A Novel Long-Acting Selective Neuropeptide Y2 Receptor Polyethylene Glycol-Conjugated Peptide Agonist Reduces Food Intake and Body Weight and Improves Glucose Metabolism in Rodents
Ortiz, Astrid A, Milardo, Lucinda F, DeCarr, Lynn B, Buckholz, Thomas M, Mays, Michelle R, Claus, Thomas H, Livingston, James N, Mahle, Cathy D, Lumb, Kevin J
Published in The Journal of pharmacology and experimental therapeutics (01.11.2007)
Published in The Journal of pharmacology and experimental therapeutics (01.11.2007)
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Dual-acting peptide with prolonged glucagon-like peptide-1 receptor agonist and glucagon receptor antagonist activity for the treatment of type 2 diabetes
Claus, Thomas H, Pan, Clark Q, Buxton, Joanne M, Yang, Ling, Reynolds, Jennifer C, Barucci, Nicole, Burns, Michael, Ortiz, Astrid A, Roczniak, Steve, Livingston, James N, Clairmont, Kevin B, Whelan, James P
Published in Journal of endocrinology (01.02.2007)
Published in Journal of endocrinology (01.02.2007)
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Chronobiotic activity of N-[2-(2,7-dimethoxyfluoren-9-yl)ethyl]-propanamide. Synthesis and melatonergic pharmacology of fluoren-9-ylethyl amides
Epperson, James R., Bruce, Marc A., Catt, John D., Deskus, Jeffrey A., Hodges, Donald B., Karageorge, George N., Keavy, Daniel J., Mahle, Cathy D., Mattson, Ronald J., Ortiz, Astrid A., Parker, Michael F., Takaki, Katherine S., Watson, Brett T., Joseph P.Yevich
Published in Bioorganic & medicinal chemistry (01.09.2004)
Published in Bioorganic & medicinal chemistry (01.09.2004)
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Pharmacological characterization and appetite suppressive properties of BMS-193885, a novel and selective neuropeptide Y1 receptor antagonist
ANTAL-ZIMANYI, Ildiko, BRUCE, Marc. A, ORTIZ, Astrid A, POINDEXTER, Graham S, LEBOULLUEC, Karen L, IBEN, Lawrence G, MATTSON, Gail K, MCGOVERN, Rachel T, HOGAN, John B, LEAHY, Christina L, FLOWERS, Sharon C, STANLEY, Jennifer A
Published in European journal of pharmacology (20.08.2008)
Published in European journal of pharmacology (20.08.2008)
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Novel Selective Neuropeptide Y2 Receptor PEGylated Peptide Agonists Reduce Food Intake and Body Weight in Mice
Lumb, Kevin J, DeCarr, Lynn B, Milardo, Lucinda F, Mays, Michelle R, Buckholz, Thomas M, Fisk, Stephen E, Pellegrino, Carla M, Ortiz, Astrid A, Mahle, Cathy D
Published in Journal of medicinal chemistry (03.05.2007)
Published in Journal of medicinal chemistry (03.05.2007)
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Constrained analogs of CB-1 antagonists: 1,5,6,7-Tetrahydro-4H-pyrrolo[3,2-c]pyridine-4-one derivatives
Smith, Roger A., Fathi, Zahra, Brown, Su-Ellen, Choi, Soongyu, Fan, Jianmei, Jenkins, Susan, Kluender, Harold C.E., Konkar, Anish, Lavoie, Rico, Mays, Ronald, Natoli, Jennifer, O’Connor, Stephen J., Ortiz, Astrid A., Podlogar, Brent, Taing, Christy, Tomlinson, Susan, Tritto, Theresa, Zhang, Zhonghua
Published in Bioorganic & medicinal chemistry letters (01.02.2007)
Published in Bioorganic & medicinal chemistry letters (01.02.2007)
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Optimization of imidazole amide derivatives as cannabinoid-1 receptor antagonists for the treatment of obesity
Smith, Roger A., Fathi, Zahra, Achebe, Furahi, Akuche, Christiana, Brown, Su-Ellen, Choi, Soongyu, Fan, Jianmei, Jenkins, Susan, Kluender, Harold C.E., Konkar, Anish, Lavoie, Rico, Mays, Ronald, Natoli, Jennifer, O’Connor, Stephen J., Ortiz, Astrid A., Su, Ning, Taing, Christy, Tomlinson, Susan, Tritto, Theresa, Wang, Gan, Wirtz, Stephan-Nicholas, Wong, Wai, Yang, Xiao-Fan, Ying, Shihong, Zhang, Zhonghua
