X-ray structure of human stromelysin catalytic domain complexed with nonpeptide inhibitors: Implications for inhibitor selectivity
PAVLOVSKY, ALEXANDER G., WILLIAMS, MARK G., YE, QI-ZHUANG, ORTWINE, DANIEL F., PURCHASE, CLAUDE F., WHITE, ANDREW D., DHANARAJ, V., ROTH, BRUCE D., JOHNSON, LINDA L., HUPE, DONALD, HUMBLET, CHRISTINE, BLUNDELL, TOM L.
Published in Protein science (01.07.1999)
Published in Protein science (01.07.1999)
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X-ray structure of a hydroxamate inhibitor complex of stromelysin catalytic domain and its comparison with members of the zinc metalloproteinase superfamily
Dhanaraj, V, Ye, Q-Z, Johnson, LL, Hupe, DJ, Ortwine, DF, Dunbar,Jr, JB, Rubin, JR, Pavlovsky, A, Humblet, C, Blundell, TL
Published in Structure (London) (15.04.1996)
Published in Structure (London) (15.04.1996)
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Inhibitors of cholesterol biosynthesis. 3. Tetrahydro-4-hydroxy-6-[2-(1H-pyrrol-1-yl)ethyl]-2H-pyran 2-one inhibitors of HMG-CoA reductase. 2. Effects of introducing substituents at positions three and four of the pyrrole nucleus
Roth, Bruce D, Blankley, C. J, Chucholowski, A. W, Ferguson, E, Hoefle, M. L, Ortwine, D. F, Newton, R. S, Sekerke, C. S, Sliskovic, D. R, Wilson, M
Published in Journal of medicinal chemistry (01.01.1991)
Published in Journal of medicinal chemistry (01.01.1991)
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Histone Deacetylase (HDAC) Inhibitor Kinetic Rate Constants Correlate with Cellular Histone Acetylation but Not Transcription and Cell Viability
Lauffer, Benjamin E.L., Mintzer, Robert, Fong, Rina, Mukund, Susmith, Tam, Christine, Zilberleyb, Inna, Flicke, Birgit, Ritscher, Allegra, Fedorowicz, Grazyna, Vallero, Roxanne, Ortwine, Daniel F., Gunzner, Janet, Modrusan, Zora, Neumann, Lars, Koth, Christopher M., Lupardus, Patrick J., Kaminker, Joshua S., Heise, Christopher E., Steiner, Pascal
Published in The Journal of biological chemistry (13.09.2013)
Published in The Journal of biological chemistry (13.09.2013)
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Substituted 2-benzothiazolamines as sodium flux inhibitors: quantitative structure-activity relationships and anticonvulsant activity
Hays, S J, Rice, M J, Ortwine, D F, Johnson, G, Schwarz, R D, Boyd, D K, Copeland, L F, Vartanian, M G, Boxer, P A
Published in Journal of pharmaceutical sciences (01.10.1994)
Published in Journal of pharmaceutical sciences (01.10.1994)
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Structure−Activity Relationships and Pharmacokinetic Analysis for a Series of Potent, Systemically Available Biphenylsulfonamide Matrix Metalloproteinase Inhibitors
O'Brien, Patrick M, Ortwine, Daniel F, Pavlovsky, Alexander G, Picard, Joseph A, Sliskovic, Drago R, Roth, Bruce D, Dyer, Richard D, Johnson, Linda L, Man, Chiu Fai, Hallak, Hussein
Published in Journal of medicinal chemistry (27.01.2000)
Published in Journal of medicinal chemistry (27.01.2000)
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Structural basis of Nav1.7 inhibition by an isoform-selective small-molecule antagonist
Ahuja, Shivani, Mukund, Susmith, Deng, Lunbin, Khakh, Kuldip, Chang, Elaine, Ho, Hoangdung, Shriver, Stephanie, Young, Clint, Lin, Sophia, Johnson, J. P., Wu, Ping, Li, Jun, Coons, Mary, Tam, Christine, Brillantes, Bobby, Sampang, Honorio, Mortara, Kyle, Bowman, Krista K., Clark, Kevin R., Estevez, Alberto, Xie, Zhiwei, Verschoof, Henry, Grimwood, Michael, Dehnhardt, Christoph, Andrez, Jean–Christophe, Focken, Thilo, Sutherlin, Daniel P., Safina, Brian S., Starovasnik, Melissa A., Ortwine, Daniel F., Franke, Yvonne, Cohen, Charles J., Hackos, David H., Koth, Christopher M., Payandeh, Jian
Published in Science (American Association for the Advancement of Science) (18.12.2015)
Published in Science (American Association for the Advancement of Science) (18.12.2015)
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A Rationalization of the Acidic pH Dependence for Stromelysin-1 (Matrix Metalloproteinase-3) Catalysis and Inhibition
Johnson, Linda L., Pavlovsky, Alexander G., Johnson, Adam R., Janowicz, Jeffrey A., Man, Chiu-Fai, Ortwine, Daniel F., Purchase, Claude F., White, Andrew D., Hupe, Donald J.
