Discovery of Novel Trypanosoma brucei Phosphodiesterase B1 Inhibitors by Virtual Screening against the Unliganded TbrPDEB1 Crystal Structure
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Published in Journal of medicinal chemistry (14.03.2013)
Published in Journal of medicinal chemistry (14.03.2013)
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Targeting a Subpocket in Trypanosoma brucei Phosphodiesterase B1 (TbrPDEB1) Enables the Structure-Based Discovery of Selective Inhibitors with Trypanocidal Activity
Blaazer, Antoni R, Singh, Abhimanyu K, de Heuvel, Erik, Edink, Ewald, Orrling, Kristina M, Veerman, Johan J. N, van den Bergh, Toine, Jansen, Chimed, Balasubramaniam, Erin, Mooij, Wouter J, Custers, Hans, Sijm, Maarten, Tagoe, Daniel N. A, Kalejaiye, Titilola D, Munday, Jane C, Tenor, Hermann, Matheeussen, An, Wijtmans, Maikel, Siderius, Marco, de Graaf, Chris, Maes, Louis, de Koning, Harry P, Bailey, David S, Sterk, Geert Jan, de Esch, Iwan J. P, Brown, David G, Leurs, Rob
Published in Journal of medicinal chemistry (10.05.2018)
Published in Journal of medicinal chemistry (10.05.2018)
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Simple Colorimetric Trypanothione Reductase-Based Assay for High-Throughput Screening of Drugs against Leishmania Intracellular Amastigotes
VAN DEN BOGAART, Erika, SCHOONE, Gerard J, ENGLAND, Paul, FABER, Dorien, ORRLING, Kristina M, DUJARDIN, Jean-Claude, SUNDAR, Shyam, SCHALLIG, Henk D. F. H, ADAMS, Emily R
Published in Antimicrobial Agents and Chemotherapy (01.01.2014)
Published in Antimicrobial Agents and Chemotherapy (01.01.2014)
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Synthesis and evaluation of analogs of the phenylpyridazinone NPD-001 as potent trypanosomal TbrPDEB1 phosphodiesterase inhibitors and in vitro trypanocidals
Veerman, Johan, van den Bergh, Toine, Orrling, Kristina M., Jansen, Chimed, Cos, Paul, Maes, Louis, Chatelain, Eric, Ioset, Jean-Robert, Edink, Ewald E., Tenor, Hermann, Seebeck, Thomas, de Esch, Iwan, Leurs, Rob, Sterk, Geert Jan
Published in Bioorganic & medicinal chemistry (01.04.2016)
Published in Bioorganic & medicinal chemistry (01.04.2016)
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Catechol Pyrazolinones as Trypanocidals: Fragment-Based Design, Synthesis, and Pharmacological Evaluation of Nanomolar Inhibitors of Trypanosomal Phosphodiesterase B1
Orrling, Kristina M, Jansen, Chimed, Vu, Xuan Lan, Balmer, Vreni, Bregy, Patrick, Shanmugham, Anitha, England, Paul, Bailey, David, Cos, Paul, Maes, Louis, Adams, Emily, van den Bogaart, Erika, Chatelain, Eric, Ioset, Jean-Robert, van de Stolpe, Andrea, Zorg, Stèphanie, Veerman, Johan, Seebeck, Thomas, Sterk, Geert Jan, de Esch, Iwan J. P, Leurs, Rob
Published in Journal of medicinal chemistry (25.10.2012)
Published in Journal of medicinal chemistry (25.10.2012)
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Fast, Acid-Free, and Selective Lactamization of Lactones in Ionic Liquids
Orrling, Kristina M, Wu, Xiongyu, Russo, Francesco, Larhed, Mats
Published in Journal of organic chemistry (07.11.2008)
Published in Journal of organic chemistry (07.11.2008)
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Fragment-based screening in tandem with phenotypic screening provides novel antiparasitic hits
Blaazer, Antoni R, Orrling, Kristina M, Shanmugham, Anitha, Jansen, Chimed, Maes, Louis, Edink, Ewald, Sterk, Geert Jan, Siderius, Marco, England, Paul, Bailey, David, de Esch, Iwan J P, Leurs, Rob
Published in Journal of biomolecular screening (01.01.2015)
Published in Journal of biomolecular screening (01.01.2015)
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Safety and Tolerability of Online Adaptive High-Field Magnetic Resonance-Guided Radiotherapy
