Influence of Alkoxy Groups on Rates of Acetal Hydrolysis and Tosylate Solvolysis: Electrostatic Stabilization of Developing Oxocarbenium Ion Intermediates and Neighboring-Group Participation To Form Oxonium Ions
Garcia, Angie, Otte, Douglas A. L, Salamant, Walter A, Sanzone, Jillian R, Woerpel, K. A
Published in Journal of organic chemistry (01.05.2015)
Published in Journal of organic chemistry (01.05.2015)
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Acceleration of Acetal Hydrolysis by Remote Alkoxy Groups: Evidence for Electrostatic Effects on the Formation of Oxocarbenium Ions
Garcia, Angie, Otte, Douglas A. L., Salamant, Walter A., Sanzone, Jillian R., Woerpel, K. A.
Published in Angewandte Chemie International Edition (02.03.2015)
Published in Angewandte Chemie International Edition (02.03.2015)
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Single-Molecule Imaging of Platinum Ligand Exchange Reaction Reveals Reactivity Distribution
Esfandiari, N. Melody, Wang, Yong, Bass, Jonathan Y, Cornell, Trevor P, Otte, Douglas A. L, Cheng, Ming H, Hemminger, John C, McIntire, Theresa M, Mandelshtam, Vladimir A, Blum, Suzanne A
Published in Journal of the American Chemical Society (03.11.2010)
Published in Journal of the American Chemical Society (03.11.2010)
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13C NMR Spectroscopy for the Quantitative Determination of Compound Ratios and Polymer End Groups
Otte, Douglas A. L, Borchmann, Dorothee E, Lin, Chin, Weck, Marcus, Woerpel, K. A
Published in Organic letters (21.03.2014)
Published in Organic letters (21.03.2014)
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Development of a Green and Sustainable Manufacturing Process for Gefapixant Citrate (MK-7264) Part 4: Formylation–Cyclization as a Flow–Batch Process Leads to Significant Improvements in Process Mass Intensity (PMI) and CO Generated versus the Batch–Batch Process
Otte, Douglas A. L, Basu, Kallol, Jellett, Lisa, Whittington, Michael, Spencer, Glenn, Burris, Matthew, Corcoran, Emily B, Stone, Kevin, Nappi, Jarod, Arvary, Rebecca A, Donoghue, David, Ren, Hong, Maloney, Kevin M, Naber, John R
Published in Organic process research & development (20.11.2020)
Published in Organic process research & development (20.11.2020)
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Development of a Green and Sustainable Manufacturing Process for Gefapixant Citrate (MK-7264) Part 1: Introduction and Process Overview
Ren, Hong, Maloney, Kevin M, Basu, Kallol, Di Maso, Michael J, Humphrey, Guy R, Peng, Feng, Desmond, Richard, Otte, Douglas A. L, Alwedi, Embarek, Liu, Wenjun, Zhang, Si-Wei, Song, Siqing, Arvary, Rebecca A, Zompa, Michael A, Lehnherr, Dan, Martin, Gary E, Chang, Hsieh Yao D, Mohan, Anne E, Guzman, Francisco J, Jellett, Lisa, Lee, Alfred Y, Spencer, Glenn, Fisher, Elizabeth S, Naber, John R, Gao, Hong, Lohani, Sachin, Ruck, Rebecca T, Campeau, Louis-Charles
Published in Organic process research & development (20.11.2020)
Published in Organic process research & development (20.11.2020)
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Journal Article
Influence of Alkoxy Groups on Rates of Acetal Hydrolysis and Tosylate Solvolysis: Electrostatic Stabilization of Developing Oxocarbenium Ion Intermediates and Neighboring-Group Participation To Form Oxoniunn Ions
Garcia, Angie, Otte, Douglas A. L., Salamant, Walter A., Sanzone, Jillian R., Woerpel, K. A.
Published in Journal of organic chemistry (01.05.2015)
Published in Journal of organic chemistry (01.05.2015)
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Journal Article
Pilot-Scale Operation and Characterization of an Organolithium-Mediated Coupling Reaction in Flow to Form a Ketone Intermediate on the Route to Nemtabrutinib
Franklin, Robert D., Armiger, Travis, Otte, Douglas A. L., Larson, Reed T., Spencer, Glenn, Patel, Pratiq A., Paulines, Mellie June, Hall, Jackson R., Xiao, Kai-Jiong, Fier, Patrick S., Rodrigues, Vailankanni L., Guetschow, Erik D., Kuhl, Nadine, Jellett, Lisa, Corry, James, Chung, Cheol K., Thaisrivongs, David A.
Published in Organic process research & development (17.05.2024)
Published in Organic process research & development (17.05.2024)
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Development of a Green and Sustainable Manufacturing Process for a Key Intermediate to Nemtabrutinib (MK-1026): Sequential Deprotonation–Lithiation as a Batch–Flow Process
Otte, Douglas A. L., Larson, Reed T., Alwedi, Embarek, Armiger, Travis, Chen, Yonggang, Chung, Cheol K., Corry, James, Desmond, Richard, Fier, Patrick S., Franklin, Robert D., Guetschow, Erik D., Hall, Jackson R., Halsey, Holst M., Hartmanshenn, Clara, Jellett, Lisa, Kuhl, Nadine, Lévesque, François, McMullen, Jonathan P., Patel, Pratiq A., Paulines, Mellie June, Ren, Hong, Rodrigues, Vailankanni L., Ruccolo, Serge, Tan, Lushi, Thaisrivongs, David A., Xiao, Kai-Jiong
Published in Organic process research & development (17.05.2024)
Published in Organic process research & development (17.05.2024)
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Journal Article
13 C NMR Spectroscopy for the Quantitative Determination of Compound Ratios and Polymer End Groups
Otte, Douglas A. L., Borchmann, Dorothee E., Lin, Chin, Weck, Marcus, Woerpel, K. A.
Published in Organic letters (21.03.2014)
Published in Organic letters (21.03.2014)
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Journal Article