Recent Progress in the Development of HIV‑1 Protease Inhibitors for the Treatment of HIV/AIDS
Ghosh, Arun K, Osswald, Heather L, Prato, Gary
Published in Journal of medicinal chemistry (09.06.2016)
Published in Journal of medicinal chemistry (09.06.2016)
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Structure-Based Design of Highly Potent HIV‑1 Protease Inhibitors Containing New Tricyclic Ring P2-Ligands: Design, Synthesis, Biological, and X‑ray Structural Studies
Ghosh, Arun K, Kovela, Satish, Osswald, Heather L, Amano, Masayuki, Aoki, Manabu, Agniswamy, Johnson, Wang, Yuan-Fang, Weber, Irene T, Mitsuya, Hiroaki
Published in Journal of medicinal chemistry (14.05.2020)
Published in Journal of medicinal chemistry (14.05.2020)
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Diversity-oriented synthesis encoded by deoxyoligonucleotides
Hudson, Liam, Mason, Jeremy W., Westphal, Matthias V., Richter, Matthieu J. R., Thielman, Jonathan R., Hua, Bruce K., Gerry, Christopher J., Xia, Guoqin, Osswald, Heather L., Knapp, John M., Tan, Zher Yin, Kokkonda, Praveen, Tresco, Ben I. C., Liu, Shuang, Reidenbach, Andrew G., Lim, Katherine S., Poirier, Jennifer, Capece, John, Bonazzi, Simone, Gampe, Christian M., Smith, Nichola J., Bradner, James E., Coley, Connor W., Clemons, Paul A., Melillo, Bruno, Hon, C. Suk-Yee, Ottl, Johannes, Dumelin, Christoph E., Schaefer, Jonas V., Faust, Ann Marie E., Berst, Frédéric, Schreiber, Stuart L., Zécri, Frédéric J., Briner, Karin
Published in Nature communications (15.08.2023)
Published in Nature communications (15.08.2023)
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Author Correction: Diversity-oriented synthesis encoded by deoxyoligonucleotides
Hudson, Liam, Mason, Jeremy W., Westphal, Matthias V., Richter, Matthieu J. R., Thielman, Jonathan R., Hua, Bruce K., Gerry, Christopher J., Xia, Guoqin, Osswald, Heather L., Knapp, John M., Tan, Zher Yin, Kokkonda, Praveen, Tresco, Ben I. C., Liu, Shuang, Reidenbach, Andrew G., Lim, Katherine S., Poirier, Jennifer, Capece, John, Bonazzi, Simone, Gampe, Christian M., Smith, Nichola J., Bradner, James E., Coley, Connor W., Clemons, Paul A., Melillo, Bruno, Hon, C. Suk-Yee, Ottl, Johannes, Dumelin, Christoph E., Schaefer, Jonas V., Faust, Ann Marie E., Berst, Frédéric, Schreiber, Stuart L., Zécri, Frédéric J., Briner, Karin
Published in Nature communications (21.11.2023)
Published in Nature communications (21.11.2023)
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A novel central nervous system-penetrating protease inhibitor overcomes human immunodeficiency virus 1 resistance with unprecedented aM to pM potency
