How allosteric control of Staphylococcus aureus penicillin binding protein 2a enables methicillin resistance and physiological function
Otero, Lisandro H., Rojas-Altuve, Alzoray, Llarrull, Leticia I., Carrasco-López, Cesar, Kumarasiri, Malika, Lastochkin, Elena, Fishovitz, Jennifer, Dawley, Matthew, Hesek, Dusan, Lee, Mijoon, Johnson, Jarrod W., Fisher, Jed F., Chang, Mayland, Mobashery, Shahriar, Hermoso, Juan A.
Published in Proceedings of the National Academy of Sciences - PNAS (15.10.2013)
Published in Proceedings of the National Academy of Sciences - PNAS (15.10.2013)
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Journal Article
Structure of the Full-Length Bacteriophytochrome from the Plant Pathogen Xanthomonas campestris Provides Clues to its Long-Range Signaling Mechanism
Otero, Lisandro Horacio, Klinke, Sebastián, Rinaldi, Jimena, Velázquez-Escobar, Francisco, Mroginski, María Andrea, Fernández López, María, Malamud, Florencia, Vojnov, Adrián Alberto, Hildebrandt, Peter, Goldbaum, Fernando Alberto, Bonomi, Hernán Ruy
Published in Journal of molecular biology (25.09.2016)
Published in Journal of molecular biology (25.09.2016)
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Journal Article
Discovery of Antibiotic (E)‑3-(3-Carboxyphenyl)-2-(4-cyanostyryl)quinazolin-4(3H)‑one
Bouley, Renee, Kumarasiri, Malika, Peng, Zhihong, Otero, Lisandro H, Song, Wei, Suckow, Mark A, Schroeder, Valerie A, Wolter, William R, Lastochkin, Elena, Antunes, Nuno T, Pi, Hualiang, Vakulenko, Sergei, Hermoso, Juan A, Chang, Mayland, Mobashery, Shahriar
Published in Journal of the American Chemical Society (11.02.2015)
Published in Journal of the American Chemical Society (11.02.2015)
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Journal Article
The Reaction Mechanism of Metallo-β-Lactamases Is Tuned by the Conformation of an Active-Site Mobile Loop
Palacios, Antonela R, Mojica, María F, Giannini, Estefanía, Taracila, Magdalena A, Bethel, Christopher R, Alzari, Pedro M, Otero, Lisandro H, Klinke, Sebastián, Llarrull, Leticia I, Bonomo, Robert A, Vila, Alejandro J
Published in Antimicrobial agents and chemotherapy (01.01.2019)
Published in Antimicrobial agents and chemotherapy (01.01.2019)
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Journal Article
Disruption of Allosteric Response as an Unprecedented Mechanism of Resistance to Antibiotics
Fishovitz, Jennifer, Rojas-Altuve, Alzoray, Otero, Lisandro H, Dawley, Matthew, Carrasco-López, Cesar, Chang, Mayland, Hermoso, Juan A, Mobashery, Shahriar
Published in Journal of the American Chemical Society (16.07.2014)
Published in Journal of the American Chemical Society (16.07.2014)
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Journal Article
Structural and mutational analyses of the Leptospira interrogans virulence-related heme oxygenase provide insights into its catalytic mechanism
Soldano, Anabel, Klinke, Sebastián, Otero, Lisandro H, Rivera, Mario, Catalano-Dupuy, Daniela L, Ceccarelli, Eduardo A
Published in PloS one (03.08.2017)
Published in PloS one (03.08.2017)
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Journal Article
Deamidation drives molecular aging of the SARS-CoV-2 spike protein receptor-binding motif
Lorenzo, Ramiro, Defelipe, Lucas A., Aliperti, Lucio, Niebling, Stephan, Custódio, Tânia F., Löw, Christian, Schwarz, Jennifer J., Remans, Kim, Craig, Patricio O., Otero, Lisandro H., Klinke, Sebastián, García-Alai, María, Sánchez, Ignacio E., Alonso, Leonardo G.
