology (1950) (01.08.2016)
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Journal Article
Oncogenic KRAS Impairs EGFR Antibodies' Efficiency by C/EBPβ-Dependent Suppression of EGFR Expression
Derer, Stefanie, Berger, Sven, Schlaeth, Martin, Schneider-Merck, Tanja, Klausz, Katja, Lohse, Stefan, Overdijk, Marije B, Dechant, Michael, Kellner, Christian, Nagelmeier, Iris, Scheel, Andreas H, Lammerts van Bueren, Jeroen J, van de Winkel, Jan G.J, Parren, Paul W.H.I, Peipp, Matthias, Valerius, Thomas
Published in Neoplasia (New York, N.Y.) (01.03.2012)
Published in Neoplasia (New York, N.Y.) (01.03.2012)
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Journal Article
Dual Epitope Targeting and Enhanced Hexamerization by DR5 Antibodies as a Novel Approach to Induce Potent Antitumor Activity Through DR5 Agonism
Overdijk, Marije B., Strumane, Kristin, Beurskens, Frank J., Ortiz Buijsse, Antonio, Vermot-Desroches, Claudine, Vuillermoz, Boris S., Kroes, Thessa, de Jong, Bart, Hoevenaars, Naomi, Hibbert, Richard G., Lingnau, Andreas, Forssmann, Ulf, Schuurman, Janine, Parren, Paul W.H.I., de Jong, Rob N., Breij, Esther C.W.
Published in Molecular cancer therapeutics (01.10.2020)
Published in Molecular cancer therapeutics (01.10.2020)
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Journal Article
DuoHexaBody-CD37®, a novel biparatopic CD37 antibody with enhanced Fc-mediated hexamerization as a potential therapy for B-cell malignancies
Oostindie, Simone C., van der Horst, Hilma J., Kil, Laurens P., Strumane, Kristin, Overdijk, Marije B., van den Brink, Edward N., van den Brakel, Jeroen H. N., Rademaker, Hendrik J., van Kessel, Berris, van den Noort, Juliette, Chamuleau, Martine E. D., Mutis, Tuna, Lindorfer, Margaret A., Taylor, Ronald P., Schuurman, Janine, Parren, Paul W. H. I., Beurskens, Frank J., Breij, Esther C. W.
Published in Blood cancer journal (New York) (28.04.2020)
Published in Blood cancer journal (New York) (28.04.2020)
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Journal Article
Epidermal Growth Factor Receptor as Target for Perioperative Elimination of Circulating Colorectal Cancer Cells
Gruijs, Mandy, Braster, Rens, Overdijk, Marije B., Hellingman, Tessa, Verploegen, Sandra, Korthouwer, Rianne, van der Wilk, Berend J., Parren, Paul W. H. I., van der Vliet, Hans J., Bögels, Marijn, van Egmond, Marjolein
Published in Journal of oncology (07.01.2022)
Published in Journal of oncology (07.01.2022)
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Journal Article
Potent preclinical activity of HexaBody-DR5/DR5 in relapsed and/or refractory multiple myeloma
van der Horst, Hilma J., Gelderloos, Anne T., Chamuleau, Martine E.D., Breij, Esther C.W., Zweegman, Sonja, Nijhof, Inger S., Overdijk, Marije B., Mutis, Tuna
Published in Blood advances (27.04.2021)
Published in Blood advances (27.04.2021)
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Journal Article
Epidermal growth factor receptor (EGFR) antibody-induced antibody-dependent cellular cytotoxicity plays a prominent role in inhibiting tumorigenesis, even of tumor cells insensitive to EGFR signaling inhibition
Overdijk, Marije B, Verploegen, Sandra, van den Brakel, Jeroen H, Lammerts van Bueren, Jeroen J, Vink, Tom, van de Winkel, Jan G J, Parren, Paul W H I, Bleeker, Wim K
Published in The Journal of immunology (1950) (15.09.2011)
Published in The Journal of immunology (1950) (15.09.2011)
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Journal Article
Illegitimate WNT Pathway Activation by β-Catenin Mutation or Autocrine Stimulation in T-Cell Malignancies
GROEN, Richard W. J, OUD, Monique E. C. M, SCHILDER-TOL, Esther J. M, OVERDIJK, Marije B, TEN BERGE, Derk, NUSSE, Roel, SPAARGAREN, Marcel, PALS, Steven T
Published in Cancer research (Chicago, Ill.) (01.09.2008)
Published in Cancer research (Chicago, Ill.) (01.09.2008)
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Journal Article
Cytokine gene expression profiles of bovine dendritic cells after interaction with Mycobacterium avium ssp. paratuberculosis ( M.a.p.), Escherichia coli ( E. coli) or recombinant M.a.p. heat shock protein 70
Langelaar, Merel F.M., Weber, Corinna N., Overdijk, Marije B., Müller, Kerstin E., Koets, Ad P., Rutten, Victor P.M.G.
