Energetic dissection of Gleevec's selectivity toward human tyrosine kinases
Agafonov, Roman V, Wilson, Christopher, Otten, Renee, Buosi, Vanessa, Kern, Dorothee
Published in Nature structural & molecular biology (01.10.2014)
Published in Nature structural & molecular biology (01.10.2014)
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Journal Article
Rescue of conformational dynamics in enzyme catalysis by directed evolution
Otten, Renee, Liu, Lin, Kenner, Lillian R., Clarkson, Michael W., Mavor, David, Tawfik, Dan S., Kern, Dorothee, Fraser, James S.
Published in Nature communications (03.04.2018)
Published in Nature communications (03.04.2018)
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Journal Article
Subpolar addition of new cell wall is directed by DivIVA in mycobacteria
Meniche, Xavier, Otten, Renee, Siegrist, M Sloan, Baer, Christina E, Murphy, Kenan C, Bertozzi, Carolyn R, Sassetti, Christopher M
Published in Proceedings of the National Academy of Sciences - PNAS (05.08.2014)
Published in Proceedings of the National Academy of Sciences - PNAS (05.08.2014)
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Journal Article
Fluoride resistance and transport by riboswitch-controlled CLC antiporters
Stockbridge, Randy B, Lim, Hyun-Ho, Otten, Renee, Williams, Carole, Shane, Tania, Weinberg, Zasha, Miller, Christopher
Published in Proceedings of the National Academy of Sciences - PNAS (18.09.2012)
Published in Proceedings of the National Academy of Sciences - PNAS (18.09.2012)
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Journal Article
The energy landscape of adenylate kinase during catalysis
Kerns, S Jordan, Agafonov, Roman V, Cho, Young-Jin, Pontiggia, Francesco, Otten, Renee, Pachov, Dimitar V, Kutter, Steffen, Phung, Lien A, Murphy, Padraig N, Thai, Vu, Alber, Tom, Hagan, Michael F, Kern, Dorothee
Published in Nature structural & molecular biology (01.02.2015)
Published in Nature structural & molecular biology (01.02.2015)
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Journal Article
Cavity as a Source of Conformational Fluctuation and High-Energy State: High-Pressure NMR Study of a Cavity-Enlarged Mutant of T4Lysozyme
Maeno, Akihiro, Sindhikara, Daniel, Hirata, Fumio, Otten, Renee, Dahlquist, Frederick W., Yokoyama, Shigeyuki, Akasaka, Kazuyuki, Mulder, Frans A.A., Kitahara, Ryo
Published in Biophysical journal (06.01.2015)
Published in Biophysical journal (06.01.2015)
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Journal Article
Conformational Selection in a Protein-Protein Interaction Revealed by Dynamic Pathway Analysis
Chakrabarti, Kalyan S., Agafonov, Roman V., Pontiggia, Francesco, Otten, Renee, Higgins, Matthew K., Schertler, Gebhard F.X., Oprian, Daniel D., Kern, Dorothee
Published in Cell reports (Cambridge) (05.01.2016)
Published in Cell reports (Cambridge) (05.01.2016)
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Journal Article
Dynamics of human protein kinase Aurora A linked to drug selectivity
Pitsawong, Warintra, Buosi, Vanessa, Otten, Renee, Agafonov, Roman V, Zorba, Adelajda, Kern, Nadja, Kutter, Steffen, Kern, Gunther, Pádua, Ricardo Ap, Meniche, Xavier, Kern, Dorothee
Published in eLife (14.06.2018)
Published in eLife (14.06.2018)
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Journal Article
Comprehensive and Cost-Effective NMR Spectroscopy of Methyl Groups in Large Proteins
Otten, Renee, Chu, Byron, Krewulak, Karla D, Vogel, Hans J, Mulder, Frans A. A
Published in Journal of the American Chemical Society (10.03.2010)
Published in Journal of the American Chemical Society (10.03.2010)
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Journal Article
A minor conformation of a lanthanide tag on adenylate kinase characterized by paramagnetic relaxation dispersion NMR spectroscopy
Hass, Mathias A. S., Liu, Wei-Min, Agafonov, Roman V., Otten, Renee, Phung, Lien A., Schilder, Jesika T., Kern, Dorothee, Ubbink, Marcellus
Published in Journal of biomolecular NMR (01.02.2015)
Published in Journal of biomolecular NMR (01.02.2015)
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Journal Article
Protein Surface and Core Dynamics Show Concerted Hydration-Dependent Activation
Wood, Kathleen, Gallat, François-Xavier, Otten, Renee, van Heel, Auke J., Lethier, Mathilde, van Eijck, Lambert, Moulin, Martine, Haertlein, Michael, Weik, Martin, Mulder, Frans A. A.