Westerhoff, Jasmijn M, Daamen, Lois A, Christodouleas, John P, Blezer, Erwin L A, Choudhury, Ananya, Westley, Rosalyne L, Erickson, Beth A, Fuller, Clifton D, Hafeez, Shaista, van der Heide, Uulke A, Intven, Martijn P W, Kirby, Anna M, Lalondrelle, Susan, Minsky, Bruce D, Mook, Stella, Nowee, Marlies E, Marijnen, Corrie A M, Orrling, Kristina M, Sahgal, Arjun, Schultz, Christopher J, Faivre-Finn, Corinne, Tersteeg, Robbert J H A, Tree, Alison C, Tseng, Chia-Lin, Schytte, Tine, Silk, Dustin M, Eggert, Dave, Luzzara, Marco, van der Voort van Zyp, Jochem R N, Verkooijen, Helena M, Hall, William A
Published in JAMA network open (01.05.2024)
Published in JAMA network open (01.05.2024)
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α-Substituted norstatines as the transition-state mimic in inhibitors of multiple digestive vacuole malaria aspartic proteases
Orrling, Kristina M., Marzahn, Melissa R., Gutiérrez-de-Terán, Hugo, Åqvist, Johan, Dunn, Ben M., Larhed, Mats
Published in Bioorganic & medicinal chemistry (15.08.2009)
Published in Bioorganic & medicinal chemistry (15.08.2009)
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Synthesis of a small library of non-symmetric cyclic sulfamide HIV-1 protease inhibitors
Ax, Anna, Joshi, Advait A., Orrling, Kristina M., Vrang, Lotta, Samuelsson, Bertil, Hallberg, Anders, Karlén, Anders, Larhed, Mats
Published in Tetrahedron (05.06.2010)
Published in Tetrahedron (05.06.2010)
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Phenyldihydropyrazolones as Novel Lead Compounds Against Trypanosoma cruzi
Sijm, Maarten, Siciliano de Araújo, Julianna, Kunz, Stefan, Schroeder, Susanne, Edink, Ewald, Orrling, Kristina M, Matheeussen, An, van de Meer, Tiffany, Sadek, Payman, Custers, Hans, Cotillo, Ignacio, Martin, Julio J, Siderius, Marco, Maes, Louis, Brown, David G, de Nazaré Correia Soeiro, Maria, Sterk, GeertJan, de Esch, Iwan J.P, Leurs, Rob
Published in ACS omega (30.04.2019)
Published in ACS omega (30.04.2019)
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An efficient method to perform milliliter-scale PCR utilizing highly controlled microwave thermocyclingElectronic Supplementary Information (ESI) available: experimental details. See http://www.rsc.org/suppdata/cc/b3/b317049g
Orrling, Kristina, Nilsson, Peter, Gullberg, Mats, Larhed, Mats
Published in Chemical communications (Cambridge, England) (2004)
Published in Chemical communications (Cambridge, England) (2004)
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The AMR Accelerator: from individual organizations to efficient antibiotic development partnerships
Fernow, Josepine, Olliver, Marie, Couet, William, Lagrange, Sophie, Lamers, Meindert H, Olesen, Ole F, Orrling, Kristina, Pieren, Michel, Sloan, Derek J, Vaquero, Juan José, Miles, Timothy J, Karlén, Anders
Published in Nature reviews. Drug discovery (23.09.2024)
Published in Nature reviews. Drug discovery (23.09.2024)
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Patterns of Care, Tolerability, and Safety of the First Cohort of Patients Treated on a Novel High-Field MR-Linac Within the MOMENTUM Study: Initial Results From a Prospective Multi-Institutional Registry
de Mol van Otterloo, Sophie R., Christodouleas, John P., Blezer, Erwin L.A., Akhiat, Hafid, Brown, Kevin, Choudhury, Ananya, Eggert, Dave, Erickson, Beth A., Daamen, Lois A., Faivre-Finn, Corinne, Fuller, Clifton D., Goldwein, Joel, Hafeez, Shaista, Hall, Emma, Harrington, Kevin J., van der Heide, Uulke A., Huddart, Robert A., Intven, Martijn P.W., Kirby, Anna M., Lalondrelle, Susan, McCann, Claire, Minsky, Bruce D., Mook, Stella, Nowee, Marlies E., Oelfke, Uwe, Orrling, Kristina, Philippens, Marielle E.P., Sahgal, Arjun, Schultz, Christopher J., Tersteeg, Robbert J.H.A., Tijssen, Rob H.N., Tree, Alison C., van Triest, Baukelien, Tseng, Chia-Lin, Hall, William A., Verkooijen, Helena M.
