Hydrophobicity drives the systemic distribution of lipid-conjugated siRNAs via lipid transport pathways
Osborn, Maire F, Coles, Andrew H, Biscans, Annabelle, Haraszti, Reka A, Roux, Loic, Davis, Sarah, Ly, Socheata, Echeverria, Dimas, Hassler, Matthew R, Godinho, Bruno M D C, Nikan, Mehran, Khvorova, Anastasia
Published in Nucleic acids research (20.02.2019)
Published in Nucleic acids research (20.02.2019)
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Journal Article
Comparison of partially and fully chemically-modified siRNA in conjugate-mediated delivery in vivo
Hassler, Matthew R, Turanov, Anton A, Alterman, Julia F, Haraszti, Reka A, Coles, Andrew H, Osborn, Maire F, Echeverria, Dimas, Nikan, Mehran, Salomon, William E, Roux, Loïc, Godinho, Bruno M D C, Davis, Sarah M, Morrissey, David V, Zamore, Phillip D, Karumanchi, S Ananth, Moore, Melissa J, Aronin, Neil, Khvorova, Anastasia
Published in Nucleic acids research (16.03.2018)
Published in Nucleic acids research (16.03.2018)
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Journal Article
Novel Cluster and Monomer-Based GalNAc Structures Induce Effective Uptake of siRNAs in Vitro and in Vivo
Sharma, Vivek K, Osborn, Maire F, Hassler, Matthew R, Echeverria, Dimas, Ly, Socheata, Ulashchik, Egor A, Martynenko-Makaev, Yury V, Shmanai, Vadim V, Zatsepin, Timofei S, Khvorova, Anastasia, Watts, Jonathan K
Published in Bioconjugate chemistry (18.07.2018)
Published in Bioconjugate chemistry (18.07.2018)
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Journal Article
Synthesis and Evaluation of Parenchymal Retention and Efficacy of a Metabolically Stable O‑Phosphocholine‑N‑docosahexaenoyl‑l‑serine siRNA Conjugate in Mouse Brain
Nikan, Mehran, Osborn, Maire F, Coles, Andrew H, Biscans, Annabelle, Godinho, Bruno M.D.C, Haraszti, Reka A, Sapp, Ellen, Echeverria, Dimas, DiFiglia, Marian, Aronin, Neil, Khvorova, Anastasia
Published in Bioconjugate chemistry (21.06.2017)
Published in Bioconjugate chemistry (21.06.2017)
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Journal Article
Hydrophobically Modified siRNAs Silence Huntingtin mRNA in Primary Neurons and Mouse Brain
Alterman, Julia F, Hall, Lauren M, Coles, Andrew H, Hassler, Matthew R, Didiot, Marie-Cecile, Chase, Kathryn, Abraham, Jasmin, Sottosanti, Emily, Johnson, Emily, Sapp, Ellen, Osborn, Maire F, Difiglia, Marian, Aronin, Neil, Khvorova, Anastasia
Published in Molecular therapy. Nucleic acids (01.12.2015)
Published in Molecular therapy. Nucleic acids (01.12.2015)
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Journal Article
Docosahexaenoic Acid Conjugation Enhances Distribution and Safety of siRNA upon Local Administration in Mouse Brain
Nikan, Mehran, Osborn, Maire F, Coles, Andrew H, Godinho, Bruno MDC, Hall, Lauren M, Haraszti, Reka A, Hassler, Matthew R, Echeverria, Dimas, Aronin, Neil, Khvorova, Anastasia
Published in Molecular therapy. Nucleic acids (2016)
Published in Molecular therapy. Nucleic acids (2016)
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Journal Article
Excited State Proton Transfer in the Red Fluorescent Protein mKeima
Henderson, J. Nathan, Osborn, Maire F, Koon, Nayden, Gepshtein, Rinat, Huppert, Dan, Remington, S. James
Published in Journal of the American Chemical Society (23.09.2009)
Published in Journal of the American Chemical Society (23.09.2009)
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Journal Article
Taking charge of siRNA delivery
Khvorova, Anastasia, Osborn, Maire F, Hassler, Matthew R
Published in Nature biotechnology (01.12.2014)
Published in Nature biotechnology (01.12.2014)
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Journal Article
RNA-Pt Adducts Following Cisplatin Treatment of Saccharomyces cerevisiae
Hostetter, Alethia A., Osborn, Maire F., DeRose, Victoria J.
Published in ACS chemical biology (20.01.2012)
Published in ACS chemical biology (20.01.2012)
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Journal Article
Guanabenz (Wytensin™) selectively enhances uptake and efficacy of hydrophobically modified siRNAs
Osborn, Maire F, Alterman, Julia F, Nikan, Mehran, Cao, Hong, Didiot, Marie C, Hassler, Matthew R, Coles, Andrew H, Khvorova, Anastasia
Published in Nucleic acids research (15.10.2015)
Published in Nucleic acids research (15.10.2015)
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Journal Article
Picazoplatin, an Azide-Containing Platinum(II) Derivative for Target Analysis by Click Chemistry
White, Jonathan D, Osborn, Maire F, Moghaddam, Alan D, Guzman, Lindsay E, Haley, Michael M, DeRose, Victoria J
Published in Journal of the American Chemical Society (14.08.2013)
Published in Journal of the American Chemical Society (14.08.2013)
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Journal Article
Efficient Gene Silencing in Brain Tumors with Hydrophobically Modified siRNAs
Osborn, Maire F, Coles, Andrew H, Golebiowski, Diane, Echeverria, Dimas, Moazami, Michael P, Watts, Jonathan K, Sena-Esteves, Miguel, Khvorova, Anastasia
Published in Molecular cancer therapeutics (01.06.2018)
Published in Molecular cancer therapeutics (01.06.2018)
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Journal Article
A High-Throughput Method for Direct Detection of Therapeutic Oligonucleotide-Induced Gene Silencing In Vivo
Coles, Andrew H., Osborn, Maire F., Alterman, Julia F., Turanov, Anton A., Godinho, Bruno M.D.C., Kennington, Lori, Chase, Kathryn, Aronin, Neil, Khvorova, Anastasia
Published in Nucleic acid therapeutics (01.04.2016)
Published in Nucleic acid therapeutics (01.04.2016)
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Journal Article
Binding of kinetically inert metal ions to RNA: the case of platinum(II)
Chapman, Erich G, Hostetter, Alethia A, Osborn, Maire F, Miller, Amanda L, DeRose, Victoria J
Published in Metal ions in life sciences (01.01.2011)
Published in Metal ions in life sciences (01.01.2011)
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Journal Article
Erratum: Corrigendum: Taking charge of siRNA delivery
Khvorova, Anastasia, Osborn, Maire F, Hassler, Matthew R
Published in Nature biotechnology (12.05.2015)
Published in Nature biotechnology (12.05.2015)
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Journal Article
Corrigendum: Taking charge of siRNA delivery
Khvorova, Anastasia, Osborn, Maire F, Hassler, Matthew R
Published in Nature biotechnology (01.05.2015)
Published in Nature biotechnology (01.05.2015)
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Journal Article
Abstract PR12: Robust modulation of gene expression in aggressive glioblastoma mouse models: A new approach for in vivo target validation
Coles, Andrew H., Osborn, Maire F., Golebowski, Diane, Hassler, Matthew, Esteves, Miguel S., Khvorova, Anastasia
Published in Cancer research (Chicago, Ill.) (15.03.2016)
Published in Cancer research (Chicago, Ill.) (15.03.2016)
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