γ-Secretase Is a Membrane Protein Complex Comprised of Presenilin, Nicastrin, Aph-1, and Pen-2
Kimberly, W. Taylor, LaVoie, Matthew J., Ostaszewski, Beth L., Ye, Wenjuan, Wolfe, Michael S., Selkoe, Dennis J.
Published in Proceedings of the National Academy of Sciences - PNAS (27.05.2003)
Published in Proceedings of the National Academy of Sciences - PNAS (27.05.2003)
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Activity-Dependent Isolation of the Presenilin- γ-Secretase Complex Reveals Nicastrin and a γ Substrate
Esler, William P., Kimberly, W. Taylor, Ostaszewski, Beth L., Ye, Wenjuan, Diehl, Thekla S., Selkoe, Dennis J., Wolfe, Michael S.
Published in Proceedings of the National Academy of Sciences - PNAS (05.03.2002)
Published in Proceedings of the National Academy of Sciences - PNAS (05.03.2002)
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Assembly of the γ-Secretase Complex Involves Early Formation of an Intermediate Subcomplex of Aph-1 and Nicastrin
LaVoie, Matthew J., Fraering, Patrick C., Ostaszewski, Beth L., Ye, Wenjuan, Kimberly, W.Taylor, Wolfe, Michael S., Selkoe, Dennis J.
Published in The Journal of biological chemistry (26.09.2003)
Published in The Journal of biological chemistry (26.09.2003)
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Transition-state analogue inhibitors of gamma-secretase bind directly to presenilin-1
Esler, W P, Kimberly, W T, Ostaszewski, B L, Diehl, T S, Moore, C L, Tsai, J Y, Rahmati, T, Xia, W, Selkoe, D J, Wolfe, M S
Published in Nature cell biology (01.07.2000)
Published in Nature cell biology (01.07.2000)
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Notch and the Amyloid Precursor Protein Are Cleaved by Similar γ-Secretase(s)
Kimberly, W. Taylor, Esler, William P, Ye, Wenjuan, Ostaszewski, Beth L, Gao, Jun, Diehl, Thekla, Selkoe, Dennis J, Wolfe, Michael S
Published in Biochemistry (Easton) (14.01.2003)
Published in Biochemistry (Easton) (14.01.2003)
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Presenilin 1 Regulates the Processing of β-Amyloid Precursor Protein C-Terminal Fragments and the Generation of Amyloid β-Protein in Endoplasmic Reticulum and Golgi
Xia, Weiming, Zhang, Jimin, Ostaszewski, Beth L, Kimberly, William Taylor, Seubert, Peter, Koo, Edward H, Shen, Jie, Selkoe, Dennis J
Published in Biochemistry (Easton) (24.11.1998)
Published in Biochemistry (Easton) (24.11.1998)
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Novel polymer-supported platinum catalyst for selective hydrogenation of crotonaldehyde
Michalska, Z.M, Ostaszewski, B, Zientarska, J, Rynkowski, J.M
Published in Journal of molecular catalysis. A, Chemical (08.07.2002)
Published in Journal of molecular catalysis. A, Chemical (08.07.2002)
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Presenilin Complexes with the C-Terminal Fragments of Amyloid Precursor Protein at the Sites of Amyloid β -Protein Generation
Xia, Weiming, Ray, William J., Ostaszewski, Beth L., Rahmati, Talat, Kimberly, W. Taylor, Wolfe, Michael S., Zhang, Jimin, Goate, Alison M., Selkoe, Dennis J.
Published in Proceedings of the National Academy of Sciences - PNAS (01.08.2000)
Published in Proceedings of the National Academy of Sciences - PNAS (01.08.2000)
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Amyloid β-peptide is produced by cultured cells during normal metabolism
Haass, Christian, Schlossmacher, Michael G, Hung, Albert Y, Vigo-Pelfrey, Carmen, Mellon, Angela, Ostaszewski, Beth L, Lieberburg, Ivan, Koo, Edward H, Schenk, Dale, Teplow, David B, Selkoe, Dennis J
Published in Nature (London) (24.09.1992)
Published in Nature (London) (24.09.1992)
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Oligomerization of Endogenous and Synthetic Amyloid β-Protein at Nanomolar Levels in Cell Culture and Stabilization of Monomer by Congo Red
Podlisny, Marcia B, Walsh, Dominic M, Amarante, Patricia, Ostaszewski, Beth L, Stimson, Evelyn R, Maggio, John E, Teplow, David B, Selkoe, Dennis J
Published in Biochemistry (Easton) (17.03.1998)
Published in Biochemistry (Easton) (17.03.1998)
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Additive Effects of PS1 and APP Mutations on Secretion of the 42-Residue Amyloid β-Protein
Citron, Martin, Eckman, Christopher B., Diehl, Thekla S., Corcoran, Chris, Ostaszewski, Beth L., Xia, Weiming, Levesque, Georges, St. George Hyslop, Peter, Younkin, Steven G., Selkoe, Dennis J.
Published in Neurobiology of disease (01.08.1998)
Published in Neurobiology of disease (01.08.1998)
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FAD Mutations in Presenilin-1 or Amyloid Precursor Protein Decrease the Efficacy of a γ-Secretase Inhibitor: Evidence for Direct Involvement of PS1 in the γ-Secretase Cleavage Complex
Xia, Weiming, Ostaszewski, Beth L., Kimberly, W.Taylor, Rahmati, Talat, Moore, Chad L., Wolfe, Michael S., Selkoe, Dennis J.
Published in Neurobiology of disease (01.12.2000)
Published in Neurobiology of disease (01.12.2000)
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Detection of distinct isoform patterns of the β-amyloid precursor protein in human platelets and lymphocytes
Schlossmacher, Michael G., Ostaszewski, Beth L., Hecker, Lanny I., Celi, Alessandro, Haass, Christian, Chin, David, Lieberburg, Ivan, Furie, Barbara C., Furie, Bruce, Selkoe, Dennis J.
Published in Neurobiology of aging (01.05.1992)
Published in Neurobiology of aging (01.05.1992)
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Mutagenesis Identifies New Signals for beta -Amyloid Precursor Protein Endocytosis, Turnover, and the Generation of Secreted Fragments, Including A beta 42
Perez, R G, Soriano, S, Hayes, J D, Ostaszewski, B, Xia, W, Selkoe, D J, Chen, X, Stokin, G B, Koo, E H
Published in The Journal of biological chemistry (02.07.1999)
Published in The Journal of biological chemistry (02.07.1999)
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Peptidomimetic Probes and Molecular Modeling Suggest That Alzheimer's γ-Secretase Is an Intramembrane-Cleaving Aspartyl Protease
Wolfe, Michael S, Xia, Weiming, Moore, Chad L, Leatherwood, Dartha D, Ostaszewski, Beth, Rahmati, Talat, Donkor, Isaac O, Selkoe, Dennis J
Published in Biochemistry (Easton) (13.04.1999)
Published in Biochemistry (Easton) (13.04.1999)
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Dopamine covalently modifies and functionally inactivates parkin
LaVoie, Matthew J, Ostaszewski, Beth L, Weihofen, Andreas, Schlossmacher, Michael G, Selkoe, Dennis J
Published in Nature medicine (01.11.2005)
Published in Nature medicine (01.11.2005)
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