Published in Veterinary immunology and immunopathology (15.08.2005)
Published in Veterinary immunology and immunopathology (15.08.2005)
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Journal Article
Potent Ex Vivo Anti-Tumor Activity in Relapsed Refractory Multiple Myeloma Using Novel DR5-Specific Antibodies with Enhanced Capacity to Form Hexamers upon Target Binding
van der Horst, Hilma J, Overdijk, Marije B, Breij, Esther CW, Chamuleau, Martine, Lokhorst, Henk M, Mutis, Tuna
Published in Blood (08.12.2017)
Published in Blood (08.12.2017)
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Journal Article
Abstract 2391: DR5 agonist activity of HexaBody®-DR5/DR5 (GEN1029) is potentiated by C1q and independent of Fc-gamma receptor binding in preclinical tumor models
Overdijk, Marije B., Strumane, Kristin, Buijsse, Antonio Ortiz, Vermot-Desroches, Claudine, Kroes, Thessa, Jong, Bart de, Hoevenaars, Naomi, Beurskens, Frank J., Jong, Rob N. de, Lingnau, Andreas, Parren, Paul W., Forssmann, Ulf, Sasser, A Kate, Schuurman, Janine, Breij, Esther C.
Published in Cancer research (Chicago, Ill.) (01.07.2019)
Published in Cancer research (Chicago, Ill.) (01.07.2019)
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Journal Article
Abstract C025: HexaBody-DR5/DR5 (GEN1029) shows potent preclinical antitumor activity in a variety of patient-derived xenograft (PDX) tumor models
Overdijk, Marije B, Cecchini, Michael, Strumane, Kristin, Brandhorst, Marcel, Lingnau, Andreas, Parren, Paul W.H.I., Ellekilde-Pedersen, Merete, Forssmann, Ulf, Ahmadi, Tahamtan, Sasser, A. Kate, Schuurman, Janine, Breij, Esther C.W., LoRusso, Patricia
Published in Molecular cancer therapeutics (01.12.2019)
Published in Molecular cancer therapeutics (01.12.2019)
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Journal Article
Abstract 4544: Multifaceted mechanism of action of DuoHexaBody-CD37 involves both complement- and Fc gamma receptor-mediated cytotoxicity in pre-clinical B-cell lymphoma models
Kil, Laurens P., Oostindie, Simone C., Strumane, Kristin, van der Horst, Hilma J., van Kessel, Berris, Overdijk, Marije B., Lingnau, Andreas, Brandhorst, Marcel, van den Brakel, Jeroen, Lindorfer, Margaret A., Taylor, Ronald P., Chamuleau, Martine E., Mutis, Tuna, Sasser, A. Kate, Schuurman, Janine, Parren, Paul W., Beurskens, Frank J., Breij, Esther C.
Published in Cancer research (Chicago, Ill.) (15.08.2020)
Published in Cancer research (Chicago, Ill.) (15.08.2020)
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Journal Article
Targeting CD37 in B-Cell Malignancies Using the Novel Therapeutic Duohexabody-CD37 Results in Efficient Killing of Tumor B-Cells Ex Vivo Via Complement-Dependent Cytotoxicity, Even in Relapsed and/or Refractory Patient Samples
Van Der Horst, Hilma J., Oostindie, Simone C., Cillessen, Saskia AGM, Gelderloos, Anne T, Overdijk, Marije B, Chamuleau, Martine E.D., Breij, Esther C.W., Mutis, Tuna
Published in Blood (29.11.2018)
Published in Blood (29.11.2018)
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Journal Article
Abstract 592: Improving therapeutic activity of agonistic DR5 antibodies by inducing target binding-dependent hexamer formation
Overdijk, Marije B., Strumane, Kristin, Ortiz Buijsse, Antonio, Vermot-Desroches, Claudine, Lingnau, Andreas, Breij, Esther C.W., Schuurman, Janine, Parren, Paul W.H.I.
Published in Cancer research (Chicago, Ill.) (15.07.2016)
Published in Cancer research (Chicago, Ill.) (15.07.2016)
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Journal Article
Duohexabody-CD37, a Novel Bispecific Antibody with a Hexamerization-Enhancing Mutation Targeting CD37, Demonstrates Superior Complement-Dependent Cytotoxicity in Preclinical B-Cell Malignancy Models
Oostindie, Simone C., Van Der Horst, Hilma J., Overdijk, Marije B., Strumane, Kristin, Verploegen, Sandra, Lindorfer, Margaret A., Cook, Erica M., Chamuleau, Martine E.D., Mutis, Tuna, Schuurman, Janine, Sasser, A. Kate, Taylor, Ronald P., Parren, Paul W. H.I., Beurskens, Frank J., Breij, Esther C.W.
Published in Blood (29.11.2018)
Published in Blood (29.11.2018)
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