Published in The Journal of biological chemistry (14.04.2000)
Published in The Journal of biological chemistry (14.04.2000)
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Synthesis of 1,4,7,8,9,10-hexahydro-9-methyl-6-nitropyrido[3,4-f]-quinoxaline-2,3-dione and related quinoxalinediones: characterization of .alpha.-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (and N-methyl-D-aspartate) receptor and anticonvulsant activity
Bigge, Christopher F, Malone, Thomas C, Boxer, Peter A, Nelson, Carrie B, Ortwine, Daniel F, Schelkun, Robert, Retz, Daniel M, Lescosky, Leonard J, Borosky, Susan A
Published in Journal of medicinal chemistry (01.09.1995)
Published in Journal of medicinal chemistry (01.09.1995)
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Styrylpyrazoles, styrylisoxazoles, and styrylisothiazoles. Novel 5-lipoxygenase and cyclooxygenase inhibitors
Flynn, Daniel L, Belliotti, Thomas R, Boctor, Amal M, Connor, David T, Kostlan, Catherine R, Nies, Donald E, Ortwine, Daniel F, Schrier, Denis J, Sircar, Jagadish C
Published in Journal of medicinal chemistry (01.02.1991)
Published in Journal of medicinal chemistry (01.02.1991)
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Distribution of tacrine and metabolites in rat brain and plasma after single- and multiple-dose regimens. Evidence for accumulation of tacrine in brain tissue
McNally, W P, Pool, W F, Sinz, M W, Dehart, P, Ortwine, D F, Huang, C C, Chang, T, Woolf, T F
Published in Drug metabolism and disposition (01.06.1996)
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Published in Drug metabolism and disposition (01.06.1996)
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Analysis of the Binding of Hydroxamic Acid and Carboxylic Acid Inhibitors to the Stromelysin-1 (Matrix Metalloproteinase-3) Catalytic Domain by Isothermal Titration Calorimetry
Parker, Matthew H, Lunney, Elizabeth A, Ortwine, Daniel F, Pavlovsky, Alexander G, Humblet, Christine, Brouillette, Christie G
Published in Biochemistry (Easton) (12.10.1999)
Published in Biochemistry (Easton) (12.10.1999)
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Inhibitors of cholesterol biosynthesis. 1. trans-6-(2-Pyrrol-1-ylethyl)-4-hydroxypyran-2-ones, a novel series of HMG-CoA reductase inhibitors. 1. Effects of structural modifications at the 2- and 5-positions of the pyrrole nucleus
Roth, Bruce D, Ortwine, D. F, Hoefle, M. L, Stratton, C. D, Sliskovic, D. R, Wilson, M. W, Newton, R. S
Published in Journal of medicinal chemistry (01.01.1990)
Published in Journal of medicinal chemistry (01.01.1990)
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Novel Series of Achiral, Low Molecular Weight, and Potent HIV-1 Protease Inhibitors
Vara Prasad, J. V. N, Para, Kimberly S, Lunney, Elizabeth A, Ortwine, Daniel F, Dunbar, James B, Ferguson, Donna, Tummino, Peter J, Hupe, Donald, Tait, Bradley D
Published in Journal of the American Chemical Society (01.07.1994)
Published in Journal of the American Chemical Society (01.07.1994)
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Synthesis and antimalarial properties of 1-imino derivatives of 7-chloro-3-substituted-3,4-dihydro-1,9(2H,10H)-acridinediones and related structures
KESTEN, S. J, DEGNAN, M. J, HUNG, J, MCNAMARA, D. J, ORTWINE, D. F, UHLENDORF, S. E, WERBEL, L. M
Published in Journal of medicinal chemistry (18.09.1992)
Published in Journal of medicinal chemistry (18.09.1992)
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Potent, Orally Active, Competitive N-Methyl-D-aspartate (NMDA) Receptor Antagonists Are Substrates for a Neutral Amino Acid Uptake System in Chinese Hamster Ovary Cells
Li, Jia-He, Bigge, Christopher F, Williamson, Rufus M, Borosky, Susan A, Vartanian, Mark G, Ortwine, Daniel F
Published in Journal of medicinal chemistry (01.05.1995)
Published in Journal of medicinal chemistry (01.05.1995)
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EVALUATION AND SYNTHESIS OF AMINOHYDROXYISOXAZOLES AND PYRAZOLES AS POTENTIAL GLYCINE AGONISTS
DRUMMOND, J, JOHNSON, G, NICKELL, DG, ORTWINE, DF, BRUNS, RF, WELBAUM, B
Published in Journal of medicinal chemistry (01.09.1989)
Published in Journal of medicinal chemistry (01.09.1989)
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Exploration of N-phosphonoalkyl-, N-phosphonoalkenyl-, and N-(phosphonoalkyl)phenyl-spaced .alpha.-amino acids as competitive N-methyl-D-aspartic acid antagonists
Bigge, Christopher F, Johnson, Graham, Ortwine, Daniel F, Drummond, James T, Retz, Daniel M, Brahce, Laura J, Coughenour, Linda L, Marcoux, Frank W, Probert, Albert W
Published in Journal of medicinal chemistry (01.04.1992)
Published in Journal of medicinal chemistry (01.04.1992)
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N6-[2-(3,5-dimethoxyphenyl)-2-(2-methylphenyl)ethyl]adenosine and its uronamide derivatives. Novel adenosine agonists with both high affinity and high selectivity for the adenosine A2 receptor
Bridges, Alexander J, Bruns, Robert F, Ortwine, Daniel F, Priebe, Steven R, Szotek, Deedee L, Trivedi, Bharat K
Published in Journal of medicinal chemistry (01.07.1988)
Published in Journal of medicinal chemistry (01.07.1988)
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Histone Deacetylase (HDAC) Inhibitor Kinetic Rate Constants Correlate with Cellular Histone Acetylation but Not Transcription and Cell Viability
Lauffer, B. E. L., Mintzer, R., Fong, R., Mukund, S., Tam, C., Zilberleyb, I., Flicke, B., Ritscher, A., Fedorowicz, G., Vallero, R., Ortwine, D. F., Gunzner, J., Modrusan, Z., Neumann, L., Koth, C. M., Lupardus, P. J., Kaminker, J. S., Heise, C. E., Steiner, P.
Published in The Journal of biological chemistry (21.03.2017)
Published in The Journal of biological chemistry (21.03.2017)
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