Expression of Erk5 in early stage breast cancer and association with disease free survival identifies this kinase as a potential therapeutic target
Montero, Juan Carlos, Ocaña, Alberto, Abad, Mar, Ortiz-Ruiz, María Jesús, Pandiella, Atanasio, Esparís-Ogando, Azucena
Published in PloS one (15.05.2009)
Published in PloS one (15.05.2009)
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Potent Antimyeloma Activity of a Novel ERK5/CDK Inhibitor
ALVAREZ-FERNANDEZ, Stela, ORTIZ-RUIZ, María Jesus, PARROTT, Tracy, ZAKNOEN, Sara, OCIO, Enrique M, SAN MIGUEL, Jesús, BURROWS, Francis J, ESPARIS-OGANDO, Azucena, PANDIELLA, Atanasio
Published in Clinical cancer research (15.05.2013)
Published in Clinical cancer research (15.05.2013)
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MEK5 promotes lung adenocarcinoma
Sánchez-Fdez, Adrián, Ortiz-Ruiz, María Jesús, Re-Louhau, María Florencia, Ramos, Isabel, Blanco-Múñez, Óscar, Ludeña, Dolores, Abad, Mar, Sánchez-Martín, Manuel, Pandiella, Atanasio, Esparís-Ogando, Azucena
Published in The European respiratory journal (01.02.2019)
Published in The European respiratory journal (01.02.2019)
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Structure-Based Optimization of Potent, Selective, and Orally Bioavailable CDK8 Inhibitors Discovered by High-Throughput Screening
Czodrowski, Paul, Mallinger, Aurélie, Wienke, Dirk, Esdar, Christina, Pöschke, Oliver, Busch, Michael, Rohdich, Felix, Eccles, Suzanne A, Ortiz-Ruiz, Maria-Jesus, Schneider, Richard, Raynaud, Florence I, Clarke, Paul A, Musil, Djordje, Schwarz, Daniel, Dale, Trevor, Urbahns, Klaus, Blagg, Julian, Schiemann, Kai
Published in Journal of medicinal chemistry (27.10.2016)
Published in Journal of medicinal chemistry (27.10.2016)
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Journal Article
Therapeutic potential of ERK5 targeting in triple negative breast cancer
Ortiz-Ruiz, María Jesús, Álvarez-Fernández, Stela, Parrott, Tracy, Zaknoen, Sara, Burrows, Francis J, Ocaña, Alberto, Pandiella, Atanasio, Esparís-Ogando, Azucena
Published in Oncotarget (30.11.2014)
Published in Oncotarget (30.11.2014)
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Journal Article
Discovery of Potent, Selective, and Orally Bioavailable Small-Molecule Modulators of the Mediator Complex-Associated Kinases CDK8 and CDK19
Mallinger, Aurélie, Schiemann, Kai, Rink, Christian, Stieber, Frank, Calderini, Michel, Crumpler, Simon, Stubbs, Mark, Adeniji-Popoola, Olajumoke, Poeschke, Oliver, Busch, Michael, Czodrowski, Paul, Musil, Djordje, Schwarz, Daniel, Ortiz-Ruiz, Maria-Jesus, Schneider, Richard, Thai, Ching, Valenti, Melanie, de Haven Brandon, Alexis, Burke, Rosemary, Workman, Paul, Dale, Trevor, Wienke, Dirk, Clarke, Paul A, Esdar, Christina, Raynaud, Florence I, Eccles, Suzanne A, Rohdich, Felix, Blagg, Julian
Published in Journal of medicinal chemistry (11.02.2016)
Published in Journal of medicinal chemistry (11.02.2016)
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Journal Article
Discovery of Potent, Orally Bioavailable, Small-Molecule Inhibitors of WNT Signaling from a Cell-Based Pathway Screen
Mallinger, Aurélie, Crumpler, Simon, Pichowicz, Mark, Waalboer, Dennis, Stubbs, Mark, Adeniji-Popoola, Olajumoke, Wood, Bozena, Smith, Elizabeth, Thai, Ching, Henley, Alan T, Georgi, Katrin, Court, William, Hobbs, Steve, Box, Gary, Ortiz-Ruiz, Maria-Jesus, Valenti, Melanie, De Haven Brandon, Alexis, TePoele, Robert, Leuthner, Birgitta, Workman, Paul, Aherne, Wynne, Poeschke, Oliver, Dale, Trevor, Wienke, Dirk, Esdar, Christina, Rohdich, Felix, Raynaud, Florence, Clarke, Paul A, Eccles, Suzanne A, Stieber, Frank, Schiemann, Kai, Blagg, Julian
Published in Journal of medicinal chemistry (26.02.2015)
Published in Journal of medicinal chemistry (26.02.2015)
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Impacto de la posicion socioeconomica sobre los defectos de desarrollo del esmalte en denticion primaria
