EZH2 Is Required for Germinal Center Formation and Somatic EZH2 Mutations Promote Lymphoid Transformation
Béguelin, Wendy, Popovic, Relja, Teater, Matt, Jiang, Yanwen, Bunting, Karen L., Rosen, Monica, Shen, Hao, Yang, Shao Ning, Wang, Ling, Ezponda, Teresa, Martinez-Garcia, Eva, Zhang, Haikuo, Zheng, Yupeng, Verma, Sharad K., McCabe, Michael T., Ott, Heidi M., Van Aller, Glenn S., Kruger, Ryan G., Liu, Yan, McHugh, Charles F., Scott, David W., Chung, Young Rock, Kelleher, Neil, Shaknovich, Rita, Creasy, Caretha L., Gascoyne, Randy D., Wong, Kwok-Kin, Cerchietti, Leandro, Levine, Ross L., Abdel-Wahab, Omar, Licht, Jonathan D., Elemento, Olivier, Melnick, Ari M.
Published in Cancer cell (13.05.2013)
Published in Cancer cell (13.05.2013)
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Journal Article
EZH2 inhibition as a therapeutic strategy for lymphoma with EZH2―activating mutations
MCCABE, Michael T, OTT, Heidi M, LAFRANCE, Louis V, MELLINGER, Mark, DUQUENNE, Celine, XINRONG TIAN, KRUGER, Ryan G, MCHUGH, Charles F, BRANDT, Martin, MILLER, William H, DHANAK, Dashyant, VERMA, Sharad K, GANJI, Gopinath, TUMMINO, Peter J, CREASY, Caretha L, KORENCHUK, Susan, THOMPSON, Christine, VAN ALLER, Glenn S, VAN LIU, GRAVES, Alan P, DELLA PIETRA, Anthony, DIAZ, Elsie
Published in Nature (London) (06.12.2012)
Published in Nature (London) (06.12.2012)
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Journal Article
Mutation of A677 in histone methyltransferase EZH2 in human B-cell lymphoma promotes hypertrimethylation of histone H3 on lysine 27 (H3K27)
McCabe, Michael T, Graves, Alan P, Ganji, Gopinath, Diaz, Elsie, Halsey, Wendy S, Jiang, Yong, Smitheman, Kimberly N, Ott, Heidi M, Pappalardi, Melissa B, Allen, Kimberly E, Chen, Stephanie B, Della Pietra, Anthony III, Dul, Edward, Hughes, Ashley M, Gilbert, Seth A, Thrall, Sara H, Tummino, Peter J, Kruger, Ryan G, Brandt, Martin, Schwartz, Benjamin, Creasy, Caretha L
Published in Proceedings of the National Academy of Sciences - PNAS (21.02.2012)
Published in Proceedings of the National Academy of Sciences - PNAS (21.02.2012)
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Journal Article
Identification of a CARM1 Inhibitor with Potent In Vitro and In Vivo Activity in Preclinical Models of Multiple Myeloma
Drew, Allison E, Moradei, Oscar, Jacques, Suzanne L, Rioux, Nathalie, Boriack-Sjodin, Ann P, Allain, Christina, Scott, Margaret Porter, Jin, Lei, Raimondi, Alejandra, Handler, Jessica L, Ott, Heidi M, Kruger, Ryan G, McCabe, Michael T, Sneeringer, Christopher, Riera, Thomas, Shapiro, Gideon, Waters, Nigel J, Mitchell, Lorna H, Duncan, Kenneth W, Moyer, Mikel P, Copeland, Robert A, Smith, Jesse, Chesworth, Richard, Ribich, Scott A
Published in Scientific reports (21.12.2017)
Published in Scientific reports (21.12.2017)
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Journal Article
Identification of Potent, Selective, Cell-Active Inhibitors of the Histone Lysine Methyltransferase EZH2
Verma, Sharad K, Tian, Xinrong, LaFrance, Louis V, Duquenne, Céline, Suarez, Dominic P, Newlander, Kenneth A, Romeril, Stuart P, Burgess, Joelle L, Grant, Seth W, Brackley, James A, Graves, Alan P, Scherzer, Daryl A, Shu, Art, Thompson, Christine, Ott, Heidi M, Aller, Glenn S. Van, Machutta, Carl A, Diaz, Elsie, Jiang, Yong, Johnson, Neil W, Knight, Steven D, Kruger, Ryan G, McCabe, Michael T, Dhanak, Dashyant, Tummino, Peter J, Creasy, Caretha L, Miller, William H