Published in International journal of radiation oncology, biology, physics (15.11.2021)
Published in International journal of radiation oncology, biology, physics (15.11.2021)
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The MOMENTUM Study: An International Registry for the Evidence-Based Introduction of MR-Guided Adaptive Therapy
de Mol van Otterloo, Sophie R, Christodouleas, John P, Blezer, Erwin L A, Akhiat, Hafid, Brown, Kevin, Choudhury, Ananya, Eggert, Dave, Erickson, Beth A, Faivre-Finn, Corinne, Fuller, Clifton D, Goldwein, Joel, Hafeez, Shaista, Hall, Emma, Harrington, Kevin J, van der Heide, Uulke A, Huddart, Robert A, Intven, Martijn P W, Kirby, Anna M, Lalondrelle, Susan, McCann, Claire, Minsky, Bruce D, Mook, Stella, Nowee, Marlies E, Oelfke, Uwe, Orrling, Kristina, Sahgal, Arjun, Sarmiento, Jeffrey G, Schultz, Christopher J, Tersteeg, Robbert J H A, Tijssen, Rob H N, Tree, Alison C, van Triest, Baukelien, Hall, William A, Verkooijen, Helena M
Published in Frontiers in oncology (07.09.2020)
Published in Frontiers in oncology (07.09.2020)
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The development of an artificial intelligence-based digital pathology for neglected tropical diseases: A platform specific analysis of the World Health Organization diagnostic target product profile for soil-transmitted helminthiasis
Ward, Peter, Broadfield, Lindsay A., Dahlberg, Peter, Leta, Gemechu, Mekonnen, Zeleke, Nabatte, Betty, Kabatereine, Narcis, Brooks, Alan, Orrling, Kristina M., Gomes, Mireille, Van Hoecke, Sofie, Levecke, Bruno, Stuyver, Lieven J.
Published in Frontiers in tropical diseases (20.12.2022)
Published in Frontiers in tropical diseases (20.12.2022)
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Identification of Phenylpyrazolone Dimers as a New Class of Anti‐Trypanosoma cruzi Agents
Sijm, Maarten, Siciliano de Araújo, Julianna, Ramos Llorca, Alba, Orrling, Kristina, Stiny, Lydia, Matheeussen, An, Maes, Louis, Esch, Iwan J. P., Nazaré Correia Soeiro, Maria, Sterk, Geert Jan, Leurs, Rob
Published in ChemMedChem (18.09.2019)
Published in ChemMedChem (18.09.2019)
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α-Substituted Norstatines as the Transistion-State Mimic in Inhibitors of Multiple Digestive Vacuole Malaria Aspartic Proteases
Orrling, Kristina M., Marzahn, Melissa, Gutiérrez-de-Terán, Hugo, Åqvist, Johan, Dunn, Ben M., Larhed, Mats
Published in Bioorganic & medicinal chemistry (2009)
Published in Bioorganic & medicinal chemistry (2009)
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