De la Rosa Santillana, Rubén, Medina Solís, Carlo Eduardo, Casanova-Rosado, Juan Fernando, Escoffié-Ramírez, Mauricio, Ortíz Ruiz, Jesús, Minaya-Sánchez, Mirna, Casanova-Rosado, Alejandro José
Published in CES odontología (01.01.2012)
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Published in CES odontología (01.01.2012)
Journal Article
A selective chemical probe for exploring the role of CDK8 and CDK19 in human disease
Dale, Trevor, Clarke, Paul A, Esdar, Christina, Waalboer, Dennis, Adeniji-Popoola, Olajumoke, Ortiz-Ruiz, Maria-Jesus, Mallinger, Aurélie, Samant, Rahul S, Czodrowski, Paul, Musil, Djordje, Schwarz, Daniel, Schneider, Klaus, Stubbs, Mark, Ewan, Ken, Fraser, Elizabeth, TePoele, Robert, Court, Will, Box, Gary, Valenti, Melanie, de Haven Brandon, Alexis, Gowan, Sharon, Rohdich, Felix, Raynaud, Florence, Schneider, Richard, Poeschke, Oliver, Blaukat, Andree, Workman, Paul, Schiemann, Kai, Eccles, Suzanne A, Wienke, Dirk, Blagg, Julian
Published in Nature chemical biology (26.10.2015)
Published in Nature chemical biology (26.10.2015)
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Journal Article
Assessing the mechanism and therapeutic potential of modulators of the human Mediator complex-associated protein kinases
Clarke, Paul A, Ortiz-Ruiz, Maria-Jesus, TePoele, Robert, Adeniji-Popoola, Olajumoke, Box, Gary, Court, Will, Czasch, Stephanie, El Bawab, Samer, Esdar, Christina, Ewan, Ken, Gowan, Sharon, De Haven Brandon, Alexis, Hewitt, Phillip, Hobbs, Stephen M, Kaufmann, Wolfgang, Mallinger, Aurélie, Raynaud, Florence, Roe, Toby, Rohdich, Felix, Schiemann, Kai, Simon, Stephanie, Schneider, Richard, Valenti, Melanie, Weigt, Stefan, Blagg, Julian, Blaukat, Andree, Dale, Trevor C, Eccles, Suzanne A, Hecht, Stefan, Urbahns, Klaus, Workman, Paul, Wienke, Dirk
Published in eLife (09.12.2016)
Published in eLife (09.12.2016)
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Abstract 2830: Multikinase inhibition by TG02 is therapeutically effective in two forms of breast cancer
Ortiz-Ruiz, M Jesús, Burrows, Francis J., Ré-Louhau, M Florencia, Ocaña, Alberto, Pandiella, Atanasio, Esparís-Ogando, Azucena
Published in Cancer research (Chicago, Ill.) (15.04.2012)
Published in Cancer research (Chicago, Ill.) (15.04.2012)
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Journal Article
A selective chemical probe for exploring the role of CDK8 and CDK19 in human disease
Dale, Trevor, Clarke, Paul A, Esdar, Christina, Waalboer, Dennis, Adeniji-Popoola, Olajumoke, Ortiz-Ruiz, Maria-Jesus, Mallinger, Aurélie, Samant, Rahul S, Czodrowski, Paul, Musil, Djordje, Schwarz, Daniel, Schneider, Klaus, Stubbs, Mark, Ewan, Ken, Fraser, Elizabeth, TePoele, Robert, Court, Will, Box, Gary, Valenti, Melanie, de Haven Brandon, Alexis, Gowan, Sharon, Rohdich, Felix, Raynaud, Florence, Schneider, Richard, Poeschke, Oliver, Blaukat, Andree, Workman, Paul, Schiemann, Kai, Eccles, Suzanne A, Wienke, Dirk, Blagg, Julian
Published in Nature chemical biology (01.12.2015)
Published in Nature chemical biology (01.12.2015)
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Journal Article
De Novo Missense Substitutions in the Gene Encoding CDK8, a Regulator of the Mediator Complex, Cause a Syndromic Developmental Disorder
Calpena, Eduardo, Hervieu, Alexia, Kaserer, Teresa, Swagemakers, Sigrid M.A., Goos, Jacqueline A.C., Popoola, Olajumoke, Ortiz-Ruiz, Maria Jesus, Barbaro-Dieber, Tina, Bownass, Lucy, Brilstra, Eva H., Brimble, Elise, Foulds, Nicola, Grebe, Theresa A., Harder, Aster V.E., Lees, Melissa M., Monaghan, Kristin G., Newbury-Ecob, Ruth A., Ong, Kai-Ren, Osio, Deborah, Reynoso Santos, Francis Jeshira, Ruzhnikov, Maura R.Z., Telegrafi, Aida, van Binsbergen, Ellen, van Dooren, Marieke F., van der Spek, Peter J., Blagg, Julian, Twigg, Stephen R.F., Mathijssen, Irene M.J., Clarke, Paul A., Wilkie, Andrew O.M.