Published in Angewandte Chemie International Edition (07.01.2013)
Published in Angewandte Chemie International Edition (07.01.2013)
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Journal Article
Probing Microsecond Time Scale Dynamics in Proteins by Methyl 1H Carr-Purcell-Meiboom-Gill Relaxation Dispersion NMR Measurements. Application to Activation of the Signaling Protein NtrCr
Otten, Renee, Villali, Janice, Kern, Dorothee, Mulder, Frans AA
Published in Journal of the American Chemical Society (08.11.2010)
Published in Journal of the American Chemical Society (08.11.2010)
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Journal Article
Predicting multiple conformations via sequence clustering and AlphaFold2
Wayment-Steele, Hannah K., Ojoawo, Adedolapo, Otten, Renee, Apitz, Julia M., Pitsawong, Warintra, Hömberger, Marc, Ovchinnikov, Sergey, Colwell, Lucy, Kern, Dorothee
Published in Nature (London) (25.01.2024)
Published in Nature (London) (25.01.2024)
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Journal Article
Structure determination of high-energy states in a dynamic protein ensemble
Stiller, John B., Otten, Renee, Häussinger, Daniel, Rieder, Pascal S., Theobald, Douglas L., Kern, Dorothee
Published in Nature (London) (17.03.2022)
Published in Nature (London) (17.03.2022)
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Journal Article
How directed evolution reshapes the energy landscape in an enzyme to boost catalysis
Otten, Renee, Pádua, Ricardo A P, Bunzel, H Adrian, Nguyen, Vy, Pitsawong, Warintra, Patterson, MacKenzie, Sui, Shuo, Perry, Sarah L, Cohen, Aina E, Hilvert, Donald, Kern, Dorothee
Published in Science (American Association for the Advancement of Science) (18.12.2020)
Published in Science (American Association for the Advancement of Science) (18.12.2020)
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Journal Article
The conformational landscape of fold-switcher KaiB is tuned to the circadian rhythm timescale
Wayment-Steele, Hannah K, Otten, Renee, Pitsawong, Warintra, Ojoawo, Adedolapo M, Glaser, Andrew, Calderone, Logan A, Kern, Dorothee
Published in Proceedings of the National Academy of Sciences - PNAS (05.11.2024)
Published in Proceedings of the National Academy of Sciences - PNAS (05.11.2024)
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Journal Article
100% complete assignment of non-labile ¹H, ¹³C, and ¹⁵N signals for calcium-loaded calbindin D₉k P43G
Complete assignment, Oktaviani, Nur Alia, Otten, Renee, Dijkstra, Klaas, Scheek, Ruud M, Thulin, Eva, Akke, Mikael, Mulder, Frans A. A
Published in Biomolecular NMR assignments (2011)
Published in Biomolecular NMR assignments (2011)
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Journal Article
From primordial clocks to circadian oscillators
Pitsawong, Warintra, Pádua, Ricardo A. P., Grant, Timothy, Hoemberger, Marc, Otten, Renee, Bradshaw, Niels, Grigorieff, Nikolaus, Kern, Dorothee
Published in Nature (London) (06.04.2023)
Published in Nature (London) (06.04.2023)
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Journal Article
Letter to the Editor: 1H, 13C, and 15N resonance assignments of the phosphorylated enzyme IIB of the mannitol-specific phosphoenolpyruvate-dependent phosphotransferase system of Escherichia coli
Otten, Renee, van Lune, Franciska S., Dijkstra, Klaas, Scheek, Ruud M.
Published in Journal of biomolecular NMR (01.12.2004)
Published in Journal of biomolecular NMR (01.12.2004)
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