Published in ACS medicinal chemistry letters (13.12.2012)
Published in ACS medicinal chemistry letters (13.12.2012)
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Journal Article
A687V EZH2 is a driver of histone H3 lysine 27 (H3K27) hypertrimethylation
Ott, Heidi M, Graves, Alan P, Pappalardi, Melissa B, Huddleston, Michael, Halsey, Wendy S, Hughes, Ashley M, Groy, Arthur, Dul, Edward, Jiang, Yong, Bai, Yuchen, Annan, Roland, Verma, Sharad K, Knight, Steven D, Kruger, Ryan G, Dhanak, Dashyant, Schwartz, Benjamin, Tummino, Peter J, Creasy, Caretha L, McCabe, Michael T
Published in Molecular cancer therapeutics (01.12.2014)
Published in Molecular cancer therapeutics (01.12.2014)
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Journal Article
Long Residence Time Inhibition of EZH2 in Activated Polycomb Repressive Complex 2
Van Aller, Glenn S, Pappalardi, Melissa Baker, Ott, Heidi M, Diaz, Elsie, Brandt, Martin, Schwartz, Benjamin J, Miller, William H, Dhanak, Dashyant, McCabe, Michael T, Verma, Sharad K, Creasy, Caretha L, Tummino, Peter J, Kruger, Ryan G
Published in ACS chemical biology (21.03.2014)
Published in ACS chemical biology (21.03.2014)
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Journal Article
JNJ-28312141, a novel orally active colony-stimulating factor-1 receptor/FMS-related receptor tyrosine kinase-3 receptor tyrosine kinase inhibitor with potential utility in solid tumors, bone metastases, and acute myeloid leukemia
Manthey, Carl L, Johnson, Dana L, Illig, Carl R, Tuman, Robert W, Zhou, Zhao, Baker, Judith F, Chaikin, Margery A, Donatelli, Robert R, Franks, Carol F, Zeng, Lee, Crysler, Carl, Chen, Yanmin, Yurkow, Edward J, Boczon, Lisa, Meegalla, Sanath K, Wilson, Kenneth J, Wall, Mark J, Chen, Jinsheng, Ballentine, Shelley K, Ott, Heidi, Baumann, Christian, Lawrence, Danielle, Tomczuk, Bruce E, Molloy, Christopher J
Published in Molecular cancer therapeutics (01.11.2009)
Published in Molecular cancer therapeutics (01.11.2009)
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Journal Article
Derivation of occupational exposure limits: Differences in methods and protection levels
Schneider, Klaus, Dilger, Marco, Drossard, Claudia, Ott, Heidi, Kaiser, Eva
Published in Journal of applied toxicology (01.05.2022)
Published in Journal of applied toxicology (01.05.2022)
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Journal Article
Abstract 5379: A potent EZH2 inhibitor exhibits long residence time and anti-tumor activity
Ott, Heidi, van Aller, Glenn, Ward, Jessica, Le, BaoChau, Rominger, Cynthia, Foley, James, Korenchuk, Susan, McHugh, Charles, Butticello, Michael, Blackledge, Charles, Brackley, James, Burgess, Joelle, Duquenne, Celine, Johnson, Neil, Kasparec, Jiri, LaFrance, Louis, Li, Mei, McNulty, Kenneth, Newlander, Kenneth, Romeril, Stuart, Schmidt, Stanley, Schulz, Mark, Su, Dai-Shi, Suarez, Dominic, Tian, Xinrong, Carpenter, Christopher, Luengo, Juan, Kruger, Ryan, Knight, Steven, McCabe, Michael T.
