High salt intake causes leptin resistance and obesity in mice by stimulating endogenous fructose production and metabolism
Lanaspa, Miguel A., Kuwabara, Masanari, Andres-Hernando, Ana, Li, Nancy, Cicerchi, Christina, Jensen, Thomas, Orlicky, David J., Roncal-Jimenez, Carlos A., Ishimoto, Takuji, Nakagawa, Takahiko, Rodriguez-Iturbe, Bernardo, MacLean, Paul S., Johnson, Richard J.
Published in Proceedings of the National Academy of Sciences - PNAS (20.03.2018)
Published in Proceedings of the National Academy of Sciences - PNAS (20.03.2018)
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Deletion of Fructokinase in the Liver or in the Intestine Reveals Differential Effects on Sugar-Induced Metabolic Dysfunction
Andres-Hernando, Ana, Orlicky, David J., Kuwabara, Masanari, Ishimoto, Takuji, Nakagawa, Takahiko, Johnson, Richard J., Lanaspa, Miguel A.
Published in Cell metabolism (07.07.2020)
Published in Cell metabolism (07.07.2020)
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Perilipin‐2 promotes obesity and progressive fatty liver disease in mice through mechanistically distinct hepatocyte and extra‐hepatocyte actions
Orlicky, David J., Libby, Andrew E., Bales, Elise S., McMahan, Rachel H., Monks, Jenifer, Rosa, Francisco G., McManaman, James L.
Published in The Journal of physiology (01.03.2019)
Published in The Journal of physiology (01.03.2019)
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Journal Article
Pharmacologic inhibition of HNF4α prevents parenteral nutrition associated cholestasis in mice
Ghosh, Swati, Devereaux, Michael W., Orlicky, David J., Sokol, Ronald J.
Published in Scientific reports (12.05.2023)
Published in Scientific reports (12.05.2023)
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Spaceflight Activates Lipotoxic Pathways in Mouse Liver
Jonscher, Karen R, Alfonso-Garcia, Alba, Suhalim, Jeffrey L, Orlicky, David J, Potma, Eric O, Ferguson, Virginia L, Bouxsein, Mary L, Bateman, Ted A, Stodieck, Louis S, Levi, Moshe, Friedman, Jacob E, Gridley, Daila S, Pecaut, Michael J
Published in PloS one (20.04.2016)
Published in PloS one (20.04.2016)
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Label-free fluorescence lifetime and second harmonic generation imaging microscopy improves quantification of experimental renal fibrosis
Ranjit, Suman, Dobrinskikh, Evgenia, Montford, John, Dvornikov, Alexander, Lehman, Allison, Orlicky, David J., Nemenoff, Raphael, Gratton, Enrico, Levi, Moshe, Furgeson, Seth
Published in Kidney international (01.11.2016)
Published in Kidney international (01.11.2016)
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CD44v6 Dependence of Premetastatic Niche Preparation by Exosomes
Jung, Thorsten, Castellana, Donatello, Klingbeil, Pamela, Hernández, Ines Cuesta, Vitacolonna, Mario, Orlicky, David J., Roffler, Steve R., Brodt, Pnina, Zöller, Margot
Published in Neoplasia (New York, N.Y.) (01.10.2009)
Published in Neoplasia (New York, N.Y.) (01.10.2009)
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Journal Article
TrxR1, Gsr, and oxidative stress determine hepatocellular carcinoma malignancy
McLoughlin, Michael R., Orlicky, David J., Prigge, Justin R., Krishna, Pushya, Talago, Emily A., Cavigli, Ian R., Eriksson, Sofi, Miller, Colin G., Kundert, Jean A., Sayin, Volkan I., Sabol, Rachel A., Heinemann, Joshua, Brandenberger, Luke O., Iverson, Sonya V., Bothner, Brian, Papagiannakopoulos, Thales, Shearn, Colin T., Arnér, Elias S. J., Schmidt, Edward E.
Published in Proceedings of the National Academy of Sciences - PNAS (04.06.2019)
Published in Proceedings of the National Academy of Sciences - PNAS (04.06.2019)
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Journal Article
Endogenous fructose production and metabolism in the liver contributes to the development of metabolic syndrome
Lanaspa, Miguel A., Ishimoto, Takuji, Li, Nanxing, Cicerchi, Christina, Orlicky, David J., Ruzycki, Philip, Rivard, Christopher, Inaba, Shinichiro, Roncal-Jimenez, Carlos A., Bales, Elise S., Diggle, Christine P., Asipu, Aruna, Petrash, J. Mark, Kosugi, Tomoki, Maruyama, Shoichi, Sanchez-Lozada, Laura G., McManaman, James L., Bonthron, David T., Sautin, Yuri Y., Johnson, Richard J.