Aoki, Manabu, Hayashi, Hironori, Rao, Kalapala Venkateswara, Das, Debananda, Higashi-Kuwata, Nobuyo, Bulut, Haydar, Aoki-Ogata, Hiromi, Takamatsu, Yuki, Yedidi, Ravikiran S, Davis, David A, Hattori, Shin-Ichiro, Nishida, Noriko, Hasegawa, Kazuya, Takamune, Nobutoki, Nyalapatla, Prasanth R, Osswald, Heather L, Jono, Hirofumi, Saito, Hideyuki, Yarchoan, Robert, Misumi, Shogo, Ghosh, Arun K, Mitsuya, Hiroaki
Published in eLife (17.10.2017)
Published in eLife (17.10.2017)
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Probing Lipophilic Adamantyl Group as the P1-Ligand for HIV‑1 Protease Inhibitors: Design, Synthesis, Protein X‑ray Structural Studies, and Biological Evaluation
Ghosh, Arun K, Osswald, Heather L, Glauninger, Kristof, Agniswamy, Johnson, Wang, Yuan-Fang, Hayashi, Hironori, Aoki, Manabu, Weber, Irene T, Mitsuya, Hiroaki
Published in Journal of medicinal chemistry (28.07.2016)
Published in Journal of medicinal chemistry (28.07.2016)
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Journal Article
Design and synthesis of potent macrocyclic HIV-1 protease inhibitors involving P1-P2 ligands
Ghosh, Arun K., Schiltz, Gary E., Rusere, Linah N., Osswald, Heather L., Walters, D. Eric, Amano, Masayuki, Mitsuya, Hiroaki
Published in Organic & biomolecular chemistry (21.09.2014)
Published in Organic & biomolecular chemistry (21.09.2014)
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Ligand-induced Dimerization of Middle East Respiratory Syndrome (MERS) Coronavirus nsp5 Protease (3CLpro): IMPLICATIONS FOR nsp5 REGULATION AND THE DEVELOPMENT OF ANTIVIRALS
Tomar, Sakshi, Johnston, Melanie L, St John, Sarah E, Osswald, Heather L, Nyalapatla, Prasanth R, Paul, Lake N, Ghosh, Arun K, Denison, Mark R, Mesecar, Andrew D
Published in The Journal of biological chemistry (07.08.2015)
Published in The Journal of biological chemistry (07.08.2015)
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Journal Article
Design and Development of Highly Potent HIV‑1 Protease Inhibitors with a Crown-Like Oxotricyclic Core as the P2-Ligand To Combat Multidrug-Resistant HIV Variants
Ghosh, Arun K, Rao, Kalapala Venkateswara, Nyalapatla, Prasanth R, Osswald, Heather L, Martyr, Cuthbert D, Aoki, Manabu, Hayashi, Hironori, Agniswamy, Johnson, Wang, Yuan-Fang, Bulut, Haydar, Das, Debananda, Weber, Irene T, Mitsuya, Hiroaki
Published in Journal of medicinal chemistry (25.05.2017)
Published in Journal of medicinal chemistry (25.05.2017)
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Journal Article
Modular, stereocontrolled Cβ–H/Cα–C activation of alkyl carboxylic acids
Shang, Ming, Feu, Karla S., Vantourout, Julien C., Barton, Lisa M., Osswald, Heather L., Kato, Nobutaka, Gagaring, Kerstin, McNamara, Case W., Chen, Gang, Hu, Liang, Ni, Shengyang, Fernández-Canelas, Paula, Chen, Miao, Merchant, Rohan R., Qin, Tian, Schreiber, Stuart L., Melillo, Bruno, Yu, Jin-Quan, Baran, Phil S.