Published in Cancer research (Chicago, Ill.) (01.08.2015)
Published in Cancer research (Chicago, Ill.) (01.08.2015)
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Reassessment of occupational exposure limits
Stouten, Hans, Ott, Heidi, Bouwman, Carolien, Wardenbach, Peter
Published in American journal of industrial medicine (01.06.2008)
Published in American journal of industrial medicine (01.06.2008)
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Journal Article
Abstract 4700: A novel selective EZH2 inhibitor exhibits anti-tumor activity in lymphoma with EZH2 activating mutations
Creasy, Caretha L., McCabe, Michael T., Korenchuk, Susan, Diaz, Elsie, Ott, Heidi, Thompson, Christine S., Ganji, Gopi, Gorman, Shelby A., LaFrance, Louis V., Brandt, Martin, McHugh, Charles, Verma, Sharad K., Tummino, Peter J.
Published in Cancer research (Chicago, Ill.) (15.04.2012)
Published in Cancer research (Chicago, Ill.) (15.04.2012)
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Journal Article
Abstract 1057: Mutation of EZH2 A677 in human B-cell lymphoma promotes hyper-trimethylation of H3K27
McCabe, Michael T., Graves, Alan P., Ganji, Gopinath, Ott, Heidi, Diaz, Elsie, Halsey, Wendy S., Jiang, Yong, Smitheman, Kimberly N., Pappalardi, Melissa B., Allen, Kimberly E., Chen, Stephanie, Della-Pietra, Anthony, Dul, Edward, Hughes, Ashley M., Thrall, Sara H., Tummino, Peter J., Kruger, Ryan G., Brandt, Martin, Schwartz, Benjamin, Verma, Sharad K., Creasy, Caretha L.
Published in Cancer research (Chicago, Ill.) (15.04.2012)
Published in Cancer research (Chicago, Ill.) (15.04.2012)
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Journal Article
Abstract 2939: Discovery and synthesis of highly potent and selective small molecule inhibitors of the histone methyltransferase EZH2
Verma, Sharad K., LaFrance, Louis V., Tian, Xinrong, Newlander, Ken, Duquenne, Céline, Suarez, Dominic, Knight, Steven D., Burgess, Joelle, Brackley, James, Johnson, Neil W., Graves, Alan P., Mellinger, Mark, Romeril, Stuart, Grant, Seth W., Scherzer, Daryl, Shu, Art, Creasy, Caretha L., Kruger, Ryan, Diaz, Elsie, Le, Baochau, Thompson, Christine, Morgan-Ott, Heidi, McCabe, Michael T., McHugh, Charles F., Miller, William H., Tummino, Peter, Dhanak, Dash
Published in Cancer research (Chicago, Ill.) (15.04.2012)
Published in Cancer research (Chicago, Ill.) (15.04.2012)
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Journal Article
Health-based workplace limit values for substances affecting male reproduction
Schuhmacher-Wolz, Ulrike, Ott, Heidi, Jung, Reinhard, Kalberlah, Fritz
Published in Toxicology letters (13.09.2009)
Published in Toxicology letters (13.09.2009)
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Journal Article
2-Hydroxy-4,6-diamino-[1,3,5]triazines: A Novel Class of VEGF-R2 (KDR) Tyrosine Kinase Inhibitors
Baindur, Nand, Chadha, Naresh, Brandt, Benjamin M, Asgari, Davoud, Patch, Raymond J, Schalk-HiHi, Celine, Carver, Theodore E, Petrounia, Ioanna P, Baumann, Christian A, Ott, Heidi, Manthey, Carl, Springer, Barry A, Player, Mark R
Published in Journal of medicinal chemistry (24.03.2005)
Published in Journal of medicinal chemistry (24.03.2005)
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