Myosin modulators: emerging approaches for the treatment of cardiomyopathies and heart failure
Day, Sharlene M, Tardiff, Jil C, Ostap, E Michael
Published in The Journal of clinical investigation (01.03.2022)
Published in The Journal of clinical investigation (01.03.2022)
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Journal Article
Modulation of Kinesin’s Load-Bearing Capacity by Force Geometry and the Microtubule Track
Pyrpassopoulos, Serapion, Shuman, Henry, Ostap, E. Michael
Published in Biophysical journal (07.01.2020)
Published in Biophysical journal (07.01.2020)
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Journal Article
Positive cardiac inotrope omecamtiv mecarbil activates muscle despite suppressing the myosin working stroke
Woody, Michael S., Greenberg, Michael J., Barua, Bipasha, Winkelmann, Donald A., Goldman, Yale E., Ostap, E. Michael
Published in Nature communications (21.09.2018)
Published in Nature communications (21.09.2018)
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Journal Article
High-resolution cryo-EM structures of actin-bound myosin states reveal the mechanism of myosin force sensing
Mentes, Ahmet, Huehn, Andrew, Liu, Xueqi, Zwolak, Adam, Dominguez, Roberto, Shuman, Henry, Ostap, E. Michael, Sindelar, Charles V.
Published in Proceedings of the National Academy of Sciences - PNAS (06.02.2018)
Published in Proceedings of the National Academy of Sciences - PNAS (06.02.2018)
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Journal Article
Single molecule mechanics resolves the earliest events in force generation by cardiac myosin
Woody, Michael S, Winkelmann, Donald A, Capitanio, Marco, Ostap, E Michael, Goldman, Yale E
Published in eLife (17.09.2019)
Published in eLife (17.09.2019)
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Journal Article
Adhesion force and attachment lifetime of the KIF16B-PX domain interaction with lipid membranes
Pyrpassopoulos, Serapion, Shuman, Henry, Ostap, E Michael
Published in Molecular biology of the cell (07.11.2017)
Published in Molecular biology of the cell (07.11.2017)
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Journal Article
Myosin with hypertrophic cardiac mutation R712L has a decreased working stroke which is rescued by omecamtiv mecarbil
Snoberger, Aaron, Barua, Bipasha, Atherton, Jennifer L, Shuman, Henry, Forgacs, Eva, Goldman, Yale E, Winkelmann, Donald A, Ostap, E Michael
Published in eLife (19.02.2021)
Published in eLife (19.02.2021)
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Journal Article
A Perspective on the Role of Myosins as Mechanosensors
Greenberg, Michael J., Arpağ, Göker, Tüzel, Erkan, Ostap, E. Michael
Published in Biophysical journal (21.06.2016)
Published in Biophysical journal (21.06.2016)
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Journal Article
Activity-Dependent Regulation of Distinct Transport and Cytoskeletal Remodeling Functions of the Dendritic Kinesin KIF21B
Ghiretti, Amy E., Thies, Edda, Tokito, Mariko K., Lin, Tianming, Ostap, E. Michael, Kneussel, Matthias, Holzbaur, Erika L.F.
Published in Neuron (Cambridge, Mass.) (23.11.2016)
Published in Neuron (Cambridge, Mass.) (23.11.2016)
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Journal Article
Mechanochemical tuning of myosin-I by the N-terminal region
Greenberg, Michael J., Lin, Tianming, Shuman, Henry, Ostap, E. Michael
Published in Proceedings of the National Academy of Sciences - PNAS (30.06.2015)
Published in Proceedings of the National Academy of Sciences - PNAS (30.06.2015)
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Journal Article
Myosin I Can Act As a Molecular Force Sensor
Laakso, Joseph M, Lewis, John H, Shuman, Henry, Ostap, E. Michael
Published in Science (American Association for the Advancement of Science) (04.07.2008)
Published in Science (American Association for the Advancement of Science) (04.07.2008)
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Journal Article
Dynactin functions as both a dynamic tether and brake during dynein-driven motility
Ayloo, Swathi, Lazarus, Jacob E., Dodda, Aditya, Tokito, Mariko, Ostap, E Michael, Holzbaur, Erika L. F.
Published in Nature communications (04.09.2014)
Published in Nature communications (04.09.2014)
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