Published in Bioorganic & medicinal chemistry letters (15.05.2007)
Published in Bioorganic & medicinal chemistry letters (15.05.2007)
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Dihydropyridine neuropeptide Y Y1 receptor antagonists
POINDEXTER, Graham S, BRUCE, Marc A, MATTSON, Gail K, KOZLOWSKI, Michael, ARCURI, Meredith, ANTAL-ZIMANYI, Ildiko, LEBOULLUEC, Karen L, MONKOVIC, Ivo, MARTIN, Scott W, PARKER, Eric M, IBEN, Larry G, MCGOVERN, Rachel T, ORTIZ, Astrid A, STANLEY, Jennifer A
Published in Bioorganic & medicinal chemistry letters (01.02.2002)
Published in Bioorganic & medicinal chemistry letters (01.02.2002)
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Quinazolinone Derivatives as Orally Available Ghrelin Receptor Antagonists for the Treatment of Diabetes and Obesity
Rudolph, Joachim, Esler, William P, O'Connor, Stephen, Coish, Philip D. G, Wickens, Philip L, Brands, Michael, Bierer, Donald E, Bloomquist, Brian T, Bondar, Georgiy, Chen, Libing, Chuang, Chih-Yuan, Claus, Thomas H, Fathi, Zahra, Fu, Wenlang, Khire, Uday R, Kristie, James A, Liu, Xiao-Gao, Lowe, Derek B, McClure, Andrea C, Michels, Martin, Ortiz, Astrid A, Ramsden, Philip D, Schoenleber, Robert W, Shelekhin, Tatiana E, Vakalopoulos, Alexandros, Tang, Weifeng, Wang, Lei, Yi, Lin, Gardell, Stephen J, Livingston, James N, Sweet, Laurel J, Bullock, William H
Published in Journal of medicinal chemistry (18.10.2007)
Published in Journal of medicinal chemistry (18.10.2007)
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Pharmacological characterization and appetite suppressive properties of BMS-193885, a novel and selective neuropeptide Y 1 receptor antagonist
Antal-Zimanyi, Ildiko, Bruce, Marc. A., LeBoulluec, Karen L., Iben, Lawrence G., Mattson, Gail K., McGovern, Rachel T., Hogan, John B., Leahy, Christina L., Flowers, Sharon C., Stanley, Jennifer A., Ortiz, Astrid A., Poindexter, Graham S.
Published in European journal of pharmacology (20.08.2008)
Published in European journal of pharmacology (20.08.2008)
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Journal Article
Pharmacological characterization and appetite suppressive properties of BMS-193885, a novel and selective neuropeptide Y(1) receptor antagonist
Antal-Zimanyi, Ildiko, Bruce, Marc A, Leboulluec, Karen L, Iben, Lawrence G, Mattson, Gail K, McGovern, Rachel T, Hogan, John B, Leahy, Christina L, Flowers, Sharon C, Stanley, Jennifer A, Ortiz, Astrid A, Poindexter, Graham S
Published in European journal of pharmacology (20.08.2008)
Published in European journal of pharmacology (20.08.2008)
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Journal Article
Dihydropyridine neuropeptide Y Y(1) receptor antagonists
Poindexter, Graham S, Bruce, Marc A, LeBoulluec, Karen L, Monkovic, Ivo, Martin, Scott W, Parker, Eric M, Iben, Larry G, McGovern, Rachel T, Ortiz, Astrid A, Stanley, Jennifer A, Mattson, Gail K, Kozlowski, Michael, Arcuri, Meredith, Antal-Zimanyi, Ildiko
Published in Bioorganic & medicinal chemistry letters (11.02.2002)
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Published in Bioorganic & medicinal chemistry letters (11.02.2002)
Journal Article
Dihydropyridine Neuropeptide Y Y 1 Receptor Antagonists
Poindexter, Graham S., Bruce, Marc A., LeBoulluec, Karen L., Monkovic, Ivo, Martin, Scott W., Parker, Eric M., Iben, Larry G., McGovern, Rachel T., Ortiz, Astrid A., Stanley, Jennifer A., Mattson, Gail K., Kozlowski, Michael, Arcuri, Meredith, Antal-Zimanyi, Ildiko
Published in Bioorganic & medicinal chemistry letters (2002)
Published in Bioorganic & medicinal chemistry letters (2002)
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