Published in Nature communications (10.09.2013)
Published in Nature communications (10.09.2013)
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Journal Article
Perilipin-2-null mice are protected against diet-induced obesity, adipose inflammation, and fatty liver disease[S]
McManaman, James L., Bales, Elise S., Orlicky, David J., Jackman, Matthew, MacLean, Paul S., Cain, Shannon, Crunk, Amanda E., Mansur, Ayla, Graham, Christine E., Bowman, Thomas A., Greenberg, Andrew S.
Published in Journal of lipid research (01.05.2013)
Published in Journal of lipid research (01.05.2013)
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Journal Article
Obesity causes renal mitochondrial dysfunction and energy imbalance and accelerates chronic kidney disease in mice
Andres-Hernando, Ana, Lanaspa, Miguel A, Kuwabara, Masanari, Orlicky, David J, Cicerchi, Christina, Bales, Elise, Garcia, Gabriela E, Roncal-Jimenez, Carlos A, Sato, Yuka, Johnson, Richard J
Published in American journal of physiology. Renal physiology (01.10.2019)
Published in American journal of physiology. Renal physiology (01.10.2019)
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Journal Article
Endogenous fructose production and fructokinase activation mediate renal injury in diabetic nephropathy
Lanaspa, Miguel A, Ishimoto, Takuji, Cicerchi, Christina, Tamura, Yoshifuru, Roncal-Jimenez, Carlos A, Chen, Wei, Tanabe, Katsuyuki, Andres-Hernando, Ana, Orlicky, David J, Finol, Esteban, Inaba, Shinichiro, Li, Nanxing, Rivard, Christopher J, Kosugi, Tomoki, Sanchez-Lozada, Laura G, Petrash, J Mark, Sautin, Yuri Y, Ejaz, A Ahsan, Kitagawa, Wataru, Garcia, Gabriela E, Bonthron, David T, Asipu, Aruna, Diggle, Christine P, Rodriguez-Iturbe, Bernardo, Nakagawa, Takahiko, Johnson, Richard J
Published in Journal of the American Society of Nephrology (01.11.2014)
Published in Journal of the American Society of Nephrology (01.11.2014)
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Serelaxin improves cardiac and renal function in DOCA-salt hypertensive rats
Wang, Dong, Luo, Yuhuan, Myakala, Komuraiah, Orlicky, David J., Dobrinskikh, Evgenia, Wang, Xiaoxin, Levi, Moshe
Published in Scientific reports (29.08.2017)
Published in Scientific reports (29.08.2017)
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Journal Article
Sugar causes obesity and metabolic syndrome in mice independently of sweet taste
Andres-Hernando, Ana, Kuwabara, Masanari, Orlicky, David J, Vandenbeuch, Aurelie, Cicerchi, Christina, Kinnamon, Sue C, Finger, Thomas E, Johnson, Richard J, Lanaspa, Miguel A
Published in American journal of physiology: endocrinology and metabolism (01.08.2020)
Published in American journal of physiology: endocrinology and metabolism (01.08.2020)
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Journal Article
Expression of circadian regulatory genes is dysregulated by increased cytokine production in mice subjected to concomitant intestinal injury and parenteral nutrition
Shearn, Colin T, Anderson, Aimee L, Devereaux, Michael W, El Kasmi, Karim C, Orlicky, David J, Sokol, Ronald J
Published in PloS one (30.08.2023)
Published in PloS one (30.08.2023)
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Journal Article
Triplication of the interferon receptor locus contributes to hallmarks of Down syndrome in a mouse model
Waugh, Katherine A., Minter, Ross, Baxter, Jessica, Chi, Congwu, Galbraith, Matthew D., Tuttle, Kathryn D., Eduthan, Neetha P., Kinning, Kohl T., Andrysik, Zdenek, Araya, Paula, Dougherty, Hannah, Dunn, Lauren N., Ludwig, Michael, Schade, Kyndal A., Tracy, Dayna, Smith, Keith P., Granrath, Ross E., Busquet, Nicolas, Khanal, Santosh, Anderson, Ryan D., Cox, Liza L., Estrada, Belinda Enriquez, Rachubinski, Angela L., Lyford, Hannah R., Britton, Eleanor C., Fantauzzo, Katherine A., Orlicky, David J., Matsuda, Jennifer L., Song, Kunhua, Cox, Timothy C., Sullivan, Kelly D., Espinosa, Joaquin M.
Published in Nature genetics (01.06.2023)
Published in Nature genetics (01.06.2023)
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