Published in Proceedings of the National Academy of Sciences - PNAS (30.04.2019)
Published in Proceedings of the National Academy of Sciences - PNAS (30.04.2019)
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Journal Article
Design and Synthesis of Highly Potent HIV‑1 Protease Inhibitors Containing Tricyclic Fused Ring Systems as Novel P2 Ligands: Structure–Activity Studies, Biological and X‑ray Structural Analysis
Ghosh, Arun K, R. Nyalapatla, Prasanth, Kovela, Satish, Rao, Kalapala Venkateswara, Brindisi, Margherita, Osswald, Heather L, Amano, Masayuki, Aoki, Manabu, Agniswamy, Johnson, Wang, Yuan-Fang, Weber, Irene T, Mitsuya, Hiroaki
Published in Journal of medicinal chemistry (24.05.2018)
Published in Journal of medicinal chemistry (24.05.2018)
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Journal Article
Coronaviruses resistant to a 3C-like protease inhibitor are attenuated for replication and pathogenesis, revealing a low genetic barrier but high fitness cost of resistance
Deng, Xufang, StJohn, Sarah E, Osswald, Heather L, O'Brien, Amornrat, Banach, Bridget S, Sleeman, Katrina, Ghosh, Arun K, Mesecar, Andrew D, Baker, Susan C
Published in Journal of virology (01.10.2014)
Published in Journal of virology (01.10.2014)
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Journal Article
Design of Highly Potent, Dual‐Acting and Central‐Nervous‐System‐Penetrating HIV‐1 Protease Inhibitors with Excellent Potency against Multidrug‐Resistant HIV‐1 Variants
Ghosh, Arun K., Rao, Kalapala Venkateswara, Nyalapatla, Prasanth R., Kovela, Satish, Brindisi, Margherita, Osswald, Heather L., Sekhara Reddy, Bhavanam, Agniswamy, Johnson, Wang, Yuan‐Fang, Aoki, Manabu, Hattori, Shin‐ichiro, Weber, Irene T., Mitsuya, Hiroaki
Published in ChemMedChem (23.04.2018)
Published in ChemMedChem (23.04.2018)
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Simultaneous Online Monitoring of Multiple Reactions Using a Miniature Mass Spectrometer
Pulliam, Christopher J, Bain, Ryan M, Osswald, Heather L, Snyder, Dalton T, Fedick, Patrick W, Ayrton, Stephen T, Flick, Tawnya G, Cooks, R. Graham
Published in Analytical chemistry (Washington) (05.07.2017)
Published in Analytical chemistry (Washington) (05.07.2017)
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Journal Article
Structure-Based Design of Potent HIV‑1 Protease Inhibitors with Modified P1-Biphenyl Ligands: Synthesis, Biological Evaluation, and Enzyme–Inhibitor X‑ray Structural Studies
Ghosh, Arun K, Yu, Xufen, Osswald, Heather L, Agniswamy, Johnson, Wang, Yuan-Fang, Amano, Masayuki, Weber, Irene T, Mitsuya, Hiroaki
Published in Journal of medicinal chemistry (09.07.2015)
Published in Journal of medicinal chemistry (09.07.2015)
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Journal Article
Highly Potent HIV‑1 Protease Inhibitors with Novel Tricyclic P2 Ligands: Design, Synthesis, and Protein–Ligand X‑ray Studies
Ghosh, Arun K, Parham, Garth L, Martyr, Cuthbert D, Nyalapatla, Prasanth R, Osswald, Heather L, Agniswamy, Johnson, Wang, Yuan-Fang, Amano, Masayuki, Weber, Irene T, Mitsuya, Hiroaki
Published in Journal of medicinal chemistry (12.09.2013)
Published in Journal of medicinal chemistry (12.09.2013)
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Journal Article
X-ray structure and inhibition of the feline infectious peritonitis virus 3C-like protease: Structural implications for drug design
St. John, Sarah E., Therkelsen, Matthew D., Nyalapatla, Prasanth R., Osswald, Heather L., Ghosh, Arun K., Mesecar, Andrew D.
Published in Bioorganic & medicinal chemistry letters (15.11.2015)
Published in Bioorganic & medicinal chemistry letters (15.11.2015)
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Journal Article
Design of HIV‑1 Protease Inhibitors with Amino-bis-tetrahydrofuran Derivatives as P2-Ligands to Enhance Backbone-Binding Interactions: Synthesis, Biological Evaluation, and Protein–Ligand X‑ray Studies
Ghosh, Arun K., Martyr, Cuthbert D., Osswald, Heather L., Sheri, Venkat Reddy, Kassekert, Luke A., Chen, Shujing, Agniswamy, Johnson, Wang, Yuan-Fang, Hayashi, Hironori, Aoki, Manabu, Weber, Irene T., Mitsuya, Hiroaki
Published in Journal of medicinal chemistry (10.09.2015)
Published in Journal of medicinal chemistry (10.09.2015)
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