Published in American journal of human genetics (04.04.2019)
Published in American journal of human genetics (04.04.2019)
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Journal Article
Abstract 3869: Phosphoproteomic-based identification of CDK8/CDK19 substrates in colorectal cancer
Popoola, Olajumoke O., Samant, Rahul, Ortiz-Ruiz, Maria-Jesus, Mallinger, Aurelie, Court, Will, Hobbs, Steve, Te-Poele, Robert, Stubbs, Mark, Burke, Rosemary, Esdar, Christina, Schiemann, Kai, Wienke, Dirk, Eccles, Sue, Blagg, Julian, Workman, Paul, Clarke, Paul
Published in Cancer research (Chicago, Ill.) (15.07.2016)
Published in Cancer research (Chicago, Ill.) (15.07.2016)
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Journal Article
Abstract 129: Assessing the mechanism and therapeutic potential of modulators of the human mediator complex-associated protein kinases CDK8 and CDK19
Clarke, Paul A., Ortiz-Ruiz, Maria-Jesus, Poele, Robert Te, Adeniji-Popoola, Olajumoke, Box, Gary, Esdar, Christina, Ewan, Kenneth, Gowan, Sharon, Brandon, Alexis De Haven, Hewitt, Phllip, Kaufmann, Wolfgang, Mallinger, Aurelie, Raynaud, Florence, Rohdich, Felix, Schiemann, Kai, Simon, Stephanie, Schneider, Richard, Valenti, Melanie, Blagg, Julian, Dale, Trevor, Eccles, Suzanne, Workman, Paul, Wienke, Dirk Wienke Dirk
Published in Cancer research (Chicago, Ill.) (01.07.2017)
Published in Cancer research (Chicago, Ill.) (01.07.2017)
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Journal Article
Abstract PR02: Identification of a potent and selective chemical probe for exploring the role of CDK8/19 in cancer biology
Clarke, Paul A., Dale, Trevor, Esdar, Christina, Waalboer, Dennis, Adeniji-Popoola, Olajumoke, Ortiz-Ruiz, Maria-Jesus, Mallinger, Aurelie, Ewan, Ken, te Poele, Robert, Gowan, Sharon, Workman, Paul, Schiemann, Kai, Eccles, Suzanne A., Wienke, Dirk, Blagg, Julian
Published in Molecular cancer therapeutics (01.12.2015)
Published in Molecular cancer therapeutics (01.12.2015)
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Abstract P4-08-02: LOXO-783: A potent, highly mutant selective and brain-penetrant allosteric PI3Kα H1047R inhibitor in combination with standard of care (SOC) treatments in preclinical PI3Kα H1047R-mutant breast cancer models
Puca, Loredana, Dowless, Michele S., Perez-Ferreiro, Carmen M., Ortiz-Ruiz, Maria Jesus, Donoho, Gregory P., Capen, Andrew, Huber, Lysiane, Bogner, Sarah M., Fei, Dongling, Manro, Jason R., Yu, Chun Ping, Xu, Wei Guo, Wang, Rui, Chen, Shuang, Hicks, Mark A., Zolfaghari, Parisa, Faber, Andrew, Gilmour, Raymond, Ramstetter, Monica D., Chang, Matthew T., Lallena, Maria Jose, Gong, Xuequian, Hyman, David M., Smyth, Lillian M., Brandhuber, Barbara J., Taylor, Barry S., Klippel, Anke
Published in Cancer research (Chicago, Ill.) (01.03.2023)
Published in Cancer research (Chicago, Ill.) (01.03.2023)
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Abstract 3025: Discovery of preclinical development candidate inhibitors of the mediator complex-associated kinases CDK8 and CDK19 and evaluation of their therapeutic potential
Clarke, Paul, Esdar, Christina, Mallinger, Aurelie, Schiemann, Kai, Waalboer, Dennis, Crumpler, Simon, Rink, Christian, Stieber, Frank, Calderini, Michel, Adeniji-Popoola, Olajumoke, Ortiz-Ruiz, Maria-Jesus, Samant, Rahul S., Czodrowski, Paul, Musil, Djordje, Schwarz, Daniel, Schneider, Klaus, Busch, Michael, Stubbs, Mark, Burke, Rosemary, TePoele, Robert, Gowan, Sharon, Rohdich, Felix, Raynaud, Florence, Schneider, Richard, Poeschke, Oliver, Blaukat, Andree, Urbahns, Klaus, Workman, Paul, Kaufmann, Wolfgang, Simon, Stephanie, Eccles, Suzanne A., Dale, Trevor, Wienke, Dirk, Blagg, Julian
Published in Cancer research (Chicago, Ill.) (15.07.2016)
Published in Cancer research (Chicago, Ill.) (15.07.2016)
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