Published in The Journal of biological chemistry (01.10.2021)
Published in The Journal of biological chemistry (01.10.2021)
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Journal Article
Dimer Asymmetry and Light Activation Mechanism in Brucella Blue-Light Sensor Histidine Kinase
Rinaldi, Jimena, Fernández, Ignacio, Shin, Heewhan, Sycz, Gabriela, Gunawardana, Semini, Kumarapperuma, Indika, Paz, Juan M, Otero, Lisandro H, Cerutti, María L, Zorreguieta, Ángeles, Ren, Zhong, Klinke, Sebastián, Yang, Xiaojing, Goldbaum, Fernando A
Published in mBio (20.04.2021)
Published in mBio (20.04.2021)
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Journal Article
Structural basis for the broad specificity of a new family of amino-acid racemases
Espaillat, Akbar, Carrasco-López, César, Bernardo-García, Noelia, Pietrosemoli, Natalia, Otero, Lisandro H., Álvarez, Laura, de Pedro, Miguel A., Pazos, Florencio, Davis, Brigid M., Waldor, Matthew K., Hermoso, Juan A., Cava, Felipe
Published in Acta crystallographica. Section D, Biological crystallography. (01.01.2014)
Published in Acta crystallographica. Section D, Biological crystallography. (01.01.2014)
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Journal Article
Pr‐favoured variants of the bacteriophytochrome from the plant pathogen Xanthomonas campestris hint on light regulation of virulence‐associated mechanisms
Conforte, Valeria, Otero, Lisandro Horacio, Toum, Laila, Sirigu, Serena, Antelo, Giuliano Tomás, Rinaldi, Jimena, Foscaldi, Sabrina, Klinke, Sebastián, Chavas, Leonard Michel Gabriel, Vojnov, Adrián Alberto, Goldbaum, Fernando Alberto, Malamud, Florencia, Bonomi, Hernán Ruy
Published in The FEBS journal (01.10.2021)
Published in The FEBS journal (01.10.2021)
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Journal Article
A Fijivirus Major Viroplasm Protein Shows RNA-Stimulated ATPase Activity by Adopting Pentameric and Hexameric Assemblies of Dimers
Llauger, Gabriela, Melero, Roberto, Monti, Demián, Sycz, Gabriela, Huck-Iriart, Cristián, Cerutti, María L, Klinke, Sebastián, Mikkelsen, Evelyn, Tijman, Ariel, Arranz, Rocío, Alfonso, Victoria, Arellano, Sofía M, Goldbaum, Fernando A, Sterckx, Yann G J, Carazo, José-María, Kaufman, Sergio B, Dans, Pablo D, Del Vas, Mariana, Otero, Lisandro H
Published in mBio (25.04.2023)
Published in mBio (25.04.2023)
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Journal Article
Snapshots of Conformational Changes Shed Light into the NtrX Receiver Domain Signal Transduction Mechanism
Fernández, Ignacio, Otero, Lisandro H., Klinke, Sebastián, Carrica, Mariela del Carmen, Goldbaum, Fernando A.
Published in Journal of molecular biology (09.10.2015)
Published in Journal of molecular biology (09.10.2015)
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Journal Article
Crystal structures of peanut lectin in the presence of synthetic β‐N‐ and β‐S‐galactosides disclose evidence for the recognition of different glycomimetic ligands
Cagnoni, Alejandro J, Primo, Emiliano D, Klinke, Sebastián, Cano, María E, Giordano, Walter, Mariño, Karina V, Kovensky, José, Goldbaum, Fernando A, Uhrig, María Laura, Otero, Lisandro H
Published in Acta crystallographica. Section D, Biological crystallography. (01.11.2020)
Published in Acta crystallographica. Section D, Biological crystallography. (01.11.2020)
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Journal Article
Engineering a bifunctional copper site in the cupredoxin fold by loop-directed mutagenesis
Espinoza-Cara, Andrés, Zitare, Ulises, Alvarez-Paggi, Damián, Klinke, Sebastián, Otero, Lisandro H, Murgida, Daniel H, Vila, Alejandro J
Published in Chemical science (Cambridge) (28.08.2018)
Published in Chemical science (Cambridge) (28.08.2018)
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Journal Article
Structural and functional characterization of a cold adapted TPM-domain with ATPase/ADPase activity
Cerutti, María L., Otero, Lisandro H., Smal, Clara, Pellizza, Leonardo, Goldbaum, Fernando A., Klinke, Sebastián, Aran, Martín
Published in Journal of structural biology (01.03.2017)
Published in Journal of structural biology (01.03.2017)
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Journal Article
An All‐Inclusive and Straightway Laboratory Activity to Solve the Three‐Dimensional Crystal Structure of a Protein
Klinke, Sebastián, Rinaldi, Jimena, Goldbaum, Fernando A., Suarez, Sebastián, Otero, Lisandro H.
Published in Biochemistry and molecular biology education (01.11.2019)
Published in Biochemistry and molecular biology education (01.11.2019)
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Journal Article
Prevention of tubulin/aldose reductase association delays the development of pathological complications in diabetic rats
Rivelli Antonelli, Juan F., Santander, Verónica S., Nigra, Ayelen D., Monesterolo, Noelia E., Previtali, Gabriela, Primo, Emilianao, Otero, Lisandro H., Casale, César H.
Published in Journal of physiology and biochemistry (01.11.2021)
Published in Journal of physiology and biochemistry (01.11.2021)
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Journal Article
A disordered region retains the full protease inhibitor activity and the capacity to induce CD8+ T cells in vivo of the oral vaccine adjuvant U-Omp19
Laura Darriba, M., Castro, Celeste Pueblas, Coria, Lorena M., Bruno, Laura, Laura Cerutti, M., Otero, Lisandro H., Chemes, Lucía B., Rasia, Rodolfo M., Klinke, Sebastián, Cassataro, Juliana, Pasquevich, Karina A.
Published in Computational and structural biotechnology journal (2022)
Published in Computational and structural biotechnology journal (2022)
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Journal Article
Structural basis for the Pr-Pfr long-range signaling mechanism of a full-length bacterial phytochrome at the atomic level
Otero, Lisandro H, Foscaldi, Sabrina, Antelo, Giuliano T, Rosano, Germán L, Sirigu, Serena, Klinke, Sebastián, Defelipe, Lucas A, Sánchez-Lamas, Maximiliano, Battocchio, Giovanni, Conforte, Valeria, Vojnov, Adrián A, Chavas, Leonard M G, Goldbaum, Fernando A, Mroginski, Maria-Andrea, Rinaldi, Jimena, Bonomi, Hernán R
Published in Science advances (26.11.2021)
Published in Science advances (26.11.2021)
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Journal Article